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Literature for peptidase M13.001: neprilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Iwamoto,S., Hatta,D., Fujii,M., Yamamoto,D., Ohta,R., Okita,K., Shirotani,K. and Iwata,N.
    Cell type- and neuronal differentiation-dependent MME 5'UTR splice variants with distinct translational outputs in human cells
    J Biochem (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Cozier,G.E., Coulson,L.B., Eyermann,C.J., Basarab,G.S., Schwager,S.L., Chibale,K., Sturrock,E.D. and Acharya,K.R.
    Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors
    J Med Chem (2025) 68, 7720-7736. PubMed  Europe PubMed DOI
    3. 2024
  3. Esser,N., Mongovin,S.M., Barrow,B.M. and Zraika,S.
    Gut-specific Neprilysin Deletion Protects Against Fat-induced Insulin Secretory Dysfunction in Male Mice
    Endocrinology (2024) 165 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Hakata,T., Ueda,Y., Yamashita,T., Yamauchi,I., Kosugi,D., Sugawa,T., Fujita,H., Okamoto,K., Fujii,T., Taura,D., Yasoda,A., Akiyama,H. and Inagaki,N.
    Neprilysin inhibition promotes skeletal growth via the CNP/NPR-B pathway
    Endocrinology (2024) 165, bqae058-bqae058. PubMed  Europe PubMed DOI
  5. Mizutani,S., Mizutani,H., Mizutani,E., Arita,H. and Kajiyama,H.
    The Fate of Angiotensin II in Placental Tissue and Blood
    Horm Metab Res (2024) 56, 477-481. PubMed  Europe PubMed DOI
  6. Shigematsu,K., Komori,N., Ideno,M. and Yamagishi,H.
    "Evaluation of neprilysin activity in Adipose-Derived stem cells from Alzheimer's disease patients"
    Neurosci Lett (2024) 825, 137705-137705. PubMed  Europe PubMed DOI
  7. Thakur,S., Sinhari,A., Gaikwad,A.B. and Jadhav,H.R.
    A structure-based pharmacophore modelling approach to identify and design new neprilysin (NEP) inhibitors: An in silico-based investigation
    Arch Biochem Biophys (2024) 756, 110019-110019. PubMed  Europe PubMed DOI
  8. Zhang,X., Hu,C., Tian,E., Shen,Y., Liu,W. and Li,J.
    Comprehensive review on neprilysin (NEP) inhibitors: design, structure-activity relationships, and clinical applications
    Front Pharmacol (2024) 15, 1501407-1501407. PubMed  Europe PubMed DOI  PMC  EPMC  I
  9. Zukowska,J., Moss,S.J., Subramanian,V. and Acharya,K.R.
    Molecular basis of selective amyloid-beta degrading enzymes in Alzheimer's disease
    FEBS J (2024) 291, 2999-3029. PubMed  Europe PubMed DOI  V
    10. 2023
  10. Ding,J., Li,C., Shu,K., Chen,W., Cai,C., Zhang,X. and Zhang,W.
    Membrane metalloendopeptidase (MME) is positively correlated with systemic lupus erythematosus and may inhibit the occurrence of breast cancer
    PLoS ONE (2023) 18, e0289960-e0289960. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Esser,N., Mundinger,T.O., Barrow,B.M. and Zraika,S.
    Acute Inhibition of Intestinal Neprilysin Enhances Insulin Secretion via GLP-1 Receptor Signaling in Male Mice
    Endocrinology (2023) 164 PubMed  Europe PubMed DOI  PMC  EPMC  I
  12. Rowland,H.A., Moxon,S.R., Corbett,N.J., Hanson,K., Fisher,K., Kellett,K.A.B. and Hooper,N.M.
    Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-beta deposition
    Neuronal Signal (2023) 7, NS20230016-NS20230016. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2022
