Substrates for peptidase A22.001: presenilin 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
amyloid beta A4 protein	P05067	672-770	peptide-Val711+peptide	P		Gly	Gly	Val	Val	Ile	Ala	Thr	Val	De Strooper et al., 1998	16067
amyloid beta A4 protein	P05067	672-770	peptide-Ala713+peptide	P		Val	Val	Ile	Ala	Thr	Val	Ile	Val	De Strooper et al., 1998	16066
amyloid beta A4 protein	P05067	672-770	peptide-Thr714+Val-peptide	P		Val	Ile	Ala	Thr	Val	Ile	Val	Ile	De Strooper et al., 1998	18338
CD44 antigen	P16070	21-742	peptide-Ala659+Leu-peptide	P		Ser	Leu	Leu	Ala	Leu	Ala	Leu	Ile	Lammich et al., 2002	18373
ephrin type-B receptor 2	P54763	27-994	peptide-Ile569+Ala-peptide	P	MS	Val	Val	Val	Ile	Ala	Ile	Val	Cys	Litterst et al., 2007	20206
epithelial-cadherin precursor	P12830	23-882	peptide-Leu731+Arg-peptide	P		Leu	Leu	Phe	Leu	Arg	Arg	Arg	Ala	Xia & Wolfe, 2003	18356
macrophage colony-stimulating factor 1 receptor	P09581	20-977	peptide-Leu532+Leu-peptide	P	NT	Leu	Leu	Leu	Leu	Leu	Leu	Leu	Tyr	Vahidi et al., 2014
macrophage colony-stimulating factor 1 receptor	P09581	20-977	peptide-Leu535+Tyr-peptide	P	NT	Leu	Leu	Leu	Leu	Tyr	Lys	Tyr	Lys	Vahidi et al., 2014
neurogenic locus notch homolog protein 1	Q01705	19-2531	peptide-Ala1731+Ala-peptide	P		Tyr	Val	Ala	Ala	Ala	Ala	Phe	Val	Okochi et al., 2002	3054
neurogenic locus notch homolog protein 1	Q01705	19-2531	peptide-Gly1743+Val-peptide	P		Val	Gly	Cys	Gly	Val	Leu	Leu	Ser	Ikeuchi & Sisodia, 2003	18376
neurogenic locus notch homolog protein 1 precursor	P46531	19-2556	peptide-Gly1753+Val-peptide	P		Val	Gly	Cys	Gly	Val	Leu	Leu	Ser	Lee et al., 2002
notch4	P31695	21-1964	peptide-Leu1462+Val-peptide	P		Gly	Ala	Leu	Leu	Val	Leu	Gln	Leu	Saxena et al., 2001	19189
protein tyrosine phosphatase, receptor type, K	P35822	1-1457	peptide-Arg643+Glu-peptide	P		Arg	Thr	Lys	Arg	Glu	Ala	Gly	Ala	Jiang et al., 1993	18761
receptor tyrosine-protein kinase erbB-4	Q15303	26-1308	peptide-Ala672+Val-peptide	P		Leu	Thr	Phe	Ala	Val	Tyr	Val	Arg	Lee et al., 2002	18370
syndecan-3	O75056	1-442	peptide-Leu403+Val-peptide	P		Ala	Ala	Phe	Leu	Val	Thr	Leu	Leu	Schulz et al., 2003
syndecan-3	O75056	1-442	peptide-Val404+Thr-peptide	P		Ala	Phe	Leu	Val	Thr	Leu	Leu	Ile	Schulz et al., 2003
syndecan-3	O75056	1-442	peptide-Thr405+Leu-peptide	P		Phe	Leu	Val	Thr	Leu	Leu	Ile	Tyr	Schulz et al., 2003
syndecan-3	O75056	1-442	peptide-Leu406+Leu-peptide	P		Leu	Val	Thr	Leu	Leu	Ile	Tyr	Arg	Schulz et al., 2003
vascular endothelial growth factor receptor 1	P17948	27-1338	peptide-Val767+Ala-peptide	P	NT	Cys	Thr	Cys	Val	Ala	Ala	Thr	Leu