Substrates for peptidase M14.018: carboxypeptidase A6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Angiotensin-1	P01019	34-43	peptide-His42+Leu	P	MS	His	Pro	Phe	His	Leu	-	-	-	Lyons et al., 2008
Angiotensin-1	P01019	34-43	peptide-Phe41+His	P	MS	Ile	His	Pro	Phe	His	-	-	-	Lyons et al., 2008
Big SAAS	Q9QXV0	34-59	peptide-Arg58+Leu	P	MS	Thr	Pro	Leu	Arg	Leu	-	-	-	Lyons et al., 2008
Carboxypeptidase D, Isoform 5	P42787-5	1427-1439	peptide-Arg1438+His	P	MS	Asn	Lys	Arg	Arg	His	-	-	-	Lyons et al., 2008
Carboxypeptidase E	P16870	467-476	peptide-Asn475+Phe	N	MS	Glu	Thr	Leu	Asn	Phe	-	-	-	Lyons et al., 2008
cathepsin D	P18242	391-409	Tyr-Tyr-Thr-Val-Phe-Asp-Arg-Asp-Asn-Asn-Arg-Val-Gly-Phe-Ala-Asn-Ala-Val+Val	N		Ala	Asn	Ala	Val	Val	-	-	-	Lyons & Fricker, 2010
cholecystokinin	P09240	46-61	Ala-Val-Leu-Arg-Thr-Asp-Gly-Glu-Pro-Arg-Ala-Arg-Leu-Gly-Ala+Leu	N		Arg	Leu	Gly	Ala	Leu	-	-	-	Lyons & Fricker, 2010
cholecystokinin	P09240	46-62	Ala-Val-Leu-Arg-Thr-Asp-Gly-Glu-Pro-Arg-Ala-Arg-Leu-Gly-Ala-Leu+Leu	N		Leu	Gly	Ala	Leu	Leu	-	-	-	Lyons & Fricker, 2010
dynorphin A(10-17)	P01213	216-223	Pro-Lys-Leu-Lys-Trp-Asp-Asn+Gln	N		Lys	Trp	Asp	Asn	Gln	-	-	-	Lyons & Fricker, 2010
FA-Arg-Leu			FA-Arg+Leu	S		-	-	FA	Arg	Leu	-	-	-	Lyons & Fricker, 2010
FA-Phe-Ala			FA-Phe+Ala	S		-	-	FA	Phe	Ala	-	-	-	Lyons & Fricker, 2010
FA-Phe-His			FA-Phe+His	S		-	-	FA	Phe	His	-	-	-	Lyons & Fricker, 2010
FA-Phe-Ile			FA-Phe+Ile	S		-	-	FA	Phe	Ile	-	-	-	Lyons & Fricker, 2010
FA-Phe-Leu			FA-Phe+Leu	S		-	-	FA	Phe	Leu	-	-	-	Lyons & Fricker, 2010
FA-Phe-Met			FA-Phe+Met	S		-	-	FA	Phe	Met	-	-	-	Lyons & Fricker, 2010
FA-Phe-Phe			FA-Phe+Phe	S		-	-	FA	Phe	Phe	-	-	-	Lyons & Fricker, 2010
FA-Phe-Trp			FA-Phe+Trp	S		-	-	FA	Phe	Trp	-	-	-	Lyons & Fricker, 2010
FA-Phe-Tyr			FA-Phe+Tyr	S		-	-	FA	Phe	Tyr	-	-	-	Lyons & Fricker, 2010
FA-Phe-Val			FA-Phe+Val	S		-	-	FA	Phe	Val	-	-	-	Lyons & Fricker, 2010
Fructose-bisphosphate aldolase C	P05063	355-363	peptide-Ala362+Tyr	N	MS	Ala	Asn	His	Ala	Tyr	-	-	-	Lyons et al., 2008
Leu-enkephalin	P01210	230-234	Tyr-Gly-Gly-Phe+Leu	P		Tyr	Gly	Gly	Phe	Leu	-	-	-	Lyons & Fricker, 2010
Leu-enkephalin	P01213	175-179	Tyr-Gly-Gly-Phe178+Leu	P	MS	Tyr	Gly	Gly	Phe	Leu	-	-	-	Lyons et al., 2008
little SAAS	Q9QXV0	42-59	Ser-Leu-Ser-Ala-Ala-Ser-Ala-Pro-Leu-Val-Glu-Thr-Ser-Thr-Pro-Leu-Arg+Leu	N		Thr	Pro	Leu	Arg	Leu	-	-	-	Lyons & Fricker, 2010
