Substrates for peptidase S08.014: ALE1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
glucagon	P01275	53-81	peptide-Gln55+Gly-peptide	P	-	His	Ser	Gln	Gly	Thr	Phe	Thr	Cedzich et al., 2009	25073
glucagon	P01275	53-81	peptide-Thr59+Ser-peptide	P	Thr	Phe	Thr	Ser	Asp	Tyr	Ser	Lys	Cedzich et al., 2009	25074
glucagon	P01275	53-81	peptide-Gln72+Asp-peptide	P	Arg	Arg	Ala	Gln	Asp	Phe	Val	Gln	Cedzich et al., 2009	25075
glucagon	P01275	53-81	peptide-Asp73+Phe-peptide	P	Arg	Ala	Gln	Asp	Phe	Val	Gln	Trp	Cedzich et al., 2009	25076
glucagon	P01275	53-81	peptide-Gln76+Trp-peptide	P	Asp	Phe	Val	Gln	Trp	Leu	Met	Asn	Cedzich et al., 2009	25077
insulin B chain (oxidized)	P01308	25-54	peptide-His29+Leu-peptide	N	Val	Asn	Gln	His	Leu	Cys	Gly	Ser	Cedzich et al., 2009	25082
insulin B chain (oxidized)	P01308	25-54	peptide-Val42+Cys-peptide	N	Leu	Tyr	Leu	Val	Cya	Gly	Glu	Arg	Cedzich et al., 2009	25083
insulin B chain (oxidized)	P01308	25-54	peptide-Cys43+Gly-peptide	N	Tyr	Leu	Val	Cya	Gly	Glu	Arg	Gly	Cedzich et al., 2009	25084
melittin	P01501	44-69	peptide-Ala47+Val-peptide	P	Gly	Ile	Gly	Ala	Val	Leu	Lys	Val	Cedzich et al., 2009	25078
melittin	P01501	44-69	peptide-Leu52+Thr-peptide	P	Leu	Lys	Val	Leu	Thr	Thr	Gly	Leu	Cedzich et al., 2009	25079
melittin	P01501	44-69	peptide-Ser61+Trp-peptide	P	Ala	Leu	Ile	Ser	Trp	Ile	Lys	Arg	Cedzich et al., 2009	25080
neurotensin	P30990	151-163	peptide-Leu2+Tyr-peptide	P	-	-	Glp	Leu	Tyr	Glu	Asn	Lys	Cedzich et al., 2009	25081
sbt3 subtilisin-like protease	O82777	23-761	peptide-His112+Thr-peptide	P	Val	Glu	Pro	His	Thr	Thr	His	Thr	Cedzich et al., 2009	25085
substance P	P20366	58-68	peptide-Pro59+Lys-peptide	P	-	-	Arg	Pro	Lys	Pro	Gln	Gln	Cedzich et al., 2009	25064
substance P	P20366	58-68	peptide-Gln63+Phe-peptide	P	Lys	Pro	Gln	Gln	Phe	Phe	Gly	Leu	Cedzich et al., 2009	25065
systemin	P27058	179-196	peptide-Gln194+Thr-peptide	P	Pro	Lys	Met	Gln	Thr	Asp	-	-	Cedzich et al., 2009	25072