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Substrates for peptidase M12.217: ADAM17 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
40S ribosomal protein S12 P63323 2-132 peptide-Lys23+Thr-peptide N MS Glu Val Leu Lys Thr Ala Leu Ile Scharfenberg et al., 2020
40S ribosomal protein S14 P62264 1-151 peptide-Met75+Leu-peptide N MS Tyr Ala Ala Met Leu Ala Ala Gln Scharfenberg et al., 2020
40S ribosomal protein S3a (Protein TU-11) P97351 1-264 peptide-Glu230+Leu-peptide N MS Lys Leu Met Glu Leu His Gly Glu Scharfenberg et al., 2020
Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa Abz-Leu-Ala-Gln-Ala+Val-Arg-Ser-Ser-Ser-Arg-Dpa S Leu Ala Gln Ala Val Arg Ser Ser Guan et al., 2010
Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] P60710 1-375 peptide-Ala7+Leu-peptide N MS Asp Ile Ala Ala Leu Val Val Asp Scharfenberg et al., 2020
Actin, cytoplasmic 2 (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] P63260 1-375 peptide-Leu8+Val-peptide N MS Ile Ala Ala Leu Val Ile Asp Asn Scharfenberg et al., 2020
ADAM17 isoform 2 precursor Q9Z0F8-2 18-655 peptide-His118+Val-peptide N MS Phe Ser Gly His Val Val Gly Glu Scharfenberg et al., 2020
ADAM17 isoform 2 precursor Q9Z0F8-2 18-655 peptide-Ala129+His-peptide N MS Arg Val Leu Ala His Ile Gly Asp Scharfenberg et al., 2020
ADAM17 isoform 2 precursor Q9Z0F8-2 18-655 peptide-Glu463+Ser-peptide N MS Lys Thr Ile Glu Ser Lys Ala Gln Scharfenberg et al., 2020
ADAM17 isoform 2 precursor Q9Z0F8-2 18-655 peptide-Leu165+Val-peptide N MS Lys Arg Met Leu Val Tyr Lys Ser Scharfenberg et al., 2020
Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) Q8BGQ7 1-968 peptide-Ala803+Thr-peptide N MS Glu Ala Leu Ala Thr Ala Val Ile Scharfenberg et al., 2020
amphiregulin P15514 101-184 peptide-Lys187+Thr-peptide N Lys Ser Met Lys Thr His Ser Met Hinkle et al., 2004 19484
amphiregulin P15514 101-184 peptide-Gln99+Val-peptide P Arg Val Glu Gln Val Val Lys Pro Hinkle et al., 2004 19485
amphiregulin precursor P31955 27-248 peptide-Lys180+Thr-peptide P Lys Ser Met Lys Thr His Ser Glu Hinkle et al., 2004
amphiregulin precursor P31955 27-248 peptide-Asn82+Glu-peptide P Glu Tyr Asp Asn Glu Pro Gln Ile Hinkle et al., 2004 20161
amphiregulin precursor P31955 27-248 peptide-Gln99+Val-peptide P Arg Val Glu Gln Val Ile Lys Pro Hinkle et al., 2004
amyloid beta A4 protein P05067 18-770 peptide-Lys687+Leu-peptide P His His Gln Lys Leu Val Phe Phe Mohan et al., 2002 19275
Amyloid beta A4 protein P05067-4 18-770 peptide-Val636+Ile-peptide P MS Gly Gly Val Val Ile Ala Thr Val Hata et al., 2009
Amyloid beta A4 protein P05067-4 18-770 peptide-Ala638+Thr-peptide P MS Val Val Ile Ala Thr Val Ile Val Hata et al., 2009
Amyloid beta A4 protein P05067-4 18-770 peptide-Lys612+Leu-peptide P MS His His Gln Lys Leu Val Phe Phe Hata et al., 2009
Angiotensin-converting enzyme P12821 30-1306 peptide-Arg1203+Ser-peptide P Asn Ser Ala Arg Ser Glu Gly Pro Corvol et al., 2004 16947
angiotensin-converting enzyme peptidase, Isoform Testis-specific P12822-2 33-737 peptide-Arg631+Ser-peptide P Asn Ser Ala Arg Ser Glu Gly Ser Corvol et al., 2004 16948
Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Q99NH0-3 1-1599 peptide-Ala+Val-peptide N MS Ala Ala Ala Ala Val Ala Ala Pro Scharfenberg et al., 2020
Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein) Q9EPB4 1-193 peptide-Ala98+Ala-peptide N MS Val Ala Ala Ala Ala Ser Val Pro Scharfenberg et al., 2020
