Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Substrates for peptidase S01.236: kallikrein-related peptidase 6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
amyloid beta A4 protein P05067 18-770 peptide-Arg676+His-peptide P Ala Glu Phe Arg His Asp Ser Gly Magklara et al., 2003 19120
amyloid beta A4 protein P05067 18-770 peptide-Lys687+Leu-peptide P His His Gln Lys Leu Val Phe Phe Magklara et al., 2003 19121
amyloid beta A4 protein P05067 18-770 peptide-Lys670+Met-peptide P Ser Glu Val Lys Met Asp Ala Glu Magklara et al., 2003 21010
Antileukoproteinase P03973 26-132 peptide-Leu97+Met-peptide P NT Gly Gln Cys Leu Met Leu Asn Pro Borgoņo et al., 2007
Asp-Pro-Arg-NHMec Asp-Pro-Arg+NHMec S - Asp Pro Arg AMC - - - Magklara et al., 2003
Boc-Gln-Ala-Arg-NHMec Boc-Gln-Ala-Arg+NHMec S Boc Gln Ala Arg AMC - - - Yamaguchi, 2004
Boc-Phe-Ser-Arg-NHMec Boc-Phe-Ser-Arg+NHMec S Boc Phe Ser Arg AMC - - - Yamaguchi, 2004
Boc-Val-Pro-Arg-NHMec Boc-Val-Pro-Arg+NHMec S Boc Val Pro Arg AMC - - - Yamaguchi, 2004
Bz-Arg-NHMec Bz-Arg+NHMec S - - Bz Arg AMC - - - Yamaguchi, 2004
Desmoglein-1 Q02413 50-1049 peptide-Lys368+Ala-peptide P NT Tyr Lys Leu Lys Ala Ser Ala Ile Borgoņo et al., 2007
Desmoglein-1 Q02413 50-1049 peptide-Arg422+Tyr-peptide P NT Thr Thr Val Arg Tyr Val Met Gly Borgoņo et al., 2007
Gln-Gly-Arg-NHMec Gln-Gly-Arg+NHMec S - Gln Gly Arg AMC - - - Magklara et al., 2003
Gly-Gly-Arg-NHMec Gly-Gly-Arg+NHMec S - Gly Gly Arg AMC - - - Magklara et al., 2003
Kallikrein-1 precursor P06870 19-262 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Yoon et al., 2007
Kallikrein-10 precursor O43240 31-276 peptide-Arg42+Leu-peptide P NT Asn Asp Thr Arg Leu Asp Pro Glu Yoon et al., 2007
Kallikrein-12 precursor Q9UKR0 18-248 Ala-Thr-Pro-Lys21+Ile-peptide P NT Ala Thr Pro Lys Ile Phe Asn Gly Yoon et al., 2007
Kallikrein-2 precursor P20151 19-261 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Yoon et al., 2007
Kallikrein-5 precursor Q9Y337 23-293 peptide-Arg66+Ile-peptide P NT Ser Ser Ser Arg Ile Ile Asn Gly Yoon et al., 2007
Kallikrein-6 precursor Q92876 17-244 peptide-Lys21+Leu-peptide P NT Glu Gln Asn Lys Leu Val His Gly Yoon et al., 2007
Kallikrein-7 precursor P49862 23-253 peptide-Lys29+Ile-peptide P NT Gln Gly Asp Lys Ile Ile Asp Gly Yoon et al., 2007
Kallikrein-9 precursor Q9UKQ9 16-250 peptide-Arg22+Ala-peptide P NT Ala Asp Thr Arg Ala Ile Gly Ala Yoon et al., 2007
kallikrein-related peptidase 6 Q92876 22-244 peptide-Arg80+Glu-peptide P Leu Arg Gln Arg Glu Ser Ser Gln Magklara et al., 2003 19116
Myelin basic protein P02686 156-162 Asp-His-Ala-Arg159+His-Gly-Phe-Dnp S CS Asp His Ala Arg His Gly Phe - Angelo et al., 2006
Myelin basic protein P02686 162-168 Phe-Leu-Pro-Arg165+His-Arg-Asp-Dnp S CS Phe Leu Pro Arg His Arg Asp - Angelo et al., 2006
Myelin basic protein P02686 164-170 Pro-Arg-His-Arg167+Asp-Thr-Gly-Dnp S CS Pro Arg His Arg Asp Thr Gly - Angelo et al., 2006
Myelin basic protein P02686 174-180 Ser-Ile-Gly-Arg177+Phe-Phe-Gly-Dnp S CS Ser Ile Gly Arg Phe Phe Gly - Angelo et al., 2006
Myelin basic protein P02686 180-186 Gly-Gly-Asp-Arg183+Gly-Ala-Pro-Dnp S CS Gly Gly Asp Arg Gly Ala Pro - Angelo et al., 2006
