Substrates for peptidase M10.017: membrane-type matrix metallopeptidase-4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
ADAMTS4 peptidase	O75173	213-837	peptide-Lys694+Phe-peptide	P		Ser	Phe	Arg	Lys	Phe	Arg	Tyr	Gly	Gao et al., 2004	20068
ADAMTS4 peptidase	O75173	213-837	peptide-Thr581+Phe-peptide	P		Ser	Ala	Leu	Thr	Phe	Arg	Glu	Glu	Gao et al., 2004	20069
amyloid beta A4 protein	P05067	18-770	peptide-Lys687+Leu-peptide	P		His	His	Gln	Lys	Leu	Val	Phe	Phe	Amour et al., 2002
amyloid beta A4 protein	P05067	681-691	Tyr-Glu-Val-His-His+Gln-Lys-Leu-Val-Phe-Phe	P		Glu	Val	His	His	Gln	Lys	Leu	Val	Amour et al., 2002
HB-EGF			Gly-Leu-Ser-Leu-Pro-Val-Glu+Asn-Arg-Leu-Tyr-Thr-Tyr-Asp	N		Leu	Pro	Val	Glu	Asn	Arg	Leu	Tyr	Amour et al., 2002
HB-EGF			Gly-Leu-Ser-Leu-Pro-Val-Glu-Asn-Arg+Leu-Tyr-Thr-Tyr-Asp	N		Val	Glu	Asn	Arg	Leu	Tyr	Thr	Tyr	Amour et al., 2002
heparin-binding EGF-like growth factor precursor	Q99075	20-208	peptide-Glu151+Asn-peptide	P		Leu	Pro	Val	Glu	Asn	Arg	Leu	Tyr	Amour et al., 2002
heparin-binding EGF-like growth factor precursor	Q99075	20-208	peptide-Arg153+Leu-peptide	P		Val	Glu	Asn	Arg	Leu	Tyr	Thr	Tyr	Amour et al., 2002
Mca-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH2			Mca-Pro-Cha-Gly+Nva-His-Ala-Dpa-NH2	S		Mca	Pro	Cha	Gly	nVa	His	Ala	Dpa
Mca-Pro-Glu-Gly-Leu-Arg-Dpa-NH2			Mca-Pro-Glu-Gly+Leu-Arg-Dpa-NH2	S		Mca	Pro	Glu	Gly	Leu	Arg	Dpa	NH2
Mca-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH2			Mca-Pro-Leu-Ala+Nva-Dpa-Ala-Arg-NH2	S		Mca	Pro	Leu	Ala	nVa	Dpa	Ala	Arg
Mca-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Lys(Dnp)-NH2			Mca-Ser-Pro-Leu-Ala+Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Lys(Dnp)-NH2	S		Ser	Pro	Leu	Ala	Gln	Ala	Val	Arg	English et al., 2000
Mca-Ser-Ser-Met-Ala-Gln-Thr-Leu-Thr-Leu-Arg-Ser-Ser-Ser-Lys(Dnp)-NH2			Mca-Ser-Ser-Met-Ala-Gln-Thr+Leu-Thr-Leu-Arg-Ser-Ser-Ser-Lys(Dnp)-NH2	S		Met	Ala	Gln	Thr	Leu	Thr	Leu	Arg	English et al., 2000
myelin basic protein isoform 1	P04370	1-246	peptide-His208+Gly-peptide	P	MS	Lys	Ser	Gln	His	Gly	Arg	Thr	Gln	Shiryaev et al., 2009	25482
myelin basic protein isoform 1	P04370	1-246	peptide-Asn75+Asn-peptide	P	MS	Asp	Pro	Lys	Asn	Asn	Trp	Gln	Gly	Shiryaev et al., 2009	25483
myelin basic protein isoform 1	P04370	1-246	peptide-Asn87+Arg-peptide	P	MS	Asp	Pro	Gly	Asn	Arg	Pro	His	Leu	Shiryaev et al., 2009	25484
myelin basic protein isoform 1	P04370	1-246	peptide-His158+Gly-peptide	P	MS	His	Ala	Arg	His	Gly	Phe	Leu	Pro	Shiryaev et al., 2009	25485
myelin basic protein isoform 1	P04370	1-246	peptide-Pro203+Gln-peptide	P	MS	Gly	Ser	Leu	Pro	Gln	Lys	Ser	Gln	Shiryaev et al., 2009	25486
myelin basic protein isoform 1	P04370	1-246	peptide-Lys205+Ser-peptide	P	MS	Leu	Pro	Gln	Lys	Ser	Gln	His	Gly	Shiryaev et al., 2009	25487
myelin basic protein isoform 1	P04370	1-246	peptide-Ala135+Ser-peptide	P	MS	Asp	Val	Met	Ala	Ser	Gln	Lys	Arg	Shiryaev et al., 2009
myelin basic protein isoform 1	P04370	1-246	peptide-Tyr146+Leu-peptide	P	MS	Arg	Ser	Lys	Tyr	Leu	Ala	Thr	Ala	Shiryaev et al., 2009
myelin basic protein isoform 1	P04370	1-246	peptide-Ser144+Lys-peptide	P	MS	Ser	Gln	Arg	Ser	Lys	Tyr	Leu	Ala	Shiryaev et al., 2009
myelin basic protein isoform 1	P04370	1-246	peptide-Glu116+Leu-peptide	P	MS	Glu	Ser	Asp	Glu	Leu	Gln	Thr	Ile	Shiryaev et al., 2009
myelin basic protein isoform 1	P04370	1-246	peptide-Ser136+Gln-peptide	P	MS	Val	Met	Ala	Ser	Gln	Lys	Arg	Pro	Shiryaev et al., 2009
QF-24			Mca-Pro-Leu-Gly+Leu-Dpa-Ala-Arg-NH2	S		Mca	Pro	Leu	Gly	Leu	Dpa	Ala	Arg	Itoh & Seiki, 2004
TNFalpha			Ser-Pro-Leu-Ala-Gln+Ala-Val-Arg-Ser-Ser-Ser-Arg-Lys	N		Pro	Leu	Ala	Gln	Ala	Val	Arg	Ser	Amour et al., 2002
tumor necrosis factor	P01375	1-233	peptide-Gln75+Ala-peptide	P		Pro	Leu	Ala	Gln	Ala	Val	Arg	Ser	Amour et al., 2002