ATP synthase subunit beta, mitochondrial (EC 3.6.3.14) P56480 47-529 peptide-Asn146+Val-peptide N MS Arg Ile Met Asn Val Ile Gly Glu Scharfenberg et al., 2020
ATP-dependent RNA helicase A (RHA) (EC 3.6.4.13) (DEAH box protein 9) (mHEL-5) (Nuclear DNA helicase II) (NDH II) O70133-2 1-1380 peptide-Ala119+Leu-peptide N MS Pro His Leu Ala Leu Lys Ala Glu Scharfenberg et al., 2020
beta-1 adrenergic receptor P08588 1-477 peptide-Arg31+Leu-peptide P NT Thr Ala Ala Arg Leu Leu Val Pro Zhu & Steinberg, 2021
Btc Q05928 32-177 peptide-Tyr111+Leu-peptide P Asp Leu Phe Tyr Leu Gln Gln Asp Hinkle et al., 2004 19487
BTC betacellulin P35070 106-117 peptide-Tyr111+Leu-peptide N Asp Leu Phe Tyr Leu Arg Gly Asp Sunnarborg et al., 2002 26300
c-{kit} ligand-1 cleavage site peptide Leu-Pro-Pro-Val-Ala-Ala+Ser-Ser-Leu-Arg N Pro Val Ala Ala Ser Ser Leu Arg Zou et al., 2004
Cadherin-2 (Neural cadherin) (N-cadherin) (CD antigen CD325) P15116 160-906 peptide-Thr386+Phe-peptide N MS Thr Ala Met Thr Phe Tyr Gly Glu Scharfenberg et al., 2020
Calsyntenin-1 O94985-2 29 -971 peptide-His814+Met-peptide P MS His Ala Asn His Met Ala Ala Gln Hata et al., 2009
Calsyntenin-1 O94985-2 29 -971 peptide-Ala816+Ala-peptide P MS Asn His Met Ala Ala Gln Pro Gln Hata et al., 2009
Calsyntenin-1 O94985-2 29 -971 peptide-Thr851+Val-peptide P MS Ser Thr Ala Thr Val Val Ile Val Hata et al., 2009
Calsyntenin-1 O94985-2 29 -971 peptide-Ile854+Val-peptide P MS Thr Val Val Ile Val Val Cys Val Hata et al., 2009
Calsyntenin-2 Q9H4D0 21-955 peptide-His803+Leu-peptide P MS His Val Asn His Leu Ile Val Gln Hata et al., 2009
Calsyntenin-2 Q9H4D0 21-955 peptide-Thr834+Val-peptide P MS Ser Ile Ala Thr Val Val Ile Ile Hata et al., 2009
Calsyntenin-2 Q9H4D0 21-955 peptide-Ile837+Ile-peptide P MS Thr Val Val Ile Ile Ile Ser Val Hata et al., 2009
Calsyntenin-3 Q9BQT9 20-956 peptide-His812+Val-peptide P MS His Pro Ser His Val Leu Ser Ser Hata et al., 2009
Calsyntenin-3 Q9BQT9 20-956 peptide-Thr849+Leu-peptide P MS Ser Ala Ala Thr Leu Ile Ile Val Hata et al., 2009
Calsyntenin-3 Q9BQT9 20-956 peptide-Ile852+Val-peptide P MS Thr Leu Ile Ile Val Val Cys Val Hata et al., 2009
Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9) P53996-2 2-178 peptide-Phe38+Val-peptide N MS Gly Phe Gln Phe Val Ser Ser Ser Scharfenberg et al., 2020
Clathrin light chain A (Lca) O08585 1-235 peptide-Arg101+Leu-peptide N MS Glu Val Asp Arg Leu Gln Ser Glu Scharfenberg et al., 2020
Coiled-coil domain-containing protein 124 Q9D8X2 1-217 peptide-Ala147+Val-peptide N MS Asp Ala Ile Ala Val Leu Ser Val Scharfenberg et al., 2020
Collagen alpha-2(IV) chain [Cleaved into: Canstatin] P08122 184-1707 peptide-Lys1391+Ile-peptide N MS Ile Pro Gln Lys Ile Ala Val Gln Scharfenberg et al., 2020
Crk-like protein P47941 1-303 peptide-Ser112+Val-peptide N MS Pro Val Gly Ser Val Ser Ala Pro Scharfenberg et al., 2020
Cystatin-C (Cystatin-3) P21460 21-140 peptide-Met29+Leu-peptide N MS Gly Pro Arg Met Leu Gly Ala Pro Scharfenberg et al., 2020
Cysteine-rich protein 1 (CRP-1) (Cysteine-rich intestinal protein) (CRIP) P63254 1-77 peptide-Arg16+Val-peptide N MS Phe Ala Glu Arg Val Thr Ser Leu Scharfenberg et al., 2020
Dabcyl-Leu-Ala-Gln-Ala-HPh-Arg-Ser-Lys(Fam)-NH2 Dabcyl-Leu-Ala-Gln-Ala+HPh-Arg-Ser-Lys(Fam)-NH2 S Leu Ala Gln Ala HPh Arg Ser LyN Moss & Rasmussen, 2007
Dabcyl-Pro-Arg-Ala-Ala-Ala-hPhe-Thr-Ser-Pro-Lys(FAM)-NH2 Dabcyl-Pro-Arg-Ala-Ala-Ala+homoPhe-Thr-Ser-Pro-Lys(FAM)-NH2 S Arg Ala Ala Ala HPh Thr Ser Pro Moss et al., 2016