Myelin basic protein P02686 185-191 Ala-Pro-Lys-Arg188+Gly-Ser-Gly-Dnp S CS Ala Pro Lys Arg Gly Ser Gly - Angelo et al., 2006
Myelin basic protein P02686 196-202 His-Pro-Ala-Arg199+Thr-Ala-His-Dnp S CS His Pro Ala Arg Thr Ala His - Angelo et al., 2006
Myelin basic protein P02686 210-216 Ser-His-Gly-Arg213+Thr-Gln-Asp-Dnp S CS Ser His Gly Arg Thr Gln Asp - Angelo et al., 2006
Myelin basic protein P02686 228-234 Val-Thr-Pro-Arg231+Thr-Pro-Pro-Dnp S CS Val Thr Pro Arg Thr Pro Pro - Angelo et al., 2006
Myelin basic protein P02686 238-244 Gly-Lys-Gly-Arg241+Gly-Leu-Ser-Dnp S CS Gly Lys Gly Arg Gly Leu Ser - Angelo et al., 2006
Myelin basic protein P02686 244-250 Ser-Leu-Ser-Arg247+Phe-Ser-Trp-Dnp S CS Ser Leu Ser Arg Phe Ser Trp - Angelo et al., 2006
Myelin basic protein P02686 261-267 Tyr-Gly-Gly-Arg264+Ala-Ser-Asp-Dnp S CS Tyr Gly Gly Arg Ala Ser Asp - Angelo et al., 2006
Myelin basic protein P02686 290-296 Leu-Gly-Gly-Arg293+Asp-Ser-Arg-Dnp S CS Leu Gly Gly Arg Asp Ser Arg - Angelo et al., 2006
Myelin basic protein P02686 293-299 Arg-Asp-Ser-Arg296+Ser-Gly-Ser-Dnp S CS Arg Asp Ser Arg Ser Gly Ser - Angelo et al., 2006
phage display octapeptide 4R-1 Glu-Ala-Val-Arg+Ser-Ala-Met-Trp N Glu Ala Val Arg Ser Ala Met Trp Li et al., 2008
phage display octapeptide 4R-11 peptide-Arg4+-peptide N His Leu Val Arg Ser Trp Asn Gly Li et al., 2008
phage display octapeptide 4R-13 peptide-Arg4+Met-peptide N Ser Leu Phe Arg Met Val Val Leu Li et al., 2008
phage display octapeptide 4R-17 peptide-Arg4+Ser-peptide N Lys Val Leu Arg Ser Ala Thr Gly Li et al., 2008
phage display octapeptide 4R-20 peptide-Arg4+Tyr-peptide N Trp Gly Trp Arg Tyr Ala Glu Thr Li et al., 2008
phage display octapeptide 4R-22 peptide-Arg4+Ser-peptide N Thr Ala Phe Arg Ser Ala Tyr Gly Li et al., 2008
phage display octapeptide 4R-24 peptide-Arg4+Ser-peptide N Ile Ser Thr Arg Ser Ala Ile Trp Li et al., 2008
phage display octapeptide 4R-3 peptide-Arg4+Ser-peptide N Glu Ala Phe Arg Ser Ser Asp Gln Li et al., 2008
phage display octapeptide 4R-6 peptide-Arg4+Ser-peptide N Tyr Met Thr Arg Ser Ala Met Gly Li et al., 2008
phage display octapeptide 4R-7 peptide-Arg4+Ser-peptide N Ala Ser Ser Arg Ser Val Lys Trp Li et al., 2008
phage display octapeptide 4R-8 peptide-Arg4+Ser-peptide N Gln Met Tyr Arg Ser Ser Trp Gly Li et al., 2008
phage display octapeptide 4R-9 peptide-Arg4+Ser-peptide N Ser Lys Val Arg Ser Ala Gly Ala Li et al., 2008
phage display octapeptide 5R-11 peptide-Arg4+Ser-peptide N Lys Glu Ala Arg Ser Ala Tyr Gly Li et al., 2008
phage display octapeptide 5R-16 peptide-Arg4+Asn-peptide N Ile Gly Phe Arg Asn Ala Gly Ala Li et al., 2008
phage display octapeptide 5R-17 peptide-Arg4+Asn-peptide N Thr Ala Phe Arg Asn Ser Leu Gly Li et al., 2008
phage display octapeptide 5R-3 peptide-Arg4+Met-peptide N Ala Phe Leu Arg Met Ala Ser Leu Li et al., 2008
phage display octapeptide 5R-6 peptide-Arg4+Ser-peptide N Val Gly Val Arg Ser Val Tyr Gly Li et al., 2008
phage display octapeptide 5R-8 peptide-Arg4+Ser-peptide N Ala Ser Val Arg Ser Ala Met Tyr Li et al., 2008
phage display octapeptide Re5R-14 peptide-Arg4+Ser-peptide N Ala Lys Ser Arg Ser Ala Gly Asp Li et al., 2008
phage display octapeptide Re5R-6 peptide-Arg4+Ser-peptide N Phe Gly Phe Arg Ser Val His Gly Li et al., 2008
