Substrates for peptidase S10.002: serine carboxypeptidase A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
angiotensin-3	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His+Leu	P	LC	His	Pro	Phe	His	Leu	-	-	-	Herbert et al., 1990
Bz-Tyr-OEt			Bz-Tyr+OEt	S		-	-	Bz	Tyr	OEt	-	-	-	Pshezhetsky, 2004
dansyl-D-Tyr-Val-NH2			dansyl-D-Tyr-Val+NH2	S		-	Dns	DTy	Val	NH2	-	-	-	Pshezhetsky, 2004
furylacryloyl-Phe-Phe			furylacryloyl-Phe+Phe	S		-	-	FA	Phe	Phe	-	-	-	Pshezhetsky, 2004
lysosome-associated membrane glycoprotein 2	P13473	29-410	peptide-Phe375+Leu	P		Asp	Asp	Asn	Phe	Leu	-	-	-	Cuervo et al., 2003	3633
lysosome-associated membrane glycoprotein 2 precursor	P13473	1-410	peptide-Phe375+Leu-peptide	P		Asp	Asp	Asn	Phe	Leu	Val	Pro	Ile	Cuervo et al., 2002	20359
Z-Glu-Tyr			Z-Glu+Tyr	S		-	-	Z	Glu	Tyr	-	-	-	Pshezhetsky, 2004
Z-Phe-Ala			Z-Phe+Ala	S		-	-	Z	Phe	Ala	-	-	-	Pshezhetsky, 2004
Z-Phe-Leu			Z-Phe+Leu	S		-	-	Z	Phe	Leu	-	-	-	Pshezhetsky, 2004
Z-Phe-Phe			Z-Phe+Phe	S		-	-	Z	Phe	Phe	-	-	-	Pshezhetsky, 2004