Substrates for peptidase M01.014: aminopeptidase B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Arg-NHMec			Arg+NHMec	S		-	-	-	Arg	AMC	-	-	-	Xu et al., 2018
Arg-NHNap			Arg+NHNap	S		-	-	-	Arg	NAP	-	-	-	Foulon et al., 2004
arginyl-amino acid			Arg+Xaa	N		-	-	-	Arg	Xaa	-	-	-	Enzyme Nomenclature, 1992
cholecystokinin	P09240	95-103	Arg+Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe	P		-	-	-	Arg	Asp	Tyr	Met	Gly	Beinfeld et al., 2009
glucagon	P55095	69-81	Arg+Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr	P	NT	-	-	-	Arg	Arg	Ala	Gln	Asp	Fontés et al., 2005
glucagon	P55095	70-81	Arg+Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr	P	NT	-	-	-	Arg	Ala	Gln	Asp	Phe	Fontés et al., 2005
kallidin 10			Lys+Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg	N		-	-	-	Lys	Arg	Pro	Pro	Gly	Foulon et al., 2004
Lys-NHNap			Lys+NHNap	S		-	-	-	Lys	NAP	-	-	-	Foulon et al., 2004
lysyl-amino acid			Lys+Xaa	N		-	-	-	Lys	Xaa	-	-	-	Enzyme Nomenclature, 1992
thymopentin	P42166	33-37	Arg+Lys-Asp-Val-Tyr	N		-	-	-	Arg	Lys	Asp	Val	Tyr	Foulon et al., 2004	16416
[Arg-1,Lys0]-somatostatin-14	P61278	101-116	Arg+Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys	N		-	-	-	Arg	Lys	Ala	Gly	Cys	Foulon et al., 2004
[Arg0,Leu5]-enkephalin	P01213	174-179	Arg+Tyr-Gly-Gly-Phe-Leu	N		-	-	-	Arg	Tyr	Gly	Gly	Phe	Foulon et al., 2004
[Arg0,Met5]-enkephalin	P01189	236-241	Arg+Tyr-Gly-Gly-Phe-Met	N		-	-	-	Arg	Tyr	Gly	Gly	Phe	Foulon et al., 2004
[Arg0]-alpha-atrial natriuretic factor (1-20)	P01160	123-143	Arg0+Ser-peptide	N		-	-	-	Arg	Ser	Leu	Arg	Arg	Foulon et al., 2004
[Arg0]-insulin	P01308	25-54,89-110	Arg+Gly-peptide	P	MS	-	-	-	Arg	Gly	Ile	Val	Glu	Kouach et al., 2009
[Arg0]-neurokinin A	P20366	97-107	Arg+His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2	N		-	-	-	Arg	His	Lys	Thr	Asp	Foulon et al., 2004