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Substrates for peptidase M16.016: YMXG peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
adrenodoxin, mitochondrial P00257 18-53 peptide-Gly32+Leu-peptide N Gly Ala Gly Gly Leu Arg Gly Ser Kitada et al., 2007
aldehyde dehydrogenase, mitochondrial P47738 1-29 peptide-Ala5+Leu-peptide N Leu Arg Ala Ala Leu Thr Thr Val Kitada et al., 2007
aldehyde dehydrogenase, mitochondrial P47738 1-29 peptide-Arg17+Leu-peptide N Arg Leu Ser Arg Leu Leu Ser Ala Kitada et al., 2007
aldehyde dehydrogenase, mitochondrial P47738 1-29 peptide-Leu18+Leu-peptide N Leu Ser Arg Leu Leu Ser Ala Ala Kitada et al., 2007
alpha-melanocyte stimulating hormone P01189 138-150 Ac-Ser-Tyr-Ser-Met-Glu-His+Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 N Ser Met Glu His Phe Arg Trp Gly Kitada et al., 2007
alpha-melanocyte stimulating hormone P01189 138-150 Ac-Ser-Tyr-Ser-Met-Glu-His-Phe+Arg-Trp-Gly-Lys-Pro-Val-NH2 N Met Glu His Phe Arg Trp Gly Lys Kitada et al., 2007
cytochrome b-c1 complex subunit 2, mitochondrial P07257 1-32 peptide-Arg16+Leu-peptide N NT Ser Val Arg Arg Leu Thr Val Ser Kitada et al., 2007
dynorphin A(1-13) P01214 209-221 Tyr-Gly-Gly-Phe+Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys N Tyr Gly Gly Phe Leu Arg Arg Ile Dabonn‚ et al., 2005
dynorphin A(1-13) P01214 209-221 Tyr-Gly-Gly-Phe-Leu+Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys N Gly Gly Phe Leu Arg Arg Ile Arg Dabonn‚ et al., 2005
dynorphin A(1-13) P01214 209-221 Tyr-Gly-Gly-Phe-Leu-Arg+Arg-Ile-Arg-Pro-Lys-Leu-Lys N Gly Phe Leu Arg Arg Ile Arg Pro Dabonn‚ et al., 2005
dynorphin A(1-13) P01214 209-221 Tyr-Gly-Gly-Phe-Leu-Arg-Arg+Ile-Arg-Pro-Lys-Leu-Lys N Phe Leu Arg Arg Ile Arg Pro Lys Dabonn‚ et al., 2005
dynorphin A(1-17) P01213 207-223 Tyr-Gly-Gly-Phe+Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln N Tyr Gly Gly Phe Leu Arg Arg Ile Kitada et al., 2007
dynorphin A(1-17) P01213 207-223 Tyr-Gly-Gly-Phe-Leu-Arg-Arg+Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln N Phe Leu Arg Arg Ile Arg Pro Lys Kitada et al., 2007
dynorphin A(1-17) P01213 207-223 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro+Lys-Leu-Lys-Trp-Asp-Asn-Gln N Arg Ile Arg Pro Lys Leu Lys Trp Kitada et al., 2007
dynorphin A(1-17) P01213 207-223 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys+Leu-Lys-Trp-Asp-Asn-Gln N Ile Arg Pro Lys Leu Lys Trp Asp Kitada et al., 2007
dynorphin A(1-17) P01213 207-223 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu+Lys-Trp-Asp-Asn-Gln N Arg Pro Lys Leu Lys Trp Asp Asn Kitada et al., 2007
heat shock protein SSC1, mitochondrial P12398 1-32 peptide-Ser16+Phe-peptide N Leu Ser Ser Ser Phe Arg Ile Ala Kitada et al., 2007
heat shock protein SSC1, mitochondrial P12398 1-32 peptide-Leu23+Gln-peptide N Ala Thr Arg Leu Gln Ser Thr Lys Kitada et al., 2007
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala N Arg Gly Phe Phe Tyr Thr Pro Lys Dabonn‚ et al., 2005
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Dabonn‚ et al., 2005
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Dabonn‚ et al., 2005
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala N Arg Gly Phe Phe Tyr Thr Pro Lys Dabonn‚ et al., 2005
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Dabonn‚ et al., 2005
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Dabonn‚ et al., 2005
malate dehydrogenase, mitochondrial P08249 2-28 peptide-Ala12+Leu-peptide N Ala Gly Ala Ala Leu Arg Arg Ser Kitada et al., 2007
malate dehydrogenase, mitochondrial P08249 2-28 peptide-Ser16+Phe-peptide N Leu Arg Arg Ser Phe Ser Thr Ser Kitada et al., 2007
malate dehydrogenase, mitochondrial P17505 2-17 Leu-Ser-Arg-Val-Ala-Lys-Arg-Ala+Phe-Ser-Ser-Thr-Val-Ala-Asn-Pro N NT Ala Lys Arg Ala Phe Ser Ser Thr Kitada et al., 2007
mastoparan-L P01514 1-14 Ile-Asn-Leu-Lys-Ala+Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu N Asn Leu Lys Ala Leu Ala Ala Leu Kitada et al., 2007
mastoparan-L P01514 1-14 Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala+Leu-Ala-Lys-Lys-Ile-Leu N Ala Leu Ala Ala Leu Ala Lys Lys Kitada et al., 2007
mastoparan-L P01514 1-14 Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys+Lys-Ile-Leu N Ala Leu Ala Lys Lys Ile Leu - Kitada et al., 2007
ornithine aminotransferase, mitochondrial P04181 1-25 Met-Phe-Ser+Lys-peptide N - Met Phe Ser Lys Leu Ala His Kitada et al., 2007
ornithine aminotransferase, mitochondrial P04181 1-25 peptide-Leu8+Gln-peptide N Leu Ala His Leu Gln Arg Phe Ala Kitada et al., 2007
ornithine aminotransferase, mitochondrial P04181 1-25 peptide-Gln9+Arg-peptide N Ala His Leu Gln Arg Phe Ala Val Kitada et al., 2007
ornithine aminotransferase, mitochondrial P04181 1-25 peptide-Ala12+Val-peptide N Gln Arg Phe Ala Val Leu Ser Arg Kitada et al., 2007
vasoactive intestinal peptide P01282 125-152 peptide-Asn133+Tyr-peptide N Phe Thr Asp Asn Tyr Thr Arg Leu Kitada et al., 2007
vasoactive intestinal peptide P01282 125-152 peptide-Thr135+Arg-peptide N Asp Asn Tyr Thr Arg Leu Arg Lys Kitada et al., 2007
vasoactive intestinal peptide P01282 125-152 peptide-Arg136+Leu-peptide N Asn Tyr Thr Arg Leu Arg Lys Gln Kitada et al., 2007
vasoactive intestinal peptide P01282 125-152 peptide-Leu137+Arg-peptide N Tyr Thr Arg Leu Arg Lys Gln Met Kitada et al., 2007
vasoactive intestinal peptide P01282 125-152 peptide-Gln140+Met-peptide N Leu Arg Lys Gln Met Ala Val Lys Kitada et al., 2007
vasoactive intestinal peptide P01282 125-152 peptide-Met141+Ala-peptide N Arg Lys Gln Met Ala Val Lys Lys Kitada et al., 2007

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