Substrates for peptidase S01.174: mesotrypsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
alpha-1-peptidase inhibitor	P01009	25-418	peptide-Lys34+Thr-peptide	P		Ala	Ala	Gln	Lys	Thr	Asp	Thr	Ser	Szepessy & Sahin-Toth, 2006	19070
alpha-1-peptidase inhibitor	P01009	25-418	peptide-Arg358+Ser-peptide	P		Ala	Ile	Pro	Arg	Ser	Ile	Pro	Pro	Szepessy & Sahin-Toth, 2006	19071
amyloid beta A4 protein	P05067	18-770	peptide-Arg301+Ala-peptide	P	NT	Gly	Pro	Cys	Arg	Ala	Met	Ile	Ser	Salameh et al., 2010
myelin basic protein	P02686	134-304	peptide-Arg231+Thr-peptide	P		Val	Thr	Pro	Arg	Thr	Pro	Pro	Pro	Medveczky et al., 2006	26556
myelin basic protein	P02686	134-304	peptide-Arg213+Thr-peptide	P		Ser	His	Gly	Arg	Thr	Gln	Asp	Glu	Medveczky et al., 2006
myelin basic protein	P02686	214-304	peptide-Arg241+Gly-peptide	P	MS	Gly	Lys	Gly	Arg	Gly	Leu	Ser	Leu	Medveczky et al., 2006
Myelin basic protein	P02686-5	1-171	peptide-Arg26+His-peptide	P	NT	Asp	His	Ala	Arg	His	Gly	Phe	Leu	Medveczky et al., 2006
myelin basic protein isoform 1	P02686	135-304	peptide-Arg26+His-peptide	P		Asp	His	Ala	Arg	His	Gly	Phe	Leu	Medveczky et al., 2006	26596
myelin basic protein isoform 1	P02686	135-304	peptide-Arg92+Thr-peptide	P		His	Pro	Ala	Arg	Thr	Ala	His	Tyr	Medveczky et al., 2006	26605
Pancreatic secretory trypsin inhibitor	P00995	24-79	peptide-Lys41+Ile-peptide	P	NT	Gly	Cys	Thr	Lys	Ile	Tyr	Asp	Pro	Belliot et al., 2003
Pancreatic secretory trypsin inhibitor	P00995	24-79	peptide-Lys75+Ser-Gly-Pro-Cys	P	NT	Leu	Ile	Gln	Lys	Ser	Gly	Pro	Cys	Belliot et al., 2003
Pancreatic secretory trypsin inhibitor	P00995	24-79	peptide-Arg28+Glu-peptide	P	NT	Ser	Leu	Gly	Arg	Glu	Ala	Lys	Cys	Belliot et al., 2003
Pancreatic secretory trypsin inhibitor	P00995	24-79	peptide-Arg67+Gln-peptide	P	NT	Asn	Arg	Lys	Arg	Gln	Thr	Ser	Ile	Belliot et al., 2003
pancreatic trypsin inhibitor	P00974	36-93	peptide-Lys50+Ala-peptide	P	NT	Gly	Pro	Cys	Lys	Ala	Arg	Ile	Ile	Salameh et al., 2008
protease-activated receptor 2	Q53XJ8	32-54	peptide-Arg36+Ser-peptide	N		Ser	Lys	Gly	Arg	Ser	Leu	Ile	Gly	Knecht et al., 2007
proteinase-activated receptor 1	P25116	35-53	peptide-Arg41+Ser-peptide	P		Leu	Asp	Pro	Arg	Ser	Phe	Leu	Leu	Knecht et al., 2007
proteinase-activated receptor 4 precursor	Q96RI0	35-53	peptide-Arg47+Gly-peptide	P		Pro	Ala	Pro	Arg	Gly	Tyr	Pro	Gly	Knecht et al., 2007
Tos-Gly-Pro-Lys-NHPhNO2			Tos-Gly-Pro-Lys+NHPhNO2	S		Tos	Gly	Pro	Lys	NAN	-	-	-	Knecht et al., 2007
Tos-Gly-Pro-Lys-NHPhNO2			Tos-Gly-Pro-Lys+NHPhNO2	S		Tos	Gly	Pro	Lys	NAN	-	-	-	Knecht et al., 2007
Trypsin inhibitor A	P01070	25-205	peptide-Arg87+Ile-peptide	P	NT	Ser	Pro	Tyr	Arg	Ile	Arg	Phe	Ile	Belliot et al., 2003
Trypsin-1	P07477	24-247	peptide-Arg122+Val-peptide	P	CS	Ile	Asn	Ala	Arg	Val	Ser	Thr	Ile	Szmola et al., 2003
Z-Gly-Pro-Arg-NHPhNO2			Z-Gly-Pro-Arg+NHPhNO2	S		Z	Gly	Pro	Arg	NAN	-	-	-	Chen & Ferec, 2004