Dabcyl-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Fam)-NH2 Dabcyl-Pro-Cha-Gly+Cys(Me)-His-Ala-Lys(Fam)-NH2 S Dab Pro Cha Gly CyM His Ala LyN Moss & Rasmussen, 2007
Dabcyl-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Lys(FAM)-NH2 Dabcyl-Ser-Pro-Leu-Ala-Gln-Ala+Val-Arg-Ser-Ser-Lys(FAM)-NH2 S Leu Ala Gln Ala Val Arg Ser Ser Moss et al., 2016
Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (mDkk-3) Q9QUN9 23-349 peptide-Thr131+Val-peptide N MS Phe Ser Glu Thr Val Ile Thr Ser Scharfenberg et al., 2020
Dihydropyrimidinase-related protein 2 (DRP-2) (Unc-33-like phosphoprotein 2) (ULIP-2) O08553 1-572 peptide-Pro523+Ala-peptide N MS Lys Thr Ser Pro Ala Lys Gln Gln Scharfenberg et al., 2020
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) P97310 2-904 peptide-Arg133+Gly-peptide N MS Arg Met Arg Arg Gly Leu Leu Tyr Scharfenberg et al., 2020
DNA replication licensing factor MCM6 (EC 3.6.4.12) (Mis5 homolog) P97311 1-821 peptide-Ala232+Val-peptide N MS Arg Ala Glu Ala Val Glu Ser Ala Scharfenberg et al., 2020
Dnp-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-NH2 Dnp-Ser-Pro-Leu-Ala-Gln-Ala+Val-Arg-Ser-Ser-Ser-Arg-NH2 S Leu Ala Gln Ala Val Arg Ser Ser Black, 2004
Dnp-Ser-Pro-Leu-Ala-Gln-Phe-Val-Arg-Ser-Ser-Ser-Arg-NH2 Dnp-Ser-Pro-Leu-Ala-Gln-Phe+Val-Arg-Ser-Ser-Ser-Arg-NH2 S Leu Ala Gln Phe Val Arg Ser Ser Black, 2004
Echinoderm microtubule-associated protein-like 4 (EMAP-4) Q3UMY5-4 1-988 peptide-Pro804+Leu-peptide N MS Pro Ser Leu Pro Leu Thr Gly Thr Scharfenberg et al., 2020
Elongation factor 1-beta (EF-1-beta) O70251 2-225 peptide-Ala40+Val-peptide N MS Val Phe Glu Ala Val Ser Gly Pro Scharfenberg et al., 2020
Envelope glycoprotein P87671 33-676 peptide-Asp637+Gln-peptide N MS Thr Leu Pro Asp Gln Gly Asp Asn Dolnik et al., 2004
EREG epiregulin preproprotein O14944 102-114 peptide-Leu108+Thr-peptide N His Phe Phe Leu Thr Val His Gln Sunnarborg et al., 2002 26301
EREG epiregulin preproprotein O14944 57-68 peptide-Gln62+Val-peptide N Arg Val Ala Gln Val Ser Ile Thr Sunnarborg et al., 2002 26302
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Q8R050-2 1-636 peptide-Tyr233+Leu-peptide N MS Gln Ile Met Tyr Leu Thr Gly Met Scharfenberg et al., 2020
Eukaryotic translation initiation factor 2A (eIF-2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally pr Q8BJW6 1-581 peptide-Val19+Asn-peptide N MS Leu Tyr Met Val Asn Gly Pro Pro Scharfenberg et al., 2020
Ezrin (Cytovillin) (Villin-2) (p81) P26040 1-586 peptide-Glu502+Leu-peptide N MS Tyr Ser Ala Glu Leu Ser Ser Glu Scharfenberg et al., 2020
Ezrin (Cytovillin) (Villin-2) (p81) P26040 1-586 peptide-Glu502+Leu-peptide N MS Tyr Ser Ala Glu Leu Ser Ser Glu Scharfenberg et al., 2020
Ezrin (Cytovillin) (Villin-2) (p81) P26040 1-586 peptide-Gly498+Tyr-peptide N MS Glu Pro Met Gly Tyr Ser Ala Glu Scharfenberg et al., 2020
Ezrin (Cytovillin) (Villin-2) (p81) P26040 1-586 peptide-Arg350+Leu-peptide N MS Leu Met Leu Arg Leu Gln Asp Tyr Scharfenberg et al., 2020
Fibronectin (FN) [Cleaved into: Anastellin] P11276 33-2477 peptide-Pro1654+Ser-peptide N MS Arg Trp Leu Pro Ser Thr Ser Pro Scharfenberg et al., 2020
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-mus Q8BTM8 2-2647 peptide-Ala1284+Leu-peptide N MS Asp Ala Arg Ala Leu Thr Gln Thr Scharfenberg et al., 2020
Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) Q923D2 1-206 peptide-Ala162+Tyr-peptide N MS Leu Thr Gly Ala Tyr Thr Val Thr Scharfenberg et al., 2020
Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Aldolase 1) (Muscle-type aldolase) P05064 2-364 peptide-Gln45+Ser-peptide N MS Lys Arg Leu Gln Ser Ile Gly Thr Scharfenberg et al., 2020
Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Aldolase 1) (Muscle-type aldolase) P05064 2-364 peptide-Arg43+Leu-peptide N MS Ile Ala Lys Arg Leu Gln Ser Ile Scharfenberg et al., 2020
Glu(EDANS)-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser(TF)-Ser-Lys(DABCYL) Glu(EDANS)-Pro-Leu-Ala-Gln-Ala+Val-Arg-Ser-Ser(TF)-Ser-Lys(DABCYL) S Leu Ala Gln Ala Val Arg Ser Ser Minond et al., 2012
Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chai O08795 15-521 peptide-Ala358+Ile-peptide N MS Glu Thr Gln Ala Ile Ile Asp Ala Scharfenberg et al., 2020
growth hormone receptor precursor P19941 19-638 peptide-Pro256+Phe-peptide P Gln Met Ser Pro Phe Thr Cys Glu Wang et al., 2002 18995
H-2 class I histocompatibility antigen, D-B alpha chain (H-2D(B)) P01899 25-362 peptide-Arg30+Tyr-peptide N MS His Ser Met Arg Tyr Phe Glu Thr Scharfenberg et al., 2020
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) P63017 2-646 peptide-Ala180+Ile-peptide N MS Thr Ala Ala Ala Ile Ala Tyr Gly Scharfenberg et al., 2020
Heat shock protein beta-1 (HspB1) (Growth-related 25 kDa protein) (Heat shock 25 kDa protein) (HSP 25) (Heat shock 27 kDa protei P14602 1-209 peptide-Gln84+Leu-peptide N MS Leu Asn Arg Gln Leu Ser Ser Gly Scharfenberg et al., 2020
Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Tumor-specific transplantation 86 kDa antigen) (TSTA) P07901 2-733 peptide-Leu672+Leu-peptide N MS Glu Thr Ala Leu Leu Ser Ser Gly Scharfenberg et al., 2020
heparin-binding EGF-like growth factor precursor Q99075 20-208 peptide-Arg31+Gly-peptide P Arg Leu Arg Arg Gly Leu Ala Ala Hinkle et al., 2004 19482
heparin-binding EGF-like growth factor precursor Q99075 20-208 peptide-Pro149+Val-peptide P Leu Ser Leu Pro Val Glu Asn Arg Hinkle et al., 2004 26303
heparin-binding EGF-like growth factor precursor Q06186 24-208 peptide-Pro149+Val-peptide P Leu Thr Leu Pro Val Glu Asn Pro Hinkle et al., 2004 20162
heparin-binding EGF-like growth factor precursor Q06186 24-208 peptide-Leu33+Ala-peptide P Arg Arg Gly Leu Ala Ala Ala Thr Hinkle et al., 2004
heparin-binding EGF-like growth factor precursor Q99075 20-208 peptide-Arg62+Asp-peptide P Arg Lys Val Arg Asp Leu Gln Glu Hinkle et al., 2004
heparin-binding EGF-like growth factor precursor Q99075 20-208 peptide-Leu72+Arg-peptide P Leu Asp Leu Leu Arg Val Thr Leu Hinkle et al., 2004
heparin-binding EGF-like growth factor precursor Q99075 20-208 peptide-Arg73+Val-peptide P Asp Leu Leu Arg Val Thr Leu Ser Hinkle et al., 2004
Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Q99020 1-285 peptide-Lys131+Val-peptide N MS Ser Val Glu Lys Val Leu Asp Gln Scharfenberg et al., 2020
Heterogeneous nuclear ribonucleoprotein F (hnRNP F) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally proce Q9Z2X1-2 2-395 peptide-Ser183+Val-peptide N MS Lys Phe Met Ser Val Gln Arg Pro Scharfenberg et al., 2020
Heterogeneous nuclear ribonucleoprotein F (hnRNP F) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally proce Q9Z2X1-2 2-395 peptide-Ser183+Val-peptide N MS Lys Phe Met Ser Val Gln Arg Pro Scharfenberg et al., 2020
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) O88569-3 1-301 peptide-Lys265+Ser-peptide N MS Gly Pro Met Lys Ser Gly Asn Phe Scharfenberg et al., 2020
Histidine triad nucleotide-binding protein 1 P70349 2-126 peptide-Lys30+Ile-peptide N MS Ile Pro Ala Lys Ile Ile Phe Glu Scharfenberg et al., 2020
