Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C16.009: severe acute respiratory syndrome coronavirus papain-like peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Sharma,A., Kaliya,K. and Maurya,S.K.
    Recent Advances in Discovery of Potent Proteases Inhibitors Targeting the SARS Coronaviruses
    Curr Top Med Chem21, 307-328. PubMed  Europe PubMed DOI  V
  2. Welker,A., Kersten,C., Muller,C., Madhugiri,R., Zimmer,C., Muller,P., Zimmermann,R., Hammerschmidt,S., Maus,H., Ziebuhr,J., Sotriffer,C. and Schirmeister,T.
    Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2
    ChemMedChem16, 340-354. PubMed  Europe PubMed DOI  I
  3. Yan,S. and Wu,G.
    Spatial and temporal roles of SARS-CoV PL(pro) -A snapshot
    FASEB J35, e21197-e21197. PubMed  Europe PubMed DOI
    4. 2020
  4. Henderson,J.A., Verma,N. and Shen,J.
    Assessment of Proton-Coupled Conformational Dynamics of SARS and MERS Coronavirus Papain-like Proteases: Implication for Designing Broad-Spectrum Antiviral Inhibitors
    bioRxiv PubMed  Europe PubMed DOI  T
    5. 2018
  5. Niemeyer,D., Mosbauer,K., Klein,E.M., Sieberg,A., Mettelman,R.C., Mielech,A.M., Dijkman,R., Baker,S.C., Drosten,C. and Muller,M.A.
    The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species
    PLoS Pathog14, e1007296-e1007296. PubMed  Europe PubMed DOI
    6. 2017
  6. Lin,M.H., Moses,D.C., Hsieh,C.H., Cheng,S.C., Chen,Y.H., Sun,C.Y. and Chou,C.Y.
    Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
    Antiviral Res150, 155-163. PubMed  Europe PubMed DOI  I
  7. Park,J.Y., Yuk,H.J., Ryu,H.W., Lim,S.H., Kim,K.S., Park,K.H., Ryu,Y.B. and Lee,W.S.
    Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors
    J Enzyme Inhib Med Chem32, 504-515. PubMed  Europe PubMed DOI  I
    8. 2016
  8. Bekes,M., van der Heden van Noort,G.J., Ekkebus,R., Ovaa,H., Huang,T.T. and Lima,C.D.
    Recognition of Lys48-linked di-ubiquitin and deubiquitinating activities of the SARS coronavirus papain-like protease
    Mol Cell62, 572-585. PubMed  Europe PubMed DOI
  9. Li,S.W., Wang,C.Y., Jou,Y.J., Huang,S.H., Hsiao,L.H., Wan,L., Lin,Y.J., Kung,S.H. and Lin,C.W.
    SARS coronavirus papain-like protease inhibits the TLR7 signaling pathway through removing Lys63-linked polyubiquitination of TRAF3 and TRAF6
    Int J Mol Sci17, PubMed  Europe PubMed DOI
    10. 2015
  10. Baez-Santos,Y.M., St John,S.E. and Mesecar,A.D.
    The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds
    Antiviral Res115, 21-38. PubMed  Europe PubMed DOI  V  I
  11. Bekes,M., Rut,W., Kasperkiewicz,P., Mulder,M.P., Ovaa,H., Drag,M., Lima,C.D. and Huang,T.T.
    SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme
    Biochem J468, 215-226. PubMed  Europe PubMed DOI
  12. Lee,H., Lei,H., Santarsiero,B.D., Gatuz,J.L., Cao,S., Rice,A.J., Patel,K., Szypulinski,M.Z., Ojeda,I., Ghosh,A.K. and Johnson,M.E.
    Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV
    ACS Chem Biol10, 1456-1465. PubMed  Europe PubMed DOI  P  I
  13. Mielech,A.M., Deng,X., Chen,Y., Kindler,E., Wheeler,D.L., Mesecar,A.D., Thiel,V., Perlman,S. and Baker,S.C.
    Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis
    J Virol89, 4907-4917. PubMed  Europe PubMed DOI
    14. 2014
  14. Baez-Santos,Y.M., Barraza,S.J., Wilson,M.W., Agius,M.P., Mielech,A.M., Davis,N.M., Baker,S.C., Larsen,S.D. and Mesecar,A.D.
    X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases
    J Med Chem57, 2393-2412. PubMed  Europe PubMed DOI  S  I
  15. Chen,X., Yang,X., Zheng,Y., Yang,Y., Xing,Y. and Chen,Z.
    SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex
    Protein Cell5, 369-381. PubMed  Europe PubMed DOI
  16. Chou,C.Y., Lai,H.Y., Chen,H.Y., Cheng,S.C., Cheng,K.W. and Chou,Y.W.
    Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease
    Acta Crystallogr D Biol Crystallogr70, 572-581. PubMed  Europe PubMed DOI  S
  17. Deng,X., Agnihothram,S., Mielech,A.M., Nichols,D.B., Wilson,M.W., StJohn,S.E., Larsen,S.D., Mesecar,A.D., Lenschow,D.J., Baric,R.S. and Baker,S.C.
