Literature for peptidase M13.001: neprilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Iwamoto,S., Hatta,D., Fujii,M., Yamamoto,D., Ohta,R., Okita,K., Shirotani,K. and Iwata,N. Cell type- and neuronal differentiation-dependent MME 5'UTR splice variants with distinct translational outputs in human cells J Biochem (2026) PubMed Europe PubMed DOI

2025

Cozier,G.E., Coulson,L.B., Eyermann,C.J., Basarab,G.S., Schwager,S.L., Chibale,K., Sturrock,E.D. and Acharya,K.R. Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors J Med Chem (2025) 68, 7720-7736. PubMed Europe PubMed DOI

2024

Esser,N., Mongovin,S.M., Barrow,B.M. and Zraika,S. Gut-specific Neprilysin Deletion Protects Against Fat-induced Insulin Secretory Dysfunction in Male Mice Endocrinology (2024) 165 PubMed Europe PubMed DOI PMC EPMC
Hakata,T., Ueda,Y., Yamashita,T., Yamauchi,I., Kosugi,D., Sugawa,T., Fujita,H., Okamoto,K., Fujii,T., Taura,D., Yasoda,A., Akiyama,H. and Inagaki,N. Neprilysin inhibition promotes skeletal growth via the CNP/NPR-B pathway Endocrinology (2024) 165, bqae058-bqae058. PubMed Europe PubMed DOI
Mizutani,S., Mizutani,H., Mizutani,E., Arita,H. and Kajiyama,H. The Fate of Angiotensin II in Placental Tissue and Blood Horm Metab Res (2024) 56, 477-481. PubMed Europe PubMed DOI
Shigematsu,K., Komori,N., Ideno,M. and Yamagishi,H. "Evaluation of neprilysin activity in Adipose-Derived stem cells from Alzheimer's disease patients" Neurosci Lett (2024) 825, 137705-137705. PubMed Europe PubMed DOI
Thakur,S., Sinhari,A., Gaikwad,A.B. and Jadhav,H.R. A structure-based pharmacophore modelling approach to identify and design new neprilysin (NEP) inhibitors: An in silico-based investigation Arch Biochem Biophys (2024) 756, 110019-110019. PubMed Europe PubMed DOI
Zhang,X., Hu,C., Tian,E., Shen,Y., Liu,W. and Li,J. Comprehensive review on neprilysin (NEP) inhibitors: design, structure-activity relationships, and clinical applications Front Pharmacol (2024) 15, 1501407-1501407. PubMed Europe PubMed DOI PMC EPMC I
Zukowska,J., Moss,S.J., Subramanian,V. and Acharya,K.R. Molecular basis of selective amyloid-beta degrading enzymes in Alzheimer's disease FEBS J (2024) 291, 2999-3029. PubMed Europe PubMed DOI V

2023

Ding,J., Li,C., Shu,K., Chen,W., Cai,C., Zhang,X. and Zhang,W. Membrane metalloendopeptidase (MME) is positively correlated with systemic lupus erythematosus and may inhibit the occurrence of breast cancer PLoS ONE (2023) 18, e0289960-e0289960. PubMed Europe PubMed DOI PMC EPMC
Esser,N., Mundinger,T.O., Barrow,B.M. and Zraika,S. Acute Inhibition of Intestinal Neprilysin Enhances Insulin Secretion via GLP-1 Receptor Signaling in Male Mice Endocrinology (2023) 164 PubMed Europe PubMed DOI PMC EPMC I
Rowland,H.A., Moxon,S.R., Corbett,N.J., Hanson,K., Fisher,K., Kellett,K.A.B. and Hooper,N.M. Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-beta deposition Neuronal Signal (2023) 7, NS20230016-NS20230016. PubMed Europe PubMed DOI PMC EPMC

2022

Kawabata,H., Suzuki,H., Ohishi,T., Kawada,M., Kaneko,M.K. and Kato,Y. A Defucosylated Mouse Anti-CD10 Monoclonal Antibody (31-mG2a-f) Exerts Antitumor Activity in a Mouse Xenograft Model of CD10-Overexpressed Tumors Monoclon Antib Immunodiagn Immunother (2022) 41, 59-66. PubMed Europe PubMed DOI
Kawabata,H., Suzuki,H., Takei,J., Kaneko,M.K. and Kato,Y. Epitope Mapping of an Anti-CD10 Monoclonal Antibody (MME/1870) Using Enzyme-Linked Immunosorbent Assay Monoclon Antib Immunodiagn Immunother (2022) 41, 15-19. PubMed Europe PubMed DOI
Nakagawa,H. and Saito,Y. Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases Biology (Basel) (2022) 11 PubMed Europe PubMed DOI PMC EPMC
Schiemann,R., Buhr,A., Cordes,E., Walter,S., Heinisch,J.J., Ferrero,P., Milting,H., Paululat,A. and Meyer,H. Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides Nat Commun (2022) 13, 4420-4420. PubMed Europe PubMed DOI PMC EPMC

2021

Alves-Lopes,R., Montezano,A.C., Neves,K.B., Harvey,A., Rios,F.J., Skiba,D.S., Arendse,L.B., Guzik,T.J., Graham,D., Poglitsch,M., Sturrock,E. and Touyz,R.M. Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension Hypertension (2021) 78, 604-616. PubMed Europe PubMed DOI
Arfsten,H., Goliasch,G., Bartko,P.E., Prausmuller,S., Spinka,G., Cho,A., Novak,J., Haslacher,H., Strunk,G., Struck,J., Hulsmann,M. and Pavo,N. Increased concentrations of bioactive adrenomedullin subsequently to angiotensin-receptor/neprilysin-inhibitor treatment in chronic systolic heart failure Br J Clin Pharmacol (2021) 87, 916-924. PubMed Europe PubMed DOI I
Gjorgova-Gjeorgjievski,S., Fritchie,K. and Folpe,A.L. CD10 (Neprilysin) Expression: A Potential Adjunct in the Distinction of Hibernoma from Morphologic Mimics Hum Pathol (2021) PubMed Europe PubMed DOI
Nemcekova,V., Malikova,E., Goncalvesova,E., Krenek,P. and Klimas,J. Altered serum levels of neprilysin in heart failure patients with reduced ejection fraction Bratisl Lek Listy (2021) 122, 28-33. PubMed Europe PubMed DOI
Polina,I., Spicer,M.J., Domondon,M., Schibalski,R.S., Sarsenova,E., Sultanova,R.F. and Ilatovskaya,D.V. Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats Ren Fail (2021) 43, 315-324. PubMed Europe PubMed DOI I
Poorgolizadeh,E., Homayouni Moghadam,F., Dormiani,K., Rezaei,N. and Nasr-Esfahani,M.H. Do neprilysin inhibitors walk the line? Heart ameliorative but brain threatening! Eur J Pharmacol (2021) 894, 173851-173851. PubMed Europe PubMed DOI I
Rofo,F., Ugur Yilmaz,C., Metzendorf,N., Gustavsson,T., Beretta,C., Erlandsson,A., Sehlin,D., Syvanen,S., Nilsson,P. and Hultqvist,G. Enhanced neprilysin-mediated degradation of hippocampal Abeta42 with a somatostatin peptide that enters the brain Theranostics (2021) 11, 789-804. PubMed Europe PubMed DOI PMC EPMC
Sankhe,R., Rathi,E., Manandhar,S., Kumar,A., Pai,S.R.K., Kini,S.G. and Kishore,A. Repurposing of existing FDA approved drugs for Neprilysin inhibition: An in-silico study J Mol Struct (2021) 1224, 129073-129073. PubMed Europe PubMed DOI PMC EPMC

