Substrates for peptidase M18.002: aspartyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
adrenocorticotrophin (5-10)	P01189	142-147	Glu1+His-peptide	N	-	-	-	Glu	His	Phe	Arg	Trp	Kelly et al., 1983
angiotensin-2	P01019	34-41	Asp+Arg-Val-Tyr-Ile-His-Pro-Phe	N	-	-	-	Asp	Arg	Val	Tyr	Ile	Kelly et al., 1983	17055
Asp-Ala			Asp+Ala	N	-	-	-	Asp	Ala	-	-	-	Kelly et al., 1983
Asp-Ala-Pro-NHNap			Asp+Ala-Pro-NHNap	S	-	-	-	Asp	Ala	Pro	NAP	-	Wilk et al., 1998
Asp-His			Asp+His	N	-	-	-	Asp	His	-	-	-	Kelly et al., 1983
Asp-Leu			Asp-Leu	N	-	-	-	Asp	Leu	-	-	-	Kelly et al., 1983
Asp-NHMec			Asp+NHMec	N	-	-	-	Asp	AMC	-	-	-
Asp-Phe			Asp+Phe	N	-	-	-	Asp	Phe	-	-	-	Kelly et al., 1983
Asp-Ser			Asp+Ser	N	-	-	-	Asp	Ser	-	-	-	Kelly et al., 1983
Glu-NHMec			Glu+NHMec	N	-	-	-	Glu	AMC	-	-	-