  13. Kawabata,H., Suzuki,H., Ohishi,T., Kawada,M., Kaneko,M.K. and Kato,Y.
    A Defucosylated Mouse Anti-CD10 Monoclonal Antibody (31-mG2a-f) Exerts Antitumor Activity in a Mouse Xenograft Model of CD10-Overexpressed Tumors
    Monoclon Antib Immunodiagn Immunother (2022) 41, 59-66. PubMed  Europe PubMed DOI
  14. Kawabata,H., Suzuki,H., Takei,J., Kaneko,M.K. and Kato,Y.
    Epitope Mapping of an Anti-CD10 Monoclonal Antibody (MME/1870) Using Enzyme-Linked Immunosorbent Assay
    Monoclon Antib Immunodiagn Immunother (2022) 41, 15-19. PubMed  Europe PubMed DOI
  15. Nakagawa,H. and Saito,Y.
    Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases
    Biology (Basel) (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  16. Schiemann,R., Buhr,A., Cordes,E., Walter,S., Heinisch,J.J., Ferrero,P., Milting,H., Paululat,A. and Meyer,H.
    Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides
    Nat Commun (2022) 13, 4420-4420. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2021
  17. Alves-Lopes,R., Montezano,A.C., Neves,K.B., Harvey,A., Rios,F.J., Skiba,D.S., Arendse,L.B., Guzik,T.J., Graham,D., Poglitsch,M., Sturrock,E. and Touyz,R.M.
    Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension
    Hypertension (2021) 78, 604-616. PubMed  Europe PubMed DOI
  18. Arfsten,H., Goliasch,G., Bartko,P.E., Prausmuller,S., Spinka,G., Cho,A., Novak,J., Haslacher,H., Strunk,G., Struck,J., Hulsmann,M. and Pavo,N.
    Increased concentrations of bioactive adrenomedullin subsequently to angiotensin-receptor/neprilysin-inhibitor treatment in chronic systolic heart failure
    Br J Clin Pharmacol (2021) 87, 916-924. PubMed  Europe PubMed DOI  I
  19. Gjorgova-Gjeorgjievski,S., Fritchie,K. and Folpe,A.L.
    CD10 (Neprilysin) Expression: A Potential Adjunct in the Distinction of Hibernoma from Morphologic Mimics
    Hum Pathol (2021) PubMed  Europe PubMed DOI
  20. Nemcekova,V., Malikova,E., Goncalvesova,E., Krenek,P. and Klimas,J.
    Altered serum levels of neprilysin in heart failure patients with reduced ejection fraction
    Bratisl Lek Listy (2021) 122, 28-33. PubMed  Europe PubMed DOI
  21. Polina,I., Spicer,M.J., Domondon,M., Schibalski,R.S., Sarsenova,E., Sultanova,R.F. and Ilatovskaya,D.V.
    Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats
    Ren Fail (2021) 43, 315-324. PubMed  Europe PubMed DOI  I
  22. Poorgolizadeh,E., Homayouni Moghadam,F., Dormiani,K., Rezaei,N. and Nasr-Esfahani,M.H.
    Do neprilysin inhibitors walk the line? Heart ameliorative but brain threatening!
    Eur J Pharmacol (2021) 894, 173851-173851. PubMed  Europe PubMed DOI  I
  23. Rofo,F., Ugur Yilmaz,C., Metzendorf,N., Gustavsson,T., Beretta,C., Erlandsson,A., Sehlin,D., Syvanen,S., Nilsson,P. and Hultqvist,G.
    Enhanced neprilysin-mediated degradation of hippocampal Abeta42 with a somatostatin peptide that enters the brain
    Theranostics (2021) 11, 789-804. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Sankhe,R., Rathi,E., Manandhar,S., Kumar,A., Pai,S.R.K., Kini,S.G. and Kishore,A.
    Repurposing of existing FDA approved drugs for Neprilysin inhibition: An in-silico study
    J Mol Struct (2021) 1224, 129073-129073. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2020
  25. Abdulsalam,T.M., Hasanin,A.H., Mohamed,R.H. and El Sayed Badawy,A.
    Angiotensin receptor-neprilysin inhibitior (thiorphan/irbesartan) decreased ischemia-reperfusion induced ventricular arrhythmias in rat; in vivo study
    Eur J Pharmacol (2020) 882, 173295-173295. PubMed  Europe PubMed DOI  I
  26. Balazki,P., Schaller,S., Eissing,T. and Lehr,T.
    A Physiologically-Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP-1 and GIP and the DPP4 Inhibitor Sitagliptin
    CPT Pharmacometrics Syst Pharmacol (2020) 9, 353-362. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. Bellis,A., Mauro,C., Barbato,E., Trimarco,B. and Morisco,C.