2020

Abdulsalam,T.M., Hasanin,A.H., Mohamed,R.H. and El Sayed Badawy,A. Angiotensin receptor-neprilysin inhibitior (thiorphan/irbesartan) decreased ischemia-reperfusion induced ventricular arrhythmias in rat; in vivo study Eur J Pharmacol (2020) 882, 173295-173295. PubMed Europe PubMed DOI I
Balazki,P., Schaller,S., Eissing,T. and Lehr,T. A Physiologically-Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP-1 and GIP and the DPP4 Inhibitor Sitagliptin CPT Pharmacometrics Syst Pharmacol (2020) 9, 353-362. PubMed Europe PubMed DOI PMC EPMC I
Bellis,A., Mauro,C., Barbato,E., Trimarco,B. and Morisco,C. The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19 Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V I
Bendre,S., Zhang,Z., Kuo,H.T., Rousseau,J., Zhang,C., Merkens,H., Roxin,A., Benard,F. and Lin,K.S. Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of (68)Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics Molecules (2020) 25 PubMed Europe PubMed DOI
Bernardi,M.H., Wagner,L., Ryz,S., Puchinger,J., Nixdorf,L., Edlinger-Stanger,M., Geilen,J., Kainz,M., Hiesmayr,M.J. and Lassnigg,A. Urinary neprilysin for early detection of acute kidney injury after cardiac surgery: A prospective observational study Eur J Anaesthesiol (2020) PubMed Europe PubMed DOI
Campos,C.R., Kemble,A.M., Niewoehner,J., Freskgard,P.O. and Urich,E. Brain shuttle neprilysin reduces central amyloid-beta levels PLoS ONE (2020) 15, e0229850-e0229850. PubMed Europe PubMed DOI U
Chatterjee,P., Gheblawi,M., Wang,K., Vu,J., Kondaiah,P. and Oudit,G.Y. Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications Clin Sci (Lond) (2020) 134, 2319-2336. PubMed Europe PubMed DOI V
Chen,H.H. and Burnett,J.C., Jr. Neprilysin in HFrEF: Differential Regulation of Tissue Versus Circulating Neprilysin JACC Basic Transl Sci (2020) 5, 727-729. PubMed Europe PubMed DOI PMC EPMC
Chen,S., Mima,D., Jin,H., Dan,Q., Wang,F., Cai,J., Shi,L., Wang,H., Du,A., Tang,Y. and Sun,Y. The Association between Neprilysin gene polymorphisms and Alzheimer's disease in Tibetan population Brain Behav (2020) , e02002-e02002. PubMed Europe PubMed DOI
Choi,I.J., Lim,S., Hwang,Y., Lee,D., Lee,W.J., Lee,K.Y., Kim,M.J. and Jeon,D.S. Soluble neprilysin and long-term clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: a retrospective cohort study BMC Cardiovasc Disord (2020) 20, 360-360. PubMed Europe PubMed DOI PMC EPMC
Cuthbert,J.J., Pellicori,P. and Clark,A.L. Cardiovascular Outcomes with Sacubitril-Valsartan in Heart Failure: Emerging Clinical Data Ther Clin Risk Manag (2020) 16, 715-726. PubMed Europe PubMed DOI PMC EPMC V I
Dani,S.S., Ganatra,S. and Vaduganathan,M. Angioedema with sacubitril/valsartan: Trial-level meta-analysis of over 14,000 patients and real-world evidence to date Int J Cardiol (2020) PubMed Europe PubMed DOI I
Docherty,K.F., Campbell,R.T., Brooksbank,K.J.M., Godeseth,R.L., Forsyth,P., McConnachie,A., Roditi,G., Stanley,B., Welsh,P., Jhund,P.S., Petrie,M.C. and McMurray,J.J.V. Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling ESC Heart Fail (2020) PubMed Europe PubMed DOI I
Esch,T., Kream,R.M. and Stefano,G.B. Emerging regulatory roles of opioid peptides, endogenous morphine, and opioid receptor subtypes in immunomodulatory processes: Metabolic, behavioral, and evolutionary perspectives Immunol Lett (2020) 227, 28-33. PubMed Europe PubMed DOI V
Galo,J., Celli,D. and Colombo,R. Effect of Sacubitril/Valsartan on Neurocognitive Function: Current Status and Future Directions Am J Cardiovasc Drugs (2020) PubMed Europe PubMed DOI PMC EPMC I
Gommans,D.H.F., Revuelta-Lopez,E., Lupon,J., Cserkoova,A., Domingo,M., Vart,P., van Royen,N., Bayes-Genis,A. and van Kimmenade,R.R.J. Soluble Neprilysin and Corin Concentrations in Relation to Clinical Outcome in Chronic Heart Failure JACC Heart Fail (2020) PubMed Europe PubMed DOI
Graykowski,D., Kasparian,K., Caniglia,J., Gritsaeva,Y. and Cudaback,E. Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin J Neuroimmunol (2020) 346, 577315-577315. PubMed Europe PubMed DOI
Gregoriou,G.C., Patel,S.D., Winters,B.L. and Bagley,E.E. Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala Mol Pharmacol (2020) PubMed Europe PubMed DOI I
Gruson,D., Fillee,C. and Pouleur,A.C. Reply to "Effect of Neprilysin Inhibition on Various Natriuretic Peptide Assays" Clin Lab (2020) 66 PubMed Europe PubMed DOI
Izadpanah,M., Dargahi,L., Ai,J., Asgari Taei,A., Ebrahimi Barough,S., Mowla,S.J., TavoosiDana,G. and Farahmandfar,M. Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer's Disease Iran J Pharm Res (2020) 19, 45-60. PubMed Europe PubMed DOI PMC EPMC
Kanuka,M., Ouchi,F., Kato,N., Katsuki,R., Ito,S., Miura,K., Hikida,M. and Tamura,T. Endoplasmic Reticulum Associated Degradation of Spinocerebellar Ataxia-Related CD10 Cysteine Mutant Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Kato,J. Natriuretic peptides and neprilysin inhibition in hypertension and hypertensive organ damage Peptides (2020) 132, 170352-170352. PubMed Europe PubMed DOI V
Kawanami,T., Karki,R.G., Cody,E., Liu,Q., Liang,G., Ksander,G.M., Rigel,D.F., Schiering,N., Gong,Y., Coppola,G.M., Iwaki,Y., Sun,R., Neubert,A., Fan,L., Ingles,S., D'arcy,A., Villard,F., Ramage,P., Jeng,A.Y., Leung-Chu,J., Liu,J., Beil,M., Fu,F., Chen,W., Cumin,F., Wiesmann,C. and Mogi,M. Structure-guided design of substituted biphenyl butanoic acid derivatives as neprilysin inhibitors ACS Med Chem Lett (2020) 11, 188-194. PubMed Europe PubMed DOI PMC EPMC S I
Kim,N. and Lee,H.J. Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease Biomed Res Int (2020) 2020, 2010728-2010728. PubMed Europe PubMed DOI PMC EPMC V
Kuwajima,Y., Nagai,M.S., Lee,C., Galaburda,A.M., Kobayashi,T., Nakasato,A., Da Silva,J.D., Nagai,S.I. and Nagai,M. Trans-trigeminal transport of masseter-derived neprilysin to hippocampus Arch Oral Biol (2020) 118, 104861-104861. PubMed Europe PubMed DOI
Li,B., Li,N., Guo,S., Zhang,M., Li,J., Zhai,N., Wang,H. and Zhang,Y. The changing features of serum adropin, copeptin, neprilysin and chitotriosidase which are associated with vascular endothelial function in type 2 diabetic retinopathy patients J Diabetes Complications (2020) , 107686-107686. PubMed Europe PubMed DOI
Li,Y., Wang,Y., Wang,J., Chong,K.Y., Xu,J., Liu,Z. and Shan,C. Expression of neprilysin in skeletal muscle by ultrasound-mediated gene transfer (sonoporation) reduces amyloid burden for AD Mol Ther Methods Clin Dev (2020) 17, 300-308. PubMed Europe PubMed DOI PMC EPMC U
Lyle,M.A., Iyer,S.R., Redfield,M.M., Reddy,Y.N.V., Felker,G.M., Cappola,T.P., Hernandez,A.F., Scott,C.G., Burnett JC Jr and Pereira,N.L. Circulating neprilysin in patients with heart failure and preserved ejection fraction JACC Heart Fail (2020) 8, 70-80. PubMed Europe PubMed DOI
Manolis,A.S., Manolis,T.A., Manolis,A.A. and Melita,H. The Controversy of Renin-Angiotensin-System Blocker Facilitation Versus Countering COVID-19 Infection J Cardiovasc Pharmacol (2020) PubMed Europe PubMed DOI
Moss,S., Subramanian,V. and Acharya,K.R. Crystal structure of peptide-bound neprilysin reveals key binding interactions FEBS Lett (2020) 594, 327-336. PubMed Europe PubMed DOI P S
Pavo,I.J., Pavo,N., Kastner,N., Traxler,D., Lukovic,D., Zlabinger,K., Spannbauer,A., Riesenhuber,M., Lorant,D., Bartko,P.E., Goliasch,G., Hulsmann,M., Winkler,J. and Gyongyosi,M. Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation JACC Basic Transl Sci (2020) 5, 715-726. PubMed Europe PubMed DOI PMC EPMC
Pavo,N., Prausmuller,S., Bartko,P.E., Goliasch,G. and Hulsmann,M. Neprilysin as a Biomarker: Challenges and Opportunities Card Fail Rev (2020) 6, e23-e23. PubMed Europe PubMed DOI PMC EPMC
Promyo,K., Iqbal,F., Chaidee,N. and Chetsawang,B. Aluminum chloride-induced amyloid beta accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin Food Chem Toxicol (2020) 146, 111829-111829. PubMed Europe PubMed DOI I
Salazar,J., Rojas-Quintero,J., Cano,C., Perez,J.L., Ramirez,P., Carrasquero,R., Torres,W., Espinoza,C., Chacin-Gonzalez,M. and Bermudez,V. Neprilysin: a potential therapeutic target of arterial hypertension? Curr Cardiol Rev (2020) 16, 25-35. PubMed Europe PubMed DOI I
Salman,A.A., Salman,M.A., Shawkat,M., Hassan,S.A., Saad,E.H., Hussein,A.M., Refaie,O.R.M., Tourky,M.S., Shaaban,H.E., Abd Allah,N., El Domiaty,H.F. and Elkassar,H. Effect of Laparoscopic Sleeve Gastrectomy on Vasoactive Mediators in Obese Hypertensive Patients: A Prospective Study Clin Endocrinol (Oxf) (2020) PubMed Europe PubMed DOI
Sanchez-Aguilar,M., Ibarra-Lara,L., Del Valle-Mondragon,L., Soria-Castro,E., Torres-Narvaez,J.C., Carreon-Torres,E., Sanchez-Mendoza,A. and Rubio-Ruiz,M.E. Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model PPAR Res (2020) 2020, 8894525-8894525. PubMed Europe PubMed DOI PMC EPMC
Sankhe,R., Kinra,M., Mudgal,J., Arora,D. and Nampoothiri,M. Neprilysin, the kidney brush border neutral proteinase: a possible potential target for ischemic renal injury Toxicol Mech Methods (2020) 30, 88-99. PubMed Europe PubMed DOI V
Sbolli,M. and deFilippi,C. BNP and NT-proBNP Interpretation in the Neprilysin Inhibitor Era Curr Cardiol Rep (2020) 22, 150-150. PubMed Europe PubMed DOI V I
Sharma,U., Cozier,G.E., Sturrock,E.D. and Acharya,K.R. Molecular basis for omapatrilat and sampatrilat binding to neprilysin-implications for dual inhibitor design with angiotensin-converting enzyme J Med Chem (2020) 63, 5488-5500. PubMed Europe PubMed DOI S I
Tamanna,S., Clifton,V.L., Rae,K., van Helden,D.F., Lumbers,E.R. and Pringle,K.G. Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age Front Physiol (2020) 11, 590787-590787. PubMed Europe PubMed DOI PMC EPMC
Teyssier,V.R., Simard,J.M., Dornan,M.H., Tournoux,F. and DaSilva,J.N. Radiosynthesis of the (11) C-methyl derivative of LBQ657 for PET investigation of the neprilysin inhibitor sacubitril J Labelled Comp Radiopharm (2020) 63, 65-71. PubMed Europe PubMed DOI I
Ugan,R.A., Un,H., Gurbuz,M.A., Kaya,G., Kahramanlar,A., Aksakalli-Magden,Z.B., Halici,Z. and Cadirci,E. Possible contribution of the neprilysin/ACE pathway to sepsis in mice Life Sci (2020) 258, 118177-118177. PubMed Europe PubMed DOI I
Verbrugge,F.H. and Borlaug,B.A. Getting the "Right" Perspective on Angiotensin Receptor-Neprilysin Inhibition in Heart Failure J Am Heart Assoc (2020) 9, e017292-e017292. PubMed Europe PubMed DOI
Wisniowska-Smialek,S., Dziewiecka,E., Holcman,K., Podolec,P., Wypasek,E. and Rubis,P. Comparison of 12-month kinetics of serum markers of fibrosis between treatment with angiotensin receptor neprilysin inhibitor (ARNI) and angiotensin converting enzyme inhibitor (ACE-I) in patients with heart failure with reduced ejection fraction Pol Arch Intern Med (2020) 130, 1017-1020. PubMed Europe PubMed DOI I
Wu,S., Zhang,J., Jiang,C., Wang,S., Que,R. and An,L. Up-regulation of neprilysin mediates the protection of fructo-oligosaccharides against Alzheimer's disease Food Funct (2020) 11, 6565-6572. PubMed Europe PubMed DOI