Phe-Ser-Arg-NHMec Phe-Ser-Arg+NHMec S - Phe Ser Arg AMC - - - Magklara et al., 2003
Plasminogen P00747 20-810 peptide-Ser460+Val-peptide P - Thr Glu Ala Ser Val Val Ala Pro Bayés et al., 2004
Pro-Phe-Arg-NHMec Pro-Phe-Arg+NHMec S - Pro Phe Arg AMC - - - Magklara et al., 2003
Prostate-specific antigen precursor P07288 18-261 peptide-Arg24+Ile-peptide P NT Ile Leu Ser Arg Ile Val Gly Gly Yoon et al., 2007
proteinase-activated receptor 1 P25116 27-425 peptide-Arg41+Ser-peptide P MS Leu Asp Pro Arg Ser Phe Leu Leu Oikonomopoulou et al., 2006 20602
proteinase-activated receptor 1 P25116 27-425 peptide-Ser42+Phe-peptide P MS Asp Pro Arg Ser Phe Leu Leu Arg Oikonomopoulou et al., 2006 20603
proteinase-activated receptor 1 P25116 27-425 peptide-Phe43+Leu-peptide P MS Pro Arg Ser Phe Leu Leu Arg Asn Oikonomopoulou et al., 2006 20604
proteinase-activated receptor 1 P25116 27-425 peptide-Leu45+Arg-peptide P MS Ser Phe Leu Leu Arg Asn Pro Asn Oikonomopoulou et al., 2006 20605
proteinase-activated receptor 1 P25116 27-425 peptide-Arg46+Asn-peptide P MS Phe Leu Leu Arg Asn Pro Asn Asp Oikonomopoulou et al., 2006 20606
proteinase-activated receptor 2 P55085 37-397 peptide-Arg36+Ser-peptide P MS Ser Lys Gly Arg Ser Leu Ile Gly Oikonomopoulou et al., 2006 20631
proteinase-activated receptor 2 P55085 37-397 peptide-Lys41+Val-peptide P MS Leu Ile Gly Lys Val Asp Gly Thr Oikonomopoulou et al., 2006 20632
proteinase-activated receptor 2 P55085 37-397 peptide-Lys51+Gly-peptide P MS Val Thr Gly Lys Gly Val Thr Val Oikonomopoulou et al., 2006 20633
proteinase-activated receptor 2 Q63645 26-397 peptide-Arg36+Ser-peptide P MS Ser Lys Gly Arg Ser Leu Ile Gly Oikonomopoulou et al., 2006
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Arg47+Gly-peptide P MS Pro Ala Pro Arg Gly Tyr Pro Gly Oikonomopoulou et al., 2006 20626
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Tyr49+Pro-peptide P MS Pro Arg Gly Tyr Pro Gly Gln Val Oikonomopoulou et al., 2006 20627
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Gly35+Asp-peptide P MS Thr Gly Gly Gly Asp Asp Ser Thr Oikonomopoulou et al., 2006 20628
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Thr39+Pro-peptide P MS Asp Asp Ser Thr Pro Ser Ile Leu Oikonomopoulou et al., 2006 20629
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Pro40+Ser-peptide P MS Asp Ser Thr Pro Ser Ile Leu Pro Oikonomopoulou et al., 2006 20630
proteinase-activated receptor 4 precursor Q920E0 17-395 peptide-Arg49+Gly-peptide P MS Pro Asn Pro Arg Gly Phe Pro Gly Oikonomopoulou et al., 2006 20639
Somatotropin P01241 27-217 Peptide-Arg160+Thr-Peptide P NT Gly Ser Pro Arg Thr Gly Gln Ile Komatsu et al., 2007
Tos-Gly-Pro-Arg-NHMec Tos-Gly-Pro-Arg+NHMec S Tos Gly Pro Arg AMC - - - Bernett et al., 2002
Tos-Gly-Pro-Lys-NHMec Tos-Gly-Pro-Lys+NHMec S Tos Gly Pro Lys AMC - - - Bernett et al., 2002
Val-Leu-Lys-NHMec Val-Leu-Lys+NHMec S - Val Leu Lys AMC - - - Magklara et al., 2003
Val-Pro-Arg-NHMec Val-Pro-Arg+NHMec S - Val Pro Arg AMC - - - Magklara et al., 2003
Z-Leu-Arg-NHMec Z-Leu-Arg+NHMec S - Z Leu Arg AMC - - - Debela et al., 2006
Z-Phe-Arg-NHMec Z-Phe-Arg-NHMec S - Z Phe Arg AMC - - - Debela et al., 2006

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use