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Substrates for peptidase S01.134: myeloblastin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
ABZ-Tyr-Tyr-Abu-ANB-Arg-NH2 ABZ-Tyr-Tyr-Abu+ANB-Arg-NH2 S Abz Tyr Tyr Abu ANB Arg NH2 - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-Asn-NH2 ABZ-Tyr-Tyr-Abu+ANB-Asn-NH2 S Abz Tyr Tyr Abu ANB Asn NH2 - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-Asp-NH2 ABZ-Tyr-Tyr-Abu+ANB-Asp-NH2 S Abz Tyr Tyr Abu ANB Asp NH2 - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-Gln-NH2 ABZ-Tyr-Tyr-Abu+ANB-Gln-NH2 S Abz Tyr Tyr Abu ANB Gln NH2 - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-Glu-NH2 ABZ-Tyr-Tyr-Abu+ANB-Glu-NH2 S Abz Tyr Tyr Abu ANB Glu NH2 - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-His-NH2 ABZ-Tyr-Tyr-Abu+ANB-His-NH2 S Abz Tyr Tyr Abu ANB His NH2 - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-Lys-NH2 ABZ-Tyr-Tyr-Abu+ANB-Lys-NH2 S Abz Tyr Tyr Abu ANB Lys NH2 - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-NH2 ABZ-Tyr-Tyr-Abu+ANB-NH2 S Abz Tyr Tyr Abu ANB NH2 - - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-Ser-NH2 ABZ-Tyr-Tyr-Abu+ANB-Ser-NH2 S Abz Tyr Tyr Abu ANB Ser NH2 - Magdalena et al., 2010
ABZ-Tyr-Tyr-Abu-ANB-Thr-NH2 ABZ-Tyr-Tyr-Abu+ANB-Thr-NH2 S Abz Tyr Tyr Abu ANB Thr NH2 - Magdalena et al., 2010
angiotensin-1 P01019 34-43 Asp-Arg-Val-Tyr-Ile-His-Pro-Phe+His-Leu N Ile His Pro Phe His Leu - - Ramaha & Patson, 2002
angiotensinogen P01019 34-485 peptide-Val44+Ile-peptide P Phe His Leu Val Ile His Asn Glu Ramaha & Patson, 2002
Boc-Ala-OPhNO2 Boc-Ala+OPhNO2 S - - Boc Ala ONA - - - Rao & Hoidal, 2004
Boc-Ala-Pro-Nva-SBzl Boc-Ala-Pro-Nva+SBzl S Boc Ala Pro Nva SBz - - - Rao & Hoidal, 2004
C-C motif chemokine 3 P10147 24-92 peptide-Thr38+Ser-peptide P MS Phe Ser Tyr Thr Ser Arg Gln Ile Ryu et al., 2005
C-C motif chemokine 3 P10147 24-92 peptide-Ser39+Arg-peptide P MS Ser Tyr Thr Ser Arg Gln Ile Pro Ryu et al., 2005
C-C motif chemokine 3 P10147 24-92 peptide-Thr53+Ser-peptide P MS Tyr Phe Glu Thr Ser Ser Gln Cys Ryu et al., 2005
C-C motif chemokine 3-like 1 P16619 24-93 peptide-Cys35+Phe-peptide P MS Thr Ala Cys Cys Phe Ser Tyr Thr Ryu et al., 2005
C-C motif chemokine 3-like 1 P16619 24-93 peptide-Thr39+Ser-peptide P MS Phe Ser Tyr Thr Ser Arg Gln Ile Ryu et al., 2005
C-C motif chemokine 3-like 1 P16619 24-93 peptide-Ser40+Arg-peptide P MS Ser Tyr Thr Ser Arg Gln Ile Pro Ryu et al., 2005
cathelicidin antimicrobial peptide P49913 31-170 peptide-Ala133+Leu-peptide P Lys Arg Phe Ala Leu Leu Gly Asp Sorensen et al., 2001 19378
cyclin-dependent kinase inhibitor 1 P38936 2-164 peptide-Thr80+Gly-peptide P Tyr Leu Pro Thr Gly Pro Arg Arg Pendergraft et al., 2004 19510
Endothelial protein C receptor Q9UNN8 18-238 peptide-Lys192+His-peptide P MS Tyr Val Gln Lys His Ile Ser Ala Villegas-Mendez et al., 2007
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val+Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Ser His Leu Val Glu Ala Leu Tyr Wiesner et al., 2005
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Wiesner et al., 2005
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu+Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Ala Leu Tyr Leu Val Cya Gly Glu Wiesner et al., 2005
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val+Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Tyr Leu Val Cya Gly Glu Arg Wiesner et al., 2005
interleukin-32 P24001 31-234 peptide-Thr103+Val-peptide P Tyr Leu Glu Thr Val Ala Ala Tyr Novick et al., 2006