2019

Bossak-Ahmad,K., Mital,M., Plonka,D., Drew,S.C. and Bal,W. Oligopeptides generated by neprilysin degradation of beta-amyloid have the highest Cu(II) affinity in the whole Abeta family Inorg Chem (2019) 58, 932-943. PubMed Europe PubMed DOI
Cervellini,I., Galino,J., Zhu,N., Fricker,F.R., Bao,L. and Bennett,D.L.H. Membrane metallo-endopeptidase is dispensable for repair after nerve injury Glia (2019) 67, 1990-2000. PubMed Europe PubMed DOI K
Esser,N. and Zraika,S. Neprilysin inhibition: a new therapeutic option for type 2 diabetes? Diabetologia (2019) 62, 1113-1122. PubMed Europe PubMed DOI I
Feygina,E.E., Katrukha,A.G. and Semenov,A.G. Neutral endopeptidase (neprilysin) in therapy and diagnostics: yin and yang Biochemistry (Mosc) (2019) 84, 1346-1358. PubMed Europe PubMed DOI T
Hornung,K., Zampar,S., Engel,N., Klafki,H., Liepold,T., Bayer,T.A., Wiltfang,J., Jahn,O. and Wirths,O. N-Terminal truncated Abeta4-42 is a substrate for neprilysin degradation in vitro and in vivo J Alzheimers Dis (2019) 67, 849-858. PubMed Europe PubMed DOI
Labiuk,S.L., Sygusch,J. and Grochulski,P. Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan Acta Crystallogr F Struct Biol Commun (2019) 75, 405-411. PubMed Europe PubMed DOI S I
Leite,J.P. and Gales,L. Alzheimer's Abeta1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Abeta product FEBS Lett (2019) 593, 128-137. PubMed Europe PubMed DOI
McKinnell,R.M., Fatheree,P., Choi,S.K., Gendron,R., Jendza,K., Olson Blair,B., Budman,J., Hill,C.M., Hegde,L.G., Yu,C., McConn,D., Hegde,S.S., Marquess,D.G. and Klein,U. Discovery of TD-0212, an orally active dual pharmacology AT1 antagonist and neprilysin inhibitor (ARNI) ACS Med Chem Lett (2019) 10, 86-91. PubMed Europe PubMed DOI PMC EPMC I
Mizerska-Kowalska,M., Kreczko-Kurzawa,J., Zdzisinska,B., Czerwonka,A., Slawinska-Brych,A., Mackiewicz,Z., Nidzworski,D. and Kandefer-Szerszen,M. Neutral endopeptidase (NEP) inhibitors - thiorphan, sialorphin, and its derivatives exert anti-proliferative activity towards colorectal cancer cells in vitro Chem Biol Interact (2019) 307, 105-115. PubMed Europe PubMed DOI U I
Ramirez,A.K., Dankel,S., Cai,W., Sakaguchi,M., Kasif,S. and Kahn,C.R. Membrane metallo-endopeptidase (neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes Mol Metab (2019) 22, 21-36. PubMed Europe PubMed DOI
Reddy,Y.N.V., Iyer,S.R., Scott,C.G., Rodeheffer,R.J., Bailey,K., Jenkins,G., Batzler,A., Redfield,M.M., Burnett JC Jr and Pereira,N.L. Soluble neprilysin in the general population: clinical determinants and its relationship to cardiovascular disease J Am Heart Assoc (2019) 8, e012943-e012943. PubMed Europe PubMed DOI
Richards,A.M., Pemberton,C. and Yandle,T. How does neprilysin inhibition in heart failure work? Eur J Heart Fail (2019) 21, 606-608. PubMed Europe PubMed DOI
Sobocinska,M., Gieldon,A., Fichna,J. and Kamysz,E. 1-Substituted sialorphin analogues - synthesis, molecular modelling and in vitro effect on enkephalins degradation by NEP Amino Acids (2019) 51, 1201-1207. PubMed Europe PubMed DOI I
Wang,W., Shen,M., Fischer,C., Basu,R., Hazra,S., Couvineau,P., Paul,M., Wang,F., Toth,S., Mix,D.S., Poglitsch,M., Gerard,N.P., Bouvier,M., Vederas,J.C., Penninger,J.M., Kassiri,Z. and Oudit,G.Y. Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs Proc Natl Acad Sci U S A (2019) 116, 13006-13015. PubMed Europe PubMed DOI