    The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V  I
  28. Bendre,S., Zhang,Z., Kuo,H.T., Rousseau,J., Zhang,C., Merkens,H., Roxin,A., Benard,F. and Lin,K.S.
    Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of (68)Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics
    Molecules (2020) 25 PubMed  Europe PubMed DOI
  29. Bernardi,M.H., Wagner,L., Ryz,S., Puchinger,J., Nixdorf,L., Edlinger-Stanger,M., Geilen,J., Kainz,M., Hiesmayr,M.J. and Lassnigg,A.
    Urinary neprilysin for early detection of acute kidney injury after cardiac surgery: A prospective observational study
    Eur J Anaesthesiol (2020) PubMed  Europe PubMed DOI
  30. Campos,C.R., Kemble,A.M., Niewoehner,J., Freskgard,P.O. and Urich,E.
    Brain shuttle neprilysin reduces central amyloid-beta levels
    PLoS ONE (2020) 15, e0229850-e0229850. PubMed  Europe PubMed DOI  U
  31. Chatterjee,P., Gheblawi,M., Wang,K., Vu,J., Kondaiah,P. and Oudit,G.Y.
    Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications
    Clin Sci (Lond) (2020) 134, 2319-2336. PubMed  Europe PubMed DOI  V
  32. Chen,H.H. and Burnett,J.C., Jr.
    Neprilysin in HFrEF: Differential Regulation of Tissue Versus Circulating Neprilysin
    JACC Basic Transl Sci (2020) 5, 727-729. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Chen,S., Mima,D., Jin,H., Dan,Q., Wang,F., Cai,J., Shi,L., Wang,H., Du,A., Tang,Y. and Sun,Y.
    The Association between Neprilysin gene polymorphisms and Alzheimer's disease in Tibetan population
    Brain Behav (2020) , e02002-e02002. PubMed  Europe PubMed DOI
  34. Choi,I.J., Lim,S., Hwang,Y., Lee,D., Lee,W.J., Lee,K.Y., Kim,M.J. and Jeon,D.S.
    Soluble neprilysin and long-term clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: a retrospective cohort study
    BMC Cardiovasc Disord (2020) 20, 360-360. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Cuthbert,J.J., Pellicori,P. and Clark,A.L.
    Cardiovascular Outcomes with Sacubitril-Valsartan in Heart Failure: Emerging Clinical Data
    Ther Clin Risk Manag (2020) 16, 715-726. PubMed  Europe PubMed DOI  PMC  EPMC  V  I
  36. Dani,S.S., Ganatra,S. and Vaduganathan,M.
    Angioedema with sacubitril/valsartan: Trial-level meta-analysis of over 14,000 patients and real-world evidence to date
    Int J Cardiol (2020) PubMed  Europe PubMed DOI  I
  37. Docherty,K.F., Campbell,R.T., Brooksbank,K.J.M., Godeseth,R.L., Forsyth,P., McConnachie,A., Roditi,G., Stanley,B., Welsh,P., Jhund,P.S., Petrie,M.C. and McMurray,J.J.V.
    Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling
    ESC Heart Fail (2020) PubMed  Europe PubMed DOI  I
  38. Esch,T., Kream,R.M. and Stefano,G.B.
    Emerging regulatory roles of opioid peptides, endogenous morphine, and opioid receptor subtypes in immunomodulatory processes: Metabolic, behavioral, and evolutionary perspectives
    Immunol Lett (2020) 227, 28-33. PubMed  Europe PubMed DOI  V
  39. Galo,J., Celli,D. and Colombo,R.
    Effect of Sacubitril/Valsartan on Neurocognitive Function: Current Status and Future Directions
    Am J Cardiovasc Drugs (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  40. Gommans,D.H.F., Revuelta-Lopez,E., Lupon,J., Cserkoova,A., Domingo,M., Vart,P., van Royen,N., Bayes-Genis,A. and van Kimmenade,R.R.J.
