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Substrates for peptidase A01.030: yapsin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH Abz-Arg-Val-Lys+Arg-Gly-Leu-Ala-Tyr(NO2)-Asp S CS Abz Arg Val Lys Arg Gly Leu Ala Cawley et al., 2003
Beta-endorphin P01189 237-267 Peptide-Lys264+Lys-Gly-Glu N Asn Ala Tyr Lys Lys Gly Glu - Cawley et al., 1996
Boc-Arg-Val-Arg-Arg-Mca Boc-Arg-Val-Arg-Arg+Mca S Arg Val Arg Arg Mca - - - Cawley & Loh, 2004
Boc-Arg-Val-Arg-Arg-NHMec Boc-Arg-Val-Arg+Arg-NHMec S Boc Arg Val Arg Arg AMC - - Cawley et al., 1996
Cholecystokinin-33 P01356 70-102 Peptide-Lys80+Asn-Peptide N AB Ser Met Ile Lys Asn Leu Gln Ser Cawley et al., 1996
Cholecystokinin-33 P01356 70-102 Peptide-Arg94+Asp-Peptide N AB Ile Ser Asp Arg Asp Tyr Met Gly Cawley et al., 1996
corticotropin P01189 138-176 peptide-Lys+Lys-peptide N Pro Val Gly Lys Lys Arg Arg Pro Cawley & Loh, 2004
Corticotropin P01189 138-176 Peptide-Arg154+Arg-Peptide N AB Gly Lys Lys Arg Arg Pro Val Lys Azaryan et al., 1993
Dynorphin A P01214 209-219 Peptide-Arg214+Arg-Peptide N NT Gly Phe Leu Arg Arg Ile Arg Pro Cawley et al., 1996
Dynorphin B P01214 209-219 Peptide-Arg234+Arg-Peptide N NT Phe Leu Arg Arg Gln Phe Lys Val Cawley et al., 1996
flavodoxin-like domain-containing protein Q6FM13 1-198 peptide-Arg174+Ser-peptide P NT Asp Gly Ser Arg Ser Pro Ser Ala Battu et al., 2021
Insulin P01317 25-105 Peptide-Arg55+Arg-Peptide N NT Pro Lys Ala Arg Arg Glu Val Glu Cawley et al., 1996
Insulin P01317 25-105 Peptide-Arg56+Glu-Peptide N NT Lys Ala Arg Arg Glu Val Glu Gly Cawley et al., 1996
Insulin P01317 25-105 Peptide-Lys83+Arg-Peptide N NT Pro Pro Gln Lys Arg Gly Ile Val Cawley et al., 1996
insulin precursor P01308 25-110 peptide-Arg56+Glu57-peptide P Lys Thr Arg Arg Glu Ala Glu Asp Cawley & Loh, 2004 15903
Lipotropin beta P01189 179-267 Peptide-Lys235-Arg-Peptide N AB Pro Lys Asp Lys Arg Tyr Gly Gly Azaryan et al., 1993
Lipotropin beta P01189 179-267 Peptide-Lys215+Lys-Peptide N NT Ala Ala Glu Lys Lys Asp Glu Gly Azaryan et al., 1993
Lipotropin beta P01189 179-267 Peptide-Lys264+Lys-Gly-Glu N NT Asn Ala Tyr Lys Lys Gly Glu - Azaryan et al., 1993
Lys-Ala-Pro-Ser-Gly-Ala-Val-Ser-Met-Ile-Arg-Asn-Leu-Gln-Ser-Leu-Asp-Pro-Ser-His-Arg Peptide-Met9+Ile-peptide S Ala Val Ser Met Ile Arg Asn Leu Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Ala-Val-Ser-Met-Ile-Arg-Asn-Leu-Gln-Ser-Leu-Asp-Pro-Ser-His-Arg Peptide-Arg11+Asn-Peptide S Ser Met Ile Arg Asn Leu Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Ala-Val-Ser-Met-Ile-Lys-Asn-Leu-Gln-Ser-Leu-Arg-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Leu Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Ala-Val-Ser-Met-Ile-Lys-Asn-Leu-Gln-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Leu Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Ala-Ile-Arg-Asn-Leu-Gln-Ser-Leu-Asp-Pro-Ser-His-Arg Peptide-Ala9+Ile-Peptide S Arg Val Ser Ala Ile Arg Asn Leu Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Ala-Ile-Arg-Asn-Leu-Gln-Ser-Leu-Asp-Pro-Ser-His-Arg Peptide-Arg11+Asn-Peptide S Ser Ala Ile Arg