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Substrates for peptidase G01.002: aspergilloglutamic peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
alpha5 peptide Pro-Leu-Glu+Thr-Leu-Met-Ala-Lys-Ala-Ile-Asp-Ala-Gly-Phe-Ile-Arg N - Pro Leu Glu Thr Leu Met Ala O'Donoghue et al., 2008
alpha5 peptide Pro-Leu-Glu-Thr-Leu-Met+Ala-Lys-Ala-Ile-Asp-Ala-Gly-Phe-Ile-Arg N Glu Thr Leu Met Ala Lys Ala Ile O'Donoghue et al., 2008
AN1 peptide Ser-Pro-Val-Tyr+Leu-Lys-Ala-Ser-Gln-Phe-Pro-Ala-Gly-Ile-Gln-Ala N Ser Pro Val Tyr Leu Lys Ala Ser O'Donoghue et al., 2008
AN1 peptide Ser-Pro-Val-Tyr-Leu+Lys-Ala-Ser-Gln-Phe-Pro-Ala-Gly-Ile-Gln-Ala N Pro Val Tyr Leu Lys Ala Ser Gln O'Donoghue et al., 2008
AN1 peptide Ser-Pro-Val-Tyr-Leu-Lys+Ala-Ser-Gln-Phe-Pro-Ala-Gly-Ile-Gln-Ala N Val Tyr Leu Lys Ala Ser Gln Phe O'Donoghue et al., 2008
angiotensin-1 P01019 34-43 peptide-Tyr37+Ile-peptide N Asp Arg Val Tyr Ile His Pro Phe O'Donoghue et al., 2008
Angiotensinogen 1-14 Asp-Arg-Val-Tyr+Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser N Asp Arg Val Tyr Ile His Pro Phe O'Donoghue et al., 2008
Angiotensinogen 1-14 Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His+Leu-Leu-Val-Tyr-Ser N His Pro Phe His Leu Leu Val Tyr O'Donoghue et al., 2008
aspergilloglutamic peptidase precursor P24665 19-282 peptide-Glu30+Ala-peptide P Ala Arg Lys Glu Ala Arg Ala Ala Huang et al., 2007
aspergilloglutamic peptidase precursor P24665 19-282 peptide-Asn55+Gly-peptide P Leu Lys Leu Asn Gly Thr Thr Asn Huang et al., 2007
aspergilloglutamic peptidase precursor P24665 19-282 peptide-Asn59+Glu-peptide P Gly Thr Thr Asn Glu Glu Tyr Ser Huang et al., 2007
aspergilloglutamic peptidase precursor P24665 19-282 peptide-Lys106+Asn-peptide P Gly Tyr Trp Lys Asn Lys Arg Gln Huang et al., 2007
bombesin P84214 1-14 peptide-Leu4+Gly-peptide N Glp Gln Arg Leu Gly Asn Gln Trp O'Donoghue et al., 2008
corticotropin-lipotropin P01189 138-161 peptide-Met141+Glu-peptide N Ser Tyr Ser Met Glu His Phe Arg O'Donoghue et al., 2008
corticotropin-lipotropin P01189 138-161 peptide-Val150+Gly-peptide N Gly Lys Pro Val Gly Lys Lys Arg O'Donoghue et al., 2008
corticotropin-lipotropin P01189 138-161 peptide-Lys153+Arg-peptide N Val Gly Lys Lys Arg Arg Pro Val O'Donoghue et al., 2008
corticotropin-lipotropin P01189 138-161 peptide-Arg154+Arg-peptide N Gly Lys Lys Arg Arg Pro Val Lys O'Donoghue et al., 2008
corticotropin-lipotropin P01189 155-176 peptide-Asp166+Glu-peptide N Gly Ala Glu Asp Glu Ser Ala Glu O'Donoghue et al., 2008
corticotropin-lipotropin P01189 155-176 peptide-Glu167+Ser-peptide N Ala Glu Asp Glu Ser Ala Glu Ala O'Donoghue et al., 2008
corticotropin-lipotropin P01189 155-176 peptide-Phe172+Pro-peptide N Ala Glu Ala Phe Pro Leu Glu Phe O'Donoghue et al., 2008
DG1 peptide Ser-Ile-Thr-Ser-Ala-Val-Leu-Gln+Ser-Gly-Phe-Arg-Lys-Met-Ala N Ala Val Leu Gln Ser Gly Phe Arg O'Donoghue et al., 2008
ELH P01362 150-158 peptide-Tyr156+Ser-peptide N Leu Arg Phe Tyr Ser Leu Arg Lys O'Donoghue et al., 2008
glutamic protease eqolisin Q8X1C6 52-59 peptide-Gln56+Val-peptide P Leu Gly Lys Gln Val Glu Tyr Ser O'Donoghue et al., 2008
glycopeptide IIb 656-667 Gly-Ala-His-Tyr-Met+Arg-Ala-Leu-Ser-Asn-Val-Glu N Ala His Tyr Met Arg Ala Leu Ser O'Donoghue et al., 2008
glycopeptide IIb 656-667 Gly-Ala-His-Tyr-Met-Arg-Ala-Leu+Ser-Asn-Val-Glu N Met Arg Ala Leu Ser Asn Val Glu O'Donoghue et al., 2008
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn+Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N - Phe Val Asn Gln His Leu Cya Takahashi, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N His Leu Val Glu Ala Leu Tyr Leu Takahashi, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr+Thr-Pro-Lys-Ala N Gly Phe Phe Tyr Thr Pro Lys Ala Takahashi, 2004
protein kinase C substrate Pro-Leu-Ser+Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys N - Pro Leu Ser Arg Thr Leu Ser O'Donoghue et al., 2008
protein kinase C substrate Pro-Leu-Ser-Arg-Thr-Leu+Ser-Val-Ala-Ala-Lys-Lys N Ser Arg Thr Leu Ser Val Ala Ala O'Donoghue et al., 2008
