Substrates for peptidase S01.422: fibrinolytic enzyme A (Annelida-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ac-Tyr-OEt [ATEE]			Ac-Tyr+OEt	S		-	-	Ac	Tyr	OEt	-	-	-	Zhao et al., 2007
Beta-amyloid protein 40	P05067	672-711	Peptide-Ser679+Gly-Peptide	N	NT	Arg	His	Asp	Ser	Gly	Tyr	Glu	Val	Nakajima et al., 1999
Beta-amyloid protein 40	P05067	672-711	Peptide-Val689+Phe-Peptide	N	NT	Gln	Lys	Leu	Val	Phe	Phe	Ala	Glu	Nakajima et al., 1999
Beta-amyloid protein 40	P05067	672-711	Peptide-Val695+Gly-Peptide	N	NT	Ala	Glu	Asp	Val	Gly	Ser	Asn	Lys	Nakajima et al., 1999
Beta-amyloid protein 40	P05067	672-711	Peptide-Ile703+Gly-Peptide	N	NT	Gly	Ala	Ile	Ile	Gly	Leu	Met	Val	Nakajima et al., 1999
Beta-amyloid protein 40	P05067	672-711	Peptide-Val707+Gly-Peptide	N	NT	Gly	Leu	Met	Val	Gly	Gly	Val	Val	Nakajima et al., 1999
Bz-Arg-OEt [BAEE]			Bz-Arg+OEt	S		-	-	Bz	Arg	OEt	-	-	-	Zhao et al., 2007
Chromozym ELA			Suc-Ala-Ala-Ala+NHPhNO2	S		Suc	Ala	Ala	Ala	NAN	-	-	-	Zhao et al., 2007
Chromozym TH			Car-Val-Gly-Arg+NHPhNO2	S		Car	Val	Gly	Arg	NAN	-	-	-	Zhao et al., 2007
Chromozym U			Bz-beta-Ala-Gly-Arg+NHPhNO2	S		Bz	Ala	Gly	Arg	NAN	-	-	-	Zhao et al., 2007
insulin B-chain (oxidized)	P01317	25-54	Phe-Val+Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	-	-	Phe	Val	Asn	Gln	His	Leu	Nakajima et al., 1999
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His+Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Val	Asn	Gln	His	Leu	Cya	Gly	Ser	Nakajima et al., 1999
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser+His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Leu	Cya	Gly	Ser	His	Leu	Val	Glu	Nakajima et al., 1999
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Nakajima et al., 1999
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val+Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Leu	Tyr	Leu	Val	Cya	Gly	Glu	Arg	Nakajima et al., 1999
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly+Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Gly	Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Nakajima et al., 1999
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Nakajima et al., 1999
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr+Thr-Pro-Lys-Ala	N	NT	Gly	Phe	Phe	Tyr	Thr	Pro	Lys	Ala	Nakajima et al., 1999
Tos-Gly-Pro-Arg-NHPhNO2 [Chromozym-TRY]			Tos-Gly-Pro-Arg+NHPhNO2	S		Tos	Gly	Pro	Arg	NAN	-	-	-	Zhao et al., 2007