Substrates for peptidase M12.244: ADAM33 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
amyloid beta A4 protein	P05067	18-770	peptide-His14+Gln-peptide	N		Glu	Val	His	His	Gln	Lys	Leu	Val	Zou et al., 2004	20118
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	MS	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Zou et al., 2004
kit ligand	P20826	26-273	Leu-Pro-Pro-Val-Ala-Ala+Ser-Ser-Leu-Arg	N		Pro	Val	Ala	Ala	Ser	Ser	Leu	Arg	Zou et al., 2004	20081
tumor necrosis factor ligand superfamily member 11	O14788	1-317	peptide-His139+Ile-peptide	P		Gly	Ser	Gln	His	Ile	Arg	Ala	Glu	Zou et al., 2004	20116