IL6R P08887 20-468 peptide-Gln357+Asp-peptide P Leu Pro Val Gln Asp Ser Ser Ser Althoff et al., 2000 18753
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Chesneau et al., 2003
interleukin-6 receptor subunit alpha P08887 20-468 peptide-Pro355+Val-peptide P NT Thr Ser Leu Pro Val Gln Asp Ser Riethmueller et al., 2017
kit ligand P20826 26-273 peptide-Ala190+Ser-peptide P Pro Val Ala Ala Ser Ser Leu Arg Kawaguchi et al., 2007 20077
KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) Q8BX02-2 1-843 peptide-Asp450+Lys-peptide N MS Asp Thr Thr Asp Lys Lys Pro Thr Scharfenberg et al., 2020
L-selectin processing site peptide P14151 318-332 ac-Lys-Leu-Asp-Lys+Ser-Phe-Ser-Met-Ile-Lys-Glu-Gly-Asp-Tyr-Asn-NH2 N Lys Leu Asp Lys Ser Phe Ser Met Peschon et al., 1998 18752
Lamina-associated polypeptide 2, isoforms alpha/zeta (Thymopoietin isoforms alpha/zeta) (TP alpha/zeta) Q61033-2 1-225 peptide-Pro162+Thr-peptide N MS Thr Pro Leu Pro Thr Val Ser Ser Scharfenberg et al., 2020
Lamina-associated polypeptide 2, isoforms alpha/zeta (Thymopoietin isoforms alpha/zeta) (TP alpha/zeta) Q61033-2 1-225 peptide-Pro75+Val-peptide N MS Glu Pro Thr Pro Val Leu Gly Ser Scharfenberg et al., 2020
Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H Q3UZ39 2-729 peptide-Ala77+Ser-peptide N MS Ala Thr Leu Ala Ser Leu Gly Gly Scharfenberg et al., 2020
Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) P70699 70-953 peptide-Lys118+Glu-peptide N MS Gln Val Leu Lys Glu Pro Gln Ile Scharfenberg et al., 2020
Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) P70699 70-953 peptide-Gly453+Ser-peptide N MS Gly Pro Ala Gly Ser Tyr Arg Pro Scharfenberg et al., 2020
Macrophage colony-stimulating factor 1 (CSF-1) (MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1] P07141 33-552 peptide-Pro217+Leu-peptide N MS Ser Met Ala Pro Leu Ala Gly Leu Scharfenberg et al., 2020
macrophage colony-stimulating factor 1 receptor P09581 20-977 peptide-Gln503+Ser-peptide P NT Ser Leu Gly Gln Ser Lys Gln Leu Vahidi et al., 2014
major prion protein P04156 23-253 peptide-His111+Met-peptide N Asn Met Lys His Met Ala Gly Ala Alfa Cisse et al., 2007 20151
Mca-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Lys(Dnp)-NH2 Mca-Ser-Pro-Leu-Ala-Gln-Ala+Val-Arg-Ser-Ser-Arg-Lys(Dnp)-NH2 S Leu Ala Gln Ala Val Arg Ser Ser Amour et al., 1998
Mca-Ser-Ser-Met-Ala-Gln-Thr-Leu-Thr-Leu-Arg-Ser-Ser-Ser-Lys(Dnp)-NH2 Mca-Ser-Ser-Met-Ala-Gln-Thr-Leu-Thr+Leu-Arg-Ser-Ser-Ser-Lys(Dnp)-NH2 S Gln Thr Leu Thr Leu Arg Ser Ser Amour et al., 1998
Mediator of DNA damage checkpoint protein 1 Q5PSV9 1-1707 peptide-Thr470+Val-peptide N MS Glu Ala Leu Thr Val Thr Gln Pro Scharfenberg et al., 2020
meprin A subunit beta Q16820 62-701 peptide-Pro602+Ser-peptide P MS Thr Pro Ala Pro Ser Val Gln Asp Werny et al., 2022
Methionine-R-sulfoxide reductase B3, mitochondrial (MsrB3) (EC 1.8.4.-) Q8BU85 57-253 peptide-His75+Leu-peptide N MS Asn Leu Leu His Leu Val Thr Lys Scharfenberg et al., 2020
Methylosome subunit pICln Q61189 2-236 Ser-Phe3+Leu-peptide N MS - - Ser Phe Leu Lys Ser Phe Scharfenberg et al., 2020
Microtubule-associated protein 1B (MAP-1B) (MAP1(X)) (MAP1.2) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] P14873 2-2464 peptide-Tyr1061+Leu-peptide N MS Gln Tyr Gly Tyr Leu Gly Thr Ser Scharfenberg et al., 2020
Microtubule-associated protein 4 (MAP-4) P27546-4 2-902 peptide-Arg742+Leu-peptide N MS Arg Val Ser Arg Leu Ala Thr Thr Scharfenberg et al., 2020