2018

Becker,M., Moore,A., Naughton,M., Boland,B., Siems,W.E. and Walther,T. Neprilysin degrades murine amyloid-beta (Abeta) more efficiently than human Abeta: further implication for species-specific amyloid accumulation Neurosci Lett (2018) 686, 74-79. PubMed Europe PubMed DOI P
Buttrick,P. Neprilysin inhibition: what we know and what we don't know J Card Fail (2018) 24, 276-277. PubMed Europe PubMed DOI I
Campbell,D.J. Neprilysin inhibitors and bradykinin Front Med (Lausanne) (2018) 5, 257-257. PubMed Europe PubMed DOI PMC EPMC I
Esser,N., Barrow,B.M., Choung,E., Shen,N.J. and Zraika,S. Neprilysin inhibition in mouse islets enhances insulin secretion in a GLP-1 receptor dependent manner Islets (2018) 10, 175-180. PubMed Europe PubMed DOI I
Kawano,D.F., de Carvalho,M.R., Machado,M.F.M., Carmona,A.K., Braga,G.U.L. and Carvalho,I. Biological and in silico studies on synthetic analogues of tyrosine betaine as inhibitors of neprilysin - a drug target for the treatment of heart failure Curr Pharm Des (2018) 24, 1899-1904. PubMed Europe PubMed DOI I
Mora Huertas,A.C., Schmelzer,C.E.H., Luise,C., Sippl,W., Pietzsch,M., Hoehenwarter,W. and Heinz,A. Degradation of tropoelastin and skin elastin by neprilysin Biochimie (2018) 146, 73-78. PubMed Europe PubMed DOI
Moss,S., Subramanian,V. and Acharya,K.R. High resolution crystal structure of substrate-free human neprilysin J Struct Biol (2018) 204, 19-25. PubMed Europe PubMed DOI S
Packer,M. Does neprilysin inhibition potentiate or minimize the adverse effects of glucagon-like peptide-1 receptor agonists in chronic heart failure? J Card Fail (2018) 24, 109-111. PubMed Europe PubMed DOI I
Packer,M., Claggett,B., Lefkowitz,M.P., McMurray,J.J.V., Rouleau,J.L., Solomon,S.D. and Zile,M.R. Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of the PARADIGM-HF trial Lancet Diabetes Endocrinol (2018) 6, 547-554. PubMed Europe PubMed DOI I
Parilla,J.H., Hull,R.L. and Zraika,S. Neprilysin deficiency is associated with expansion of islet beta-cell mass in high fat-fed mice J Histochem Cytochem (2018) 66, 523-530. PubMed Europe PubMed DOI K
Raffa,R.B., Pergolizzi JV Jr, Taylor R Jr and Ossipov,M.H. Indirect-acting strategy of opioid action instead of direct receptor activation: dual-acting enkephalinase inhibitors (DENKIs) J Clin Pharm Ther (2018) 43, 443-449. PubMed Europe PubMed DOI I
Sakai,M., Ueda,S., Daito,T., Asada-Utsugi,M., Komatsu,Y., Kinoshita,A., Maki,T., Kuzuya,A., Takahashi,R., Makino,A. and Tomonaga,K. Degradation of amyloid beta peptide by neprilysin expressed from Borna disease virus vector Microbiol Immunol (2018) PubMed Europe PubMed DOI U

2017

Bartell,N. and Frishman,W.H. Neprilysin inhibition and the treatment of heart failure: recent steps in the right direction Cardiol Rev (2017) 25, 315-320. PubMed Europe PubMed DOI I
Brar,G.S., Barrow,B.M., Watson,M., Griesbach,R., Choung,E., Welch,A., Ruzsicska,B., Raleigh,D.P. and Zraika,S. Neprilysin is required for angiotensin-(1-7)'s ability to enhance insulin secretion via its proteolytic activity to generate angiotensin-(1-2) Diabetes (2017) 66, 2201-2212. PubMed Europe PubMed DOI
Chen,Y. and Burnett JC Jr Biochemistry, therapeutics, and biomarker implications of neprilysin in cardiorenal disease Clin Chem (2017) 63, 108-115. PubMed Europe PubMed DOI
Fujisawa,M., Sano,Y., Omoto,M., Ogasawara,J.I., Koga,M., Takashima,H. and Kanda,T. Charcot-Marie-Tooth disease type 2 caused by homozygous MME gene mutation superimposed by chronic inflammatory demyelinating polyneuropathy Rinsho Shinkeigaku (2017) 57, 515-520. PubMed Europe PubMed DOI M
Haase,G., Gavert,N., Brabletz,T. and Ben-Ze'ev,A. A point mutation in the extracellular domain of L1 blocks its capacity to confer metastasis in colon cancer cells via CD10 Oncogene (2017) 36, 1597-1606. PubMed Europe PubMed DOI
Owens,A.T., Brozena,S. and Jessup,M. Neprilysin inhibitors: emerging therapy for heart failure Annu Rev Med (2017) 68, 41-49. PubMed Europe PubMed DOI I
Poras,H., Patouret,R., Leiris,S., Ouimet,T., Fournie-Zaluski,M.C. and Roques,B.P. Substituted alpha-mercaptoketones, new types of specific neprilysin inhibitors Bioorg Med Chem Lett (2017) 27, 3883-3890. PubMed Europe PubMed DOI I
Riddell,E. and Vader,J.M. Potential expanded indications for neprilysin inhibitors Curr Heart Fail Rep (2017) 14, 134-145. PubMed Europe PubMed DOI I
Salazar Adum,J.P. and Arora,R. Role of neprilysin inhibitors in heart failure Am J Ther (2017) 24, e737-e737. PubMed Europe PubMed DOI I
Sargin,Z.G., Erin,N., Tazegul,G., Elpek,G.O. and Yildirim,B. Profound loss of neprilysin accompanied by decreased levels of neuropeptides and increased CRP in ulcerative colitis PLoS ONE (2017) 12, e0189526-e0189526. PubMed Europe PubMed DOI
Yamamoto,N., Shibata,M., Ishikuro,R., Tanida,M., Taniguchi,Y., Ikeda-Matsuo,Y. and Sobue,K. Epigallocatechin gallate induces extracellular degradation of amyloid beta-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways Neuroscience (2017) 362, 70-78. PubMed Europe PubMed DOI I
Zhang,H., Liu,D., Wang,Y., Huang,H., Zhao,Y. and Zhou,H. Meta-analysis of expression and function of neprilysin in Alzheimer's disease Neurosci Lett (2017) 657, 69-76. PubMed Europe PubMed DOI

