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Peptidase

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Substrates for peptidase A26.001: omptin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Ala-Arg-Arg-Ala-Dbn-Gly Abz-Ala-Arg+Arg-Ala-Dbn-Gly S - Abz Ala Arg Arg Ala Dbn Gly Dekker, 2004
Abz-Ala-Arg-Arg-Ala-Tyn-NH2 Abz-Ala-Arg+Arg-Ala-Tyn-NH2 S - Abz Ala Arg Arg Ala Tyn NH2 Dekker, 2004
Abz-Arg+Arg-Ala-Dnb-Gly Abz-Arg+Arg-Ala-Dnb-Gly S - - Abz Arg Arg Ala Dbn Gly Dekker, 2004
Ac-Trp-Gly-Gly-Arg-Arg-Ile-Lys-Gly-Trp-Gly-Thr-Ile-NH2 Ac-Trp-Gly-Gly-Arg+Arg-Ile-Lys-Gly-Trp-Gly-Thr-Ile-NH2 S Trp Gly Gly Arg Arg Ile Lys Gly McCarter et al., 2004
Ac-Trp-Gly-Gly-Arg-Arg-Ser-Arg-Arg-Val-Gly-Thr-Ile-NH2 Ac-Trp-Gly-Gly-Arg-Arg-Ser-Arg+Arg-Val-Gly-Thr-Ile-NH2 S Arg Arg Ser Arg Arg Val Gly Thr McCarter et al., 2004
Ac-Trp-Gly-Gly-Arg-Lys-Ala-Trp-Ile-Lys-Gly-Thr-Ile-NH2 Ac-Trp-Gly-Gly-Arg+Lys-Ala-Trp-Ile-Lys-Gly-Thr-Ile-NH2 S Trp Gly Gly Arg Lys Ala Trp Ile McCarter et al., 2004
Ac-Trp-Gly-Gly-Arg-Trp-Ala-Arg-Lys-Lys-Gly-Thr-Ile-NH2 Ac-Trp-Gly-Gly-Arg-Trp-Ala-Arg+Lys-Lys-Gly-Thr-Ile-NH2 S Arg Trp Ala Arg Lys Lys ly Thr McCarter et al., 2004
Ac-Trp-Gly-Gly-Arg-Tyr-Lys-Arg-Val-Trp-Gly-Thr-Ile-NH2 Ac-Trp-Gly-Gly-Arg-Tyr-Lys+Arg-Val-Trp-Gly-Thr-Ile-NH2 S Gly Arg Tyr Lys Arg Val Trp Gly McCarter et al., 2004
Ac-Trp-Gly-Gly-Lys-Tyr-Arg-Arg-Ala-Trp-Gly-Thr-Ile-NH2 Ac-Trp-Gly-Gly-Lys-Tyr-Arg+Arg-Ala-Trp-Gly-Thr-Ile-NH2 S Gly Lys Tyr Arg Arg Ala Trp Gly McCarter et al., 2004
AIDA-I autotransporter Q03155 50-1286 peptide-Arg926+Val-peptide P Leu Lys Asn Arg Val Val Ala Gly Maurer et al., 1997 16075
alpha-neoendorphin P01213 175-184 peptide-Arg180+Lys-peptide N Gly Phe Leu Arg Lys Tyr Pro Lys McCarter et al., 2004 21137
Colicin-A P04480 1-592 Peptide-Lys225+Arg-Peptide P CS Asp Ala Gly Lys Arg Val Glu Ala Cavard & Lazdunski, 1990
Colicin-A P04480 1-592 Peptide-Lys258+Gln-Peptide P CS Ile Thr Gln Lys Gln Ala Glu Met Cavard & Lazdunski, 1990
Colicin-A P04480 1-592 Peptide-Lys309+Gln-Peptide P CS Val Asp Thr Lys Gln Asn Glu Ile Cavard & Lazdunski, 1990
Colicin-A P04480 1-592 Peptide-Arg188+Gln-Peptide P CS Met Arg Ile Arg Gln Glu Ala Ala Cavard & Lazdunski, 1990
Colicin-A P04480 1-592 Peptide-Arg373+Gln-Peptide P CS Glu Lys Ala Arg Gln Arg Gln Ala Cavard & Lazdunski, 1990
Colicin-A P04480 1-592 Peptide-Arg375+Gln-Peptide P CS Ala Arg Gln Arg Gln Ala Glu Glu Cavard & Lazdunski, 1990
Colicin-A P04480 1-592 Peptide-Arg382+Gln-Peptide P CS Glu Ala Glu Arg Gln Arg Gln Ala Cavard & Lazdunski, 1990
Colicin-A P04480 1-592 Peptide-Arg384+Gln-Peptide P CS Glu Arg Gln Arg Gln Ala Met Glu Cavard & Lazdunski, 1990
Colicin-E1 P02978 1-522 Peptide-Lys63+Lys-Peptide P CS Ala Gln Leu Lys Lys Thr Gln Ala Cavard & Lazdunski, 1990
Colicin-E1 P02978 1-522 Peptide-Lys469+Lys-Peptide P CS Thr Leu Glu Lys Lys Ala Ala Asp Cavard & Lazdunski, 1990
creatine kinase M-type P00566 1-381 peptide-Lys40+Lys-peptide N Asp Ile Tyr Lys Lys Leu Arg Asp McCarter et al., 2004 21133
creatine kinase M-type P00566 1-381 peptide-Arg151+Arg-peptide N Arg Gly Glu Arg Arg Leu Val Glu McCarter et al., 2004
creatine kinase M-type P00563 1-381 peptide-Lys40+Lys-peptide N Asp Leu Tyr Lys Lys Leu Arg Asp McCarter et al., 2004
creatine kinase M-type P00563 1-381 peptide-Arg151+Arg-peptide N Arg Gly Glu Arg Arg Ala Val Glu McCarter et al., 2004 21132
cyclin-A2 P20248 1-432 peptide-Arg70+Arg-peptide P Pro Lys Thr Arg Arg Val Ala Pro Yam et al., 2001 18732
