Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01019

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
33	unknown peptidase	1-485	P	release of a signal peptide	NT	Arakawa et al., 1968
34	aminopeptidase A	34-41	N		NT	Goto et al., 2007
34	endoplasmic reticulum aminopeptidase 1	34-41	N			Schomburg, 2004
34	aspartyl aminopeptidase	34-41	N			Kelly et al., 1983
34	BcepAP aminopeptidase (Burkholderia cepacia)	34-43	N			Jamdar 2009
34	aminopeptidase X	34-43	P			Sim & Lim, 1997
34	serine carboxypeptidase Z (Absidia zachae) and similar	34-35	N		AA	Lee et al., 1993
35	arginine aminopeptidase (Streptococcus-type)	35-41	N			Goldstein et al., 2002
35	aminopeptidase A	35-41	N		NT	Goto et al., 2007
35	cystinyl aminopeptidase	35-41	N			Keller, 1998
35	endoplasmic reticulum aminopeptidase 1	35-41	N			Schomburg, 2004
35	ERAP2 aminopeptidase	35-41	N			Tanioka et al., 2003
35	aminopeptidase Q	35-41	N			Maruyama et al., 2007
35	aminopeptidase O	35-41	N			Díaz-Perales et al., 2005
35	neprilysin	34-41	P		LC	Stewart et al., 1981
35	dipeptidyl-peptidase III	34-41	N			Chen & Barrett, 2004
35	aminopeptidase AMZ2	35-41	N			Diaz-Perales et al., 2005
35	oligopeptidase B	34-43	N			Mäkinen et al., 1995
35	serine carboxypeptidase Z (Absidia zachae) and similar	34-36	N		AA	Lee et al., 1993
35	family S10 unassigned peptidases	34-36	N		NT	Umetsu et al., 1998
36	cystinyl aminopeptidase	36-41	N			Keller, 1998
36	endoplasmic reticulum aminopeptidase 1	36-41	N			Schomburg, 2004
36	ERAP2 aminopeptidase	36-41	N		MS	Tanioka et al., 2003
36	neprilysin	34-41	P		LC	Stewart et al., 1981
36	endothelin-converting enzyme 1	34-43	N			Carson et al., 2002
36	dipeptidyl-peptidase III	35-38	N			McDonald, 1998
36	elastase-2	34-41	P			Ramaha & Patson, 2002
36	serine carboxypeptidase Z (Absidia zachae) and similar	34-37	N		AA	Lee et al., 1993
36	family S10 unassigned peptidases	34-37	N		NT	Umetsu et al., 1998
36	tripeptidyl-peptidase I	34-43	P	normal turnover	MS	Du et al., 2001
37	aspergillopepsin I	34-41	N			Ichishima, 2004
37	pycnoporopepsin	34-43	N			Ichishima, 2004
37	aspergilloglutamic peptidase	34-43	N			O'Donoghue et al., 2008
37	endoplasmic reticulum aminopeptidase 1	37-41	N			Schomburg, 2004
37	ERAP2 aminopeptidase	37-41	N		MS	Tanioka et al., 2003
37	thimet oligopeptidase	34-41	P		NT	Dando et al., 1993
37	coccolysin	34-41	N			Makinen & Makinen, 2004
37	vimelysin	34-43	N			Oda, 2004
37	neprilysin	34-43	P		LC	Stewart et al., 1981
37	endothelin-converting enzyme 1	34-43	N			Carson et al., 2002
37	neprilysin-2	34-43	N		NT	Rose et al., 2002
37	Zmp1 peptidase (Mycobacterium-type)	34-43	N			Carson et al., 2002
37	eupitrilysin	34-43	N			Chow et al., 2009
37	dipeptidyl-peptidase III	36-41	N			Chen & Barrett, 2004
37	dactylysin	34-41	N			Clamagirand et al., 2004
37	cathepsin G	34-43	P		MS	Raymond et al., 2010
37	chymase (Homo sapiens-type)	34-43	P			Raymond et al., 2003
37	duodenase	34-43	N		NT	Pemberton et al., 1997
37	mast cell peptidase 4 (mouse numbering)	34-43	P			Caughey et al., 2000
37	unknown peptidase	34-41	N		MS	Siigur et al., 2011
37	harobin	34-43	N			He et al., 2007
37	tripeptidyl-peptidase II	35-41	N			Wilson &etal, 1993
37	serine carboxypeptidase Z (Absidia zachae) and similar	34-38	N		AA	Lee et al., 1993
37	family S10 unassigned peptidases	34-38	N		NT	Umetsu et al., 1998
37	sedolisin	34-43	N
37	tripeptidyl-peptidase I	35-41	N			McDonald, 1998
38	endoplasmic reticulum aminopeptidase 1	38-41	N			Schomburg, 2004
38	ERAP2 aminopeptidase	38-41	N		MS	Tanioka et al., 2003
38	dipeptidyl-peptidase III	37-41	N			McDonald, 1998
38	dentilisin	34-43	N			Mäkinen et al., 1995
38	serine carboxypeptidase Z (Absidia zachae) and similar	34-39	N		AA	Lee et al., 1993
38	family S10 unassigned peptidases	34-39	N		NT	Umetsu et al., 1998
38	unknown peptidase	34-40	P		NT	Deddish et al., 1998
