Substrates for peptidase C01.064: RD21 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
beta-casein	P02666	16-224	peptide-Thr93+Gln-peptide	N		Pro	Pro	Leu	Thr	Gln	Thr	Pro	Val	Kikuchi et al., 2008
beta-casein	P02666	16-224	peptide-Lys114+Glu-peptide	N		Ser	Lys	Val	Lys	Glu	Ala	Met	Ala	Kikuchi et al., 2008
Boc-Gln-Arg-Arg-NHMec			Boc-Gln-Arg-Arg+NHMec	S		Boc	Gln	Arg	Arg	AMC	-	-	-	Kikuchi et al., 2008
Boc-Ile-Glu-Gly-Arg-NHMec			Boc-Ile-Glu-Gly-Arg+NHMec	S		Ile	Glu	Gly	Arg	AMC	-	-	-	Kikuchi et al., 2008
Boc-Leu-Arg-Arg-NHMec			Boc-Leu-Arg-Arg+NHMec	S		Boc	Leu	Arg	Arg	AMC	-	-	-	Kikuchi et al., 2008
Boc-Leu-Lys-Arg-NHMec			Boc-Leu-Lys-Arg+NHMec	S		Boc	Leu	Lys	Arg	AMC	-	-	-	Kikuchi et al., 2008
Boc-Phe-Ser-Arg-NHMec			Boc-Phe-Ser-Arg+NHMec	S		Boc	Phe	Ser	Arg	AMC	-	-	-	Kikuchi et al., 2008
Boc-Val-Leu-Lys-NHMec			Boc-Val-Leu-Lys+NHMec	S		Boc	Val	Leu	Lys	AMC	-	-	-	Kikuchi et al., 2008
Glt-Ala-Ala-Phe-NHMec			Glt-Ala-Ala-Phe+NHMec	S		Glt	Ala	Ala	Phe	AMC	-	-	-	Kikuchi et al., 2008
glucagon	P01275	53-81	peptide-Thr59+Ser-peptide	N		Gly	Thr	Phe	Thr	Ser	Asp	Tyr	Ser	Kikuchi et al., 2008
glucagon	P01275	53-81	peptide-Asp67+Ser-peptide	N		Lys	Tyr	Leu	Asp	Ser	Arg	Arg	Ala	Kikuchi et al., 2008
glucagon	P01275	53-81	peptide-Gln76+Trp-peptide	N		Asp	Phe	Val	Gln	Trp	Leu	Met	Asn	Kikuchi et al., 2008
pro-opiomelanocortin	P01189	138-162	Ser+Tyr-peptide	N		-	-	-	Ser	Tyr	Ser	Met	Glu	Kikuchi et al., 2008
pro-opiomelanocortin	P01189	138-162	peptide-Arg145+Trp-peptide	N		Glu	His	Phe	Arg	Trp	Gly	Lys	Pro	Kikuchi et al., 2008
pro-opiomelanocortin	P01189	138-162	peptide-Gly151+Lys-peptide	N		Lys	Pro	Val	Gly	Lys	Lys	Arg	Arg	Kikuchi et al., 2008
pro-opiomelanocortin	P01189	138-162	peptide-Lys158+Val-peptide	N		Arg	Pro	Val	Lys	Val	Tyr	Pro	Asn	Kikuchi et al., 2008
Pyr-Arg-Thr-Lys-Arg-NHMec			Pyr-Arg-Thr-Lys-Arg+NHMec	S		Arg	Thr	Lys	Arg	AMC	-	-	-	Kikuchi et al., 2008
serpin-ZX	Q9S7T8	1-391	peptide-Arg351+Gly-peptide	P	CS	Ile	Lys	Leu	Arg	Gly	Leu	Leu	Met	Lampl et al., 2010
Z-Arg-Arg-NHMec			Z-Arg-Arg+NHMec	S		-	Z	Arg	Arg	AMC	-	-	-	Kikuchi et al., 2008
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S		-	Z	Phe	Arg	AMC	-	-	-	Kikuchi et al., 2008