2016

Auer-Grumbach,M., Toegel,S., Schabhuttl,M., Weinmann,D., Chiari,C., Bennett,D.L., Beetz,C., Klein,D., Andersen,P.M., Bohme,I., Fink-Puches,R., Gonzalez,M., Harms,M.B., Motley,W., Reilly,M.M., Renner,W., Rudnik-Schoneborn,S., Schlotter-Weigel,B., Themistocleous,A.C., Weishaupt,J.H., Ludolph,A.C., Wieland,T., Tao,F., Abreu,L., Windhager,R., Zitzelsberger,M., Strom,T.M., Walther,T., Scherer,S.S., Zuchner,S., Martini,R. and Senderek,J. Rare variants in MME, encoding metalloprotease neprilysin, are linked to late-onset autosomal-dominant axonal polyneuropathies Am J Hum Genet (2016) 99, 607-623. PubMed Europe PubMed DOI PMC EPMC M
Bayes-Genis,A., Prickett,T.C., Richards,A.M., Barallat,J. and Lupon,J. Soluble neprilysin retains catalytic activity in heart failure J Heart Lung Transplant (2016) 35, 684-685. PubMed Europe PubMed DOI
Bayes-Genis,A., Morant-Talamante,N. and Lupon,J. Neprilysin and natriuretic peptide regulation in heart failure Curr Heart Fail Rep (2016) 13, 151-157. PubMed Europe PubMed DOI I
Bayes-Genis,A., Barallat,J. and Richards,A.M. A test in context: neprilysin: function, inhibition, and biomarker J Am Coll Cardiol (2016) 68, 639-653. PubMed Europe PubMed DOI V
Burrell,M., Henderson,S.J., Ravnefjord,A., Schweikart,F., Fowler,S.B., Witt,S., Hansson,K.M. and Webster,C.I. Neprilysin inhibits coagulation through proteolytic inactivation of fibrinogen PLoS ONE (2016) 11, e0158114-e0158114. PubMed Europe PubMed DOI
Chen,P.T., Chen,C.L., Lin,L.T., Lo,C.H., Hu,C.J., Chen,R.P. and Wang,S.S. Design of peptide substrate for sensitively and specifically detecting two Abeta-degrading enzymes: neprilysin and angiotensin-converting enzyme PLoS ONE (2016) 11, e0153360-e0153360. PubMed Europe PubMed DOI A
Depondt,C., Donatello,S., Rai,M., Wang,F.C., Manto,M., Simonis,N. and Pandolfo,M. MME mutation in dominant spinocerebellar ataxia with neuropathy (SCA43) Neurol Genet (2016) 2, e94-e94. PubMed Europe PubMed DOI PMC EPMC M
Domenig,O., Manzel,A., Grobe,N., Konigshausen,E., Kaltenecker,C.C., Kovarik,J.J., Stegbauer,J., Gurley,S.B., van Oyen,D., Antlanger,M., Bader,M., Motta-Santos,D., Santos,R.A., Elased,K.M., Saemann,M.D., Linker,R.A. and Poglitsch,M. Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney Sci Rep (2016) 6, 33678-33678. PubMed Europe PubMed DOI PMC EPMC
Feldman,A.M. Neprilysin inhibition in the time of precision medicine JACC Heart Fail (2016) S2213-1779, 30049-X-30049-X. PubMed Europe PubMed DOI I
Freitas,A.C., Pacheco,D.F., Machado,M.F., Carmona,A.K., Duarte,I.D. and de Lima,M.E. PnPP-19, a spider toxin peptide, induces peripheral antinociception through opioid and cannabinoid receptors and inhibition of neutral endopeptidase Br J Pharmacol (2016) 173, 1491-1501. PubMed Europe PubMed DOI P
Goliasch,G., Pavo,N., Zotter-Tufaro,C., Kammerlander,A., Duca,F., Mascherbauer,J. and Bonderman,D. Soluble neprilysin does not correlate with outcome in heart failure with preserved ejection fraction Eur J Heart Fail (2016) 18, 89-93. PubMed Europe PubMed DOI
Griggs,D.W., Prinsen,M.J., Oliva,J., Campbell,M.A., Arnett,S.D., Tajfirouz,D., Ruminski,P.G., Yu,Y., Bond,B.R., Ji,Y., Neckermann,G., Choy,R.K., de Hostos,E. and Meyers,M.J. Pharmacologic comparison of clinical neutral endopeptidase inhibitors in a rat model of acute secretory diarrhea J Pharmacol Exp Ther (2016) 357, 423-431. PubMed Europe PubMed DOI I
Higuchi,Y., Hashiguchi,A., Yuan,J., Yoshimura,A., Mitsui,J., Ishiura,H., Tanaka,M., Ishihara,S., Tanabe,H., Nozuma,S., Okamoto,Y., Matsuura,E., Ohkubo,R., Inamizu,S., Shiraishi,W., Yamasaki,R., Ohyagi,Y., Kira,J., Oya,Y., Yabe,H., Nishikawa,N., Tobisawa,S., Matsuda,N., Masuda,M., Kugimoto,C., Fukushima,K., Yano,S., Yoshimura,J., Doi,K., Nakagawa,M., Morishita,S., Tsuji,S. and Takashima,H. Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2 Ann Neurol (2016) 79, 659-672. PubMed Europe PubMed DOI M
Howell,E.H. and Cameron,S.J. Neprilysin inhibition: a brief review of past pharmacological strategies for heart failure treatment and future directions Cardiol J (2016) 23, 591-598. PubMed Europe PubMed DOI I
Hsiao,R. and Greenberg,B. Neprilysin Inhibition as a PARADIGM Shift in heart failure therapy Curr Heart Fail Rep (2016) 13, 172-180. PubMed Europe PubMed DOI I
Imokawa,G. Epithelial-mesenchymal interaction mechanisms leading to the over-expression of neprilysin are involved in the UVB-induced formation of wrinkles in the skin Exp Dermatol (2016) 25 Suppl 3, 2-13. PubMed Europe PubMed DOI
Lin,C.Y., Perche,F., Ikegami,M., Uchida,S., Kataoka,K. and Itaka,K. Messenger RNA-based therapeutics for brain diseases: an animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles J Control Release (2016) 235, 268-275. PubMed Europe PubMed DOI U
McKinnie,S.M., Fischer,C., Tran,K.M., Wang,W., Mosquera,F., Oudit,G.Y. and Vederas,J.C. The metalloprotease neprilysin degrades and inactivates apelin peptides Chembiochem (2016) 17, 1495-1498. PubMed Europe PubMed DOI
Nakajima,H., Terazawa,S., Niwano,T., Yamamoto,Y. and Imokawa,G. The inhibitory effects of anti-oxidants on ultraviolet-induced up-regulation of the wrinkling-inducing enzyme neutral endopeptidase in human fibroblasts PLoS ONE (2016) 11, e0161580-e0161580. PubMed Europe PubMed DOI
Oh,J.H., Choi,S., Shin,J. and Park,J.S. Protective effect of recombinant soluble neprilysin against beta-amyloid induced neurotoxicity Biochem Biophys Res Commun (2016) 477, 614-619. PubMed Europe PubMed DOI U
Schiering,N., D'arcy,A., Villard,F., Ramage,P., Logel,C., Cumin,F., Ksander,G.M., Wiesmann,C., Karki,R.G. and Mogi,M. Structure of neprilysin in complex with the active metabolite of sacubitril Sci Rep (2016) 6, 27909-27909. PubMed Europe PubMed DOI S I
Semenov,A.G. and Katrukha,A.G. Different susceptibility of B-type natriuretic peptide (BNP) and BNP precursor (proBNP) to cleavage by neprilysin: the N-terminal part does matter Clin Chem (2016) 62, 617-622. PubMed Europe PubMed DOI
Smith,A.I., Rajapakse,N.W., Kleifeld,O., Lomonte,B., Sikanyika,N.L., Spicer,A.J., Hodgson,W.C., Conroy,P.J., Small,D.H., Kaye,D.M., Parkington,H.C., Whisstock,J.C. and Kuruppu,S. N-terminal domain of Bothrops asper myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin Sci Rep (2016) 6, 22413-22413. PubMed Europe PubMed DOI PMC EPMC
Stephen,H.M., Khoury,R.J., Majmudar,P.R., Blaylock,T., Hawkins,K., Salama,M.S., Scott,M.D., Cosminsky,B., Utreja,N.K., Britt,J. and Conway,R.E. Epigenetic suppression of neprilysin regulates breast cancer invasion Oncogenesis (2016) 5, e207-e207. PubMed Europe PubMed DOI
Ul-Haq,Z., Usmani,S., Iqbal,S. and Zia,S.R. In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity Mol Biosyst (2016) 12, 1024-1036. PubMed Europe PubMed DOI P
Wang,H.Z., Bi,R., Zhang,D.F., Li,G.D., Ma,X.H., Fang,Y., Li,T., Zhang,C. and Yao,Y.G. Neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese Mol Neurobiol (2016) 53, 4883-4892. PubMed Europe PubMed DOI M
Wick,M.J., Loomis,Z.L., Harral,J.W., Le,M., Wehling,C.A., Miller,Y.E. and Dempsey,E.C. Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern Transgenic Res (2016) 25, 773-784. PubMed Europe PubMed DOI

