Structure for peptidase C16.009: severe acute respiratory syndrome coronavirus papain-like peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
2FE8	SARS coronavirus	1.85 Å	mature
One molecule of the homotrimer is shown. Catalytic residues are shown in ball-and-stick representation: Cys1651 in yellow, His1812 in purple and Asp1826 in pink.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
SARS coronavirus
mature peptidase	0.00 Å	1P76	1P76	1P76	1P76	1P76	1P76
mature peptidase	0.00 Å	1P9T	1P9T	1P9T	1P9T	1P9T	1P9T
mature peptidase	0.00 Å	1PA5	1PA5	1PA5	1PA5	1PA5	1PA5
mature peptidase	0.00 Å	1PUK	1PUK	1PUK	1PUK	1PUK	1PUK
mature peptidase	0.00 Å	1Q1X	1Q1X	1Q1X	1Q1X	1Q1X	1Q1X
mature peptidase	1.86 Å	1Q2W	1Q2W	1Q2W	1Q2W	1Q2W	1Q2W
mature peptidase	2.70 Å	1QZ8	1QZ8	1QZ8	1QZ8	1QZ8	1QZ8	Egloff et al., 2004
mature peptidase	1.90 Å	1UJ1	1UJ1	1UJ1	1UJ1	1UJ1	1UJ1	Yang et al., 2003
mature peptidase	2.20 Å	1UK2	1UK2	1UK2	1UK2	1UK2	1UK2	Yang et al., 2003
mature peptidase	2.40 Å	1UK3	1UK3	1UK3	1UK3	1UK3	1UK3	Yang et al., 2003
mature peptidase	2.80 Å	1UW7	1UW7	1UW7	1UW7	1UW7	1UW7	Sutton et al., 2004
mature peptidase	2.00 Å	1WOF	1WOF	1WOF	1WOF	1WOF	1WOF	Yang et al., 2005
mature peptidase	0.00 Å	1YSY	1YSY	1YSY	1YSY	1YSY	1YSY	Peti et al., 2005
mature peptidase	2.80 Å	1Z1I	1Z1I	1Z1I	1Z1I	1Z1I	1Z1I	Hsu et al., 2005
mature peptidase	2.80 Å	1Z1J	1Z1J	1Z1J	1Z1J	1Z1J	1Z1J	Hsu et al., 2005
mature peptidase	2.08 Å	2A5A	2A5A	2A5A	2A5A	2A5A	2A5A	Lee et al., 2005
mature peptidase	1.88 Å	2A5I	2A5I	2A5I	2A5I	2A5I	2A5I	Lee et al., 2005
mature peptidase	2.30 Å	2A5K	2A5K	2A5K	2A5K	2A5K	2A5K	Lee et al., 2005
mature peptidase	1.40 Å	2ACF	2ACF	2ACF	2ACF	2ACF	2ACF	Saikatendu et al., 2005
mature peptidase	2.40 Å	2AHM	2AHM	2AHM	2AHM	2AHM	2AHM	Zhai et al., 2005
mature peptidase	0.00 Å	2AJ5	2AJ5	2AJ5	2AJ5	2AJ5	2AJ5
mature peptidase	1.90 Å	2ALV	2ALV	2ALV	2ALV	2ALV	2ALV	Ghosh et al., 2005
mature peptidase	1.85 Å	2AMD	2AMD	2AMD	2AMD	2AMD	2AMD	Yang et al., 2005
mature peptidase	2.30 Å	2AMQ	2AMQ	2AMQ	2AMQ	2AMQ	2AMQ	Yang et al., 2005
mature peptidase	2.00 Å	2BX3	2BX3	2BX3	2BX3	2BX3	2BX3	Tan et al., 2005
mature peptidase	2.79 Å	2BX4	2BX4	2BX4	2BX4	2BX4	2BX4	Tan et al., 2005
