Substrates for U9G.033: substance P endopeptidase (of CSF)

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
calcitonin gene-related peptide 1 P06881 83-119 peptide-Leu98+Ser-peptide P NT Ala Gly Leu Leu Ser Arg Ser Gly Le Greves et al., 1989
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln-Gln-Phe+Phe-Gly-Leu-Met P NT Pro Gln Gln Phe Phe Gly Leu Met Nyberg et al., 1984
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe+Gly-Leu-Met P NT Gln Gln Phe Phe Gly Leu Met - Nyberg et al., 1984