Substrates for peptidase C16.009: severe acute respiratory syndrome coronavirus papain-like peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
SARS coronavirus papain-like peptidase P59641 1-7073 peptide-Gly180+Ala-peptide P Leu Asn Gly Gly Ala Val Thr Arg Ziebuhr et al., 2007
SARS coronavirus papain-like peptidase P59641 1-7073 peptide-Gly818+Ala-peptide P Leu Lys Gly Gly Ala Pro Ile Lys Ziebuhr et al., 2007
SARS coronavirus papain-like peptidase P59641 1-7073 peptide-Gly2740+Lys-peptide P Leu Lys Gly Gly Lys Ile Val Ser Ziebuhr et al., 2007