    A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses
    J Virol88, 11825-11833. PubMed  Europe PubMed DOI  I
  18. Gomez-Jeria,J.S.
    A DFT study of the inhibition of the papain-like protease (PLpro) from the SARS coronavirus by a group of 4-piperidinecarboxamide derivatives
    Res J Pharm , Biol Chem Sci5, 424-436.  I
  19. Hilgenfeld,R.
    From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
    FEBS J281, 4085-4096. PubMed  Europe PubMed DOI  V  S
  20. Kim,D.W., Seo,K.H., Curtis-Long,M.J., Oh,K.Y., Oh,J.W., Cho,J.K., Lee,K.H. and Park,K.H.
    Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia
    J Enzyme Inhib Med Chem29, 59-63. PubMed  Europe PubMed DOI  I
  21. Matthews,K., Schafer,A., Pham,A. and Frieman,M.
    The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity
    Virol J11, 209-209. PubMed  Europe PubMed DOI
  22. Ratia,K., Kilianski,A., Baez-Santos,Y.M., Baker,S.C. and Mesecar,A.
    Structural basis for the ubiquitin-linkage specificity and deISGylating activity of SARS-CoV papain-like protease
    PLoS Pathog10, e1004113-e1004113. PubMed  Europe PubMed DOI
    23. 2012
  23. Chou,Y.W., Cheng,S.C., Lai,H.Y. and Chou,C.Y.
    Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease
    Arch Biochem Biophys520, 74-80. PubMed  Europe PubMed DOI
  24. Li,S.W., Yang,T.C., Wan,L., Lin,Y.J., Tsai,F.J., Lai,C.C. and Lin,C.W.
    Correlation between TGF-beta1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease
    Proteomics12, 3193-3205. PubMed  Europe PubMed DOI
  25. Park,J.Y., Kim,J.H., Kim,Y.M., Jeong,H.J., Kim,D.W., Park,K.H., Kwon,H.J., Park,S.J., Lee,W.S. and Ryu,Y.B.
    Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases
    Bioorg Med Chem20, 5928-5935. PubMed  Europe PubMed DOI  I
  26. Park,J.Y., Jeong,H.J., Kim,J.H., Kim,Y.M., Park,S.J., Kim,D., Park,K.H., Lee,W.S. and Ryu,Y.B.
    Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus
    Biol Pharm Bull35, 2036-2042. PubMed  Europe PubMed DOI  I
  27. Ratia,K., Mesecar,A., O'Brien,A. and Baker,S.C.
    Coronavirus papain-like peptidases
    [ISSN:978-0-12-407743-0]3, 2195-2199. DOI
  28. Sun,L., Xing,Y., Chen,X., Zheng,Y., Yang,Y., Nichols,D.B., Clementz,M.A., Banach,B.S., Li,K., Baker,S.C. and Chen,Z.
    Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling
    PLoS ONE7, e30802-e30802. PubMed  Europe PubMed DOI
    29. 2011
  29. Chaudhuri,R., Tang,S., Zhao,G., Lu,H., Case,D.A. and Johnson,M.E.
    Comparison of SARS and NL63 papain-like protease binding sites and binding site dynamics: inhibitor design implications
    J Mol Biol414, 272-288. PubMed  Europe PubMed DOI  S  I
  30. Frieman,M., Basu,D., Matthews,K., Taylor,J., Jones,G., Pickles,R., Baric,R. and Engel,D.A.
    Yeast based small molecule screen for inhibitors of SARS-CoV
    PLoS ONE6, e28479-e28479. PubMed  Europe PubMed DOI  I
    31. 2010
  31. Clementz,M.A., Chen,Z., Banach,B.S., Wang,Y., Sun,L., Ratia,K., Baez-Santos,Y.M., Wang,J., Takayama,J., Ghosh,A.K., Li,K., Mesecar,A.D. and Baker,S.C.
    Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases
    J Virol84, 4619-4629. PubMed  Europe PubMed DOI
  32. Ghosh,A.K., Takayama,J., Rao,K.V., Ratia,K., Chaudhuri,R., Mulhearn,D.C., Lee,H., Nichols,D.B., Baliji,S., Baker,S.C., Johnson,M.E. and Mesecar,A.D.
    Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation
    J Med Chem53, 4968-4979. PubMed  Europe PubMed DOI  S  I
    33. 2009
  33. Chen,X., Chou,C.Y. and Chang,G.G.
    Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme
    Antivir Chem Chemother19, 151-156. PubMed  Europe PubMed  I
  34. Frieman,M., Ratia,K., Johnston,R.E., Mesecar,A.D. and Baric,R.S.
    Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling
    J Virol83, 6689-6705. PubMed  Europe PubMed DOI
  35. Ghosh,A.K., Takayama,J., Aubin,Y., Ratia,K., Chaudhuri,R., Baez,Y., Sleeman,K., Coughlin,M., Nichols,D.B., Mulhearn,D.C., Prabhakar,B.S., Baker,S.C., Johnson,M.E. and Mesecar,A.D.
    Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease
    J Med Chem52, 5228-5240. PubMed  Europe PubMed DOI  I
    36. 2008
  36. Chou,C.Y., Chien,C.H., Han,Y.S., Prebanda,M.T., Hsieh,H.P., Turk,B., Chang,G.G. and Chen,X.
    Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus
    Biochem Pharmacol75, 1601-1609. PubMed  Europe PubMed DOI  I
  37. Nicholson,B., Leach,C.A., Goldenberg,S.J., Francis,D.M., Kodrasov,M.P., Tian,X., Shanks,J., Sterner,D.E., Bernal,A., Mattern,M.R., Wilkinson,K.D. and Butt,T.R.
    Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities
    Protein Sci17, 1035-1043. PubMed  Europe PubMed DOI  A  I
  38. Ratia,K., Pegan,S., Takayama,J., Sleeman,K., Coughlin,M., Baliji,S., Chaudhuri,R., Fu,W., Prabhakar,B.S., Johnson,M.E., Baker,S.C., Ghosh,A.K. and Mesecar,A.D.
    A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
    Proc Natl Acad Sci U S A105, 16119-16124. PubMed  Europe PubMed DOI  S  I
    39. 2007
  39. Devaraj,S.G., Wang,N., Chen,Z., Chen,Z., Tseng,M., Barretto,N., Lin,R., Peters,C.J., Tseng,C.T., Baker,S.C. and Li,K.
    Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus
    J Biol Chem282, 32208-32221. PubMed  Europe PubMed DOI
  40. Lindner,H.A., Lytvyn,V., Qi,H., Lachance,P., Ziomek,E. and Menard,R.
    Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease
    Arch Biochem Biophys466, 8-14. PubMed  Europe PubMed DOI
    41. 2006
  41. Barretto,N., Jukneliene,D., Ratia,K., Chen,Z., Mesecar,A.D. and Baker,S.C.
    Deubiquitinating activity of the SARS-CoV papain-like protease
    Adv Exp Med Biol581, 37-41. PubMed  Europe PubMed DOI
  42. [YEAR:11-4-2006]Ratia,K., Saikatendu,K.S., Santarsiero,B.D., Barretto,N., Baker,S.C., Stevens,R.C. and Mesecar,A.D.
    Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme
    Proc Natl Acad Sci U S A103, 5717-5722. PubMed  Europe PubMed DOI  S  I
    43. 2005
  43. Barretto,N., Jukneliene,D., Ratia,K., Chen,Z., Mesecar,A.D. and Baker,S.C.
    The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity
    J Virol79, 15189-15198. PubMed  Europe PubMed DOI
  44. [YEAR:2-8-2005]Han,Y.S., Chang,G.G., Juo,C.G., Lee,H.J., Yeh,S.H., Hsu,J.T. and Chen,X.
    Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition
    Biochemistry44, 10349-10359. PubMed  Europe PubMed DOI
  45. Lindner,H.A., Fotouhi-Ardakani,N., Lytvyn,V., Lachance,P., Sulea,T. and Menard,R.
    The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme
    J Virol79, 15199-15208. PubMed  Europe PubMed DOI  I
  46. Sulea,T., Lindner,H.A., Purisima,E.O. and Menard,R.
    Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease?
    J Virol79, 4550-4551. PubMed  Europe PubMed DOI
    47. 2004
  47. Harcourt,B.H., Jukneliene,D., Kanjanahaluethai,A., Bechill,J., Severson,K.M., Smith,C.M., Rota,P.A. and Baker,S.C.
    Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity
    J Virol78, 13600-13612. PubMed  Europe PubMed DOI
  48. Kanjanahaluethai,A. and Baker,S.C.
    Coronavirus papain-like endopeptidases
    [ISSN:0-12-079610-4]2, 1265-1269.  V
    49. 2003
  49. [YEAR:23-10-2003]Gao,F., Ou,H.Y., Chen,L.L., Zheng,W.X. and Zhang,C.T.
    Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS-CoV genomes
    FEBS Lett553, 451-456. PubMed  Europe PubMed DOI
  50. Thiel,V., Ivanov,K.A., Putics,A., Hertzig,T., Schelle,B., Bayer,S., Weissbrich,B., Snijder,E.J., Rabenau,H., Doerr,H.W., Gorbalenya,A.E. and Ziebuhr,J.
    Mechanisms and enzymes involved in SARS coronavirus genome expression
    J Gen Virol84, 2305-2315. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use