    Soluble Neprilysin and Corin Concentrations in Relation to Clinical Outcome in Chronic Heart Failure
    JACC Heart Fail (2020) PubMed  Europe PubMed DOI
  41. Graykowski,D., Kasparian,K., Caniglia,J., Gritsaeva,Y. and Cudaback,E.
    Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin
    J Neuroimmunol (2020) 346, 577315-577315. PubMed  Europe PubMed DOI
  42. Gregoriou,G.C., Patel,S.D., Winters,B.L. and Bagley,E.E.
    Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala
    Mol Pharmacol (2020) PubMed  Europe PubMed DOI  I
  43. Gruson,D., Fillee,C. and Pouleur,A.C.
    Reply to "Effect of Neprilysin Inhibition on Various Natriuretic Peptide Assays"
    Clin Lab (2020) 66 PubMed  Europe PubMed DOI
  44. Izadpanah,M., Dargahi,L., Ai,J., Asgari Taei,A., Ebrahimi Barough,S., Mowla,S.J., TavoosiDana,G. and Farahmandfar,M.
    Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer's Disease
    Iran J Pharm Res (2020) 19, 45-60. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Kanuka,M., Ouchi,F., Kato,N., Katsuki,R., Ito,S., Miura,K., Hikida,M. and Tamura,T.
    Endoplasmic Reticulum Associated Degradation of Spinocerebellar Ataxia-Related CD10 Cysteine Mutant
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  46. Kato,J.
    Natriuretic peptides and neprilysin inhibition in hypertension and hypertensive organ damage
    Peptides (2020) 132, 170352-170352. PubMed  Europe PubMed DOI  V
  47. Kawanami,T., Karki,R.G., Cody,E., Liu,Q., Liang,G., Ksander,G.M., Rigel,D.F., Schiering,N., Gong,Y., Coppola,G.M., Iwaki,Y., Sun,R., Neubert,A., Fan,L., Ingles,S., D'arcy,A., Villard,F., Ramage,P., Jeng,A.Y., Leung-Chu,J., Liu,J., Beil,M., Fu,F., Chen,W., Cumin,F., Wiesmann,C. and Mogi,M.
    Structure-guided design of substituted biphenyl butanoic acid derivatives as neprilysin inhibitors
    ACS Med Chem Lett (2020) 11, 188-194. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  48. Kim,N. and Lee,H.J.
    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
    Biomed Res Int (2020) 2020, 2010728-2010728. PubMed  Europe PubMed DOI  PMC  EPMC  V
  49. Kuwajima,Y., Nagai,M.S., Lee,C., Galaburda,A.M., Kobayashi,T., Nakasato,A., Da Silva,J.D., Nagai,S.I. and Nagai,M.
    Trans-trigeminal transport of masseter-derived neprilysin to hippocampus
    Arch Oral Biol (2020) 118, 104861-104861. PubMed  Europe PubMed DOI
  50. Li,B., Li,N., Guo,S., Zhang,M., Li,J., Zhai,N., Wang,H. and Zhang,Y.
    The changing features of serum adropin, copeptin, neprilysin and chitotriosidase which are associated with vascular endothelial function in type 2 diabetic retinopathy patients
    J Diabetes Complications (2020) , 107686-107686. PubMed  Europe PubMed DOI
  51. Li,Y., Wang,Y., Wang,J., Chong,K.Y., Xu,J., Liu,Z. and Shan,C.
    Expression of neprilysin in skeletal muscle by ultrasound-mediated gene transfer (sonoporation) reduces amyloid burden for AD
    Mol Ther Methods Clin Dev (2020) 17, 300-308. PubMed  Europe PubMed DOI  PMC  EPMC  U
  52. Lyle,M.A., Iyer,S.R., Redfield,M.M., Reddy,Y.N.V., Felker,G.M., Cappola,T.P., Hernandez,A.F., Scott,C.G., Burnett JC Jr and Pereira,N.L.
