Substrates for peptidase M14.017: carboxypeptidase A4
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.
| Substrate | Uniprot | Residue range | Cleavage Site | Cleavage type | Evidence | P4 | P3 | P2 | P1 | P1' | P2' | P3' | P4' | Reference | CutDB | MERNUM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 40S ribosomal protein S21 | Q9CQR2 | 73-83 | Ala-Lys-Ala-Asp-Gly-Ile-Val-Ser-Lys-Asn+Phe | P | MS | Val | Ser | Lys | Asn | Phe | - | - | - | Tanco et al., 2010 | ||
| 60S ribosomal protein L23a | P62750 | 2-156 | Peptide-Ile155+Ile | N | MS | Lys | Ile | Gly | Ile | Ile | - | - | - | Van Damme et al., 2010 | ||
| actin, cytoplasmic 1 | P60710 | 170-178 | Ala-Leu-Pro-His-Ala-Ile-Leu-Arg+Leu | P | MS | Ala | Ile | Leu | Arg | Leu | - | - | - | Tanco et al., 2010 | ||
| Actin-related protein 2/3 complex subunit 4 | P59998 | 2-168 | Peptide-Asn167+Phe | N | MS | Phe | Leu | Lys | Asn | Phe | - | - | - | Van Damme et al., 2010 | ||
| AN1-type zinc finger protein 6 | Q6FIF0 | 1-208 | Peptide-Lys207+Ile | N | MS | Lys | Ile | Gln | Lys | Ile | - | - | - | Van Damme et al., 2010 | ||
| angiotensin-1 | P01019 | 34-43 | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His+Leu | N | His | Pro | Phe | His | Leu | - | - | - | Tanco et al., 2010 | |||
| big SAAS | Q9QXU9 | 34-59 | peptide-Arg58+Arg | N | Thr | Pro | Leu | Arg | Leu | - | - | - | Tanco et al., 2010 | |||
| big SAAS 1-25 | Q9QXV0 | 34-59 | peptide-Arg58+Arg | N | Thr | Pro | Leu | Arg | Leu | - | - | - | Tanco et al., 2010 | |||
| carboxypeptidase A5 | Q8WXQ8 | 425-436 | Cys-Gln-Thr-Ile-Met-Glu-His-Thr-Leu-Asn-His-Pro+Tyr | N | Leu | Asn | His | Pro | Tyr | - | - | - | Tanco et al., 2010 | |||
| cathepsin D | P18242 | 392-409 | Tyr-Thr-Val-Phe-Asp-Arg-Asp-Asn-Asn-Arg-Val-Gly-Phe-Ala-Asn-Ala-Val+Val | P | ms | Ala | Asn | Ala | Val | Val | - | - | - | Tanco et al., 2010 | ||
| cholecystokinin | P09240 | 46-61 | Ala-Val-Leu-Arg-Thr-Asp-Gly-Glu-Pro-Arg-Ala-Arg-Leu-Gly-Ala+Leu | N | Arg | Leu | Gly | Ala | Leu | - | - | - | Tanco et al., 2010 | |||
| cholecystokinin | P09240 | 46-62 | Ala-Val-Leu-Arg-Thr-Asp-Gly-Glu-Pro-Arg-Ala-Arg-Leu-Gly-Ala-Leu+Leu | N | Leu | Gly | Ala | Leu | Leu | - | - | - | Tanco et al., 2010 | |||
| cholecystokinin | P09240 | 46-63 | Ala-Val-Leu-Arg-Thr-Asp-Gly-Glu-Pro-Arg-Ala-Arg-Leu-Gly-Ala-Leu-Leu+Ala | P | MS | Gly | Ala | Leu | Leu | Ala | - | - | - | Tanco et al., 2010 | ||
| chromogranin B | Q3TY66 | 64-86 | peptide-Leu85+Leu | P | ms | Glu | Val | Arg | Leu | Leu | - | - | - | Tanco et al., 2010 | ||
| chromogranin B | Q3TY66 | 600-613 | Gln-Tyr-Asp-Gly-Val-Ala-Glu-Leu-Asp-Gln-Leu-Leu-His+Tyr | P | ms | Gln | Leu | Leu | His | Tyr | - | - | - | Tanco et al., 2010 | ||
