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Literature for peptidase C16.009: severe acute respiratory syndrome coronavirus papain-like peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Sharma,A., Kaliya,K. and Maurya,S.K.<br>Recent Advances in Discovery of Potent Proteases Inhibitors Targeting the SARS Coronaviruses<br>Curr Top Med Chem (2021) 21, 307-328. PubMed  Europe PubMed DOI  V
  2. Welker,A., Kersten,C., Muller,C., Madhugiri,R., Zimmer,C., Muller,P., Zimmermann,R., Hammerschmidt,S., Maus,H., Ziebuhr,J., Sotriffer,C. and Schirmeister,T.<br>Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2<br>ChemMedChem (2021) 16, 340-354. PubMed  Europe PubMed DOI  I
  3. Yan,S. and Wu,G.<br>Spatial and temporal roles of SARS-CoV PL(pro) -A snapshot<br>FASEB J (2021) 35, e21197-e21197. PubMed  Europe PubMed DOI
    4. 2020
  4. Henderson,J.A., Verma,N. and Shen,J.<br>Assessment of Proton-Coupled Conformational Dynamics of SARS and MERS Coronavirus Papain-like Proteases: Implication for Designing Broad-Spectrum Antiviral Inhibitors<br>bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  T
    5. 2018
  5. Niemeyer,D., Mosbauer,K., Klein,E.M., Sieberg,A., Mettelman,R.C., Mielech,A.M., Dijkman,R., Baker,S.C., Drosten,C. and Muller,M.A.<br>The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species<br>PLoS Pathog (2018) 14, e1007296-e1007296. PubMed  Europe PubMed DOI
    6. 2017
  6. Lin,M.H., Moses,D.C., Hsieh,C.H., Cheng,S.C., Chen,Y.H., Sun,C.Y. and Chou,C.Y.<br>Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes<br>Antiviral Res (2017) 150, 155-163. PubMed  Europe PubMed DOI  I
  7. Park,J.Y., Yuk,H.J., Ryu,H.W., Lim,S.H., Kim,K.S., Park,K.H., Ryu,Y.B. and Lee,W.S.<br>Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors<br>J Enzyme Inhib Med Chem (2017) 32, 504-515. PubMed  Europe PubMed DOI  I
    8. 2016
  8. Bekes,M., van der Heden van Noort,G.J., Ekkebus,R., Ovaa,H., Huang,T.T. and Lima,C.D.<br>Recognition of Lys48-linked di-ubiquitin and deubiquitinating activities of the SARS coronavirus papain-like protease<br>Mol Cell (2016) 62, 572-585. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Li,S.W., Wang,C.Y., Jou,Y.J., Huang,S.H., Hsiao,L.H., Wan,L., Lin,Y.J., Kung,S.H. and Lin,C.W.<br>SARS coronavirus papain-like protease inhibits the TLR7 signaling pathway through removing Lys63-linked polyubiquitination of TRAF3 and TRAF6<br>Int J Mol Sci (2016) 17 PubMed  Europe PubMed DOI
    10. 2015
  10. Baez-Santos,Y.M., St John,S.E. and Mesecar,A.D.<br>The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds<br>Antiviral Res (2015) 115, 21-38. PubMed  Europe PubMed DOI  V  I
  11. Bekes,M., Rut,W., Kasperkiewicz,P., Mulder,M.P., Ovaa,H., Drag,M., Lima,C.D. and Huang,T.T.<br>SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme<br>Biochem J (2015) 468, 215-226. PubMed  Europe PubMed DOI
  12. Lee,H., Lei,H., Santarsiero,B.D., Gatuz,J.L., Cao,S., Rice,A.J., Patel,K., Szypulinski,M.Z., Ojeda,I., Ghosh,A.K. and Johnson,M.E.<br>Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV<br>ACS Chem Biol (2015) 10, 1456-1465. PubMed  Europe PubMed DOI  P  I
  13. Mielech,A.M., Deng,X., Chen,Y., Kindler,E., Wheeler,D.L., Mesecar,A.D., Thiel,V., Perlman,S. and Baker,S.C.<br>Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis<br>J Virol (2015) 89, 4907-4917. PubMed  Europe PubMed DOI
    14. 2014
  14. Baez-Santos,Y.M., Barraza,S.J., Wilson,M.W., Agius,M.P., Mielech,A.M., Davis,N.M., Baker,S.C., Larsen,S.D. and Mesecar,A.D.<br>X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases<br>J Med Chem (2014) 57, 2393-2412. PubMed  Europe PubMed DOI  S  I
  15. Chen,X., Yang,X., Zheng,Y., Yang,Y., Xing,Y. and Chen,Z.<br>SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex<br>Protein Cell (2014) 5, 369-381. PubMed  Europe PubMed DOI
  16. Chou,C.Y., Lai,H.Y., Chen,H.Y., Cheng,S.C., Cheng,K.W. and Chou,Y.W.<br>Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease<br>Acta Crystallogr D Biol Crystallogr (2014) 70, 572-581. PubMed  Europe PubMed DOI  S
