Substrates for peptidase C01.070: dipeptidyl-peptidase I

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Cholecystokinin-5	P06307	99-103	Gly-Trp100+Met-Asp-Phe-NH2	P	MS	-	-	Gly	Trp	Met	Asp	Phe	-	Bernardini & Warburton, 2002
dipeptidyl-peptidase 1 precursor	P53634	160-463	Gln-Glu161+Lys-peptide	P		-	-	Gln	Glu	Lys	Tyr	Ser	Asn	Dahl et al., 2001
dipeptidyl-peptidase 1 precursor	P53634	222-463	Ala-Glu223+Ile-peptide	P		-	-	Ala	Glu	Ile	Gln	Gln	Lys	Dahl et al., 2001
dipeptidyl-peptidase 1 precursor	P53634	158-463	Asn-Ser159+Gln-peptide	P		-	-	Asn	Ser	Gln	Glu	Lys	Tyr	Dahl et al., 2001
Glucagon	P01274	53-81	His-Ser54+Gln-peptide	P	NT	-	-	His	Ser	Gln	Gly	Thr	Phe	McDonald et al., 1969
Glucagon	P01274	53-81	His-Ser-Gln-Gly56+Thr-peptide	P	NT	His	Ser	Gln	Gly	Thr	Phe	Thr	Ser	McDonald et al., 1969
Glucagon	P01274	53-81	peptide-Phe58+Thr-peptide	P	NT	Gln	Gly	Thr	Phe	Thr	Ser	Asp	Tyr	McDonald et al., 1969
Glucagon	P01274	53-81	peptide-Tyr62+Ser-peptide	P	NT	Thr	Ser	Asp	Tyr	Ser	Lys	Tyr	Leu	McDonald et al., 1969
Glucagon	P01274	53-81	peptide-Ser60+Asp-peptide	P	NT	Thr	Phe	Thr	Ser	Asp	Tyr	Ser	Lys	McDonald et al., 1969
Glucagon	P01274	53-81	peptide-Lys64+Tyr-peptide	P	NT	Asp	Tyr	Ser	Lys	Tyr	Leu	Asp	Ser	McDonald et al., 1969
Glucagon	P01274	53-81	peptide-Leu66+Asp-peptide	P	NT	Ser	Lys	Tyr	Leu	Asp	Ser	Arg	Arg	McDonald et al., 1969
Glucagon	P01274	53-81	peptide-Ser68+Arg-peptide	P	NT	Tyr	Leu	Asp	Ser	Arg	Arg	Ala	Gln	McDonald et al., 1969
Gly-Phe-2-(4-methoxy)naphthylamide			Gly-Phe+2-(4-methoxy)naphthylamide	S		-	-	Gly	Phe	MNA	-	-	-	Turk et al., 2004
Granzyme A	P12544	1-262	peptide-Lys28+Ile-peptide	P	CS	Val	Cys	Glu	Lys	Ile	Ile	Gly	Gly	McGuire et al., 1993
granzyme A precursor	P11032	27-260	Glu-Arg+Ile-peptide	P		-	-	Glu	Arg	Ile	Ile	Gly	Gly	Pham & Ley, 1999
granzyme B precursor	P04187	19-247	Gly-Glu+Ile-peptide	P		-	-	Gly	Glu	Ile	Ile	Gly	Gly	Pham & Ley, 1999
Granzyme B precursor	P10144	1-247	peptide-Glu20+Ile-peptide	P	CS	Asp	Ala	Gly	Glu	Ile	Ile	Gly	Gly	McGuire et al., 1993
Leu-enkephalin	P04094	232-236	Tyr-Gly233+Gly-Phe-Leu	P	-	-	-	Tyr	Gly	Gly	Phe	Leu	-	Pal et al., 1993
Mast cell protease 2	P15119	1-244	peptide-Glu20+Ile-peptide	P	CS	Gly	Ala	Glu	Glu	Ile	Ile	Gly	Gly	McGuire et al., 1993
Mast cell protease 4	P21812	1-246	peptide-Glu20+Ile-peptide	P	CS	Gly	Ala	Glu	Glu	Ile	Ile	Gly	Gly	McGuire et al., 1993
Melanotropin beta	P01189	217-234	Asp-Glu218+Gly-peptide	P	NT	-	-	Asp	Glu	Gly	Pro	Tyr	Arg	Hsiung et al., 2005
Neutrophil elastase	P08246	1-267	peptide-Glu29+Ile-peptide	P	CS	Leu	Ala	Ser	Glu	Ile	Val	Gly	Gly	McGuire et al., 1993
Secretin	P63298	30-56	His-Ser31+Asp-peptide	P	NT	-	-	His	Ser	Asp	Gly	Thr	Phe	McDonald et al., 1969
Secretin	P63298	30-56	His-Ser-Asp-Gly33+Thr-peptide	P	NT	His	Ser	Asp	Gly	Thr	Phe	Thr	Ser	McDonald et al., 1969
Secretin	P63298	30-56	peptide-Phe35+Thr-peptide	P	NT	Asp	Gly	Thr	Phe	Thr	Ser	Glu	Leu	McDonald et al., 1969
Secretin	P63298	30-56	peptide-Ser37+Glu-peptide	P	NT	Thr	Phe	Thr	Ser	Glu	Leu	Ser	Arg	McDonald et al., 1969
Secretin	P63298	30-56	peptide-Leu39+Ser-peptide	P	NT	Thr	Ser	Glu	Leu	Ser	Arg	Leu	Arg	McDonald et al., 1969
Secretin	P63298	30-56	peptide-Arg41+Leu-peptide	P	NT	Glu	Leu	Ser	Arg	Leu	Arg	Asp	Ser	McDonald et al., 1969
Secretin	P63298	30-56	peptide-Arg43+Asp-peptide	P	NT	Ser	Arg	Leu	Arg	Asp	Ser	Ala	Arg	McDonald et al., 1969
Secretin	P63298	30-56	peptide-Ser45+Ala-peptide	P	NT	Leu	Arg	Asp	Ser	Ala	Arg	Leu	Gln	McDonald et al., 1969
Secretin	P63298	30-56	peptide-Arg47+Leu-peptide	P	NT	Asp	Ser	Ala	Arg	Leu	Gln	Arg	Leu	McDonald et al., 1969
Secretin	P63298	30-56	peptide-Gln49+Arg-peptide	P	NT	Ala	Arg	Leu	Gln	Arg	Leu	Leu	Gln	McDonald et al., 1969
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S		-	Z	Phe	Arg	AMC	-	-	-	Turk et al., 2004