| chromogranin-A | P26339 | 374-388 | Leu-Glu-Gly-Glu-Asp-Asp-Pro-Asp-Arg-Ser-Met-Lys-Leu-Ser+Phe | P | MS | Met | Lys | Leu | Ser | Phe | - | - | - | Tanco et al., 2010 | ||
| chromogranin-A | P26339 | 392-402 | Ala-Tyr-Gly-Phe-Arg-Asp-Pro-Gly-Pro-Gln+Leu | P | MS | Pro | Gly | Pro | Gln | Leu | - | - | - | Tanco et al., 2010 | ||
| clathrin coat assembly protein AP180 | Q61548 | 873-901 | peptide-Phe900+Phe | P | MS | Ile | Lys | Asp | Phe | Leu | - | - | - | Tanco et al., 2010 | ||
| clathrin light chain A | O08585 | 223-235 | Ser-Val-Leu-Ile-Ser-Leu-Lys-Gln-Ala-Pro-Leu-Val+His | P | MS | Ala | Pro | Leu | Val | His | - | - | - | Tanco et al., 2010 | ||
| Coiled-coil domain-containing protein 86 | Q9H6F5 | 1-360 | Peptide-Lys359+Ile | N | MS | Pro | Ala | Ala | Lys | Ile | - | - | - | Van Damme et al., 2010 | ||
| Cytochrome c oxidase subunit 6B1 | P14854 | 2-86 | Peptide-Lys85+Ile | N | MS | Phe | Pro | Gly | Lys | Ile | - | - | - | Van Damme et al., 2010 | ||
| elongation factor 1-beta | O70251 | 2-15 | Gly-Phe-Gly-Asp-Leu-Lys-Thr-Pro-Ala-Gly-Leu-Gln-Val+Leu | P | ms | Gly | Leu | Gln | Val | Leu | - | - | - | Tanco et al., 2010 | ||
| Elongation factor 2 | P13639 | 2-858 | Peptide-Lys857+Leu | N | MS | Phe | Leu | Asp | Lys | Leu | - | - | - | Van Damme et al., 2010 | ||
| furylacryloyl-Phe-Ala | furylacryloyl-Phe+Ala | S | - | - | FA | Phe | Ala | - | - | - | Tanco et al., 2010 | |||||
| furylacryloyl-Phe-Ile | furylacryloyl-Phe+Ile | S | - | - | FA | Phe | Ile | - | - | - | Tanco et al., 2010 | |||||
| furylacryloyl-Phe-Leu | furylacryloyl-Phe+Leu | S | - | - | FA | Phe | Leu | - | - | - | Tanco et al., 2010 | |||||
| furylacryloyl-Phe-Met | furylacryloyl-Phe+Met | S | - | - | FA | Phe | Met | - | - | - | Tanco et al., 2010 | |||||
| furylacryloyl-Phe-Phe (FAPP) | furylacryloyl-Phe+Phe | S | - | - | FA | Phe | Phe | - | - | - | Tanco et al., 2010 | |||||
| furylacryloyl-Phe-Trp | furylacryloyl-Phe+Trp | S | - | - | FA | Phe | Trp | - | - | - | Tanco et al., 2010 | |||||
| furylacryloyl-Phe-Val | furylacryloyl-Phe+Val | S | - | - | FA | Phe | Val | - | - | - | Tanco et al., 2010 | |||||
| Glutamine synthetase | P15104 | 1-373 | Peptide-Lys372+Asn | N | MS | Phe | Gln | Tyr | Lys | Asn | - | - | - | Van Damme et al., 2010 | ||
| Glutaminyl-tRNA synthetase | P47897 | 2-775 | Peptide-Lys774+Val | N | MS | Asp | Pro | Gly | Lys | Val | - | - | - | Van Damme et al., 2010 | ||
| Hippocalcin-like protein 1 | P37235 | 2-193 | Peptide-Gln192+Phe | N | MS | Ser | Ala | Ser | Gln | Phe | - | - | - | Van Damme et al., 2010 | ||
| Leu-enkephalin | P01213 | 226-230 | Tyr-Gly-Gly-Phe+Leu | N | Tyr | Gly | Gly | Phe | Leu | - | - | - | Tanco et al., 2010 | |||
