Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P05067

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
17	unknown peptidase	1-639	P	release of a signal peptide	NT	Gevaert et al., 2003
124	meprin alpha subunit	18-770	N		MS	Becker-Pauly et al., 2011
124	meprin beta subunit	18-770	N		MS	Becker-Pauly et al., 2011
229	HIV-1 retropepsin	18-770	N			Tomasselli et al., 1991
286	unknown peptidase	1-770	P		NT	<%Agarwal et al., 2012[]%>
301	mesotrypsin	18-770	P		NT	Salameh et al., 2010
380	meprin beta subunit	18-770	N		MS	Becker-Pauly et al., 2011
396	EcpA peptidase	394-410	N			Oleksy et al., 2004
399	EcpA peptidase	394-410	N			Oleksy et al., 2004
463	membrane-type matrix metallopeptidase-3	18-770	P			Ahmad et al., 2006
579	membrane-type matrix metallopeptidase-1	18-770	P			Higashi & Miyazaki, 2003
579	membrane-type matrix metallopeptidase-3	18-770	P			Ahmad et al., 2006
609	HtrA2 peptidase	18-770	P			Park et al., 2006
610	HIV-1 retropepsin	18-770	N			Tomasselli et al., 1991
622	membrane-type matrix metallopeptidase-3	18-770	P			Ahmad et al., 2006
627	cathepsin D	621-770	N		NT	Higaki et al., 1996
668	cathepsin D	621-770	N		NT	Higaki et al., 1996
670	kallikrein-related peptidase 6	18-770	P			Magklara et al., 2003
670	beta-secretase Matsumoto	667-683	P			Matsumoto & Fujiwara, 1994
671	BACE1 g.p. (Homo sapiens)	18-770	P	normal turnover		Lin et al., 2000
671	BACE2 g.p. (Homo sapiens)	667-678	N		MS	Kim et al., 2002
671	beta-secretase Matsumoto	667-683	P			Matsumoto & Fujiwara, 1994
672	BACE2 g.p. (Homo sapiens)	667-678	N		MS	Kim et al., 2002
672	caspase-6	18-770	P			LeBlanc et al., 1999
672	HtrA1 peptidase (Homo sapiens-type)	18-770	P			Grau et al., 2005
672	transthyretin	672-713	N		NT	Costa et al., 2008
673	cathepsin D	671-770	N		MS	Higaki et al., 1996
674	cathepsin D	621-770	N		NT	Higaki et al., 1996
674	BACE2 g.p. (Homo sapiens)	667-678	N		MS	Kim et al., 2002
674	endothelin-converting enzyme 1	672-713	P			Yan et al., 2006
674	insulysin	672-713	P			Yan et al., 2006
674	transthyretin	672-713	N		NT	Costa et al., 2008
675	cathepsin D	671-770	N		MS	Higaki et al., 1996
675	insulysin	672-713	P			Yan et al., 2006
675	lumbrokinase	672-711	N		NT	Nakajima et al., 1999
676	BACE2 g.p. (Homo sapiens)	667-678	N		MS	Kim et al., 2002
676	angiotensin-converting enzyme peptidase unit 1	671-687	N		MS	Toropygin et al., 2008
676	plasmin	672-711	P		MS	Tucker et al., 2000
676	kallikrein-related peptidase 6	18-770	P			Magklara et al., 2003
676	lumbrokinase	672-711	N		NT	Nakajima et al., 1999
676	transthyretin	672-713	N		NT	Costa et al., 2008
678	D-aspartyl endopeptidase	672-681	P		NT	Kinouchi et al., 2004
679	fibrinolytic enzyme A (Annelida-type)	672-711	N		NT	Nakajima et al., 1999
681	cathepsin B	672-711	N		MS	Mackay et al., 1997
683	insulysin	672-713	P		NT	Malito et al., 2008
683	HtrA1 peptidase (Homo sapiens-type)	18-770	P			Grau et al., 2005
684	BACE2 g.p. (Homo sapiens)	672-694	N		MS	Kim et al., 2002
684	insulysin	672-713	N			Yan et al., 2006
684	acylaminoacyl-peptidase	672-713	P		MS	Yamin et al., 2009
