Substrates for peptidase S08.024: dentilisin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
angiotensin-1	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe+His-Leu	N		Ile	His	Pro	Phe	His	Leu	-	-	Mäkinen et al., 1995	17508
angiotensin-1	P01019	34-43	Asp-Arg-Val-Tyr-Ile+His-Pro-Phe-His-Leu	N		Arg	Val	Tyr	Ile	His	Pro	Phe	His	Mäkinen et al., 1995
Antibacterial protein LL-37	P49913	134-170	Peptide-Phe138+Phe-Peptide	N	MS	Leu	Gly	Asp	Phe	Phe	Arg	Lys	Ser
Antibacterial protein LL-37	P49913	134-170	Peptide-Ile146+Gly-Peptide	N	MS	Lys	Glu	Lys	Ile	Gly	Lys	Glu	Phe
Antibacterial protein LL-37	P49913	134-170	Peptide-Lys151+Arg-Peptide	N	MS	Lys	Glu	Phe	Lys	Arg	Ile	Val	Gln
Antibacterial protein LL-37	P49913	134-170	Peptide-Val154+Gln-Peptide	N	MS	Lys	Arg	Ile	Val	Gln	Arg	Ile	Lys
Antibacterial protein LL-37	P49913	134-170	Peptide-Gln155+Arg-Peptide	N	MS	Arg	Ile	Val	Gln	Arg	Ile	Lys	Ile
Antibacterial protein LL-37	P49913	134-170	Peptide-Lys158+Asp-Peptide	N	MS	Gln	Arg	Ile	Lys	Asp	Phe	Leu	Arg
fibrinogen alpha chain	P02672	20-615	peptide-Arg38+Gly-peptide	P		Gly	Gly	Val	Arg	Gly	Pro	Arg	Leu	Uitto, 2004
Phe-8(4-nitro)-substrance P			Arg-Pro-Lys-Pro-Gln-Gln-Phe(NO2)-Phe+Gly-Leu-Met-NH2	S		Gln	Gln	PhN	Phe	Gly	Leu	Met	NH2	Mäkinen et al., 1995
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe+Gly-Leu-Met-NH2	N		Gln	Gln	Phe	Phe	Gly	Leu	Met	NH2	Mäkinen et al., 1995	21564
Suc-Ala-Ala-Ala-NHPhNO2			Suc-Ala-Ala-Ala+NHPhNO2	S		Suc	Ala	Ala	Ala	NAN	-	-	-	Mäkinen et al., 1995
Suc-Ala-Ala-Phe-NHPhNO2			Suc-Ala-Ala-Phe+NHPhNO2	S		Suc	Ala	Ala	Phe	NAN	-	-	-	Mäkinen et al., 1995
Suc-Ala-Ala-Pro-Ala-NHPhNO2			Suc-Ala-Ala-Pro-Ala+NHPhNO2	S		Ala	Ala	Pro	Ala	NAN	-	-	-	Mäkinen et al., 1995
Suc-Ala-Ala-Pro-Leu-NHPhNO2			Suc-Ala-Ala-Pro-Leu+NHPhNO2	S		Ala	Ala	Pro	Leu	NAN	-	-	-	Mäkinen et al., 1995
Suc-Ala-Ala-Pro-Phe-NHPhNO2			Suc-Ala-Ala-Pro-Phe+NHPhNO2	S		Ala	Ala	Pro	Phe	NAN	-	-	-	Uitto, 2004
Suc-Ala-Ala-Pro-Phe-NHPhNO2 (SAAPFNA)			Suc-Ala-Ala-Pro-Phe+NHPhNO2	S		Ala	Ala	Pro	Phe	NAN	-	-	-	Mäkinen et al., 1995