macrophage migration inhibitory factor	P34884	28-48	Ala-Gln-Ala-Thr-Gly-Lys-Pro-Ala-Gln-Tyr-Ile-Ala-Val-His-Val-Val-Pro-Asp-Gln+Met-peptide	N		Pro	Asp	Gln	Leu	Met	-	-	-	Lyons & Fricker, 2010
Met-enkephalin	P01210	210-214	Tyr-Gly-Gly-Phe+Met	P	NT	Tyr	Gly	Gly	Phe	Met	-	-	-	Lyons & Fricker, 2010
Met-enkephalin	P01210	100-104	Tyr-Gly-Gly-Phe103+Met	P	MS	Tyr	Gly	Gly	Phe	Met	-	-	-	Lyons et al., 2008
Met-enkephalin-Arg-Phe	P01210	261-267	Tyr-Gly-Gly-Phe-Met-Arg+Phe	P	NT	Gly	Phe	Met	Arg	Phe	-	-	-	Lyons & Fricker, 2010
Met-enkephalin-Arg-Ser-Leu			Tyr-Gly-Gly-Phe-Met-Arg-Ser+Leu	N		Phe	Met	Arg	Ser	Leu	-	-	-	Lyons & Fricker, 2010
myelin basic protein	P04370	135-148	Ala-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu+Ala	N		Ser	Lys	Tyr	Leu	Ala	-	-	-	Lyons & Fricker, 2010
myelin basic protein	P04370	135-150	Ala-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-Ala-Thr+Ala	N		Tyr	Leu	Ala	Thr	Ala	-	-	-	Lyons & Fricker, 2010
Neurotensin	P30990	151-163	peptide-Ile162+Leu	P	MS	Arg	Pro	Tyr	Ile	Leu	-	-	-	Lyons et al., 2008
PEN	Q9QXV0	219-240	peptide-Arg239+Val	N		Ala	Leu	Leu	Arg	Val	-	-	-	Lyons & Fricker, 2010
peptidyl-prolyl cis-trans isomerase A	P62937	26-39	Ala-Asp-Lys-Val-Pro-Lys-Thr-Ala-Glu-Asn-Phe-Arg-Ala+Leu	N		Asn	Phe	Arg	Ala	Leu	-	-	-	Lyons & Fricker, 2010
proenkephalin-A	P01210	217-227	Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr+Gln	N		Trp	Met	Asp	Tyr	Gln	-	-	-	Lyons & Fricker, 2010
secretogranin-1	P16014	600-613	Gln-Tyr-Asp-Gly-Val-Ala-Glu-Leu-Asp-Gln-Leu-Leu-His+Tyr	N		Gln	Leu	Leu	His	Tyr	-	-	-	Lyons & Fricker, 2010
secretogranin-1	P16014	64-86	peptide-Leu85+Leu	N		Glu	Val	Arg	Leu	Leu	-	-	-	Lyons & Fricker, 2010
secretogranin-1	P16014	438-446	Leu-Leu-Asp-Glu-Gly-His-Tyr-Pro+Val	N		Gly	His	Tyr	Pro	Val	-	-	-	Lyons & Fricker, 2010
secretogranin-1	P16014	438-454	Leu-Leu-Asp-Glu-Gly-His-Tyr-Pro-Val-Arg-Glu-Ser-Pro-Ile-Asp-Thr+Ala	N		Pro	Ile	Asp	Thr	Ala	-	-	-	Lyons & Fricker, 2010
secretogranin-2	Q03517	300-316	Glu-Ser-Lys-Asp-Gln-Leu-Ser-Glu-Asp-Ala-Ser-Lys-Val-Ile-Thr-Tyr+Leu	N		Val	Ile	Thr	Tyr	Leu	-	-	-	Lyons & Fricker, 2010
thioredoxin	P11232	2-15	Val-Lys-Leu-Ile-Glu-Ser-Lys-Glu-Ala-Phe-Gln-Glu-Ala+Leu	N		Phe	Gln	Glu	Ala	Leu	-	-	-	Lyons & Fricker, 2010
[Des-Asp1] Angiotensin-1	P01019	35-43	peptide-His42+Leu	N	MS	His	Pro	Phe	His	Leu	-	-	-	Lyons et al., 2008
[Des-Asp1] Angiotensin-1	P01019	35-43	peptide-Phe41+His	N	MS	Ile	His	Pro	Phe	His	-	-	-	Lyons et al., 2008