    Circulating neprilysin in patients with heart failure and preserved ejection fraction
    JACC Heart Fail (2020) 8, 70-80. PubMed  Europe PubMed DOI
  53. Manolis,A.S., Manolis,T.A., Manolis,A.A. and Melita,H.
    The Controversy of Renin-Angiotensin-System Blocker Facilitation Versus Countering COVID-19 Infection
    J Cardiovasc Pharmacol (2020) PubMed  Europe PubMed DOI
  54. Moss,S., Subramanian,V. and Acharya,K.R.
    Crystal structure of peptide-bound neprilysin reveals key binding interactions
    FEBS Lett (2020) 594, 327-336. PubMed  Europe PubMed DOI  P  S
  55. Pavo,I.J., Pavo,N., Kastner,N., Traxler,D., Lukovic,D., Zlabinger,K., Spannbauer,A., Riesenhuber,M., Lorant,D., Bartko,P.E., Goliasch,G., Hulsmann,M., Winkler,J. and Gyongyosi,M.
    Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation
    JACC Basic Transl Sci (2020) 5, 715-726. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Pavo,N., Prausmuller,S., Bartko,P.E., Goliasch,G. and Hulsmann,M.
    Neprilysin as a Biomarker: Challenges and Opportunities
    Card Fail Rev (2020) 6, e23-e23. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Promyo,K., Iqbal,F., Chaidee,N. and Chetsawang,B.
    Aluminum chloride-induced amyloid beta accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin
    Food Chem Toxicol (2020) 146, 111829-111829. PubMed  Europe PubMed DOI  I
  58. Salazar,J., Rojas-Quintero,J., Cano,C., Perez,J.L., Ramirez,P., Carrasquero,R., Torres,W., Espinoza,C., Chacin-Gonzalez,M. and Bermudez,V.
    Neprilysin: a potential therapeutic target of arterial hypertension?
    Curr Cardiol Rev (2020) 16, 25-35. PubMed  Europe PubMed DOI  I
  59. Salman,A.A., Salman,M.A., Shawkat,M., Hassan,S.A., Saad,E.H., Hussein,A.M., Refaie,O.R.M., Tourky,M.S., Shaaban,H.E., Abd Allah,N., El Domiaty,H.F. and Elkassar,H.
    Effect of Laparoscopic Sleeve Gastrectomy on Vasoactive Mediators in Obese Hypertensive Patients: A Prospective Study
    Clin Endocrinol (Oxf) (2020) PubMed  Europe PubMed DOI
  60. Sanchez-Aguilar,M., Ibarra-Lara,L., Del Valle-Mondragon,L., Soria-Castro,E., Torres-Narvaez,J.C., Carreon-Torres,E., Sanchez-Mendoza,A. and Rubio-Ruiz,M.E.
    Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model
    PPAR Res (2020) 2020, 8894525-8894525. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Sankhe,R., Kinra,M., Mudgal,J., Arora,D. and Nampoothiri,M.
    Neprilysin, the kidney brush border neutral proteinase: a possible potential target for ischemic renal injury
    Toxicol Mech Methods (2020) 30, 88-99. PubMed  Europe PubMed DOI  V
  62. Sbolli,M. and deFilippi,C.
    BNP and NT-proBNP Interpretation in the Neprilysin Inhibitor Era
    Curr Cardiol Rep (2020) 22, 150-150. PubMed  Europe PubMed DOI  V  I
  63. Sharma,U., Cozier,G.E., Sturrock,E.D. and Acharya,K.R.
    Molecular basis for omapatrilat and sampatrilat binding to neprilysin-implications for dual inhibitor design with angiotensin-converting enzyme
    J Med Chem (2020) 63, 5488-5500. PubMed  Europe PubMed DOI  S  I
  64. Tamanna,S., Clifton,V.L., Rae,K., van Helden,D.F., Lumbers,E.R. and Pringle,K.G.
    Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age
    Front Physiol (2020) 11, 590787-590787. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Teyssier,V.R., Simard,J.M., Dornan,M.H., Tournoux,F. and DaSilva,J.N.
