Substrates for peptidase M12.209: ADAM9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
ADAM9 peptidase	Q61072	30-845	peptide-Arg205+Ala-peptide	P	Arg	Arg	Arg	Arg	Ala	Val	Leu	Pro	Koike et al., 1999	19966
amyloid beta A4 protein	P05067	18-770	peptide-His685+Gln-peptide	P	Glu	Val	His	His	Gln	Lys	Leu	Val	Amour et al., 2002
amyloid precursor alpha secretase cleavage site peptide			Glu-Val-His-His+Gln-Lys-Leu-Val-Phe	N	Glu	Val	His	His	Gln	Lys	Leu	Val	Blobel, 2004
c-{kit} ligand-1 cleavage site peptide			Pro-Val-Ala-Ala-Ser+Ser-Leu-Arg-Asn-Asp	N	Val	Ala	Ala	Ser	Ser	Leu	Arg	Asn	Blobel, 2004
c-{kit} ligand-1 cleavage site peptide			Pro-Pro-Ala-Ala+Ser-Ser-Leu-Arg-Asp	N	Pro	Pro	Ala	Ala	Ser	Ser	Leu	Arg	Blobel, 2004
c-{kit} ligand-1 cleavage site peptide			Leu-Pro-Pro-Val-Ala+Ser-Ser-Leu-Arg-Asn	N	Pro	Pro	Val	Ala	Ser	Ser	Leu	Arg	Blobel, 2004
c-{kit} ligand-1 cleavage site peptide			Leu-Pro-Pro-Val-Ala+Ala-Ser-Ser-Leu-Arg	N	Pro	Pro	Val	Ala	Ala	Ser	Ser	Leu	Zou et al., 2004
Dabcyl-Pro-Arg-Ala-Ala-Ala-hPhe-Thr-Ser-Pro-Lys(FAM)-NH2			Dabcyl-Pro-Arg-Ala-Ala-Ala+homoPhe-Thr-Ser-Pro-Lys(FAM)-NH2	S	Arg	Ala	Ala	Ala	HPh	Thr	Ser	Pro	Moss et al., 2016
Glu(EDANS)-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Lys(DABCYL)			Glu(EDANS)-Pro-Leu-Ala-Gln-Ala+Val-Arg-Ser-Ser(TF)-Ser-Lys(DABCYL)	S	Leu	Ala	Gln	Ala	Val	Arg	Ser	Ser	Minond et al., 2012
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr+Thr-Pro-Lys-Ala	N	Gly	Phe	Phe	Tyr	Thr	Pro	Lys	Ala	Chesneau et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Glu	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Chesneau et al., 2003	20930
kit ligand	P20826	26-273	peptide-Ala190+Ser-peptide	P	Pro	Val	Ala	Ala	Ser	Ser	Leu	Arg	Kawaguchi et al., 2007	20082
kit ligand	P20826	26-273	peptide-Ala189+Ala-peptide	P	Pro	Pro	Val	Ala	Ala	Ser	Ser	Leu	Kawaguchi et al., 2007	20083
kit ligand	P20826	26-273	peptide-Ser191+Ser-peptide	P	Val	Ala	Ala	Ser	Ser	Leu	Arg	Asn	Kawaguchi et al., 2007	20084
P-Cha-Gly-Cys(Me)-His-Ala-Lys(Nma)			P-Cha-Gly+Cys(Me)-His-Ala-Lys(Nma)	N	-	-	Cha	Gly	CyM	His	Ala	LyN	Blobel, 2004
p75 tumor necrosis factor receptor cleavage site peptide			Pro-Gly-Ala-Val-His+Leu-Pro-Gln-Pro	N	Gly	Ala	Val	His	Leu	Pro	Gln	Pro	Blobel, 2004
TNFalpha proximal cleavage site peptide			Ser-Pro-Leu-Ala+Gln-Ala-Val-Arg-Ser	N	Ser	Pro	Leu	Ala	Gln	Ala	Val	Arg	Blobel, 2004
TNFalpha proximal cleavage site peptide			Gln-Ala-Val-Arg-Ser+Ser-Ser-Arg	N	Ala	Val	Arg	Ser	Ser	Ser	Arg	-	Blobel, 2004
tumor necrosis factor	P01375	1-233	peptide-Ala74+Gln-peptide	P	Ser	Pro	Leu	Ala	Gln	Ala	Val	Arg	Amour et al., 2002	4009
tumor necrosis factor	P01375	1-233	peptide-Ser79+Ser-peptide	P	Ala	Val	Arg	Ser	Ser	Ser	Arg	Thr	Amour et al., 2002	4010