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) Q61166 2-268 peptide-Lys204+Leu-peptide N MS Lys Val Leu Lys Leu Thr Val Glu Scharfenberg et al., 2020
Mitochondrial import inner membrane translocase subunit Tim13 P62075 1-95 peptide-Ala31+Val-peptide N MS Val Gln Ile Ala Val Ala Asn Ala Scharfenberg et al., 2020
myelin basic protein P02687 1-169 peptide-Ala16+Ser-peptide P Leu Ala Ser Ala Ser Thr Met Asp Chesneau et al., 2003 20191
myelin basic protein P02687 1-169 peptide-Arg63+Thr-peptide P His Ala Ala Arg Thr Thr His Tyr Chesneau et al., 2003 20192
myelin basic protein P02687 1-169 peptide-Phe88+Phe-peptide P Val Val His Phe Phe Lys Asn Ile Chesneau et al., 2003 20193
myelin basic protein P02687 1-169 peptide-Ala14+Ser-peptide P Lys Tyr Leu Ala Ser Ala Ser Thr Chesneau et al., 2003 20194
Myosin light chain 4 (MLC1EMB) (Myosin light chain 1, atrial/fetal isoform) (MLC1A) P09541 2-193 peptide-Arg121+Asn-peptide N MS His Ile Ser Arg Asn Lys Glu Gln Scharfenberg et al., 2020
neurogenic locus notch homolog protein 1 Q01705 19-2531 peptide-Ala1710+Val-peptide P Lys Ile Glu Ala Val Lys Ser Glu Brou et al., 2000
neurogenic locus notch homolog protein 1 precursor P46531 19-2555 peptide-Gly1753+Val-peptide P Val Gly Cys Gly Val Leu Leu Ser Schroeter et al., 1998 4019
Nptxr neuronal pentraxin receptor Q99J85 1-493 peptide-Ala35+Leu-peptide P Pro Ala Arg Ala Leu Pro Gly Gly Cho et al., 2008 22595
Nptxr neuronal pentraxin receptor Q99J85 1-493 peptide-Ala175+Asp-peptide P Asp Thr Met Ala Asp Gly Ala Trp Cho et al., 2008 22596
Nucleolin (Protein C23) P09405 2-707 peptide-Tyr464+Tyr-peptide N MS Val Ser Leu Tyr Tyr Thr Gly Glu Scharfenberg et al., 2020
Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific) P09041 1-417 peptide-Leu157+Gly-peptide N MS Leu Ser Lys Leu Gly Asp Val Tyr Scharfenberg et al., 2020
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) (Heart adapter protein 1) Q3UIL6-3 1-1118 peptide-Ser895+Leu-peptide N MS Pro Ser Leu Ser Leu Val Gly Ser Scharfenberg et al., 2020
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) P60335 1-356 peptide-Pro191+Val-peptide N MS Ala Ser Ser Pro Val Ile Cys Ala Scharfenberg et al., 2020
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) P60335 1-356 peptide-Pro187+Ala-peptide N MS Gln Pro Met Pro Ala Ser Ser Pro Scharfenberg et al., 2020
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protei Q8CCS6-2 2-292 peptide-Ala7+Ala-peptide N MS Ala Ala Ala Ala Ala Ala Ala Ala Scharfenberg et al., 2020
Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK homol P54823 1-483 peptide-Gly13+Leu-peptide N MS Val Ile Met Gly Leu Ser Ser Gln Scharfenberg et al., 2020
Procollagen C-endopeptidase enhancer 1 Q61398 25-468 peptide-Pro118+Val-peptide N MS Arg Pro Ala Pro Val Val Ala Pro Scharfenberg et al., 2020
Procollagen C-endopeptidase enhancer 1 Q61398 25-468 peptide-Glu95+Val-peptide N MS Asp Ala Leu Glu Val Phe Ala Gly Scharfenberg et al., 2020
Procollagen C-endopeptidase enhancer 1 Q61398 25-468 peptide-Gly112+Thr-peptide N MS Arg Phe Cys Gly Thr Phe Arg Pro Scharfenberg et al., 2020
proepiregulin O14944 29-169 peptide-Arg59+Val-peptide P NT Asp Asn Pro Arg Val Ala Gln Val Minond et al., 2012
Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) P56812 2-126 peptide-Glu16+Leu-peptide N MS Arg Leu Ala Glu Leu Gln Ala Lys Scharfenberg et al., 2020
Protein CDV3 (Carnitine deficiency-associated protein 3) (Tyrosine-phosphorylated protein 36) (TPP36) Q4VAA2-2 2-281 peptide-Ala127+Met-peptide N MS Arg Val Gln Ala Met Gln Ile Ser Scharfenberg et al., 2020