mature peptidase	1.90 Å	2C3S	2C3S	2C3S	2C3S	2C3S	2C3S	Xu et al., 2005
mature peptidase	2.70 Å	2D2D	2D2D	2D2D	2D2D	2D2D	2D2D	Yang et al., 2005
mature peptidase	1.70 Å	2DUC	2DUC	2DUC	2DUC	2DUC	2DUC
mature peptidase	1.80 Å	2FAV	2FAV	2FAV	2FAV	2FAV	2FAV	Egloff et al., 2006
mature peptidase	1.85 Å	2FE8	2FE8	2FE8	2FE8	2FE8	2FE8	Ratia et al., 2006
mature peptidase	1.80 Å	2FYG	2FYG	2FYG	2FYG	2FYG	2FYG	Joseph et al., 2006
mature peptidase	2.10 Å	2G9T	2G9T	2G9T	2G9T	2G9T	2G9T	Su et al., 2006
mature peptidase	2.70 Å	2GA6	2GA6	2GA6	2GA6	2GA6	2GA6	Su et al., 2006
mature peptidase	0.00 Å	2GDT	2GDT	2GDT	2GDT	2GDT	2GDT	Almeida et al., 2007
mature peptidase	0.00 Å	2GRI	2GRI	2GRI	2GRI	2GRI	2GRI	Serrano et al., 2007
mature peptidase	1.93 Å	2GX4	2GX4	2GX4	2GX4	2GX4	2GX4
mature peptidase	1.86 Å	2GZ7	2GZ7	2GZ7	2GZ7	2GZ7	2GZ7	Lu et al., 2006
mature peptidase	1.97 Å	2GZ8	2GZ8	2GZ8	2GZ8	2GZ8	2GZ8	Lu et al., 2006
mature peptidase	2.17 Å	2GZ9	2GZ9	2GZ9	2GZ9	2GZ9	2GZ9	Lu et al., 2006
mature peptidase	1.60 Å	2H2Z	2H2Z	2H2Z	2H2Z	2H2Z	2H2Z	Xue et al., 2007
mature peptidase	1.95 Å	2HOB	2HOB	2HOB	2HOB	2HOB	2HOB	Xue et al., 2007
mature peptidase	0.00 Å	2HSX	2HSX	2HSX	2HSX	2HSX	2HSX	Almeida et al., 2007
mature peptidase	0.00 Å	2IDY	2IDY	2IDY	2IDY	2IDY	2IDY	Serrano et al., 2007
mature peptidase	0.00 Å	2KAF	2KAF	2KAF	2KAF	2KAF	2KAF	Johnson et al., 2010
mature peptidase	0.00 Å	2KQV	2KQV	2KQV	2KQV	2KQV	2KQV	Johnson et al., 2010
mature peptidase	0.00 Å	2KQW	2KQW	2KQW	2KQW	2KQW	2KQW	Johnson et al., 2010
mature peptidase	0.00 Å	2KYS	2KYS	2KYS	2KYS	2KYS	2KYS	Johnson et al., 2010
mature peptidase	0.00 Å	2LIZ	2LIZ	2LIZ	2LIZ	2LIZ	2LIZ
mature peptidase	1.80 Å	2OP9	2OP9	2OP9	2OP9	2OP9	2OP9	Goetz et al., 2007
Gly11Ala mutant	2.50 Å	2PWX	2PWX	2PWX	2PWX	2PWX	2PWX	Chen et al., 2008
Asn214Ala mutant	2.70 Å	2QC2	2QC2	2QC2	2QC2	2QC2	2QC2
monomeric form of mutant	1.75 Å	2QCY	2QCY	2QCY	2QCY	2QCY	2QCY	Shi et al., 2008
structure-based design and synthesis and biological evaluation of peptidomimetic sars-3clpro inhibitors	1.90 Å	2QIQ	2QIQ	2QIQ	2QIQ	2QIQ	2QIQ	Ghosh et al., 2007
mature peptidase	2.22 Å	2W2G	2W2G	2W2G	2W2G	2W2G	2W2G	Tan et al., 2009
