Substrates for U9G.071: transthyretin

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
apolipoprotein A-I	P02647	25-267	peptide-Phe249+Lys-peptide	P	NT	Leu	Glu	Ser	Phe	Lys	Val	Ser	Phe	Lis et al., 2004
Beta-amyloid protein 42	P05067	672-713	Asp672+Ala-Peptide	N	NT	-	-	-	Asp	Ala	Glu	Phe	Arg	Costa et al., 2008
Beta-amyloid protein 42	P05067	672-713	Asp-Ala-Glu674+Phe-Peptide	N	NT	-	Asp	Ala	Glu	Phe	Arg	His	Asp	Costa et al., 2008
Beta-amyloid protein 42	P05067	672-713	Peptide-Arg676+His-Peptide	N	NT	Ala	Glu	Phe	Arg	His	Asp	Ser	Gly	Costa et al., 2008
Beta-amyloid protein 42	P05067	672-713	Peptide-Asn698+Lys-Peptide	N	NT	Val	Gly	Ser	Asn	Lys	Gly	Ala	Ile	Costa et al., 2008