ribonuclease pancreatic P61823 27-150 peptide-Phe34+Glu-peptide N Ala Ala Lys Phe Glu Arg Gln His Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Ala30+Ala-peptide N Lys Glu Thr Ala Ala Ala Lys Phe Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Glu35+Arg-peptide N Ala Lys Phe Glu Arg Gln His Met Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-His38+Met-peptide N Glu Arg Gln His Met Asp Ser Ser Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Lys57+Ser-peptide N Gln Met Met Lys Ser Arg Asn Leu Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Asn60+Leu-peptide N Lys Ser Arg Asn Leu Thr Lys Asp Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Asn70+Thr-peptide N Lys Pro Val Asn Thr Phe Val His Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Glu75+Ser-peptide N Phe Val His Glu Ser Leu Ala Asp Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Gln81+Ala-peptide N Ala Asp Val Gln Ala Val Cys Ser Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Asp79+Val-peptide N Ser Leu Ala Asp Val Gln Ala Val Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Asp40+Ser-peptide N Gln His Met Asp Ser Ser Thr Ser Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Gln100+Ser-peptide N Asn Cys Tyr Gln Ser Tyr Ser Thr Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Asn129+Lys-peptide N Thr Gln Ala Asn Lys His Ile Ile Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Phe146+Asp-peptide N Pro Val His Phe Asp Ala Ser Val Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-His131+Ile-peptide N Ala Asn Lys His Ile Ile Val Ala Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Tyr141+Val-peptide N Gly Asn Pro Tyr Val Pro Val His Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Gln127+Ala-peptide N Lys Thr Thr Gln Ala Asn Lys His Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-His145+Phe-peptide N Val Pro Val His Phe Asp Ala Ser Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Asp147+Ala-Ser-Val N NT Val His Phe Asp Ala Ser Val - Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Met105+Ser-peptide N NT Tyr Ser Thr Met Ser Ile Thr Asp Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Asp109+Cys-peptide N NT Ser Ile Thr Asp Cys Arg Glu Thr Takahashi, 1997
ribonuclease pancreatic P61823 27-150 peptide-Glu112+Thr-peptide N NT Asp Cys Arg Glu Thr Gly Ser Ser Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-His74+Glu-Peptide N AA Thr Phe Val His Glu Ser Leu Ala Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-Gln86+Lys-Peptide N AA Val Cys Ser Gln Lys Asn Val Ala Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-Asn88+Val-Peptide N AA Ser Gln Lys Asn Val Ala Cys Lys Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-Asn93+Gly-Peptide N AA Ala Cys Lys Asn Gly Gln Thr Asn Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-Tyr102+Ser-Peptide N AA Tyr Gln Ser Tyr Ser Thr Met Ser Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-Lys117+Tyr-Peptide N AA Gly Ser Ser Lys Tyr Pro Asn Cys Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-Tyr123+Lys-Peptide N AA Asn Cys Ala Tyr Lys Thr Thr Gln Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-Lys124+Thr-Peptide N AA Cys Ala Tyr Lys Thr Thr Gln Ala Takahashi, 1997
Ribonuclease pancreatic (oxidized) P61823 27-150 Peptide-Glu137+Gly-Peptide N AA Val Ala Cys Glu Gly Asn Pro Tyr Takahashi, 1997
substance P P20366 58-58 peptide-Phe65+Gly-peptide N Gln Gln Phe Phe Gly Leu Met - O'Donoghue et al., 2008
[Gln4]-neurotensin Glp-Leu-Tyr-Gln+Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu N Glu Leu Tyr Gln Asn Lys Pro Arg O'Donoghue et al., 2008
[Gln4]-neurotensin Glp-Leu-Tyr-Gln-Asn+Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu N Leu Tyr Gln Asn Lys Pro Arg Arg O'Donoghue et al., 2008
[Lys0]-somatostatin-14 P61278 102-116 peptide-Lys106+Asn-peptide N Ala Gly Cys Lys Asn Phe Phe Trp O'Donoghue et al., 2008
[Lys0]-somatostatin-14 P61278 102-116 peptide-Phe108+Phe-peptide N Cys Lys Asn Phe Phe Trp Lys Thr O'Donoghue et al., 2008
[Lys0]-somatostatin-14 P61278 102-116 peptide-Lys111+Thr-peptide N Phe Phe Trp Lys Thr Phe Thr Ser O'Donoghue et al., 2008
[Val5]-angiotensin-2 Asp-Arg-Val-Tyr+Val-His-Pro-Phe N Asp Arg Val Tyr Val His Pro Phe O'Donoghue et al., 2008

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