Substrates for peptidase M04.010: vimelysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
angiotensin-1 P01019 34-43 Asp-Arg-Val-Tyr-Ile-His-Pro+Phe-His-Leu N Tyr Ile His Pro Phe His Leu - Oda, 2004 16479
angiotensin-1 P01019 34-43 Asp-Arg-Val-Tyr+Ile-His-Pro-Phe-His-Leu N Ala Arg Val Tyr Ile His Pro Phe Oda, 2004
furylacryloyl-Gly-Leu-NH2 furylacryloyl-Gly+Leu-NH2 S - - FA Gly Leu NH2 - - Oda, 2004
furylacryloyl-Gly-Phe-NH2 furylacryloyl-Gly+Phe-NH2 S - - FA Gly Phe NH2 - - Oda, 2004
furylacryloyl-Phe-Leu-NH2 furylacryloyl-Phe+Leu-NH2 S - - FA Phe Leu NH2 - - Oda, 2004
furylacryloyl-Phe-Phe-NH2 furylacryloyl-Phe+Phe-NH2 S - - FA Phe Phe NH2 - - Oda, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Oda, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His+Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Asn Gln His Leu Cya Gly Ser Oda, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly+Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Gly Glu Arg Gly Phe Phe Tyr Thr Oda, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Oda, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala N Glu Arg Gly Phe Phe Tyr Thr Pro Oda, 2004
QF-24 Mca-Pro-Leu-Gly+Leu-Dpa-Ala-Arg-NH2 S Mca Pro Leu Gly Leu Dpa Ala Arg Oda, 2004