Substrates for peptidase A9G.020: yapsin A

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
insulin precursor	P01308	25-110	peptide-Arg32+Glu-peptide	N	Lys	Thr	Arg	Arg	Glu	Ala	Glu	Asp	Loh & Cawley, 2004
insulin precursor	P01308	25-110	peptide-Arg65+Gly-peptide	N	Leu	Gln	Lys	Arg	Gly	Ile	Val	Glu	Loh & Cawley, 2004
pro-opiomelanocortin	P01189	26-267	peptide-Arg112+Ser-peptide	N	Glu	Gly	Lys	Arg	Ser	Tyr	Ser	Met	Loh & Cawley, 2004
pro-opiomelanocortin	P01189	26-267	peptide-Lys151+Arg-peptide	N	Leu	Glu	Phe	Lys	Arg	Glu	Leu	Thr	Loh & Cawley, 2004
pro-opiomelanocortin	P01189	26-267	peptide-Arg152+Glu-peptide	N	Glu	Phe	Lys	Arg	Glu	Leu	Thr	Gly	Loh & Cawley, 2004
pro-opiomelanocortin	P01189	26-267	peptide-Arg210+Tyr-peptide	N	Lys	Asp	Lys	Arg	Tyr	Gly	Gly	Phe	Loh & Cawley, 2004
pro-opiomelanocortin	P01189	26-267	peptide-Lys51+Tyr-peptide	N	Asn	Pro	Arg	Lys	Tyr	Val	Met	Gly	Loh & Cawley, 2004
provasopressin	P01180	20-166	peptide-Arg31+Ala-peptide	N	Gly	Gly	Lys	Arg	Ala	Met	Ser	Asp	Loh & Cawley, 2004
provasopressin	P01180	20-166	peptide-Arg127+peptide	N	Arg	Arg	Val	Arg	Ala	Asn	Asp	Arg	Loh & Cawley, 2004