| little SAAS | Q9UHG2 | 42-59 | Gly-Leu-Ser-Ala-Ala-Ser-Pro-Pro-Leu-Ala-Glu-Thr-Gly-Ala-Pro-Arg-Arg+Phe | N | Ala | Pro | Arg | Arg | Phe | - | - | - | Tanco et al., 2010 | |||
| little SAAS 1-17 | Q9QXV0 | 42-59 | Ser-Leu-Ser-Ala-Ala-Ser-Ala-Pro-Leu-Val-Glu-Thr-Ser-Thr-Pro-Leu-Arg+Leu | N | Thr | Pro | Leu | Arg | Leu | - | - | - | Tanco et al., 2010 | |||
| Met-enkephalin | P01210 | 100-104 | Tyr-Gly-Gly-Phe+Met | N | Tyr | Gly | Gly | Phe | Met | - | - | - | Tanco et al., 2010 | |||
| Met-enkephalin-Arg-Phe | P01210 | 261-267 | Tyr-Gly-Gly-Phe-Met-Arg+Phe | N | Gly | Phe | Met | Arg | Phe | - | - | - | Tanco et al., 2010 | |||
| N-(4-methoxyphenyl-azoformyl)-Phe-OH | N-(4-methoxyphenyl-azoformyl)+Phe-OH | S | - | - | - | MFA | Phe | - | - | - | Pallares et al., 2005 | |||||
| Nascent polypeptide-associated complex subunit alpha | Q13765 | 1-215 | Peptide-Thr214+Met | N | MS | Met | Glu | Leu | Thr | Met | - | - | - | Van Damme et al., 2010 | ||
| neurotensin | P30990 | 151-163 | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile+Leu | N | Arg | Pro | Tyr | Ile | Leu | - | - | - | Tanco et al., 2010 | |||
| neurotensin | Q9D3P9 | 150-162 | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile+Leu | N | Arg | Pro | Tyr | Ile | Leu | - | - | - | Tanco et al., 2010 | |||
| neurotensin 1-11 | Q9D3P9 | 150-161 | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr+Ile | N | Arg | Arg | Pro | Tyr | Ile | - | - | - | Tanco et al., 2010 | |||
| neurotensin/neuromedin N | Q9D3P9 | 142-147 | Lys-Ile-Pro-Tyr-Ile+Leu | P | MS | Ile | Pro | Tyr | Ile | Leu | - | - | - | Tanco et al., 2010 | ||
| PEN | Q9QXU9 | 221-242 | peptide-Arg241+Val | N | Ala | Leu | Leu | Arg | Val | - | - | - | Tanco et al., 2010 | |||
| PEN 1-21 | Q9QXV0 | 219-240 | peptide-Arg239+Val | N | Ala | Leu | Leu | Arg | Val | - | - | - | Tanco et al., 2010 | |||
| peptidyl-prolyl cis-trans isomerase A | P17742 | 118-129 | Lys-Thr-Glu-Trp-Leu-Asp-Gly-Lys-His-Val-Val+Phe | P | MS | Lys | His | Val | Val | Phe | - | - | - | Tanco et al., 2010 | ||
| peptidyl-prolyl cis-trans isomerase A | P17742 | 26-39 | Ala-Asp-Lys-Val-Pro-Lys-Thr-Ala-Glu-Asn-Phe-Arg-Ala+Leu | P | MS | Asn | Phe | Arg | Ala | Leu | - | - | - | Tanco et al., 2010 | ||
| peptidyl-prolyl cis-trans isomerase A | P17742 | 23-39 | Glu-Leu-Phe-Ala-Asp-Lys-Val-Pro-Lys-Thr-Ala-Glu-Asn-Phe-Arg-Ala+Leu | P | ms | Asn | Phe | Arg | Ala | Leu | - | - | - | Tanco et al., 2010 | ||
| peptidyl-prolyl cis-trans isomerase A | P17742 | 84-92 | Glu-Asp-Glu-Asn-Phe-Ile-Leu-Lys+His | P | ms | Phe | Ile | Leu | Lys | His | - | - | - | Tanco et al., 2010 | ||
| peptidyl-prolyl cis-trans isomerase A | P17742 | 84-100 | Glu-Asp-Glu-Asn-Phe-Ile-Leu-Lys-His-Thr-Gly-Pro-Gly-Ile-Leu-Ser+Met | P | ms | Gly | Ile | Leu | Ser | Met | - | - | - | Tanco et al., 2010 | ||
