Substrates for peptidase S09.004: acylaminoacyl-peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Abz-Gly-Phe-Glu-Pro-NPh-Arg-Ala			Abz-Gly-Phe+Glu-Pro-NPh-Arg-Ala	S		-	Abz	Gly	Phe	Glu	Pro	NPh	Arg	Kiss et al., 2007
Ac-Ala-NHMec			Ac-Ala+NHMec	S		-	-	Ac	Ala	AMC	-	-	-	Kiss et al., 2007
Ac-Ala-NHPhNO2			Ac-Ala+NHPhNO2	S		-	-	Ac	Ala	NAN	-	-	-	Manning, 2004
Ac-Glu-NHPhNO2			Ac-Glu+NHPhNO2	S		-	-	Ac	Glu	NAN	-	-	-	Manning, 2004
Ac-Phe-NHNap			Ac-Phe+NHNap	S		-	-	Ac	Phe	NAP	-	-	-	Kiss et al., 2007
acetylaminoacyl bond			Ac-Xaa+peptide	S		-	-	Ac	Xaa	CPe	-	-	-	Manning, 2004
alpha-melanocyte stimulating hormone	P01189	138-150	Ac-Ser+Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2	N		-	-	Ac	Ser	Tyr	Ser	Met	Glu	Manning, 2004
beta-amyloid protein 42	P05067	672-713	peptide-His684+His-peptide	P	MS	Tyr	Glu	Val	His	His	Gln	Lys	Leu	Yamin et al., 2009
beta-amyloid protein 42	P05067	672-713	peptide-His685+Gln-peptide	P	MS	Glu	Val	His	His	Gln	Lys	Leu	Val	Yamin et al., 2009
beta-amyloid protein 42	P05067	672-713	peptide-Phe690+Phe-peptide	P	MS	Lys	Leu	Val	Phe	Phe	Ala	Glu	Asp	Yamin et al., 2009
carbamylaminoacyl bond			carbamyl-Xaa+peptide	N		-	-	Car	Xaa	CPe	-	-	-	Manning, 2004
chloroacetylaminoacyl bond			chloroacetyl-Xaa+peptide	N		-	-	CAc	Xaa	CPe	-	-	-	Manning, 2004
formylaminoacyl bond			formyl-Xaa+peptide	N		-	-	For	Xaa	CPe	-	-	-	Manning, 2004
Gly-Phe-NHNap			Gly-Phe+NHNap	S		-	-	Gly	Phe	NAP	-	-	-	Kiss et al., 2007