Substrates for peptidase S08.090: tripeptidyl-peptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
(Gln)17-Arg-Arg-Gly-Arg-Arg			Gln-Gln-Gln+(Gln)14-Arg-Arg-Gly-Arg-Arg	N	-	Gln	Gln	Gln	Gln	Gln	Gln	Gln	Bhutani et al., 2007
(Gln)20-Arg-Arg-Gly-Arg-Arg			Gln-Gln-Gln+(Gln)17-Arg-Arg-Gly-Arg-Arg	N	-	Gln	Gln	Gln	Gln	Gln	Gln	Gln	Bhutani et al., 2007
Ala-Ala-Phe-NHMec			Ala-Ala-Phe+NHMec	S	-	Ala	Ala	Phe	AMC	-	-	-	Tomkinson, 2004
Ala-Ala-Phe-NHPhNO2			Ala-Ala-Phe+NHPhNO2	S	-	Ala	Ala	Phe	NAN	-	-	-	Tomkinson, 2004
angiotensin-3	P01019	35-41	Arg-Val-Tyr+Ile-His-Pro-Phe	N	-	Arg	Val	Tyr	Ile	His	Pro	Phe	Wilson &etal, 1993
Arg-Arg-Ala-Ser-Val-Ala			Arg-Arg-Ala+Ser-Val-Ala	N	-	Arg	Arg	Ala	Ser	Val	Ala	-	Tomkinson, 2004
cholecystokinin-8	P06307	96-103	Asp-Tyr-Met+Gly-Trp-Met-Asp-Phe-NH2	P	-	Asp	Tyr	Met	Gly	Trp	Met	Asp	Wilson &etal, 1993
neurokinin A			His-Lys-Thr+Asp-Ser-Phe-Val-Gly-Leu-Met-NH2	N	-	His	Lys	Thr	Asp	Ser	Phe	Val	Wilson &etal, 1993