Substrates for peptidase C01.084: bleomycin hydrolase (animal)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ala-NHMec			Ala+NHMec	S		-	-	-	Ala	AMC	-	-	-	Bromme et al., 1996
amyloid beta A4 protein	P05067	672-711	peptide-His685+Gln-peptide	P	NT	Glu	Val	His	His	Gln	Lys	Leu	Val	Kajiya et al., 2006
amyloid beta A4 protein	P05067	672-711	peptide-Val689+Phe-peptide	P	NT	Gln	Lys	Leu	Val	Phe	Phe	Ala	Glu	Kajiya et al., 2006
Arg-NHMec			Arg+NHMec	S		-	-	-	Arg	AMC	-	-	-	Bromme et al., 1996
Arg-NHPhNO2			Arg+NHPhNO2	S		-	-	-	Arg	NAN	-	-	-	Nishimura et al., 1989
Asn-NHMec			Asn+NHMec	S		-	-	-	Asn	AMC	-	-	-	Bromme et al., 1996
Beta-amyloid protein 3-42	P05067	675-713	peptide-His685+Gln-peptide	P	MS	Glu	Val	His	His	Gln	Lys	Leu	Val	Kajiya et al., 2006
Beta-amyloid protein 40	P05067	672-711	peptide-Phe690+Phe-peptide	P	MS	Lys	Leu	Val	Phe	Phe	Ala	Glu	Asp	Kajiya et al., 2006
Beta-amyloid protein 42	P05067	672-713	peptide-His685+Gln-peptide	P	MS	Glu	Val	His	His	Gln	Lys	Leu	Val	Kajiya et al., 2006
Beta-amyloid protein 42	P05067	672-713	peptide-Phe690+Phe-peptide	P	MS	Lys	Leu	Val	Phe	Phe	Ala	Glu	Asp	Kajiya et al., 2006
Bz-Arg-NHNap			Bz-Arg+NHNap	S		-	-	Bz	Arg	NAP	-	-	-
Cit-NHMec			Cit+NHMec	S		-	-	-	Cit	AMC	-	-	-	Bromme et al., 1996
Glu-NHMec			Glu+NHMec	S		-	-	-	Glu	AMC	-	-	-	Bromme et al., 1996
His-NHMec			His+NHMec	S		-	-	-	His	AMC	-	-	-	Bromme et al., 1996
homocysteine-thiolactone			homocysteine	N		-	-	-	HCy	-	-	-	-	Zimny et al., 2006
Leu-Gly			Leu+Gly	N		-	-	-	Leu	Gly	-	-	-	Nishimura et al., 1989
Leu-NHMec			Leu+NHMec	S		-	-	-	Leu	AMC	-	-	-	Bromme et al., 1996
Leu-NHNap			Leu+NHNap	S		-	-	-	Leu	NAP	-	-	-
Met-NHMec			Met+NHMec	S		-	-	-	Met	AMC	-	-	-	Bromme et al., 1996