    Radiosynthesis of the (11) C-methyl derivative of LBQ657 for PET investigation of the neprilysin inhibitor sacubitril
    J Labelled Comp Radiopharm (2020) 63, 65-71. PubMed  Europe PubMed DOI  I
  66. Ugan,R.A., Un,H., Gurbuz,M.A., Kaya,G., Kahramanlar,A., Aksakalli-Magden,Z.B., Halici,Z. and Cadirci,E.
    Possible contribution of the neprilysin/ACE pathway to sepsis in mice
    Life Sci (2020) 258, 118177-118177. PubMed  Europe PubMed DOI  I
  67. Verbrugge,F.H. and Borlaug,B.A.
    Getting the "Right" Perspective on Angiotensin Receptor-Neprilysin Inhibition in Heart Failure
    J Am Heart Assoc (2020) 9, e017292-e017292. PubMed  Europe PubMed DOI
  68. Wisniowska-Smialek,S., Dziewiecka,E., Holcman,K., Podolec,P., Wypasek,E. and Rubis,P.
    Comparison of 12-month kinetics of serum markers of fibrosis between treatment with angiotensin receptor neprilysin inhibitor (ARNI) and angiotensin converting enzyme inhibitor (ACE-I) in patients with heart failure with reduced ejection fraction
    Pol Arch Intern Med (2020) 130, 1017-1020. PubMed  Europe PubMed DOI  I
  69. Wu,S., Zhang,J., Jiang,C., Wang,S., Que,R. and An,L.
    Up-regulation of neprilysin mediates the protection of fructo-oligosaccharides against Alzheimer's disease
    Food Funct (2020) 11, 6565-6572. PubMed  Europe PubMed DOI
    70. 2019
  70. Bossak-Ahmad,K., Mital,M., Plonka,D., Drew,S.C. and Bal,W.
    Oligopeptides generated by neprilysin degradation of beta-amyloid have the highest Cu(II) affinity in the whole Abeta family
    Inorg Chem (2019) 58, 932-943. PubMed  Europe PubMed DOI
  71. Cervellini,I., Galino,J., Zhu,N., Fricker,F.R., Bao,L. and Bennett,D.L.H.
    Membrane metallo-endopeptidase is dispensable for repair after nerve injury
    Glia (2019) 67, 1990-2000. PubMed  Europe PubMed DOI  K
  72. Esser,N. and Zraika,S.
    Neprilysin inhibition: a new therapeutic option for type 2 diabetes?
    Diabetologia (2019) 62, 1113-1122. PubMed  Europe PubMed DOI  I
  73. Feygina,E.E., Katrukha,A.G. and Semenov,A.G.
    Neutral endopeptidase (neprilysin) in therapy and diagnostics: yin and yang
    Biochemistry (Mosc) (2019) 84, 1346-1358. PubMed  Europe PubMed DOI  T
  74. Hornung,K., Zampar,S., Engel,N., Klafki,H., Liepold,T., Bayer,T.A., Wiltfang,J., Jahn,O. and Wirths,O.
    N-Terminal truncated Abeta4-42 is a substrate for neprilysin degradation in vitro and in vivo
    J Alzheimers Dis (2019) 67, 849-858. PubMed  Europe PubMed DOI
  75. Labiuk,S.L., Sygusch,J. and Grochulski,P.
    Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan
    Acta Crystallogr F Struct Biol Commun (2019) 75, 405-411. PubMed  Europe PubMed DOI  S  I
  76. Leite,J.P. and Gales,L.
    Alzheimer's Abeta1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Abeta product
    FEBS Lett (2019) 593, 128-137. PubMed  Europe PubMed DOI
  77. McKinnell,R.M., Fatheree,P., Choi,S.K., Gendron,R., Jendza,K., Olson Blair,B., Budman,J., Hill,C.M., Hegde,L.G., Yu,C., McConn,D., Hegde,S.S., Marquess,D.G. and Klein,U.
    Discovery of TD-0212, an orally active dual pharmacology AT1 antagonist and neprilysin inhibitor (ARNI)
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  78. Mizerska-Kowalska,M., Kreczko-Kurzawa,J., Zdzisinska,B., Czerwonka,A., Slawinska-Brych,A., Mackiewicz,Z., Nidzworski,D. and Kandefer-Szerszen,M.
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