Substrates for peptidase C47.003: EcpA peptidase

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
amyloid beta A4 protein (Lys395Leu, Leu398Ile mutant) P05067 394-410 Ala-Leu-Glu+Arg-Ile-Glu-Ala-Lys-His-Arg-Glu-Arg-Met-Ser-Gln-Val-Met N - Ala Leu Glu Arg Ile Glu Ala Oleksy et al., 2004
amyloid beta A4 protein (Lys395Leu, Leu398Ile mutant) P05067 394-410 Ala-Leu-Glu-Arg-Ile-Glu+Ala-Lys-His-Arg-Glu-Arg-Met-Ser-Gln-Val-Met N Glu Arg Ile Glu Ala Lys His Arg Oleksy et al., 2004
archaemetzincin-2 (Glu280Phe mutant) Q86W34 271-286 Leu-Met-Gln-Gly-Ser-Asn-His-Leu-Glu+Phe-Ala-Asp-Arg-Arg-Pro-Leu N Asn His Leu Glu Phe Ala Asp Arg Oleksy et al., 2004
fibrinogen alpha chain P02671 20-35 Ala-Asp-Ser-Gly-Glu+Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg N Asp Ser Gly Glu Gly Asp Phe Leu Oleksy et al., 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N His Leu Val Glu Ala Leu Tyr Leu Potempa & Travis, 2004
myoglobin-derived peptide P02144 peptide-Glu12+Leu-peptide N Lys Ala Leu Glu Leu Phe Arg Lys Potempa & Travis, 2004 16360
neurotensin (Gln151Glu mutant) P30990 151-163 Glu-Leu-Tyr-Glu+Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu N Glu Leu Tyr Glu Asn Lys Pro Arg Oleksy et al., 2004
Z-Phe-Leu-Glu-NHPhNO2 Z-Phe-Leu-Glu+NHPhNO2 S Z Phe Leu Glu NAN - - - Potempa & Travis, 2004