685	BACE2 g.p. (Homo sapiens)	672-694	N		MS	Kim et al., 2002
685	cathepsin B	672-711	N		MS	Mackay et al., 1997
685	bleomycin hydrolase (animal)	675-713	P		MS	Kajiya et al., 2006
685	membrane-type matrix metallopeptidase-3	18-770	P			Ahmad et al., 2006
685	membrane-type matrix metallopeptidase-4	681-691	P			Amour et al., 2002
685	ADAM8 peptidase	18-770	P			Amour et al., 2002
685	ADAM9 peptidase	18-770	P			Amour et al., 2002
685	ADAM33 peptidase	18-770	N			Zou et al., 2004
685	insulysin	672-713	N			Yan et al., 2006
685	dactylysin	672-711	N		MS	Clamagirand et al., 2002
685	acylaminoacyl-peptidase	672-713	P		MS	Yamin et al., 2009
686	BACE2 g.p. (Homo sapiens)	672-694	N		MS	Kim et al., 2002
686	ADAM10 peptidase	18-770	P			<%De Strooper et al., 1998[]%>
686	insulysin	672-713	N			Yan et al., 2006
686	eupitrilysin	672-711	P		MS	Falkevall et al., 2006
686	HtrA1 peptidase (Homo sapiens-type)	18-770	P			Grau et al., 2005
687	yapsin-3	672-700	N		NT	Olsen et al., 1999
687	BACE2 g.p. (Homo sapiens)	672-694	N		MS	Kim et al., 2002
687	cathepsin B	672-711	N		MS	Mackay et al., 1997
687	matrix metallopeptidase-2	672-711	P			Roher et al., 1995
687	matrix metallopeptidase-9	18-770	P			Yan et al., 2006
687	membrane-type matrix metallopeptidase-1	18-770	P			Amour et al., 2002
687	membrane-type matrix metallopeptidase-4	18-770	P			Amour et al., 2002
687	ADAM10 peptidase	18-770	P			Amour et al., 2002
687	ADAM17 peptidase	18-770	P			Mohan et al., 2002
687	endothelin-converting enzyme 1	18-770	P			Yan et al., 2006
687	neprilysin-2	672-711	P		MS	Huang et al., 2008
687	insulysin	672-713	N			Yan et al., 2006
687	eupitrilysin	672-711	P		MS	Falkevall et al., 2006
687	plasmin	672-711	P		MS	Tucker et al., 2000
687	kallikrein-related peptidase 6	18-770	P			Magklara et al., 2003
687	lumbrokinase	672-711	N		NT	Nakajima et al., 1999
688	endothelin-converting enzyme 1	18-770	P			Yan et al., 2006
688	neprilysin-2	672-711	P		MS	Huang et al., 2008
688	insulysin	672-713	N			Yan et al., 2006
688	dactylysin	683-692	N		MS	Clamagirand et al., 2002
689	bleomycin hydrolase (animal)	672-711	P		NT	Kajiya et al., 2006
689	neprilysin	18-770	P			Yan et al., 2006
689	insulysin	672-713	N			Yan et al., 2006
689	fibrinolytic enzyme A (Annelida-type)	672-711	N		NT	Nakajima et al., 1999
690	cathepsin D	18-770	N			Sadik et al., 1999
690	cathepsin E	672-711	N		MS	Mackay et al., 1997
690	BACE2 g.p. (Homo sapiens)	18-770	P			Fluhrer et al., 2002
690	bleomycin hydrolase (animal)	672-713	P		MS	Kajiya et al., 2006
690	endothelin-converting enzyme 1	18-770	P			Yan et al., 2006
690	insulysin	672-713	N			Yan et al., 2006
690	eupitrilysin	672-711	P		MS	Falkevall et al., 2006
690	dactylysin	683-692	N		MS	Clamagirand et al., 2002
690	lumbrokinase	672-711	N		NT	Nakajima et al., 1999
690	acylaminoacyl-peptidase	672-713	P		MS	Yamin et al., 2009
691	cathepsin D	18-770	N			Sadik et al., 1999
691	cathepsin E	672-711	N		MS	Mackay et al., 1997
691	BACE2 g.p. (Homo sapiens)	18-770	P			Farzan et al., 2000
691	matrix metallopeptidase-9	18-770	P			Yan et al., 2006
691	insulysin	672-713	P		NT	Malito et al., 2008