| peroxiredoxin-5, mitochondrial | P99029 | 50-64 | Ala-Pro-Ile-Lys-Val-Gly-Asp-Ala-Ile-Pro-Ser-Val-Glu-Val+Phe | P | MS | Ser | Val | Glu | Val | Phe | - | - | - | Tanco et al., 2010 | ||
| Plectin | Q15149 | 1-4684 | Peptide-Val4683+Ala | N | MS | Glu | Ser | Ala | Val | Ala | - | - | - | Van Damme et al., 2010 | ||
| proenkephalin-A | P22005 | 261-268 | Tyr-Gly-Gly-Phe-Met-Arg+Phe | P | MS | Gly | Phe | Met | Arg | Phe | - | - | - | Tanco et al., 2010 | ||
| proenkephalin-B | O35417 | 221-228 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg+Gln | P | MS | Phe | Leu | Arg | Arg | Gln | - | - | - | Tanco et al., 2010 | ||
| proSAAS | Q9QXV0 | 219-238 | Ser-Val-Asp-Gln-Asp-Leu-Gly-Pro-Glu-Val-Pro-Pro-Glu-Asn-Val-Leu-Gly-Ala-Leu+Leu | P | ms | Leu | Gly | Ala | Leu | Leu | - | - | - | Tanco et al., 2010 | ||
| proteasome subunit beta type-6 | Q60692 | 34-41 | Thr-Thr-Ile-Met-Ala-Val-Gln+Phe | P | ms | Met | Ala | Val | Gln | Phe | - | - | - | Tanco et al., 2010 | ||
| secretogranin-1 | P16014 | 600-613 | Gln-Tyr-Asp-Gly-Val-Ala-Glu-Leu-Asp-Gln-Leu-Leu-His+Tyr | N | Gln | Leu | Leu | His | Tyr | - | - | - | Tanco et al., 2010 | |||
| secretogranin-1 | P16014 | 438-454 | Leu-Leu-Asp-Glu-Gly-His-Tyr-Pro-Val-Arg-Glu-Ser-Pro-Ile-Asp-Thr+Ala | N | Pro | Ile | Asp | Thr | Ala | - | - | - | Tanco et al., 2010 | |||
| secretogranin-2 | Q03517 | 287-316 | peptide-Tyr315+Tyr | P | ms | Val | Ile | Thr | Tyr | Leu | - | - | - | Tanco et al., 2010 | ||
| secretogranin-2 | Q03517 | 300-316 | Glu-Ser-Lys-Asp-Gln-Leu-Ser-Glu-Asp-Ala-Ser-Lys-Val-Ile-Thr-Tyr+Leu | P | ms | Val | Ile | Thr | Tyr | Leu | - | - | - | Tanco et al., 2010 | ||
| Septin-7 | Q16181 | 1-437 | Peptide-Ile436+Phe | N | MS | Lys | Gly | Lys | Ile | Phe | - | - | - | Van Damme et al., 2010 | ||
| Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | Q14738 | 1-602 | Peptide-Ala601+Leu | N | MS | Ser | Gln | Glu | Ala | Leu | - | - | - | Van Damme et al., 2010 | ||
| Splicing factor 3B subunit 2 | Q13435 | 1-895 | Peptide-Lys894+Phe | N | MS | Lys | Glu | Phe | Lys | Phe | - | - | - | Van Damme et al., 2010 | ||
| thioredoxin | P10639 | 2-15 | Val-Lys-Leu-Ile-Glu-Ser-Lys-Glu-Ala-Phe-Gln-Glu-Ala+Leu | P | MS | Phe | Gln | Glu | Ala | Leu | - | - | - | Tanco et al., 2010 | ||
| triosephosphate isomerase | P17751-2 | 199-213 | Lys-Val-Ile-Ala-Asp-Asn-Val-Lys-Asp-Trp-Ser-Lys-Val-Val+Leu | P | MS | Ser | Lys | Val | Val | Leu | - | - | - | Tanco et al., 2010 | ||
| valine--tRNA ligase | P26640 | 2-1264 | Peptide-Met1263+Leu | N | MS | Phe | Gln | Lys | Met | Leu | - | - | - | Van Damme et al., 2010 | ||
| [Des-Asp1] Angiotensin-1 | P01019 | 35-43 | Arg-Val-Tyr-Ile-His-Pro-Phe-His+Leu | N | His | Pro | Phe | His | Leu | - | - | - | Tanco et al., 2010 |
