Substrates for peptidase M10.016: membrane-type matrix metallopeptidase-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
amyloid beta A4 protein	P05067	18-770	peptide-Ala463+Met-peptide	P		Arg	Val	Glu	Ala	Met	Leu	Asn	Asp	Ahmad et al., 2006	18326
amyloid beta A4 protein	P05067	18-770	peptide-Asn579+Met-peptide	P		Val	Leu	Ala	Asn	Met	Ile	Ser	Glu	Ahmad et al., 2006	18327
amyloid beta A4 protein	P05067	18-770	peptide-His622+Ser-peptide	P		Gln	Pro	Trp	His	Ser	Phe	Gly	Ala	Ahmad et al., 2006	18328
amyloid beta A4 protein	P05067	18-770	peptide-His685+Gln-peptide	P		Glu	Val	His	His	Gln	Lys	Leu	Val	Ahmad et al., 2006	18329
collagen alpha-1(III) chain	P02461	154-1221	peptide-Gly781+Ile-peptide	P		Gly	Pro	Leu	Gly	Ile	Ala	Gly	Ile	Shimada et al., 1999
collagen alpha-1(III) chain	P02461	154-1221	peptide-Gly784+Ile-peptide	P		Gly	Ile	Ala	Gly	Ile	Thr	Gly	Ala	Shimada et al., 1999
metastasis-suppressor KiSS-1	Q15726	20-145	peptide-Gly118+Leu-peptide	P		Asn	Ser	Phe	Gly	Leu	Arg	Phe	Gly	Takino et al., 2003	3998
myelin basic protein isoform 1	P04370	1-246	peptide-His208+Gly-peptide	P	MS	Lys	Ser	Gln	His	Gly	Arg	Thr	Gln	Shiryaev et al., 2009	25488
myelin basic protein isoform 1	P04370	1-246	peptide-Asn75+Asn-peptide	P	MS	Asp	Pro	Lys	Asn	Asn	Trp	Gln	Gly	Shiryaev et al., 2009	25489
myelin basic protein isoform 1	P04370	1-246	peptide-Glu116+Leu-peptide	P	MS	Glu	Ser	Asp	Glu	Leu	Gln	Thr	Ile	Shiryaev et al., 2009	25490
myelin basic protein isoform 1	P04370	1-246	peptide-Ser144+Lys-peptide	P	MS	Ser	Gln	Arg	Ser	Lys	Tyr	Leu	Ala	Shiryaev et al., 2009	25491
myelin basic protein isoform 1	P04370	1-246	peptide-Ala150+Ser-peptide	P	MS	Leu	Ala	Thr	Ala	Ser	Thr	Met	Asp	Shiryaev et al., 2009	25492
myelin basic protein isoform 1	P04370	1-246	peptide-Pro203+Gln-peptide	P	MS	Gly	Ser	Leu	Pro	Gln	Lys	Ser	Gln	Shiryaev et al., 2009	25493
myelin basic protein isoform 1	P04370	1-246	peptide-Lys205+Ser-peptide	P	MS	Leu	Pro	Gln	Lys	Ser	Gln	His	Gly	Shiryaev et al., 2009	25494
myelin basic protein isoform 2	P04370-2	1-190	peptide-Lys34+Leu-peptide	P	MS	Ser	Val	Gly	Lys	Leu	Ser	Gln	Thr	Shiryaev et al., 2009	25455
myelin basic protein isoform 2	P04370-2	1-190	peptide-His81+Pro-peptide	P	MS	Gln	Gly	Ala	His	Pro	Ala	Asp	Pro	Shiryaev et al., 2009	25456
myelin basic protein isoform 2	P04370-2	1-190	peptide-Thr119+Ile-peptide	P	MS	Glu	Leu	Gln	Thr	Ile	Gln	Glu	Asp	Shiryaev et al., 2009	25457
myelin basic protein isoform 2	P04370-2	1-190	peptide-Ala135+Ser-peptide	P	MS	Asp	Val	Met	Ala	Ser	Gln	Lys	Arg	Shiryaev et al., 2009	25458
myelin basic protein isoform 2	P04370-2	1-190	peptide-Ser136+Gln-peptide	P	MS	Val	Met	Ala	Ser	Gln	Lys	Arg	Pro	Shiryaev et al., 2009	25459
myelin basic protein isoform 2	P04370-2	1-190	peptide-Tyr146+Leu-peptide	P	MS	Arg	Ser	Lys	Tyr	Leu	Ala	Thr	Ala	Shiryaev et al., 2009	25460