DNA-directed RNA polymerase P00573 1-883 peptide-Lys172+Arg-peptide N Gln Leu Asn Lys Arg Val Gly His McCarter et al., 2004 21141
DNA-directed RNA polymerase P00573 1-883 peptide-Lys179+Lys-peptide N His Val Tyr Lys Lys Ala Phe Met McCarter et al., 2004 21142
DNA-directed RNA polymerase P00573 1-883 peptide-Arg391+Lys-peptide N Asp Lys Ala Arg Lys Ser Arg Arg McCarter et al., 2004 21143
dynorphin A (1-13) P01213 207-219 peptide-Arg212+Arg-peptide N Gly Phe Leu Arg Arg Ile Arg Lys McCarter et al., 2004 21138
IAA-Arg-Arg-NHPhNO2 IAA-Arg+Arg-NHPhNO2 S - - NBk Arg Arg NAN - - Dekker, 2004
IFNG interferon, gamma P01579 24-161 peptide-Lys151+Arg-peptide N Lys Thr Gly Lys Arg Lys Arg Ser McCarter et al., 2004 21134
IFNG interferon, gamma P01579 24-161 peptide-Arg162+Arg-peptide N Phe Arg Gly Arg Arg Ala Ser Gln McCarter et al., 2004 21135
insulin-like growth factor II P01344 25-91 peptide-Arg114+Arg-peptide P Arg Val Ser Arg Arg Ser Arg Gly Hammarberg et al., 1990 16076
long-chain-fatty-acid--CoA ligase Q8XDR6 1-561 peptide-Lys172+Arg-peptide P Lys Tyr Ile Lys Arg Leu Val Pro Yoo et al., 2001 18731
mastoparan-L P01514 1-14 peptide-Lys11+Lys-peptide P Ala Leu Ala Lys Lys Ile Leu Gly McCarter et al., 2004 21144
parathyroid hormone P01270 32-115 peptide-Lys58+Lys-peptide N Trp Leu Arg Lys Lys Leu Gln Asp McCarter et al., 2004 21140
parathyroid hormone P01270 32-115 peptide-Arg56+Lys-peptide N Glu Trp Leu Arg Lys Lys Leu Gln McCarter et al., 2004
phage display peptide DGDYKDDDDKGLEAWEEGGRRIGRGGKGAETVES DGDYKDDDDKGLEAWEEGGR+RIGRGGKGAETVES N Glu Gly Gly Arg Arg Ile Gly Arg Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLAAKKGAGGAETVES DGDYKDDDDKGLEAWLAAK+KGAGGAETVES N Leu Ala Ala Lys Lys Gly Ala Gly Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLAARRGAGGAETVES DGDYKDDDDKGLEAWLAAR+RGAGGAETVES N Leu Ala Ala Arg Arg Gly Ala Gly Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLAARRGRGGAETVES DGDYKDDDDKGLEAWLAAR+RGRGGAETVES N Leu Ala Ala Arg Arg Gly Arg Gly Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLAASRGAGGAETVES DGDYKDDDDKGLEAWLAAS+RGAGGAETVES N Leu Ala Ala Ser Arg Gly Ala Gly Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLARRRGAGGAETVES peptide-Arg+Arg-peptide N Trp Leu Ala Arg Arg Arg Gly Ala Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLATRRGAGGAETVES DGDYKDDDDKGLEAWLATR+RGAGGAETVES N Leu Ala Thr Arg Arg Gly Ala Gly Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLRARRGAGGAETVES DGDYKDDDDKGLEAWLRAR+RGAGGAETVES N Leu Arg Ala Arg Arg Gly Ala Gly Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLSARRGAGGAETVES DGDYKDDDDKGLEAWLSAR+RGAGGAETVES N Leu Ser Ala Arg Arg Gly Ala Gly Hwang et al., 2007
phage display peptide DGDYKDDDDKGLEAWLSERRGAGGAETVES DGDYKDDDDKGLEAWLSER+RGAGGAETVES N Leu Ser Glu Arg Arg Gly Ala Gly Hwang et al., 2007
plasminogen P00747 20-810 peptide-Arg580+Val-peptide N Cys Pro Gly Arg Val Val Gly Gly McCarter et al., 2004 21136
pseudoazurin fusion protein peptide-Arg+Ser-peptide S - - NPe Arg Ser CPe - - Shimada et al., 1994
RNase 3 A5HAK0 26-149 peptide-Arg55-Arg-peptide P Met Arg Gln Arg Arg Ile Thr Arg Zanfardino et al., 2010
tryptophan synthase beta subunit (Gly281->Arg mutant) peptide-Arg280+Met-peptide N Ile Tyr Phe Arg Met Lys Ala Pro Zhao & Somerville, 1993
Z-Ala-Lys-Arg-NHMec Z-Ala-Lys+Arg-NHMec S - Z Ala Lys Arg AMC - - Toledo & Mangel, 1998
Z-Arg-Arg-NHMec Z-Arg+Arg-NHMec S - - Z Arg Arg AMC - - Toledo & Mangel, 1998

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