Substrates for peptidase M01.004: leukotriene A4 hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ala-NHNAP			Ala+NHNAP	S	-	-	-	Ala	NAP	-	-	-	Mueller et al., 1995
Ala-NHNAP			Ala+NHNAP	S	-	-	-	Ala	NAP	-	-	-	Sarker et al., 2011
Ala-NHPhNO2			Ala+NHPhNO2	S	-	-	-	Ala	NAN	-	-	-	Wetterholm & Haeggström, 1992
Arg-Gly-Asp			Arg+Gly-Asp	N	-	-	-	Arg	Gly	Asp	-	-	Orning et al., 1994
Arg-Gly-Gly			Arg+Gly-Gly	N	-	-	-	Arg	Gly	Gly	-	-	Orning et al., 1994
Arg-His-Phe			Arg+His-Phe	N	-	-	-	Arg	His	Phe	-	-	Orning et al., 1994
Arg-NHNAP			Arg+NHNAP	S	-	-	-	Arg	NAP	-	-	-	Orning et al., 1994
Arg-NHNAP			Arg+NHNAP	S	-	-	-	Arg	NAP	-	-	-	Sarker et al., 2011
Arg-NHPhNO2			Arg+NHPhNO2	S	-	-	-	Arg	NAN	-	-	-	Tholander et al., 2005
Leu-Gly			Leu+Gly	N	-	-	-	Leu	Gly	-	-	-	Sarker et al., 2011
Leu-NHNAP			Leu+NHNAP	S	-	-	-	Leu	NAP	-	-	-	Sarker et al., 2011
Leu-NHPhNO2			Leu+NHPhNO2	S	-	-	-	Leu	NAN	-	-	-	Tholander et al., 2005
Lys-NHPhNO2			Lys+NHPhNO2	S	-	-	-	Lys	NAN	-	-	-	Tholander et al., 2005
Met-NHNAP			Met+NHNAP	S	-	-	-	Met	NAP	-	-	-	Sarker et al., 2011
Met-NHPhNO2			Met+NHPhNO2	S	-	-	-	Met	NAN	-	-	-	Tholander et al., 2005
Pro-NHNAP			Pro+NHNAP	S	-	-	-	Pro	NAP	-	-	-	Sarker et al., 2011
Pro-NHPhNO2			Pro+NHPhNO2	S	-	-	-	Pro	NAN	-	-	-	Griffin et al., 1992
Tyr-Gly			Tyr+Gly	N	-	-	-	Tyr	Gly	-	-	-	Sarker et al., 2011
Val-Gly			Val+Gly	N	-	-	-	Val	Gly	-	-	-	Sarker et al., 2011
[Leu5]-enkephalin	P01213	175-179	Tyr+Gly-Gly-Phe-Leu	N	-	-	-	Tyr	Gly	Gly	Phe	Leu	Griffin et al., 1992
[Met5]-enkephalin	P01189	237-241	Tyr+Gly-Gly-Phe-Leu-NH2	N	-	-	-	Tyr	Gly	Gly	Phe	Met	Griffin et al., 1992