39	aspergillopepsin I	34-43	P	normal turnover		Ichishima, 2004
39	cathepsin B	34-41	N			Takahashi et al., 1986
39	scytalidoglutamic peptidase	34-43	P			Oda, 2004
39	ruberlysin	34-43	N			Tu, 2004
39	serine carboxypeptidase Z (Absidia zachae) and similar	34-40	N		AA	Lee et al., 1993
39	family S10 unassigned peptidases	34-40	N		NT	Umetsu et al., 1998
40	angiotensin-converting enzyme-2	34-41	P		MS	Vickers et al., 2002
40	thimet oligopeptidase	34-43	P		NT	Dando et al., 1993
40	tropolysin	34-43	N			Morty et al., 2005
40	coccolysin	34-43	N			Makinen & Makinen, 2004
40	vimelysin	34-43	N			Oda, 2004
40	matrix metallopeptidase-8	34-43	P		NT	Diekmann & Tschesche, 1994
40	BHRa hemorrhagin (Bitis arietans)	34-43	N			Yamakawa, 2004
40	bothrolysin	34-43	N			Tanizaki, 2004
40	ruberlysin	34-43	N			Tu, 2004
40	hemorrhagic metallopeptidase b (Trimeresurus mucrosquamatus)	34-43	N			Komori & Nikai, 2004
40	acutolysin C	34-43	N			Komori & Nikai, 2004
40	BHRb haemorrhagin (Bitis arietans)	34-43	N			Yamakawa, 2004
40	neprilysin	34-43	P		LC	Stewart et al., 1981
40	endothelin-converting enzyme 1	34-43	N			Carson et al., 2002
40	endothelin-converting enzyme 2	34-43	P		MS	Mzhavia et al., 2003
40	neprilysin-2	34-43	N		NT	Rose et al., 2002
40	Zmp1 peptidase (Mycobacterium-type)	34-43	N			Carson et al., 2002
40	eupitrilysin	34-43	N			Chow et al., 2009
40	membrane Pro-Xaa carboxypeptidase	34-41	N			Hiraoka, 2004
40	prolyl oligopeptidase	34-41	N			Koida & Walter, 1976
40	oligopeptidase B	34-43	P			Morty et al., 2005
40	serine carboxypeptidase Z (Absidia zachae) and similar	34-41	N		AA	Lee et al., 1993
40	family S10 unassigned peptidases	34-41	N		NT	Umetsu et al., 1998
40	lysosomal Pro-Xaa carboxypeptidase	35-41	N			Tan & Erdos, 2004
40	tripeptidyl-peptidase I	37-41	N			Vines & Warburton, 1998
41	cathepsin B	34-43	N			Takahashi et al., 1986
41	peptidyl-dipeptidase Ance	34-43	N			Wijffels et al., 1996
41	peptidyl-dipeptidase A (Theromyzon-type)	34-43	P			Laurent & Salzet, 1996
41	peptidyl-dipeptidase A (Crassostrea-type)	34-43	N			Riviere et al., 2011
41	peptidyl-dipeptidase Dcp	34-43	N			Cunha et al., 2009
41	matrix metallopeptidase-8	34-43	P		NT	Diekmann & Tschesche, 1994
41	carboxypeptidase A6	35-43	N		MS	Lyons et al., 2008
41	vascular chymase (Rattus norvegicus)	34-43	P		NT	Guo et al., 2001
41	elastase-2	34-43	N			Ramaha & Patson, 2002
41	cathepsin G	34-43	N			Ramaha & Patson, 2002
41	myeloblastin	34-43	N			Ramaha & Patson, 2002
41	chymase (Homo sapiens-type)	34-43	P			Caughey et al., 2000
41	duodenase	34-43	N		NT	Pemberton et al., 1997
41	pancreatic elastase II	34-43	P	release of a bioactive peptide	NT	Becari et al., 2005
41	kallikrein 1-related peptidase c2 (Rattus norvegicus)	34-43	N			Chao, 2004
41	harobin	34-43	N			He et al., 2007
41	dentilisin	34-43	N			Mäkinen et al., 1995
41	serine carboxypeptidase Z (Absidia zachae) and similar	34-42	N		AA	Lee et al., 1993
41	family S10 unassigned peptidases	34-42	N		NT	Umetsu et al., 1998
41	unknown peptidase	34-43	N			Corvol et al., 2004
42	pycnoporopepsin	34-43	N			Ichishima, 2004
42	angiotensin-converting enzyme-2	34-43	P		MS	Vickers et al., 2002
42	hemorrhagic metallopeptidase a (Trimeresurus mucrosquamatus)	34-43	N			Komori & Nikai, 2004
42	carboxypeptidase A3	34-43	N
42	carboxypeptidase A4	35-43	N			Tanco et al., 2010
42	carboxypeptidase A6	35-43	N		MS	Lyons et al., 2008
42	serine carboxypeptidase A	34-43	P		LC	Herbert et al., 1990
42	serine carboxypeptidase Z (Absidia zachae) and similar	34-43	N		AA	Lee et al., 1993
42	family S10 unassigned peptidases	34-43	N		NT	Umetsu et al., 1998
43	renin	34-46	N			<%Hatae et al., 1994[]%>
43	renin-2	34-485	N		AB	<%Hatae et al., 1994[]%>
43	harobin	34-43	N			He et al., 2007
44	elastase-2	34-485	P			Ramaha & Patson, 2002
44	myeloblastin	34-485	P			Ramaha & Patson, 2002