2015

Bayes-Genis,A., Barallat,J., Galan,A., de Antonio,M., Domingo,M., Zamora,E., Urrutia,A. and Lupon,J. Soluble neprilysin is predictive of cardiovascular death and heart failure hospitalization in heart failure patients J Am Coll Cardiol (2015) 65, 657-665. PubMed Europe PubMed DOI
Bayes-Genis,A. Neprilysin in heart failure: from oblivion to center stage JACC Heart Fail (2015) 3, 637-640. PubMed Europe PubMed DOI
Bonnard,E., Poras,H., Nadal,X., Maldonado,R., Fournie-Zaluski,M.C. and Roques,B.P. Long-lasting oral analgesic effects of N-protected aminophosphinic dual enkephalinase inhibitors (DENKIs) in peripherally controlled pain Pharmacol Res Perspect (2015) 3, e00116-e00116. PubMed Europe PubMed DOI PMC EPMC I
Chin-Chan,M., Segovia,J., Quintanar,L., Arcos-Lopez,T., Hersh,L.B., Chow,K.M., Rodgers,D.W. and Quintanilla-Vega,B. Mercury reduces the enzymatic activity of neprilysin in differentiated SH-SY5Y cells Toxicol Sci (2015) 145, 128-137. PubMed Europe PubMed DOI
Devi,L. and Ohno,M. A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice Mol Brain (2015) 8, 19- PubMed Europe PubMed DOI PMC EPMC
Grimm,M.O., Mett,J., Stahlmann,C.P., Grosgen,S., Haupenthal,V.J., Blumel,T., Hundsdorfer,B., Zimmer,V.C., Mylonas,N.T., Tanila,H., Muller,U., Grimm,H.S. and Hartmann,T. APP intracellular domain derived from amyloidogenic beta- and gamma-secretase cleavage regulates neprilysin expression Front Aging Neurosci (2015) 7, 77-77. PubMed Europe PubMed DOI
Huttenrauch,M., Baches,S., Gerth,J., Bayer,T.A., Weggen,S. and Wirths,O. Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease J Alzheimers Dis (2015) 44, 1291-1302. PubMed Europe PubMed DOI K
Imokawa,G. and Ishida,K. Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging I: reduced skin elasticity, highly associated with enhanced dermal elastase activity, triggers wrinkling and sagging Int J Mol Sci (2015) 16, 7753-7775. PubMed Europe PubMed DOI
Imokawa,G., Nakajima,H. and Ishida,K. Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging ii: over-expression of neprilysin plays an essential role Int J Mol Sci (2015) 16, 7776-7795. PubMed Europe PubMed DOI
Jha,N.K., Jha,S.K., Kumar,D., Kejriwal,N., Sharma,R., Ambasta,R.K. and Kumar,P. Impact of insulin degrading enzyme and neprilysin in Alzheimer's disease biology: characterization of putative cognates for therapeutic applications J Alzheimers Dis (2015) 48, 891-917. PubMed Europe PubMed DOI
Judge,P., Haynes,R., Landray,M.J. and Baigent,C. Neprilysin inhibition in chronic kidney disease Nephrol Dial Transplant (2015) 30, 738-743. PubMed Europe PubMed DOI I
Klein,C., Mathis,C., Leva,G., Patte-Mensah,C., Cassel,J.C., Maitre,M. and Mensah-Nyagan,A.G. gamma-Hydroxybutyrate (Xyrem) ameliorates clinical symptoms and neuropathology in a mouse model of Alzheimer's disease Neurobiol Aging (2015) 36, 832-844. PubMed Europe PubMed DOI
Krohn,M., Bracke,A., Avchalumov,Y., Schumacher,T., Hofrichter,J., Paarmann,K., Frohlich,C., Lange,C., Bruning,T., von Bohlen Und Halbach,O. and Pahnke,J. Accumulation of murine amyloid-beta mimics early Alzheimer's disease Brain (2015) 138, 2370-2382. PubMed Europe PubMed DOI K
Li,Y., Wang,J., Zhang,S. and Liu,Z. Neprilysin gene transfer: a promising therapeutic approach for Alzheimer's disease J Neurosci Res (2015) 93, 1325-1329. PubMed Europe PubMed DOI U
McMurray,J.J. Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances Eur J Heart Fail (2015) 17, 242-247. PubMed Europe PubMed DOI I
Nilsson,P., Loganathan,K., Sekiguchi,M., Winblad,B., Iwata,N., Saido,T.C. and Tjernberg,L.O. Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice Proteomics (2015) 15, 3349-3355. PubMed Europe PubMed DOI
Parthasarathy,R., Chow,K.M., Derafshi,Z., Fautsch,M.P., Hetling,J.R., Rodgers,D.W., Hersh,L.B. and Pepperberg,D.R. Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin Exp Eye Res (2015) 138, 134-144. PubMed Europe PubMed DOI U
Poras,H., Bonnard,E., Fournie-Zaluski,M.C. and Roques,B.P. Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route Eur J Med Chem (2015) 102, 58-67. PubMed Europe PubMed DOI I
Roksnoer,L.C., van Veghel,R., de Vries,R., Garrelds,I.M., Bhaggoe,U.M., Friesema,E.C., Leijten,F.P., Poglitsch,M., Domenig,O., Clahsen-van Groningen,M.C., Hoorn,E.J., Jan Danser,A.H. and Batenburg,W.W. Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats Kidney Int (2015) 88, 109-120. PubMed Europe PubMed DOI I
Takahashi,G., Tabata,M., Taguchi,K. and Chikuma,T. Fluorimetric assay for measuring neprilysin activity using HPLC Chromatographia (2015) 78, 593-597. DOI A
Vodovar,N., Seronde,M.F., Laribi,S., Gayat,E., Lassus,J., Januzzi JL Jr, Boukef,R., Nouira,S., Manivet,P., Samuel,J.L., Logeart,D., Cohen-Solal,A., Richards,A.M., Launay,J.M. and Mebazaa,A. Elevated plasma B-type natriuretic peptide concentrations directly inhibit circulating neprilysin activity in heart failure JACC Heart Fail (2015) 3, 629-636. PubMed Europe PubMed DOI
Vodovar,N., Paquet,C., Mebazaa,A., Launay,J.M., Hugon,J. and Cohen-Solal,A. Neprilysin, cardiovascular, and Alzheimer's diseases: the therapeutic split? Eur Heart J (2015) 36, 902-905. PubMed Europe PubMed DOI I

