Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 19 |
unknown peptidase |
1-129 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 56 |
unknown peptidase |
1-129 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 57 |
kallikrein-related peptidase 4 |
1-126 |
P |
|
CS |
Matsumura et al., 2005 |
| 58 |
arginine aminopeptidase (Streptococcus-type) |
58-68 |
N |
|
|
Goldstein et al., 2002 |
| 58 |
aminopeptidase Ey |
58-61 |
N |
|
|
Ichishima, 2004 |
| 58 |
aminopeptidase P1 |
58-61 |
N |
|
|
Harbeck & Mentlein, 1991 |
| 59 |
lebetase |
58-68 |
N |
|
MS |
Trummal et al., 2000 |
| 59 |
ALE1 peptidase |
58-68 |
P |
|
|
Cedzich et al., 2009 |
| 59 |
SlSBT3 g.p. (Solanum lycopersicum) |
58-68 |
N |
|
|
Cedzich et al., 2009 |
| 59 |
dipeptidyl-peptidase IV (eukaryote) |
58-68 |
P |
|
- |
Sedo et al., 2005 |
| 59 |
dipeptidyl-peptidase 4 (bacteria-type 2) |
58-68 |
N |
|
MS |
Banbula et al., 2000 |
| 59 |
dipeptidyl-peptidase II |
58-68 |
N |
|
|
McDonald & Ohkubo, 2004 |
| 61 |
thimet oligopeptidase |
58-68 |
P |
|
NT |
Dando et al., 1993 |
| 61 |
lebetase |
58-68 |
N |
|
MS |
Trummal et al., 2000 |
| 61 |
Zmp1 peptidase (Mycobacterium-type) |
58-68 |
N |
|
|
Carson et al., 2002 |
| 61 |
penicillolysin |
58-68 |
N |
|
|
Ichishima, 2004 |
| 61 |
prolyl oligopeptidase |
58-68 |
N |
|
|
Mäkinen et al., 1995 |
| 61 |
dipeptidyl-peptidase 4 (bacteria-type 2) |
60-68 |
N |
|
MS |
Banbula et al., 2000 |
| 62 |
Pz-peptidase A |
58-68 |
N |
|
|
Miyake et al., 2005 |
| 62 |
plinsulysin |
58-68 |
N |
|
|
Huet et al., 2008 |
| 62 |
FALGPA-peptidase (Treponema denticola) |
58-68 |
N |
|
|
Mäkinen et al., 1995 |
| 63 |
Pz-peptidase A |
58-68 |
N |
|
|
Miyake et al., 2005 |
| 63 |
coccolysin |
58-68 |
N |
|
|
Makinen & Makinen, 2004 |
| 63 |
matrix metallopeptidase-8 |
58-68 |
P |
|
NT |
Diekmann & Tschesche, 1994 |
| 63 |
matrix metallopeptidase-9 |
58-68 |
P |
|
|
Backstrom & Tokes, 1995 |
| 63 |
matrix metallopeptidase-3 |
58-68 |
N |
|
|
Nagase, 2004 |
| 63 |
meprin alpha subunit |
58-68 |
N |
|
NT |
Bertenshaw et al., 2001 |
| 63 |
nephrosin |
58-68 |
N |
|
|
Hung et al., 1997 |
| 63 |
neprilysin |
58-68 |
P |
|
|
Matsas et al., 1984 |
| 63 |
endothelin-converting enzyme 1 |
58-68 |
N |
|
|
Carson et al., 2002 |
| 63 |
neprilysin-2 |
58-68 |
N |
|
NT |
Rose et al., 2002 |
| 63 |
Zmp1 peptidase (Mycobacterium-type) |
58-68 |
N |
|
|
Carson et al., 2002 |
| 63 |
Kell blood-group peptidase |