leukocyte elastase inhibitor P30740 1-379 peptide-Cys344+Met-peptide P Ala Thr Phe Cys Met Leu Met Pro Cooley et al., 2001 20492
Mca-Phe-Val-Thr-Gnf-Ser-Trp-ANB-NH2 Mca-Phe-Val+Thr-Gnf-Ser-Trp-ANB-NH2 S - Mca Phe Val Thr Gnf Ser Trp Lesner et al., 2008
MeOSuc-Ala-Ala-Pro-Val-NHPhNO2 MeOSuc-Ala-Ala-Pro-Val+NHPhNO2 S Ala Ala Pro Val NAN - - - Rao & Hoidal, 2004
MeOSuc-Lys(2-picolinoyl)-Ala-Pro-Val-NHPhNO2 MeOSuc-Lys(2-picolinoyl)-Ala-Pro-Val+NHPhNO2 S Lyp Ala Pro Val NAN - - - Rao & Hoidal, 2004
proteinase-activated receptor 1 P25116 27-425 peptide-Ala36+Thr-peptide P Ala Thr Asn Ala Thr Leu Asp Pro Loew et al., 2000 26204
proteinase-activated receptor 1 P25116 27-425 peptide-Pro48+Asn-peptide P Leu Arg Asn Pro Asn Asp Lys Tyr Loew et al., 2000 26205
proteinase-activated receptor 1 P25116 27-425 peptide-Val72+Ser-peptide P Tyr Arg Leu Val Ser Ile Asn Lys Loew et al., 2000 19005
proteinase-activated receptor 1 P25116 27-425 peptide-Ala92+Ser-peptide P Ser Glu Asp Ala Ser Gly Tyr Leu Loew et al., 2000 26206
proteinase-activated receptor 1 P25116 27-425 peptide-Pro54+Phe-peptide P Lys Tyr Glu Pro Phe Trp Glu Asp Loew et al., 2000 26207
proteinase-activated receptor 2 P55085 26-397 peptide-Val48+Thr-peptide P Thr Ser His Val Thr Gly Lys Gly Loew et al., 2000 3570
proteinase-activated receptor 2 P55085 26-397 peptide-Thr74+Thr-peptide P Gly Lys Leu Thr Thr Val Phe Leu Loew et al., 2000 3571
proteinase-activated receptor 2 P55085 26-397 peptide-Thr75+Val-peptide P Lys Leu Thr Thr Val Phe Leu Pro Loew et al., 2000 3572
proteinase-activated receptor 2 P55085 26-397 peptide-Val76+Phe-peptide P Leu Thr Thr Val Phe Leu Pro Ile Loew et al., 2000 3573
proteinase-activated receptor 2 P55085 26-397 peptide-Val55+Glu-peptide P Gly Val Thr Val Glu Thr Val Phe Loew et al., 2000 26208
proteinase-activated receptor 2 P55085 26-397 peptide-Thr57+Val-peptide P Thr Val Glu Thr Val Phe Ser Val Loew et al., 2000 26209
proteinase-activated receptor 2 P55085 26-397 peptide-Val61+Asp-peptide P Val Phe Ser Val Asp Glu Phe Ser Loew et al., 2000 26210
proteinase-activated receptor 2 P55085 26-397 peptide-Asp62+Glu-peptide P Phe Ser Val Asp Glu Phe Ser Ala Loew et al., 2000 26211
proteinase-activated receptor 2 P55085 26-397 peptide-Lys72+Leu-peptide P Leu Thr Gly Lys Leu Thr Thr Val Loew et al., 2000 26212
Proteinase-activated receptor 2 P55085 26-397 Peptide-Arg36+Ser-Peptide P MS Ser Lys Gly Arg Ser Leu Ile Gly Uehara et al., 2002
Proteinase-activated receptor 2 P55085 26-397 Peptide-Lys34+Gly-Peptide P MS Arg Ser Ser Lys Gly Arg Ser Leu Uehara et al., 2002
Proteinase-activated receptor 2 P55085 26-397 Peptide-Lys41+Val-Peptide P MS Leu Ile Gly Lys Val Asp Gly Thr Uehara et al., 2002
spike glycoprotein P0DTC2 1-1273 peptide-Val687+Ala-peptide P NT Ala Arg Ser Val Ala Ser Gln Ser Mustafa et al., 2021
spike glycoprotein P0DTC2 1-1273 peptide-Ala688+Ser-peptide P NT Arg Ser Val Ala Ser Gln Ser Ile Mustafa et al., 2021
spike glycoprotein P59594 1-1255 peptide-Val663+Ser-peptide P NT Tyr His Thr Val Ser Leu Leu Arg Mustafa et al., 2021
transcription factor p65 Q04206 1-551 peptide-Cys95+Arg-peptide P Gly Lys Asp Cys Arg Asp Gly Phe Preston et al., 2002 19475
von Willebrand factor P04275 764-2813 Peptide-Val1607+Thr-Peptide P NT Val Tyr Met Val Thr Gly Asn Pro Raife et al., 2009
von Willebrand factor P04275 1596-1669 Peptide-Ala1612+Ser-Peptide N MS Gly Asn Pro Ala Ser Asp Glu Ile Lancellotti et al., 2011

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