2014

Doi,Y., Takeuchi,H., Mizoguchi,H., Fukumoto,K., Horiuchi,H., Jin,S., Kawanokuchi,J., Parajuli,B., Sonobe,Y., Mizuno,T. and Suzumura,A. Granulocyte-colony stimulating factor attenuates oligomeric amyloid beta neurotoxicity by activation of neprilysin PLoS ONE (2014) 9, e103458-e103458. PubMed Europe PubMed DOI PMC EPMC
Guo,X., Tang,P., Liu,P., Liu,Y., Hou,C. and Li,R. Meta-analysis of the association between two neprilysin gene polymorphisms and Alzheimer's disease J Neurol Sci (2014) 346, 6-10. PubMed Europe PubMed DOI M
He,L., Uceyler,N., Kramer,H.H., Colaco,M.N., Lu,B., Birklein,F. and Sommer,C. Methylprednisolone prevents nerve injury-induced hyperalgesia in neprilysin knockout mice Pain (2014) 155, 574-580. PubMed Europe PubMed DOI K
Henderson,S.J., Andersson,C., Narwal,R., Janson,J., Goldschmidt,T.J., Appelkvist,P., Bogstedt,A., Steffen,A.C., Haupts,U., Tebbe,J., Freskgard,P.O., Jermutus,L., Burrell,M., Fowler,S.B. and Webster,C.I. Sustained peripheral depletion of amyloid-beta with a novel form of neprilysin does not affect central levels of amyloid-beta Brain (2014) 137, 553-564. PubMed Europe PubMed DOI
Jessup,M. Neprilysin inhibition - a novel therapy for heart failure N Engl J Med (2014) 371, 1062-1064. PubMed Europe PubMed DOI I
Kuruppu,S., Rajapakse,N.W., Minond,D. and Smith,A.I. Production of soluble neprilysin by endothelial cells Biochem Biophys Res Commun (2014) 446, 423-427. PubMed Europe PubMed DOI
Lim,C.S. and Alkon,D.L. PKCepsilon promotes HuD-mediated neprilysin mRNA stability and enhances neprilysin-induced Abeta degradation in brain neurons PLoS ONE (2014) 9, e97756-e97756. PubMed Europe PubMed DOI PMC EPMC
Miners,J.S., Palmer,J.C., Tayler,H., Palmer,L.E., Ashby,E., Kehoe,P.G. and Love,S. Abeta degradation or cerebral perfusion? Divergent effects of multifunctional enzymes Front Aging Neurosci (2014) 6, 238-238. PubMed Europe PubMed DOI PMC EPMC
Pope,D., Madura,J.D. and Cascio,M. beta-Amyloid and neprilysin computational studies identify critical residues implicated in binding specificity J Chem Inf Model (2014) 54, 1157-1165. PubMed Europe PubMed DOI
Poras,H., Bonnard,E., Dange,E., Fournie-Zaluski,M.C. and Roques,B.P. New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment J Med Chem (2014) 57, 5748-5763. PubMed Europe PubMed DOI I
Spencer,B., Verma,I., Desplats,P., Morvinski,D., Rockenstein,E., Adame,A. and Masliah,E. A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis J Biol Chem (2014) 289, 17917-17931. PubMed Europe PubMed DOI U
von Lueder,T.G., Atar,D. and Krum,H. Current role of neprilysin inhibitors in hypertension and heart failure Pharmacol Ther (2014) 144, 41-49. PubMed Europe PubMed DOI I
Webster,C.I., Burrell,M., Olsson,L.L., Fowler,S.B., Digby,S., Sandercock,A., Snijder,A., Tebbe,J., Haupts,U., Grudzinska,J., Jermutus,L. and Andersson,C. Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease PLoS ONE (2014) 9, e104001-e104001. PubMed Europe PubMed DOI PMC EPMC U

2013

Carty,N., Nash,K.R., Brownlow,M., Cruite,D., Wilcock,D., Selenica,M.L., Lee,D.C., Gordon,M.N. and Morgan,D. Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice PLoS ONE (2013) 8, e59626-e59626. PubMed Europe PubMed DOI PMC EPMC U
Cattaruzza,F., Poole,D.P. and Bunnett,N.W. Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease Biochem Soc Trans (2013) 41, 137-143. PubMed Europe PubMed DOI
Grimm,M.O., Mett,J., Stahlmann,C.P., Haupenthal,V.J., Zimmer,V.C. and Hartmann,T. Neprilysin and Abeta clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer's disease Front Aging Neurosci (2013) 5, 98-98. PubMed Europe PubMed DOI PMC EPMC V
Huang,W., Mo,X.A., Qin,C., Zheng,J.O., Liang,Z.J., Cheng,D.B. and Wei,Y.F. The efficiency of expressing human neprilysin by using lentiviral vector transduction in neural stem cells Chin J Neurol (2013) 46, 17-21. DOI E
Iwata,N., Sekiguchi,M., Hattori,Y., Takahashi,A., Asai,M., Ji,B., Higuchi,M., Staufenbiel,M., Muramatsu,S. and Saido,T.C. Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice Sci Rep (2013) 3, 1472-1472. PubMed Europe PubMed DOI PMC EPMC U
Karoor,V., Oka,M., Walchak,S.J., Hersh,L.B., Miller,Y.E. and Dempsey,E.C. Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism Hypertension (2013) 61, 921-930. PubMed Europe PubMed DOI
Katsuda,T., Tsuchiya,R., Kosaka,N., Yoshioka,Y., Takagaki,K., Oki,K., Takeshita,F., Sakai,Y., Kuroda,M. and Ochiya,T. Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes Sci Rep (2013) 3, 1197-1197. PubMed Europe PubMed DOI PMC EPMC U
Klein,C., Patte-Mensah,C., Taleb,O., Bourguignon,J.J., Schmitt,M., Bihel,F., Maitre,M. and Mensah-Nyagan,A.G. The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction Neuropharmacology (2013) 70, 254-260. PubMed Europe PubMed DOI
Mazurov,D., Barbashova,L. and Filatov,A. Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes FEBS J (2013) 280, 1200-1213. PubMed Europe PubMed DOI
Morisaki,N., Ohuchi,A. and Moriwaki,S. The role of neprilysin in regulating the hair cycle PLoS ONE (2013) 8, e55947-e55947. PubMed Europe PubMed DOI PMC EPMC I
Park,M.H., Lee,J.K., Choi,S., Ahn,J., Jin,H.K., Park,J.S. and Bae,J.S. Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice Brain Res (2013) 1529, 113-124. PubMed Europe PubMed DOI U
Schwacke,J.H., Spainhour,J.C., Ierardi,J.L., Chaves,J.M., Arthur,J.M., Janech,M.G. and Velez,J.C. Network modeling reveals steps in angiotensin peptide processing Hypertension (2013) 61, 690-700. PubMed Europe PubMed DOI
Turner,A.J. and Nalivaeva,N.N. Peptide degradation (neprilysin and other regulatory peptidases) (2013) 2, 1757-1764. DOI V
Walker,J.R., Pacoma,R., Watson,J., Ou,W., Alves,J., Mason,D.E., Peters,E.C., Urbina,H.D., Welzel,G., Althage,A., Liu,B., Tuntland,T., Jacobson,L.H., Harris,J.L. and Schumacher,A.M. Enhanced proteolytic clearance of plasma abeta by peripherally administered neprilysin does not result in reduced levels of brain abeta in mice J Neurosci (2013) 33, 2457-2464. PubMed Europe PubMed DOI
Zraika,S., Koh,D.S., Barrow,B.M., Lu,B., Kahn,S.E. and Andrikopoulos,S. Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx Diabetes (2013) 62, 1593-1601. PubMed Europe PubMed DOI K