58-68 |
P |
|
MS |
Clapéron et al., 2005 |
| 63 |
ALE1 peptidase |
58-68 |
P |
|
|
Cedzich et al., 2009 |
| 63 |
SlSBT3 g.p. (Solanum lycopersicum) |
58-68 |
N |
|
|
Cedzich et al., 2009 |
| 63 |
unknown peptidase |
58-68 |
N |
|
|
Bertenshaw et al., 2001 |
| 64 |
cathepsin D |
58-68 |
N |
|
|
Kageyama et al., 1995 |
| 64 |
cathepsin E |
58-68 |
N |
|
|
Kageyama et al., 1995 |
| 64 |
thimet oligopeptidase |
58-68 |
N |
|
|
Miyake et al., 2005 |
| 64 |
oligopeptidase F |
59-68 |
N |
|
MS |
Chao et al., 2006 |
| 64 |
coccolysin |
58-68 |
N |
|
|
Makinen & Makinen, 2004 |
| 64 |
meprin alpha subunit |
58-68 |
N |
|
NT |
Bertenshaw et al., 2001 |
| 64 |
nephrosin |
58-68 |
N |
|
|
Hung et al., 1997 |
| 64 |
neprilysin |
58-68 |
N |
|
|
Turner, 2004 |
| 64 |
endothelin-converting enzyme 1 |
58-68 |
N |
|
|
Ahn & Johnson, 2004 |
| 64 |
Zmp1 peptidase (Mycobacterium-type) |
58-68 |
N |
|
|
Carson et al., 2002 |
| 64 |
Kell blood-group peptidase |
58-68 |
P |
|
MS |
Clapéron et al., 2005 |
| 64 |
eupitrilysin |
58-68 |
N |
|
|
Chow et al., 2009 |
| 64 |
dactylysin |
58-68 |
N |
|
|
Clamagirand et al., 2004 |
| 64 |
chymase (Homo sapiens-type) |
58-68 |
P |
|
MS |
Schiemann et al., 2006 |
| 64 |
duodenase |
58-68 |
N |
|
NT |
Pemberton et al., 1997 |
| 64 |
kallikrein 1-related peptidase c2 (Rattus norvegicus) |
58-68 |
N |
|
|
Moreau et al., 1992 |
| 64 |
substance P endopeptidase (of CSF) |
58-68 |
P |
|
NT |
Nyberg et al., 1984 |
| 64 |
unknown peptidase |
58-68 |
N |
|
|
Bertenshaw et al., 2001 |
| 65 |
aspergilloglutamic peptidase |
58-58 |
N |
|
|
O'Donoghue et al., 2008 |
| 65 |
peptidyl-dipeptidase Acer |
58-68 |
N |
|
|
Isaac, 2004 |
| 65 |
angiotensin-converting enzyme peptidase unit 2 |
58-68 |
N |
|
|
Corvol et al., 2004 |
| 65 |
thimet oligopeptidase |
58-68 |
N |
|
|
Miyake et al., 2005 |
| 65 |
oligopeptidase F |
58-68 |
N |
|
|
Miyake et al., 2005 |
| 65 |
meprin alpha subunit |
58-68 |
N |
|
NT |
Bertenshaw et al., 2001 |
| 65 |
neprilysin-4 (Drosophila melanogaster) |
58-68 |
N |
|
|
Meyer et al., 2009 |
| 65 |
penicillolysin |
58-68 |
N |
|
|
Ichishima, 2004 |
| 65 |
chymase (Homo sapiens-type) |
58-68 |
P |
|
MS |
Schiemann et al., 2006 |
| 65 |
kallikrein 1-related peptidase c2 (Rattus norvegicus) |
58-68 |
N |
|
|
Moreau et al., 1992 |
| 65 |
dentilisin |
58-68 |
N |
|
|
Mäkinen et al., 1995 |
| 65 |
substance P endopeptidase (of CSF) |
58-68 |
P |
|
NT |
