Substrates for peptidase M14.005: carboxypeptidase E

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Tyr-Ala-Arg			Ac-Tyr-Ala+Arg	S		-	Ac	Tyr	Ala	Arg	-	-	-	Fricker, 2004
Bz-Phe-Ala-Arg			Bz-Phe-Ala+Arg	S		-	Bz	Phe	Ala	Arg	-	-	-	Fricker, 2004
cholecystokinin	P06307	96-105	peptide-Arg105+Arg	P		Asp	Phe	Gly	Arg	Arg	-	-	-	Beinfeld, 2002
cholecystokinin	P06307	96-105	peptide-Gly104+Arg	P		Met	Asp	Phe	Gly	Arg	-	-	-	Beinfeld, 2002	3086
Dns-Phe-Ala-Arg			Dns-Phe-Ala+Arg	S		-	Dns	Phe	Ala	Arg	-	-	-	Fricker, 2004
furylacryloyl-Ala-Arg (FAAR)			furylacryloyl-Ala+Arg	S		-	-	FA	Ala	Arg	-	-	-	Grimwood et al., 1989
furylacryloyl-Ala-Lys (FAAK)			furylacryloyl-Ala+Lys	S		-	-	FA	Ala	Lys	-	-	-	Grimwood et al., 1989
gastrin precursor	P01350	76-94	peptide-Gly93+Arg	P		Met	Asp	Phe	Gly	Arg	-	-	-	Lacourse et al., 1997	3087
gastrin precursor	P01350	59-95	peptide-Arg94+Arg-peptide	P	NT	Asp	Phe	Gly	Arg	Arg	-	-	-	Sawada et al., 2000
gastrin precursor	P01350	59-94	peptide-Gly93+Arg-peptide	P	NT	Met	Asp	Phe	Gly	Arg	-	-	-	Sawada et al., 2000
glucagon	P55095	92-130	peptide-Arg129+Arg	P	AB	Gly	Arg	Gly	Arg	Arg	'-'	'-'	'-'	Friis-Hansen et al., 2001
glucagon	P55095	92-129	peptide-Gly128+Arg	P	AB	Lys	Gly	Arg	Gly	Arg	'-'	'-'	'-'	Friis-Hansen et al., 2001
insulin	P01308	25-55	peptide-Thr54+Arg	P		Thr	Pro	Lys	Thr	Arg	-	-	-	Goodge & Hutton, 2000
insulin	P01308	57-89	peptide-Lys88+Arg	P		Ser	Leu	Gln	Lys	Arg	-	-	-	Goodge & Hutton, 2000
insulin	P01308	57-88	peptide-Gln87+Lys	P		Gly	Ser	Leu	Gln	Lys	-	-	-	Goodge & Hutton, 2000
islet amyloid polypeptide	Q0ZD87	33-73	peptide-Lys72+Arg	P		Thr	Tyr	Gly	Lys	Arg	-	-	-	Wang et al., 2001
islet amyloid polypeptide	Q0ZD87	33-72	peptide-Gly71+Lys	P		Asn	Thr	Tyr	Gly	Lys	-	-	-	Wang et al., 2001
islet amyloid polypeptide	Q0ZD87	33-71	peptide-Tyr70+Gly	P		Ser	Asn	Thr	Tyr	Gly	-	-	-	Wang et al., 2001
oxidized insulin B chain	P01308	25-56	peptide-Arg55+Arg	N		Pro	Lys	Thr	Arg	Arg	-	-	-	Goodge & Hutton, 2000	3088
progonadoliberin-1	P01148	24-36	Gln-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-Gly-Lys+Arg	P		Pro	Gly	Gly	Lys	Arg	'-'	'-'	'-'
progonadoliberin-1	P01148	24-35	Gln-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-Gly+Lys	P		Arg	Pro	Gly	Gly	Lys	'-'	'-'	'-'
prolyl-arginine bond			Pro+Arg	N		-	-	NPe	Pro	Arg	CPe	-	-	Fricker, 2004
[Leu5]enkephalin-Arg6	P01213	207-212	Tyr-Gly-Gly-Phe-Leu+Arg	P	LC	Gly	Gly	Phe	Leu	Arg	-	-	-	Grimwood et al., 1989
[Leu5]enkephalin-Arg6-Arg7	P01213	207-213	Tyr-Gly-Gly-Phe-Leu-Arg+Arg	P	LC	Gly	Phe	Leu	Arg	Arg	-	-	-	Grimwood et al., 1989