Protein disulfide-isomerase A3 P27773 25-505 peptide-Phe171+Leu-peptide N MS His Ser Glu Phe Leu Lys Ala Ala Scharfenberg et al., 2020
Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1) Q03173-2 1-802 peptide-Pro299+Ile-peptide N MS Asp Ala Glu Pro Ile Thr Ala Lys Scharfenberg et al., 2020
Protein lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) O88952 2-197 peptide-Phe82+Ala-peptide N MS Val Ala Ala Phe Ala Ala Ser Glu Scharfenberg et al., 2020
Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Ndr2) Q9QYG0-2 2-357 peptide-Ser318+Leu-peptide N MS Arg Thr Ala Ser Leu Thr Ser Ala Scharfenberg et al., 2020
Protein phosphatase 1 regulatory subunit 14B (Phosphatase holoenzyme inhibitor 1) (PHI-1) (Phospholipase C-beta-3 neighbouring g Q62084 2-147 peptide-Ala15+Leu-peptide N MS Gly Gly Ala Ala Leu Ala Ala Pro Scharfenberg et al., 2020
Protein phosphatase inhibitor 2 (IPP-2) Q9DCL8 2-206 peptide-Lys104+Leu-peptide N MS Leu Ala Lys Lys Leu Ala Ala Ala Scharfenberg et al., 2020
Protein PRRC2C (BAT2 domain-containing protein 1) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containin Q3TLH4-5 1-2846 peptide-Ala415+Gln-peptide N MS Lys Leu Leu Ala Gln Gln His Pro Scharfenberg et al., 2020
protransforming growth factor alpha precursor P01135 24-160 peptide-Ala16+Val-peptide P Val Ala Ala Ala Val Val Ser His Hinkle et al., 2003 19489
protransforming growth factor alpha precursor P01135 24-160 peptide-Ala66+Val-peptide P Asp Leu Leu Ala Val Val Ala Ala Sunnarborg et al., 2002 16950
Radixin (ESP10) P26043 1-583 peptide-Arg330+Glu-peptide N MS Lys Lys Lys Arg Glu Ile Ala Glu Scharfenberg et al., 2020
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) P97379-2 1-482 peptide-Pro237+Ala-peptide N MS Pro Ala Glu Pro Ala Ser Leu Pro Scharfenberg et al., 2020
receptor tyrosine-protein kinase erbB-4 Q15303 26-1308 peptide-His641+Ser-peptide P NT Trp Thr Gly His Ser Thr Leu Pro Cheng et al., 2003 18831
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (GDI-1) (Rho-GDI alpha) Q99PT1 2-204 peptide-Lys33+Ser-peptide N MS Pro Ala Gln Lys Ser Ile Gln Glu Scharfenberg et al., 2020
Scaffold attachment factor B1 (SAF-B1) D3YXK2 2-937 peptide-Ala244+Thr-peptide N MS Phe Ala Gln Ala Thr Ser Ser Val Scharfenberg et al., 2020
Serpin H1 (47 kDa heat shock protein) (Collagen-binding protein) (Colligin) (Serine protease inhibitor J6) P19324 18-417 peptide-Lys34+Leu-peptide N MS Thr Ala Glu Lys Leu Ser Ser Lys Scharfenberg et al., 2020
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) P16546-2 1-2452 peptide-Leu1208+Leu-peptide N MS Arg Ser Gln Leu Leu Gly Ser Ala Scharfenberg et al., 2020
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) P16546-2 1-2452 peptide-Gln1207+Leu-peptide N MS Glu Arg Ser Gln Leu Leu Gly Ser Scharfenberg et al., 2020
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (U2 snRNP auxiliary factor large subunit) P26369 2-475 peptide-Pro138+Val-peptide N MS Thr Pro Val Pro Val Val Gly Ser Scharfenberg et al., 2020
Stress-induced-phosphoprotein 1 (STI1) (mSTI1) (Hsc70/Hsp90-organizing protein) (Hop) Q60864 1-543 peptide-Ala+Val-peptide N MS Asn Gln Ala Ala Val His Phe Glu Scharfenberg et al., 2020
Talin-1 P26039 1-2541 peptide-Ala1904+Val-peptide N MS Lys Pro Ala Ala Val Ala Ala Glu Scharfenberg et al., 2020
Thrombospondin-4 Q9Z1T2 27-963 peptide-Ala214+Ala-peptide N MS Glu Pro Leu Ala Ala Thr Ser Thr Scharfenberg et al., 2020
