Substrates for peptidase S01.277: HtrA1 peptidase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
aggrecan core protein	P16112	17-2415	peptide-Val375+Thr-peptide	P	NT	Val	Gln	Thr	Val	Thr	Trp	Pro	Asp	Chamberland et al., 2009
amyloid beta A4 protein	P05067	18-770	peptide-Asp672+Ala-peptide	P		Val	Lys	Met	Asp	Ala	Glu	Phe	Arg	Grau et al., 2005
amyloid beta A4 protein	P05067	18-770	peptide-Val683+His-peptide	P		Gly	Tyr	Glu	Val	His	His	Gln	Lys	Grau et al., 2005
amyloid beta A4 protein	P05067	18-770	peptide-Gln686+Lys-peptide	P		Val	His	His	Gln	Lys	Leu	Val	Phe	Grau et al., 2005
amyloid beta A4 protein	P05067	18-770	peptide-Asn755+Gly-peptide	P		Met	Gln	Gln	Asn	Gly	Tyr	Glu	Asn	Grau et al., 2005