Substrates for peptidase S01.172: kallikrein 1-related peptidase c2 (Rattus norvegicus)

Summary Gene structure Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
angiotensin-1	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe+His-Leu	N	Ile	His	Pro	Phe	His	Leu	-	-	Chao, 2004
angiotensinogen	P01019	34-485	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe+His-peptide	P	Ile	His	Pro	Phe	His	Leu	Val	Ile	Chao, 2004	17308
angiotensinogen	P01015	25-477	peptide-Phe32+His-peptide	P	Ile	His	Pro	Phe	His	Leu	Leu	Tyr	Moreau et al., 1992
big endothelin 1	P05305	53-90	peptide-Tyr83+Gly-peptide	P	Val	Val	Pro	Tyr	Gly	Leu	Gly	Ser	Moreau et al., 1992
Boc-Ala-Gly-Pro-Arg-NHMec			Boc-Ala-Gly-Pro-Arg+NHMec	S	Ala	Gly	Pro	Arg	AMC	-	-	-	Moreau et al., 1992
Boc-Leu-Ser-Thr-Arg-NHMec			Boc-Leu-Ser-Thr-Arg+NHMec	S	Leu	Ser	Thr	Arg	AMC	-	-	-	Moreau et al., 1992
Bz-Arg-NHPhNO2 (BAPNA)			Bz-Arg+NHPhNO2	S	-	-	Bz	Arg	NAN	-	-	-	Chao, 2004
Bz-Arg-OEt [BAEE]			Bz-Arg+OEt	S	-	-	Bz	Arg	OEt	-	-	-	Chao, 2004
Bz-Arg-OMe			Bz-Arg+OMe	S	-	-	Bz	Arg	OMe	-	-	-	Chao, 2004
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln+His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Phe	Val	Asn	Gln	His	Leu	Cya	Gly	Moreau et al., 1992
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Moreau et al., 1992
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg+Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Cya	Gly	Glu	Arg	Gly	Phe	Phe	Tyr	Moreau et al., 1992
lysozyme C	P00698	19-147	peptide-Arg23+Cys-peptide	N	Val	Phe	Gly	Arg	Cys	Glu	Leu	Ala	Moreau et al., 1992
lysozyme C	P00698	19-147	peptide-Tyr41+Ser-peptide	N	Tyr	Arg	Gly	Tyr	Ser	Leu	Gly	Asn	Moreau et al., 1992
lysozyme C	P00698	19-147	peptide-Arg79+Trp-peptide	N	Ile	Asn	Ser	Arg	Trp	Trp	Cys	Asn	Moreau et al., 1992
Pro-Phe-Arg-NHMec			Pro-Phe-Arg+NHMec	S	-	Pro	Phe	Arg	AMC	-	-	-	Moreau et al., 1992
substance P	P20366	58-68	peptide-Phe64+Phe-peptide	N	Pro	Gln	Gln	Phe	Phe	Gly	Leu	Met	Moreau et al., 1992
substance P	P20366	58-68	peptide-Phe65+Gly-peptide	N	Gln	Gln	Phe	Phe	Gly	Leu	Met	Gly	Moreau et al., 1992
Tos-Arg-OMe (TAME)			Tos-Arg+OMe	S	-	-	Tos	Arg	OMe	-	-	-	Chao, 2004
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S	-	Z	Phe	Arg	AMC	-	-	-	Moreau et al., 1992
Z-Val-Lys-Lys-Arg-7-amino-4-trifluoromethylcoumarin			Z-Val-Lys-Lys-Arg+7-amino-4-trifluoromethylcoumarin	S	Val	Lys	Lys	Arg	FMC	-	-	-	Chao, 2004