  17. Deng,X., Agnihothram,S., Mielech,A.M., Nichols,D.B., Wilson,M.W., StJohn,S.E., Larsen,S.D., Mesecar,A.D., Lenschow,D.J., Baric,R.S. and Baker,S.C.<br>A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses<br>J Virol (2014) 88, 11825-11833. PubMed  Europe PubMed DOI  I
  18. Gomez-Jeria,J.S.<br>A DFT study of the inhibition of the papain-like protease (PLpro) from the SARS coronavirus by a group of 4-piperidinecarboxamide derivatives<br>Res J Pharm , Biol Chem Sci (2014) 5, 424-436.  I
  19. Hilgenfeld,R.<br>From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design<br>FEBS J (2014) 281, 4085-4096. PubMed  Europe PubMed DOI  V  S
  20. Kim,D.W., Seo,K.H., Curtis-Long,M.J., Oh,K.Y., Oh,J.W., Cho,J.K., Lee,K.H. and Park,K.H.<br>Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia<br>J Enzyme Inhib Med Chem (2014) 29, 59-63. PubMed  Europe PubMed DOI  I
  21. Matthews,K., Schafer,A., Pham,A. and Frieman,M.<br>The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity<br>Virol J (2014) 11, 209-209. PubMed  Europe PubMed DOI
  22. Ratia,K., Kilianski,A., Baez-Santos,Y.M., Baker,S.C. and Mesecar,A.<br>Structural basis for the ubiquitin-linkage specificity and deISGylating activity of SARS-CoV papain-like protease<br>PLoS Pathog (2014) 10, e1004113-e1004113. PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2012
  23. Chou,Y.W., Cheng,S.C., Lai,H.Y. and Chou,C.Y.<br>Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease<br>Arch Biochem Biophys (2012) 520, 74-80. PubMed  Europe PubMed DOI
  24. Li,S.W., Yang,T.C., Wan,L., Lin,Y.J., Tsai,F.J., Lai,C.C. and Lin,C.W.<br>Correlation between TGF-beta1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease<br>Proteomics (2012) 12, 3193-3205. PubMed  Europe PubMed DOI
  25. Park,J.Y., Jeong,H.J., Kim,J.H., Kim,Y.M., Park,S.J., Kim,D., Park,K.H., Lee,W.S. and Ryu,Y.B.<br>Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus<br>Biol Pharm Bull (2012) 35, 2036-2042. PubMed  Europe PubMed DOI  I
  26. Park,J.Y., Kim,J.H., Kim,Y.M., Jeong,H.J., Kim,D.W., Park,K.H., Kwon,H.J., Park,S.J., Lee,W.S. and Ryu,Y.B.<br>Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases<br>Bioorg Med Chem (2012) 20, 5928-5935. PubMed  Europe PubMed DOI  I
  27. Ratia,K., Mesecar,A., O'Brien,A. and Baker,S.C.<br>Coronavirus papain-like peptidases<br>[ISSN:978-0-12-407743-0] (2012) 3, 2195-2199. DOI
  28. Sun,L., Xing,Y., Chen,X., Zheng,Y., Yang,Y., Nichols,D.B., Clementz,M.A., Banach,B.S., Li,K., Baker,S.C. and Chen,Z.<br>Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling<br>PLoS ONE (2012) 7, e30802-e30802. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2011
  29. Chaudhuri,R., Tang,S., Zhao,G., Lu,H., Case,D.A. and Johnson,M.E.<br>Comparison of SARS and NL63 papain-like protease binding sites and binding site dynamics: inhibitor design implications<br>J Mol Biol (2011) 414, 272-288. PubMed  Europe PubMed DOI  S  I
  30. Frieman,M., Basu,D., Matthews,K., Taylor,J., Jones,G., Pickles,R., Baric,R. and Engel,D.A.<br>Yeast based small molecule screen for inhibitors of SARS-CoV<br>PLoS ONE (2011) 6, e28479-e28479. PubMed  Europe PubMed DOI  PMC  EPMC  I
    31. 2010
  31. Clementz,M.A., Chen,Z., Banach,B.S., Wang,Y., Sun,L., Ratia,K., Baez-Santos,Y.M., Wang,J., Takayama,J., Ghosh,A.K., Li,K., Mesecar,A.D. and Baker,S.C.<br>Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases<br>J Virol (2010) 84, 4619-4629. PubMed  Europe PubMed DOI
  32. Ghosh,A.K., Takayama,J., Rao,K.V., Ratia,K., Chaudhuri,R., Mulhearn,D.C., Lee,H., Nichols,D.B., Baliji,S., Baker,S.C., Johnson,M.E. and Mesecar,A.D.<br>Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation<br>J Med Chem (2010) 53, 4968-4979. PubMed  Europe PubMed DOI  S  I
    33. 2009
  33. Chen,X., Chou,C.Y. and Chang,G.G.<br>Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme<br>Antivir Chem Chemother (2009) 19, 151-156. PubMed  Europe PubMed  I