Asn Leu Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Leu-Ile-Arg-Asn-Leu-Gln-Ser-Leu-Asp-Pro-Ser-His-Arg Peptide-Leu9+Ile-Peptide S Arg Val Ser Leu Ile Arg Asn Leu Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Leu-Ile-Arg-Asn-Leu-Gln-Ser-Leu-Asp-Pro-Ser-His-Arg Peptide-Arg11+Asn-Peptide S Ser Leu Ile Arg Asn Leu Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Ala-Asn-Arg-Gln-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Arg13+Gln-Peptide S Ile Ala Asn Arg Gln Ser Leu Asp Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Ala-Asn-Leu-Gln-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Met9-Ile-Peptide S Arg Val Ser Met Ile Ala Asn Leu Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Arg-Asn-Leu-Gln-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Met9+Ile-peptide S Arg Val Ser Met Ile Arg Asn Leu Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Arg-Asn-Leu-Gln-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Arg11+Asn-Peptide S Ser Met Ile Arg Asn Leu Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Arg-Gln-Ser-Leu-Arg-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Leu Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Arg-Gln-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Arg Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Asp-Gln-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Asp Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Leu-Arg-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Leu Arg Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Leu-Asp-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Leu Asp Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Leu-Gln-Ser-Leu-Arg-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Leu Gln Ser Olsen et al., 1998
Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Lys-Gln-Ser-Leu-Asp-Pro-ser-His-Arg Peptide-Lys11+Asn-Peptide S Ser Met Ile Lys Asn Lys Gln Ser Olsen et al., 1998
parathyroid hormone P01270 32-115 peptide-Arg56+Lys-peptide N Glu Trp Leu Arg Lys Lys Leu Gln Sohn et al., 2012
Pro-opiomelanocortin P01190 27-103 Peptide-Arg76+Lys-Peptide N AB Asn Pro Arg Lys Tyr Val Met Gly Azaryan et al., 1993
Pro-opiomelanocortin P01193 27-235 Peptide-Arg123+Ser-Peptide N AB Glu Gly Lys Arg Ser Tyr Ser Met Azaryan et al., 1993
Pro-opiomelanocortin P01193 27-235 Peptide-Arg164+Glu-Peptide N AB Glu Phe Lys Arg Glu Leu Glu Gly Azaryan et al., 1993
Pro-opiomelanocortin P01193 27-235 Peptide-Arg204+Tyr-Peptide N AB Lys Asp Lys Arg Tyr Gly Gly Phe Azaryan et al., 1993
proenkephalin-A P01210 107-119 Tyr-Gly-Gly-Phe-Met-Lys-Lys+Met-Asp-Glu-Leu-Tyr-Pro P NT Phe Met Lys Lys Met Asp Glu Leu Cawley et al., 1996
prosomatostatin I P01169 25-121 peptide-Arg+Ala-peptide P Asp Leu Glu Arg Ala Ala Ser Gly Cawley & Loh, 2004 15904
prosomatostatin II P01170 25-125 peptide-Arg+Ser-peptide P Asn Leu Glu Arg Ser Val Asp Ser Cawley & Loh, 2004 15905
yapsin-1 precursor P32329 22-569 peptide-Lys66+Arg-peptide P Arg Leu Leu Lys Arg Ala Asp Gly Cawley & Loh, 2004 15906

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