Substrates for peptidase A01.008: renin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
angiotensinogen	P11859	25-477	peptide-Leu10+Leu-peptide	P		Pro	Phe	His	Leu	Leu	Tyr	His	Asn	Suzuki et al., 2004	15759
Angiotensinogen	P01019	34-485	Peptide-Leu43+Val-Peptide	N	AB	Pro	Phe	His	Leu	Val	Ile	His	Asn	Hatae et al., 1994
renin substrate tridecapeptide (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His)	P01019	34-46	Peptide-Leu43+Val-Ile-His	N		Pro	Phe	His	Leu	Val	Ile	His	-	Hatae et al., 1994