Substrates for peptidase M13.090: Kell blood-group peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
big endothelin 1 P05305 53-90 peptide-Trp21+Val22-peptide P Asp Ile Ile Trp Val Asn Thr Pro Lee et al., 1999 3059
big endothelin 3 precursor P14138 17-238 peptide-Trp21+Ile22-peptide P Asp Ile Ile Trp Ile Asn Thr Pro Lee et al., 1999 3060
endothelin-2 precursor P20800 25-178 peptide-Trp21+Val22-peptide P Asp Ile Ile Trp Val Asn Thr Pro Lee et al., 1999
Neurokinin A P20366 98-107 peptide-Gly105+Leu-Met-NH2 P MS Ser Phe Val Gly Leu Met NH2 - Clapéron et al., 2005
Substance P P20366 58-68 peptide-Gln63+Phe-peptide P MS Lys Pro Gln Gln Phe Phe Gly Leu Clapéron et al., 2005
Substance P P20366 58-68 peptide-Gly66+Leu-Met-NH2 P MS Gln Phe Phe Gly Leu Met NH2 - Clapéron et al., 2005
Substance P P20366 58-68 peptide-Phe64+Phe-Gly-Leu-Met-NH2 P MS Pro Gln Gln Phe Phe Gly Leu Met Clapéron et al., 2005