mature peptidase	2.79 Å	2WCT	2WCT	2WCT	2WCT	2WCT	2WCT	Tan et al., 2009
mature peptidase	2.20 Å	2YY4	2YY4	2YY4	2YY4	2YY4	2YY4
mature peptidase	1.79 Å	2Z3C	2Z3C	2Z3C	2Z3C	2Z3C	2Z3C	Yin et al., 2007
mature peptidase	2.10 Å	2Z3D	2Z3D	2Z3D	2Z3D	2Z3D	2Z3D	Yin et al., 2007
mature peptidase	2.32 Å	2Z3E	2Z3E	2Z3E	2Z3E	2Z3E	2Z3E	Yin et al., 2007
complex with tdt	1.78 Å	2Z94	2Z94	2Z94	2Z94	2Z94	2Z94	Lee et al., 2007
complex with pma	1.86 Å	2Z9G	2Z9G	2Z9G	2Z9G	2Z9G	2Z9G	Lee et al., 2007
complex with epdtc	1.95 Å	2Z9J	2Z9J	2Z9J	2Z9J	2Z9J	2Z9J	Lee et al., 2007
complex with jmf1600	1.85 Å	2Z9K	2Z9K	2Z9K	2Z9K	2Z9K	2Z9K	Lee et al., 2007
complex with jmf1586	2.10 Å	2Z9L	2Z9L	2Z9L	2Z9L	2Z9L	2Z9L	Lee et al., 2007
mature peptidase	1.93 Å	2ZU4	2ZU4	2ZU4	2ZU4	2ZU4	2ZU4	Lee et al., 2009
mature peptidase	1.65 Å	2ZU5	2ZU5	2ZU5	2ZU5	2ZU5	2ZU5	Lee et al., 2009
mature peptidase	2.36 Å	3ATW	3ATW	3ATW	3ATW	3ATW	3ATW	Akaji et al., 2011
mature peptidase	2.46 Å	3AVZ	3AVZ	3AVZ	3AVZ	3AVZ	3AVZ	Akaji et al., 2011
mature peptidase	2.30 Å	3AW0	3AW0	3AW0	3AW0	3AW0	3AW0	Akaji et al., 2011
mature peptidase	2.00 Å	3AW1	3AW1	3AW1	3AW1	3AW1	3AW1	Akaji et al., 2011
development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3clpro	2.70 Å	3D62	3D62	3D62	3D62	3D62	3D62	Bacha et al., 2008
mature peptidase	2.55 Å	3E91	3E91	3E91	3E91	3E91	3E91
a new class of papain-like protease/deubiquitinase inhibitors blocks sars virus replication	2.50 Å	3E9S	3E9S	3E9S	3E9S	3E9S	3E9S
mature peptidase	2.65 Å	3EA7	3EA7	3EA7	3EA7	3EA7	3EA7
mature peptidase	2.25 Å	3EA8	3EA8	3EA8	3EA8	3EA8	3EA8
mature peptidase	2.40 Å	3EA9	3EA9	3EA9	3EA9	3EA9	3EA9
mature peptidase	2.70 Å	3EAJ	3EAJ	3EAJ	3EAJ	3EAJ	3EAJ
mature peptidase	2.60 Å	3EE7	3EE7	3EE7	3EE7	3EE7	3EE7	Miknis et al., 2009
mature peptidase	2.50 Å	3F9E	3F9E	3F9E	3F9E	3F9E	3F9E	Hu et al., 2009
mature peptidase	2.30 Å	3F9F	3F9F	3F9F	3F9F	3F9F	3F9F	Hu et al., 2009
mature peptidase	2.60 Å	3F9G	3F9G	3F9G	3F9G	3F9G	3F9G	Hu et al., 2009
mature peptidase	2.90 Å	3F9H	3F9H	3F9H	3F9H	3F9H	3F9H	Hu et al., 2009
mature peptidase	2.35 Å	3FZD	3FZD	3FZD	3FZD	3FZD	3FZD	Barrila et al., 2010