Nyberg et al., 1984 |
| 65 |
unknown peptidase |
58-68 |
N |
|
|
Corvol et al., 2004 |
| 65 |
unknown peptidase |
58-68 |
N |
|
|
Bertenshaw et al., 2001 |
| 66 |
peptidyl-dipeptidase Acer |
58-68 |
N |
|
|
Isaac, 2004 |
| 66 |
angiotensin-converting enzyme peptidase unit 2 |
58-68 |
N |
|
|
Corvol et al., 2004 |
| 66 |
coccolysin |
58-68 |
N |
|
|
Makinen & Makinen, 2004 |
| 66 |
matrix metallopeptidase-8 |
58-68 |
P |
|
NT |
Diekmann & Tschesche, 1994 |
| 66 |
matrix metallopeptidase-9 |
58-68 |
P |
|
|
Backstrom & Tokes, 1995 |
| 66 |
meprin alpha subunit |
58-68 |
N |
|
NT |
Bertenshaw et al., 2001 |
| 66 |
lebetase |
58-68 |
N |
|
MS |
Trummal et al., 2000 |
| 66 |
neprilysin |
58-68 |
N |
|
|
Matsas et al., 1984 |
| 66 |
endothelin-converting enzyme 1 |
58-68 |
N |
|
|
Carson et al., 2002 |
| 66 |
endothelin-converting enzyme 2 |
58-68 |
P |
|
MS |
Mzhavia et al., 2003 |
| 66 |
neprilysin-2 |
58-68 |
N |
|
NT |
Rose et al., 2002 |
| 66 |
Zmp1 peptidase (Mycobacterium-type) |
58-68 |
N |
|
|
Carson et al., 2002 |
| 66 |
neprilysin-4 (Drosophila melanogaster) |
58-68 |
N |
|
|
Meyer et al., 2009 |
| 66 |
Kell blood-group peptidase |
58-68 |
P |
|
MS |
Clapéron et al., 2005 |
| 66 |
pitrilysin |
58-68 |
N |
|
|
Cornista et al., 2004 |
| 66 |
eupitrilysin |
58-68 |
N |
|
|
Chow et al., 2009 |
| 66 |
penicillolysin |
58-68 |
N |
|
|
Ichishima, 2004 |
| 66 |
dactylysin |
58-68 |
N |
|
|
Clamagirand et al., 2004 |
| 66 |
unknown peptidase |
58-68 |
N |
|
|
Bertenshaw et al., 2001 |
| 67 |
Zmp1 peptidase (Mycobacterium-type) |
58-68 |
N |
|
|
Carson et al., 2002 |
| 67 |
pitrilysin |
58-68 |
N |
|
|
Cornista et al., 2004 |
| 67 |
duodenase |
58-68 |
N |
|
NT |
Pemberton et al., 1997 |
| 67 |
peptidyl-glycinamidase |
58-68 |
N |
|
|
Simmons, 2004 |
| 68 |
calpain-1 |
58-68 |
N |
|
|
McDermott et al., 1985 |
| 98 |
lysyl aminopeptidase (bacteria) |
98-107 |
N |
|
MS |
Richards & Nuñez, 2006 |
| 98 |
aminopeptidase B |
97-107 |
N |
|
|
Foulon et al., 2004 |
| 99 |
lysyl aminopeptidase (bacteria) |
98-107 |
N |
|
MS |
Richards & Nuñez, 2006 |
| 101 |
thimet oligopeptidase |
98-107 |
P |
|
NT |
Dando et al., 1993 |
| 103 |
cathepsin D |
98-107 |
N |
|
|
Kageyama et al., 1995 |
| 103 |
cathepsin E |
98-107 |
N |
|
|
Kageyama et al., 1995 |
| 104 |
thimet oligopeptidase |
98-107 |
P |
|
NT |
Dando et al., 1993 |
| 105 |
Kell blood-group peptidase |
98-107 |
P |
|
MS |
Clapéron et al., 2005 |
