Substrates for peptidase A01.004: BACE1 g.p. (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
amyloid beta A4 protein	P05067	18-770	peptide-Met671+peptide	P		Glu	Val	Lys	Met	Asp	Ala	Glu	Phe	Lin et al., 2000	15744
amyloid beta A4 protein	P05067-4	18-770	peptide-Met596+Asp-peptide	P	MS	Glu	Val	Lys	Met	Asp	Ala	Glu	Phe	Hata et al., 2009
amyloid beta A4 protein	P05067-4	18-770	peptide-Val636+Ile-peptide	P	MS	Gly	Gly	Val	Val	Ile	Ala	Thr	Val	Hata et al., 2009
amyloid beta A4 protein	P05067-4	18-770	peptide-Ala638+Thr-peptide	P	MS	Val	Val	Ile	Ala	Thr	Val	Ile	Val	Hata et al., 2009
Beta-secretase 1 precursor	P56817	1-501	Peptide-Arg45+Glu-Peptide	P	NT	Arg	Leu	Pro	Arg	Glu	Thr	Asp	Glu	Sidera et al., 2002
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase	Q64685	1-403	peptide-Leu37+Gln-peptide	P		Ala	Leu	Thr	Leu	Gln	Ala	Lys	Val	Kitazume et al., 2003	19481
FS-1			Arg-Glu(EDANS)-Glu-Val-Asn-Leu+Asp-Ala-Glu-Phe-Lys(DABCYL)-Arg	N		Glu	Val	Asn	Leu	Asp	Ala	Glu	Phe	Ermolieff et al., 2000
FS-2			Ser-MCA-Glu-Val-Asn-Leu+Asp-Ala-Glu-Phe-Lys(DNP)	N		Glu	Val	Asn	Leu	Asp	Ala	Glu	Phe	Ermolieff et al., 2000
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly+Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		His	Leu	Cya	Gly	Ser	His	Leu	Val	Lin et al., 2000
memapsin-2	P56817	46-501	peptide-Phe99+Ala-peptide	P		Ser	Ser	Asn	Phe	Ala	Val	Gly	Ala	Lin et al., 2000
memapsin-2	P56817	46-501	peptide-Tyr184+Ala-peptide	P		Gly	Leu	Ala	Tyr	Ala	Glu	Ile	Ala	Lin et al., 2000
memapsin-2 precursor	P56817	22-501	peptide-His24+Gly-peptide	P		Gly	Thr	Gln	His	Gly	Ile	Arg	Leu	Lin et al., 2000
neuregulin-1, isoform Beta1A	Q02297-6		peptide-Phe237+Met-peptide	P		Gly	Ile	Glu	Phe	Met	Glu	Ala	Glu
P-selectin glycoprotein ligand 1	Q14242	42-412	peptide-Leu303+Ser-peptide	P		Ala	Ser	Asn	Leu	Ser	Val	Asn	Tyr	Lichtenthaler et al., 2003	18462
peptide OK			Glu-Ile-Asp-Leu+Met-Val-Leu-Asp-Trp-His-Asp-Arg	S		Glu	Ile	Asp	Leu	Met	Val	Leu	Asp	Turner et al., 2001
peptide SW			Glu-Val-Asn-Leu+Asp-Ala-Glu-Phe-Trp-His-Asp-Arg	S		Glu	Val	Asn	Leu	Asp	Ala	Glu	Phe	Turner et al., 2001
seizure protein 6	Q7TSK2	894-918	peptide-Leu906+Asp-peptide	P	NT	Gly	Arg	Ser	Leu	Asp	Val	Ala	Lys	Pigoni et al., 2016
sodium channel beta-4 subunit precursor	Q7M729	31-228	peptide-Leu149+Gln-peptide	P		Thr	Ile	Phe	Leu	Gln	Val	Val	Asp	Wong et al., 2005	19673
sodium channel subunit beta-1 precursor	P97952	19-218	peptide-Leu144+Glu-peptide	P		Lys	Ile	His	Leu	Glu	Val	Val	Asp	Wong et al., 2005	19670
sodium channel subunit beta-2 precursor	Q56A07	30-215	peptide-Leu144+Gln-peptide	P		Lys	Ile	Tyr	Leu	Gln	Val	Leu	Leu	Wong et al., 2005
sodium channel subunit beta-3 precursor	Q8BHK2	25-215	peptide-Phe128+Glu-peptide	P		Glu	Phe	Glu	Phe	Glu	Ala	His	Arg	Wong et al., 2005	19672
sodium channel subunit beta-3 precursor	Q8BHK2	25-215	peptide-Phe153+Thr-peptide	P		Gly	Glu	Asp	Phe	Thr	Ser	Val	Val	Wong et al., 2005	19674
Val-Gly-Ser-Gly-Val-Leu-Leu-Ser-Arg-Lys			Val-Gly-Ser-Gly-Val-Leu-Leu+Ser-Arg-Lys	N		Gly	Val	Leu	Leu	Ser	Arg	Lys	-	Lin et al., 2000
Val-Gly-Ser-Gly-Val-Leu-Leu-Ser-Arg-Lys			Val-Gly-Ser+Gly-Val-Leu-Leu-Ser-Arg-Lys	N		-	Val	Gly	Ser	Gly	Val	Leu	Leu	Lin et al., 2000
Val-Gly-Ser-Gly-Val-Leu-Leu-Ser-Arg-Lys			Val+Gly-Ser-Gly-Val-Leu-Leu-Ser-Arg-Lys	N		-	-	-	Val	Gly	Ser	Gly	Val	Lin et al., 2000