Substrates for peptidase M49.001: dipeptidyl-peptidase III

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ala-Ala-Ala-Ala			Ala-Ala+Ala-Ala	N		-	-	Ala	Ala	Ala	Ala	-	-	Chen & Barrett, 2004
Ala-Arg-MCA			Ala-Arg+MCA	N		-	-	Ala	Arg	Mca	-	-	-	Ohkubo et al., 2000
Ala-Arg-NHNap			Ala-Arg+NHNap	S		-	-	Ala	Arg	NAP	-	-	-	McDonald, 1998
alpha-melanocyte stimulating hormone 6-9	P01189	143-146	His-Phe+Arg-Trp	N		-	-	His	Phe	Arg	Trp	-	-	Chen & Barrett, 2004
angiotensin-1	P01019	34-43	Asp-Arg+Val-Tyr-Ile-His-Pro-Phe-His-Leu	P	MS	'-'	'-'	Asp	Arg	Val	Tyr	Ile	His	Jha et al., 2020
angiotensin-2	P01019	34-41	Asp-Arg+Val-Tyr-Ile-His-Pro-Phe	N		-	-	Asp	Arg	Val	Tyr	Ile	His	Chen & Barrett, 2004	17166
angiotensin-3	P01019	37-41	Tyr-Ile+His-Pro-Phe	N		-	-	Tyr	Ile	His	Pro	Phe	-	McDonald, 1998	17167
angiotensin-3 1-4	P01019	35-38	Arg-Val+Tyr-Ile	N		-	-	Arg	Val	Tyr	Ile	His	Pro	McDonald, 1998	17168
angiotensin-4	P01019	36-41	Val-Tyr+Ile-His-Pro-Phe	N		-	-	Val	Tyr	Ile	His	Pro	Phe	Chen & Barrett, 2004
Arg-Arg-MCA			Arg-Arg+MCA	S		-	-	Arg	Arg	Mca	-	-	-	Ohkubo et al., 2000
Arg-Arg-NHNap			Arg-Arg+NHNap	S		-	-	Arg	Arg	NAP	-	-	-	McDonald, 1998
Glu-Glu-Glu-Glu			Glu-Glu+Glu-Glu	N		-	-	Glu	Glu	Glu	Glu	-	-	Enzyme Nomenclature, 1992
Gly-Gly-Gly-Gly			Gly-Gly+Gly-Gly	N		-	-	Gly	Gly	Gly	Gly	-	-	Enzyme Nomenclature, 1992
Leu-Arg-Arg-Ala-Ser-Leu-Gly			Leu-Arg+Arg-Ala-Ser-Leu-Gly	N		-	-	Leu	Arg	Arg	Ala	Ser	Leu	McDonald, 1998
Leu-Arg-NHNap			Leu-Arg+NHNap	S		-	-	Leu	Arg	NAP	-	-	-	McDonald, 1998
Leu-Trp-Met-Arg-Phe-Ala			Leu-Trp+Met-Arg-Phe-Ala	N		-	-	Leu	Trp	Met	Arg	Phe	Ala	McDonald, 1998
Leu-Trp-Met-Arg-Phe-Ala 3-6			Met-Arg+Phe-Ala	N		-	-	Met	Arg	Phe	Ala	-	-	McDonald, 1998
Lys-Ala-CBk			Lys-Ala+CBk	S		-	-	Lys	Ala	CBk	-	-	-	Chen & Barrett, 2004
Lys-Lys-Lys-Lys			Lys-Lys+Lys-Lys	N		-	-	Lys	Lys	Lys	Lys	-	-	Chen & Barrett, 2004
Phe-Phe-Phe-Phe			Phe-Phe+Phe-Phe	N		-	-	Phe	Phe	Phe	Phe	-	-	Chen & Barrett, 2004
proctolin	P67859	1-5	Arg-Tyr+Leu-Pro-Thr	N		-	-	Arg	Tyr	Leu	Pro	Thr	-	Chen & Barrett, 2004	17169
Val-Leu-Ser-Glu-Gly			Val-Leu+Ser-Glu-Gly	N		-	-	Val	Leu	Ser	Glu	Gly	-	McDonald, 1998
[Leu5]-enkephalin	P01213	175-179	Tyr-Gly+Gly-Phe-Leu-NH2	N		-	-	Tyr	Gly	Gly	Phe	Leu	-	McDonald, 1998
[Val5]-angiotensin-2			Asn-Arg+Val-Tyr-Val-His-Pro-Phe	N		-	-	Asn	Arg	Val	Tyr	Val	His	McDonald, 1998
[Val5]-angiotensin-2 3-8			Val-Tyr+Val-His-Pro-Phe	N		-	-	Val	Tyr	Val	His	Pro	Phe	McDonald, 1998