TNFtide (PLAQAVRSS) P01375 72-80 Pro-Leu-Ala-Gln-Ala+Val-Arg-Ser-Ser S Leu Ala Gln Ala Val Arg Ser Ser Liu et al., 2014
TNFtide4A (PLAAAVRSS) P01375 72-80 Pro-Leu-Ala-Ala-Ala+Val-Arg-Ser-Ser S Leu Ala Ala Ala Val Arg Ser Ser Liu et al., 2014
TNFtide4A7F (PLAAAVFSS) P01375 72-80 Pro-Leu-Ala-Ala-Ala+Val-Phe-Ser-Ser S Leu Ala Ala Ala Val Phe Ser Ser Liu et al., 2014
TNFtide7F (PLAQAVFSS P01375 72-80 Pro-Leu-Ala-Gln-Ala+Val-Phe-Ser-Ser S Leu Ala Gln Ala Val Phe Ser Ser Liu et al., 2014
Transcription factor Sp5 Q9JHX2 1-398 peptide-Ala34+Leu-peptide N MS Ser Pro Leu Ala Leu Leu Ala Ala Scharfenberg et al., 2020
transferrin receptor protein 1 P02786 1-760 peptide-Arg100+Leu-peptide P NT Glu Cys Glu Arg Leu Ala Gly Thr Minond et al., 2012
Transketolase (TK) (EC 2.2.1.1) (P68) P40142 1-623 peptide-Lys11+Leu-peptide N MS Asp Gln Gln Lys Leu Gln Ala Leu Scharfenberg et al., 2020
Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) P17751 2-249 peptide-Gly172+Thr-peptide N MS Trp Ala Ile Gly Thr Gly Lys Thr Scharfenberg et al., 2020
Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) P17751 2-249 peptide-Trp192+Leu-peptide N MS Leu Arg Gly Trp Leu Lys Ser Asn Scharfenberg et al., 2020
Tubulin alpha-1B chain (Alpha-tubulin 2) (Alpha-tubulin isotype M-alpha-2) (Tubulin alpha-2 chain) [ P05213 1-451 peptide-Gln91+Leu-peptide N MS His Pro Glu Gln Leu Ile Thr Gly Scharfenberg et al., 2020
tumor necrosis factor P01375 1-233 peptide-Ala76+Val-peptide P Leu Ala Gln Ala Val Arg Ser Ser 4017
tumor necrosis factor ligand superfamily member 11 Q3TWY5 1-316 peptide-Arg138+Phe-peptide P Gly Pro Gln Arg Phe Ser Gly Ala Lum et al., 1999 19217
tumor necrosis factor receptor superfamily member 16 Q9Z0W1 225-240 Val-Thr-Thr-Val-Met-Gly-Ser-Ser-Gln-Pro+Val-Val-Thr-Arg-Gly-Thr N Ser Ser Gln Pro Val Val Thr Arg Weskamp et al., 2004
Twinfilin-1 (Protein A6) Q91YR1 2-350 peptide-Pro146+Leu-peptide N MS Ser Pro Ala Pro Leu Thr Ala Ala Scharfenberg et al., 2020
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) P56399 2-858 peptide-Ala419+Leu-peptide N MS Met Phe Lys Ala Leu Ile Gly Lys Scharfenberg et al., 2020
Ubiquitin-like modifier-activating enzyme 1 Q02053 2-1058 peptide-Phe861+Ile-peptide N MS His Met Asp Phe Ile Val Ala Ala Scharfenberg et al., 2020
Ubiquitin-like modifier-activating enzyme 1 Q02053 2-1058 peptide-Phe861+Ile-peptide N MS His Met Asp Phe Ile Val Ala Ala Scharfenberg et al., 2020
UV excision repair protein RAD23 homolog B (HR23B) (mHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58) P54728 1-416 peptide-Ala259+Ala-peptide N MS Val Ala Ala Ala Ala Ala Thr Thr Scharfenberg et al., 2020
Vimentin P20152 2-466 peptide-Pro432+Leu-peptide N MS Glu Ser Leu Pro Leu Val Asp Thr Scharfenberg et al., 2020
Vimentin P20152 2-466 peptide-Pro416+Thr-peptide N MS Leu Pro Leu Pro Thr Phe Ser Ser Scharfenberg et al., 2020
Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Y-box protein 3) Q9JKB3-2 2-292 peptide-Pro223+Ala-peptide N MS Arg Pro Ala Pro Ala Ile Gly Glu Scharfenberg et al., 2020
Zinc finger protein ZPR1 (Zinc finger protein 259) Q62384 1-459 peptide-Gly237+Leu-peptide N MS Glu Met Leu Gly Leu Gln Ala Glu Scharfenberg et al., 2020
Zinc finger RNA-binding protein O88532 1-1074 peptide-Ala556+Leu-peptide N MS Ser Leu Ala Ala Leu Gln Ser Asp Scharfenberg et al., 2020
Zyxin Q62523 2-564 peptide-Pro235+Val-peptide N MS Gln Pro Gln Pro Val Ser Ser Ala Scharfenberg et al., 2020

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