Substrates for peptidase S53.001: sedolisin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ala-Pro-Ala-Lys-Phe-Nph-Arg-Leu			Ala-Pro-Ala-Lys-Phe+Nph-Arg-Leu	S	Pro	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
angiotensin-1	P01019	34-43	Asp-Arg-Val-Tyr+Ile-His-Pro-Phe-His-Leu	N	Asp	Arg	Val	Tyr	Ile	His	Pro	Phe		17769
Arg-Pro-Ala-Lys-Phe-Nph-Arg-Leu			Arg-Pro-Ala-Lys-Phe+Nph-Arg-Leu	S	Pro	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Asp-Pro-Ala-Lys-Phe-Nph-Arg-Leu			Asp-Pro-Ala-Lys-Phe+Nph-Arg-Leu	S	Pro	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	His	Leu	Val	Glu	Ala	Leu	Tyr	Leu
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Val	Glu	Ala	Leu	Tyr	Leu	Val	Cya
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala	N	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Lys
Leu-Pro-Ala-Lys-Phe-Nph-Arg-Leu			Leu-Pro-Ala-Lys-Phe+Nph-Arg-Leu	S	Pro	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Ala-Ala-Lys-Phe-Nph-Arg-Leu			Lys-Ala-Ala-Lys-Phe+Nph-Arg-Leu	S	Ala	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Arg-Ala-Lys-Phe-Nph-Arg-Leu			Lys-Arg-Ala-Lys-Phe+Nph-Arg-Leu	S	Arg	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Asp-Ala-Lys-Phe-Nph-Arg-Leu			Lys-Asp-Ala-Lys-Phe+Nph-Arg-Leu	S	Asp	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Leu-Ala-Lys-Phe-Nph-Arg-Leu			Lys-Leu-Ala-Lys-Phe+Nph-Arg-Leu	S	Leu	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Pro-Ala-Asp-Phe-Nph-Arg-Leu			Lys-Pro-Ala-Asp-Phe+Nph-Arg-Leu	S	Pro	Ala	Asp	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Pro-Ala-Leu-Phe-Nph-Arg-Leu			Lys-Pro-Ala-Leu-Phe+Nph-Arg-Leu	S	Pro	Ala	Leu	Phe	Nph	Arg	Leu	-	Murao, 1998
Lys-Pro-Ala-Leu-Phe-Nph-Asp-Leu			Lys-Pro-Ala-Leu-Phe+Nph-Asp-Leu	S	Pro	Ala	Leu	Phe	Nph	Asp	Leu	-	Murao, 1998
Lys-Pro-Ala-Lys-Phe-Nph-Arg-Leu			Lys-Pro-Ala-Lys-Phe+Nph-Arg-Leu	S	Pro	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Pro-Asn-Gln-Phe-Nph-Arg-Leu			Lys-Pro-Asn-Gln-Phe+Nph-Arg-Leu	S	Pro	Asn	Gln	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Pro-Ile-Glu-Phe-Nph-Arg-Leu			Lys-Pro-Ile-Glu-Phe+Nph-Arg-Leu	S	Pro	Ile	Glu	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Pro-Val-Ser-Tyr-Nph-Arg-Leu			Lys-Pro-Val-Ser-Tyr+Nph-Arg-Leu	S	Pro	Val	Ser	Tyr	Nph	Arg	Leu	-	Oda et al., 1992
Lys-Ser-Ala-Lys-Phe-Nph-Arg-Leu			Lys-Ser-Ala-Lys-Phe+Nph-Arg-Leu	S	Ser	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Ser-Pro-Ala-Lys-Phe-Nph-Arg-Leu			Ser-Pro-Ala-Lys-Phe+Nph-Arg-Leu	S	Pro	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992
Ser-Pro-Ala-Lys-Phe-Nph-Arg-Leu			Ser-Pro-Ala-Lys-Phe+Nph-Arg-Leu	S	Pro	Ala	Lys	Phe	Nph	Arg	Leu	-	Oda et al., 1992