  34. Frieman,M., Ratia,K., Johnston,R.E., Mesecar,A.D. and Baric,R.S.<br>Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling<br>J Virol (2009) 83, 6689-6705. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Ghosh,A.K., Takayama,J., Aubin,Y., Ratia,K., Chaudhuri,R., Baez,Y., Sleeman,K., Coughlin,M., Nichols,D.B., Mulhearn,D.C., Prabhakar,B.S., Baker,S.C., Johnson,M.E. and Mesecar,A.D.<br>Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease<br>J Med Chem (2009) 52, 5228-5240. PubMed  Europe PubMed DOI  I
    36. 2008
  36. Chou,C.Y., Chien,C.H., Han,Y.S., Prebanda,M.T., Hsieh,H.P., Turk,B., Chang,G.G. and Chen,X.<br>Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus<br>Biochem Pharmacol (2008) 75, 1601-1609. PubMed  Europe PubMed DOI  I
  37. Nicholson,B., Leach,C.A., Goldenberg,S.J., Francis,D.M., Kodrasov,M.P., Tian,X., Shanks,J., Sterner,D.E., Bernal,A., Mattern,M.R., Wilkinson,K.D. and Butt,T.R.<br>Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities<br>Protein Sci (2008) 17, 1035-1043. PubMed  Europe PubMed DOI  PMC  EPMC  A  I
  38. Ratia,K., Pegan,S., Takayama,J., Sleeman,K., Coughlin,M., Baliji,S., Chaudhuri,R., Fu,W., Prabhakar,B.S., Johnson,M.E., Baker,S.C., Ghosh,A.K. and Mesecar,A.D.<br>A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication<br>Proc Natl Acad Sci U S A (2008) 105, 16119-16124. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    39. 2007
  39. Devaraj,S.G., Wang,N., Chen,Z., Chen,Z., Tseng,M., Barretto,N., Lin,R., Peters,C.J., Tseng,C.T., Baker,S.C. and Li,K.<br>Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus<br>J Biol Chem (2007) 282, 32208-32221. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Lindner,H.A., Lytvyn,V., Qi,H., Lachance,P., Ziomek,E. and Menard,R.<br>Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease<br>Arch Biochem Biophys (2007) 466, 8-14. PubMed  Europe PubMed DOI
    41. 2006
  41. Barretto,N., Jukneliene,D., Ratia,K., Chen,Z., Mesecar,A.D. and Baker,S.C.<br>Deubiquitinating activity of the SARS-CoV papain-like protease<br>Adv Exp Med Biol (2006) 581, 37-41. PubMed  Europe PubMed DOI
  42. [YEAR:11-4-2006]Ratia,K., Saikatendu,K.S., Santarsiero,B.D., Barretto,N., Baker,S.C., Stevens,R.C. and Mesecar,A.D.<br>Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme<br>Proc Natl Acad Sci U S A (11-4-2006) 103, 5717-5722. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    43. 2005
  43. Barretto,N., Jukneliene,D., Ratia,K., Chen,Z., Mesecar,A.D. and Baker,S.C.<br>The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity<br>J Virol (2005) 79, 15189-15198. PubMed  Europe PubMed DOI  PMC  EPMC
  44. [YEAR:2-8-2005]Han,Y.S., Chang,G.G., Juo,C.G., Lee,H.J., Yeh,S.H., Hsu,J.T. and Chen,X.<br>Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition<br>Biochemistry (2-8-2005) 44, 10349-10359. PubMed  Europe PubMed DOI
  45. Lindner,H.A., Fotouhi-Ardakani,N., Lytvyn,V., Lachance,P., Sulea,T. and Menard,R.<br>The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme<br>J Virol (2005) 79, 15199-15208. PubMed  Europe PubMed DOI  PMC  EPMC  I
  46. Sulea,T., Lindner,H.A., Purisima,E.O. and Menard,R.<br>Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease?<br>J Virol (2005) 79, 4550-4551. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2004
  47. Harcourt,B.H., Jukneliene,D., Kanjanahaluethai,A., Bechill,J., Severson,K.M., Smith,C.M., Rota,P.A. and Baker,S.C.<br>Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity<br>J Virol (2004) 78, 13600-13612. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Kanjanahaluethai,A. and Baker,S.C.<br>Coronavirus papain-like endopeptidases<br>[ISSN:0-12-079610-4] (2004) 2, 1265-1269.  V
    49. 2003
  49. [YEAR:23-10-2003]Gao,F., Ou,H.Y., Chen,L.L., Zheng,W.X. and Zhang,C.T.<br>Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS-CoV genomes<br>FEBS Lett (23-10-2003) 553, 451-456. PubMed  Europe PubMed DOI
  50. Thiel,V., Ivanov,K.A., Putics,A., Hertzig,T., Schelle,B., Bayer,S., Weissbrich,B., Snijder,E.J., Rabenau,H., Doerr,H.W., Gorbalenya,A.E. and Ziebuhr,J.<br>Mechanisms and enzymes involved in SARS coronavirus genome expression<br>J Gen Virol (2003) 84, 2305-2315. PubMed  Europe PubMed DOI

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