Substrates for peptidase M9A.011: neuron-specific aminopeptidase

Summary Distribution Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-NHNap Ala+NHNap S - - - Ala NAP - - - Hui et al., 1998
Arg-NHNap Arg+NHNap S - - - Arg NAP - - - Hui et al., 1998
Ile-NHNap Ile+NHNap S - - - Ile NAP - - - Hui et al., 1998
Leu-NHNap Leu+NHNap S - - - Leu NAP - - - Hui et al., 1998
Lys-NHNap Lys+NHNap S - - - Lys NAP - - - Hui et al., 1998
Met-NHNap Met+NHNap S - - - Met NAP - - - Hui et al., 1998
Phe-NHNap Phe+NHNap S - - - Phe NAP - - - Hui et al., 1998
Tyr-NHNap Tyr+NHNap S - - - Tyr NAP - - - Hui et al., 1998
[Leu5]-enkephalin P01213 175-179 Tyr+Gly-Gly-Phe-Leu-NH2 N - - - Tyr Gly Gly Phe Leu Hui et al., 1998
[Met5]-enkephalin P01189 237-241 Tyr+Gly-Gly-Phe-Met-NH2 N - - - Tyr Gly Gly Phe Met Hui et al., 1998