mature peptidase	3.20 Å	3IWM	3IWM	3IWM	3IWM	3IWM	3IWM	Zhang et al., 2010
mature peptidase	2.30 Å	3M3S	3M3S	3M3S	3M3S	3M3S	3M3S
mature peptidase	2.90 Å	3M3T	3M3T	3M3T	3M3T	3M3T	3M3T
mature peptidase	2.70 Å	3M3V	3M3V	3M3V	3M3V	3M3V	3M3V
mature peptidase	2.63 Å	3MJ5	3MJ5	3MJ5	3MJ5	3MJ5	3MJ5	Ghosh et al., 2010
mature peptidase	2.00 Å	3R24	3R24	3R24	3R24	3R24	3R24	Chen et al., 2011
mature peptidase	1.99 Å	3SN8	3SN8	3SN8	3SN8	3SN8	3SN8	Zhu et al., 2011
mature peptidase	3.05 Å	3SNA	3SNA	3SNA	3SNA	3SNA	3SNA	Zhu et al., 2011
mature peptidase	2.40 Å	3SNB	3SNB	3SNB	3SNB	3SNB	3SNB	Zhu et al., 2011
mature peptidase	2.58 Å	3SNC	3SNC	3SNC	3SNC	3SNC	3SNC	Zhu et al., 2011
mature peptidase	1.89 Å	3SND	3SND	3SND	3SND	3SND	3SND	Zhu et al., 2011
mature peptidase	2.60 Å	3SNE	3SNE	3SNE	3SNE	3SNE	3SNE	Zhu et al., 2011
mature peptidase	1.69 Å	3SZN	3SZN	3SZN	3SZN	3SZN	3SZN
mature peptidase	1.99 Å	3TIT	3TIT	3TIT	3TIT	3TIT	3TIT
mature peptidase	2.08 Å	3TIU	3TIU	3TIU	3TIU	3TIU	3TIU
mature peptidase	1.99 Å	3TNS	3TNS	3TNS	3TNS	3TNS	3TNS
mature peptidase	1.59 Å	3TNT	3TNT	3TNT	3TNT	3TNT	3TNT
mature peptidase	1.96 Å	3V3M	3V3M	3V3M	3V3M	3V3M	3V3M	Jacobs et al., 2013
mature peptidase	2.20 Å	3VB3	3VB3	3VB3	3VB3	3VB3	3VB3	Chuck et al., 2013
mature peptidase	2.20 Å	3VB4	3VB4	3VB4	3VB4	3VB4	3VB4	Chuck et al., 2013
mature peptidase	1.95 Å	3VB5	3VB5	3VB5	3VB5	3VB5	3VB5	Chuck et al., 2013
mature peptidase	2.50 Å	3VB6	3VB6	3VB6	3VB6	3VB6	3VB6	Chuck et al., 2013
mature peptidase	1.95 Å	3VB7	3VB7	3VB7	3VB7	3VB7	3VB7	Chuck et al., 2013
mature peptidase	2.09 Å	4HI3	4HI3	4HI3	4HI3	4HI3	4HI3	Wu et al., 2013
mature peptidase	1.40 Å	4M0W	4M0W	4M0W	4M0W	4M0W	4M0W	Chou et al., 2014
mature peptidase	1.60 Å	4MDS	4MDS	4MDS	4MDS	4MDS	4MDS	Turlington et al., 2013
mature peptidase	2.75 Å	4MM3	4MM3	4MM3	4MM3	4MM3	4MM3	Ratia et al., 2014
mature peptidase	2.50 Å	4OVZ	4OVZ	4OVZ	4OVZ	4OVZ	4OVZ	Baez-Santos et al., 2014
mature peptidase	2.10 Å	4OW0	4OW0	4OW0	4OW0	4OW0	4OW0	Baez-Santos et al., 2014
complex with glycerol	1.65 Å	5Y3E	5Y3E	5Y3E	5Y3E	5Y3E	5Y3E
crystal structure of sars coronavirus papain-like protease conjugated with beta-mercaptoethanol	1.65 Å	5Y3Q	5Y3Q	5Y3Q	5Y3Q	5Y3Q	5Y3Q