691	eupitrilysin	18-770	P			Falkevall et al., 2006
693	cathepsin D	671-770	N		MS	Higaki et al., 1996
693	cathepsin B	671-770	N		MS	Mackay et al., 1997
694	cathepsin D	671-770	N		MS	Higaki et al., 1996
694	matrix metallopeptidase-9	18-770	P			Yan et al., 2006
695	fibrinolytic enzyme A (Annelida-type)	672-711	N		NT	Nakajima et al., 1999
698	transthyretin	672-713	N		NT	Costa et al., 2008
699	insulysin	18-770	N			Yan et al., 2006
699	plasmin	672-711	P		MS	Tucker et al., 2000
699	lumbrokinase	672-711	N		NT	Nakajima et al., 1999
700	eupitrilysin	672-711	P		MS	Falkevall et al., 2006
701	matrix metallopeptidase-9	18-770	P			Yan et al., 2006
701	eupitrilysin	672-711	P		MS	Falkevall et al., 2006
703	fibrinolytic enzyme A (Annelida-type)	672-711	N		NT	Nakajima et al., 1999
704	cathepsin B	672-770	P		NT	Mueller-Steiner et al., 2006
704	matrix metallopeptidase-9	18-770	P			Yan et al., 2006
704	eupitrilysin	672-711	P		MS	Falkevall et al., 2006
705	cathepsin D	18-770	P	normal turnover		Sadik et al., 1999
705	matrix metallopeptidase-2	672-711	P			Roher et al., 1995
705	matrix metallopeptidase-9	18-770	P			Yan et al., 2006
705	eupitrilysin	672-711	N			Chow et al., 2009
705	lumbrokinase	672-711	N		NT	Nakajima et al., 1999
706	matrix metallopeptidase-2	672-711	P			Roher et al., 1995
707	fibrinolytic enzyme A (Annelida-type)	672-711	N		NT	Nakajima et al., 1999
708	cathepsin B	672-770	P		NT	Mueller-Steiner et al., 2006
709	intramembrane aspartyl peptidase (Methanoculleus marisnigri JR1)	700-722	N			Torres-Arancivia et al., 2010
709	cathepsin B	672-711	N		MS	Mackay et al., 1997
709	eupitrilysin	672-711	P		MS	Falkevall et al., 2006
711	presenilin 1	672-770	P			De Strooper et al., 1998
711	intramembrane aspartyl peptidase (Methanoculleus marisnigri JR1)	700-722	N			Torres-Arancivia et al., 2010
711	cathepsin B	672-770	P		MS	Mueller-Steiner et al., 2006
711	angiotensin-converting enzyme peptidase unit 1	672-713	P		MS	Zou et al., 2007
713	cathepsin D	18-770	P	normal turnover		Sadik et al., 1999
713	presenilin 1	672-770	P			De Strooper et al., 1998
714	cathepsin D	18-770	P	normal turnover		Sadik et al., 1999
714	presenilin 1	672-770	P			De Strooper et al., 1998
719	cathepsin D	18-770	P	normal turnover		Sadik et al., 1999
720	cathepsin D	18-770	P	normal turnover		Sadik et al., 1999
722	cathepsin D	671-770	N		MS	Higaki et al., 1996
723	cathepsin D	671-770	N		MS	Mackay et al., 1997
737	cathepsin E	671-770	N		MS	Mackay et al., 1997
737	cathepsin B	671-770	N		MS	Mackay et al., 1997
739	cathepsin D	18-770	N		NT	Higaki et al., 1996
739	cathepsin E	671-770	N		MS	Mackay et al., 1997
739	caspase-3	18-770	P	normal turnover		Gervais et al., 1999
739	caspase-6	18-770	P			LeBlanc et al., 1999
741	cathepsin E	671-770	N		MS	Mackay et al., 1997
753	cathepsin B	671-770	N		MS	Mackay et al., 1997
755	HtrA1 peptidase (Homo sapiens-type)	18-770	P			Grau et al., 2005
764	cathepsin D	18-770	N			Sadik et al., 1999
764	cathepsin E	671-770	N		MS	Mackay et al., 1997
765	cathepsin D	671-770	N		MS	Higaki et al., 1996
767	cathepsin D	671-770	N		MS	Higaki et al., 1996