Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01213

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-254	P	release of an initiating methionine	MS	Adamski et al., 2005
20	unknown peptidase	1-254	P		NT	<%Agarwal et al., 2012[]%>
172	unknown peptidase	1-254	P		NT	<%Agarwal et al., 2012[]%>
174	aminopeptidase B	174-179	N			Foulon et al., 2004
175	aminopeptidase N	175-179	N			Turner, 2004
175	leukotriene A4 hydrolase	175-179	N			Griffin et al., 1992
175	cytosol alanyl aminopeptidase	175-179	N			Hui et al., 1998
175	cystinyl aminopeptidase	175-179	P		NT	Ye et al., 2008
175	aminopeptidase Ey	175-179	N			Ichishima, 2004
175	eupitrilysin	175-179	N			Chow et al., 2009
175	glycyl aminopeptidase	175-179	N			Byun & Blinkovsky, 2004
175	neuron-specific aminopeptidase	175-179	N			Hui et al., 1998
175	neuron-specific aminopeptidase-2	175-179	N			Hui et al., 2008
176	cathepsin L	175-179	N			Marks et al., 1988
176	aminopeptidase Ey	176-179	N			Ichishima, 2004
176	dipeptidyl-peptidase III	175-179	N			McDonald, 1998
176	glycyl aminopeptidase	176-179	N			Byun & Blinkovsky, 2004
177	cathepsin B	175-179	N			Takahashi et al., 1986
177	aminopeptidase Ey	177-179	N			Ichishima, 2004
177	peptidyl-dipeptidase Acer	175-179	N			Isaac, 2004
177	neprilysin	175-179	N			Matsas et al., 1984
177	neprilysin-2	175-179	N			Carpentier et al., 2003
177	glycyl aminopeptidase	177-179	N			Byun & Blinkovsky, 2004
177	tripeptidyl-peptidase I	175-183	N			Du et al., 2001
178	aminopeptidase Ey	178-179	N			Ichishima, 2004
178	gametolysin	175-184	N			Matsuda & Kubo, 2004
178	carboxypeptidase A6	175-179	P		MS	Lyons et al., 2008
178	penicillolysin	175-184	N			Ichishima, 2004
178	dactylysin	174-180	N			Clamagirand et al., 2004
179	carboxypeptidase M	175-180	N			Skidgel, 2004
179	penicillolysin	175-184	N			Ichishima, 2004
180	omptin	175-184	N			McCarter et al., 2004
180	sporangin	175-184	N			Matsuda et al., 1995
180	tryase	175-184	P		NT	Tamanoue, et al., 1993
180	unknown peptidase	175-184	N			Tsuchiya et al., 1994
181	sporangin	175-184	N			Matsuda et al., 1995
181	unknown peptidase	175-183	N			Corvol et al., 2004
204	unknown peptidase	1-254	P		NT	<%Agarwal et al., 2012[]%>
207	aminopeptidase Q	207-214	N			Maruyama et al., 2007
207	eupitrilysin	207-223	N			Chow et al., 2009
208	aminopeptidase Q	208-214	N			Maruyama et al., 2007
209	aminopeptidase Q	209-214	N			Maruyama et al., 2007
209	thimet oligopeptidase	207-214	P		NT	Dando et al., 1993
209	neprilysin	207-215	N			Matsas et al., 1984
209	dactylysin	207-211	N		MS	Clamagirand et al., 2002
209	tripeptidyl-peptidase I	207-214	N			Oyama et al., 2005
210	neprilysin	207-215	P			Matsas et al., 1984
210	YMXG peptidase	207-223	N			Kitada et al., 2007
211	cathepsin H	207-219	P		-	Brguljan et al., 2003
211	angiotensin-converting enzyme peptidase unit 1	207-214	P		MS	Isaac et al., 1997
211	thimet oligopeptidase	207-214	P		NT	Dando et al., 1993
211	neurolysin	207-214	N		NT	Serizawa et al., 1995
211	carboxypeptidase E	207-212	P		HP	Grimwood et al., 1989
212	omptin	207-219	N			McCarter et al., 2004
212	cathepsin B	207-214	N			Takahashi et al., 1986
212	carboxypeptidase E	207-213	P		HP	Grimwood et al., 1989
212	tryase	207-223	P		NT	Tamanoue, et al., 1993
212	unknown peptidase	207-223	P			Sadler, 2004
212	dibasic processing endopeptidase (unsequenced)	207-223	P		NT	Watanabe et al., 1992
213	epralysin	207-223	N			Kim et al., 1997
213	neprilysin	207-215	P			Matsas et al., 1984
213	eupitrilysin	207-223	N			Chow et al., 2009
213	YMXG peptidase	207-223	N			Kitada et al., 2007
216	eupitrilysin	207-223	N			Chow et al., 2009
216	YMXG peptidase	207-223	N			Kitada et al., 2007
217	neurolysin	207-223	N		NT	Serizawa et al., 1995
217	YMXG peptidase	207-223	N			Kitada et al., 2007
218	angiotensin-converting enzyme-2	207-219	P		MS	Vickers et al., 2002
218	neurolysin	207-223	N		NT	Serizawa et al., 1995
218	YMXG peptidase	207-223	N			Kitada et al., 2007
218	leulysin	207-223	N			Okada et al., 1987
222	carboxypeptidase A6	216-223	N			Lyons & Fricker, 2010
226	eupitrilysin	226-254	N			Chow et al., 2009
229	carboxypeptidase A4	226-230	N			Tanco et al., 2010
230	thimet oligopeptidase	226-238	P		NT	Dando et al., 1993
233	endothelin-converting enzyme 2	226-238	P		MS	Mzhavia et al., 2003
234	thimet oligopeptidase	226-238	P		NT	Dando et al., 1993
234	eupitrilysin	226-238	N			Chow et al., 2009
235	endothelin-converting enzyme 2	226-238	P		MS	Mzhavia et al., 2003
235	eupitrilysin	226-238	N			Chow et al., 2009
238	eupitrilysin	226-254	N			Chow et al., 2009
239	eupitrilysin	226-254	P			Mzhavia et al., 1999