2012

Barua,N.U., Miners,J.S., Bienemann,A.S., Wyatt,M.J., Welser,K., Tabor,A.B., Hailes,H.C., Love,S. and Gill,S.S. Convection-enhanced delivery of neprilysin: a novel amyloid-beta-degrading therapeutic strategy J Alzheimers Dis (2012) 32, 43-56. PubMed Europe PubMed DOI U
Guan,H., Chow,K.M., Shah,R., Rhodes,C.J. and Hersh,L.B. Degradation of islet amyloid polypeptide by neprilysin Diabetologia (2012) 55, 2989-2998. PubMed Europe PubMed DOI
Kakiya,N., Saito,T., Nilsson,P., Matsuba,Y., Tsubuki,S., Takei,N., Nawa,H. and Saido,T.C. Cell surface expression of the major amyloid-beta peptide (abeta)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a J Biol Chem (2012) 287, 29362-29372. PubMed Europe PubMed DOI
Maul,B., Becker,M., Gembardt,F., Becker,A., Schultheiss,H.P., Siems,W.E. and Walther,T. Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in mice PLoS ONE (2012) 7, e50187-e50187. PubMed Europe PubMed DOI PMC EPMC K I
Miners,S., Van Helmond,Z., Barker,R., Passmore,P.A., Johnston,J.A., Todd,S., McGuinness,B.M., Panza,F., Seripa,D., Solfrizzi,V., Love,S., Prince,J.A. and Kehoe,P.G. Genetic variation in MME in relation to neprilysin protein and enzyme activity, Abeta levels, and Alzheimer's disease risk Int J Mol Epidemiol Genet (2012) 3, 30-38. PubMed Europe PubMed M
Nalivaeva,N.N., Belyaev,N.D., Zhuravin,I.A. and Turner,A.J. The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it? Int J Alzheimers Dis (2012) 2012, 383796-383796. PubMed Europe PubMed DOI PMC EPMC V
Nalivaeva,N.N. and Turner,A.J. Neprilysin [ISSN:978-0-12-407744-7] (2012) 3, 612-619. DOI
Nalivaeva,N.N., Belyaev,N.D., Lewis,D.I., Pickles,A.R., Makova,N.Z., Bagrova,D.I., Dubrovskaya,N.M., Plesneva,S.A., Zhuravin,I.A. and Turner,A.J. Effect of sodium valproate administration on brain neprilysin expression and memory in rats J Mol Neurosci (2012) 46, 569-577. PubMed Europe PubMed DOI U
Ottaviani,E., Malagoli,D., Grimaldi,A. and deEguileor,M. The immuneregulator role of neprilysin (NEP) in invertebrates Invertebrate Surviv J (2012) 9, 207-211.
Roques,B.P., Fournie-Zaluski,M.C. and Wurm,M. Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain Nat Rev Drug Discov (2012) 11, 292-310. PubMed Europe PubMed DOI I
Sandoval,K.E., Farr,S.A., Banks,W.A., Crider,A.M., Morley,J.E. and Witt,K.A. Somatostatin receptor subtype-4 agonist NNC 26-9100 decreases extracellular and intracellular Abeta1-42 trimers Eur J Pharmacol (2012) 683, 116-124. PubMed Europe PubMed DOI U
Sato,B., Katagiri,Y.U., Iijima,K., Yamada,H., Ito,S., Kawasaki,N., Okita,H., Fujimoto,J. and Kiyokawa,N. The human CD10 lacking an N-glycan at Asn(628) is deficient in surface expression and neutral endopeptidase activity Biochim Biophys Acta (2012) 1820, 1715-1723. PubMed Europe PubMed DOI
Sato,K., Tanabe,C., Yonemura,Y., Watahiki,H., Zhao,Y., Yagishita,S., Ebina,M., Suo,S., Futai,E., Murata,M. and Ishiura,S. Localization of mature neprilysin in lipid rafts J Neurosci Res (2012) 90, 870-877. PubMed Europe PubMed DOI
Sexton,T., Hitchcook,L.J., Rodgers,D.W., Bradley,L.H. and Hersh,L.B. Active site mutations change the cleavage specificity of neprilysin PLoS ONE (2012) 7, e32343-e32343. PubMed Europe PubMed DOI PMC EPMC

2011

Hennig,T., Mogensen,C., Kirsch,J., Pohl,U. and Gloe,T. Shear stress induces the release of an endothelial elastase: role in integrin alpha(v)beta(3)-mediated FGF-2 release J Vasc Res (2011) 48, 453-464. PubMed Europe PubMed DOI
Maguer-Satta,V., Besancon,R. and Bachelard-Cascales,E. Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer Stem Cells (2011) 29, 389-396. PubMed Europe PubMed DOI
Miners,J.S., Kehoe,P. and Love,S. Neprilysin protects against cerebral amyloid angiopathy and Abeta-induced degeneration of cerebrovascular smooth muscle cells Brain Pathol (2011) 21, 594-605. PubMed Europe PubMed DOI U
Spencer,B., Marr,R.A., Gindi,R., Potkar,R., Michael,S., Adame,A., Rockenstein,E., Verma,I.M. and Masliah,E. Peripheral delivery of a CNS targeted, metalo-protease reduces abeta toxicity in a mouse model of Alzheimer's disease PLoS ONE (2011) 6, e16575-e16575. PubMed Europe PubMed DOI PMC EPMC U
Wang,Z., Yang,D., Zhang,X., Li,T., Li,J., Tang,Y. and Le,W. Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons PLoS ONE (2011) 6, e19229-e19229. PubMed Europe PubMed DOI PMC EPMC
Zhuravin,I.A., Dubrovskaya,N.M., Vasilev,D.S., Tumanova,N.L. and Nalivaeva,N.N. Epigenetic and pharmacological regulation of the amyloid-degrading enzyme neprilysin results in modulation of cognitive functions in mammals Dokl Biol Sci (2011) 438, 145-148. PubMed Europe PubMed DOI

2010

Bachelard-Cascales,E., Chapellier,M., Delay,E., Pochon,G., Voeltzel,T., Puisieux,A., Caron de Fromentel,C. and Maguer-Satta,V. The CD10 enzyme is a key player to identify and regulate human mammary stem cells Stem Cells (2010) 28, 1081-1088. PubMed Europe PubMed DOI
Becker,M., Siems,W.E., Kluge,R., Gembardt,F., Schultheiss,H.P., Schirner,M. and Walther,T. New function for an old enzyme: NEP deficient mice develop late-onset obesity PLoS ONE (2010) 5, e12793-e12793. PubMed Europe PubMed DOI PMC EPMC K I
Chen,P.T., Liao,T.Y., Hu,C.J., Wu,S.T., Wang,S.S. and Chen,R.P. A highly sensitive peptide substrate for detecting two Abeta-degrading enzymes: neprilysin and insulin-degrading enzyme J Neurosci Methods (2010) 190, 57-62. PubMed Europe PubMed DOI A
Groubman,M.A., Kamanina,Y.V., Petrushanko,I.Y., Rubtsov,A.M. and Lopina,O.D. Neutral endopeptidase neprilysin is copurified with Na,K-atpase from rabbit outer medulla and hydrolyzes its alpha-subunit Biochemistry (Mosc) (2010) 75, 1281-1284. PubMed Europe PubMed DOI
Gunia,S. Molecular interaction between arsenic hydrate microcrystals and the cell-surface endopeptidase CD10 (neprilysin) - a possible link to the development of renal and cutaneous malignancies upon occupational exposure to arsenic compounds? Med Hypotheses (2010) 75, 35-37. PubMed Europe PubMed DOI
Lebson,L., Nash,K., Kamath,S., Herber,D., Carty,N., Lee,D.C., Li,Q., Szekeres,K., Jinwal,U., Koren,J., Dickey,C.A., Gottschall,P.E., Morgan,D. and Gordon,M.N. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice J Neurosci (2010) 30, 9651-9658. PubMed Europe PubMed DOI U
Li,Y., Wang,J., Liu,J. and Liu,F. A novel system for in vivo neprilysin gene delivery using a syringe electrode J Neurosci Methods (2010) 193, 226-231. PubMed Europe PubMed DOI U
Liang,K., Yang,L., Yin,C., Xiao,Z., Zhang,J., Liu,Y. and Huang,J. Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin J Biol Chem (2010) 285, 935-942. PubMed Europe PubMed DOI
Liu,Y., Studzinski,C., Beckett,T., Murphy,M.P., Klein,R.L. and Hersh,L.B. Circulating neprilysin clears brain amyloid Mol Cell Neurosci (2010) 45, 101-107. PubMed Europe PubMed DOI U
Marr,R.A. and Spencer,B.J. NEP-like endopeptidases and Alzheimer's disease [corrected] Curr Alzheimer Res (2010) 7, 223-229. PubMed Europe PubMed DOI I
Morisaki,N., Moriwaki,S., Sugiyama-Nakagiri,Y., Haketa,K., Takema,Y. and Imokawa,G. Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses J Biol Chem (2010) 285, 39819-39827. PubMed Europe PubMed DOI
Siepmann,M., Kumar,S., Mayer,G. and Walter,J. Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt PLoS ONE (2010) 5, e13134-e13134. PubMed Europe PubMed DOI PMC EPMC
Zheng,R., Horiguchi,A., Iida,K., Lee,J., Shen,R., Goodman,O.B., Jr. and Nanus,D.M. Neutral endopeptidase is a myristoylated protein Mol Cell Biochem (2010) 335, 173-180. PubMed Europe PubMed DOI
Zraika,S., Aston-Mourney,K., Marek,P., Hull,R.L., Green,P.S., Udayasankar,J., Subramanian,S.L., Raleigh,D.P. and Kahn,S.E. Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation J Biol Chem (2010) 285, 18177-18183. PubMed Europe PubMed DOI

2009

Belyaev,N.D., Nalivaeva,N.N., Makova,N.Z. and Turner,A.J. Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease EMBO Rep (2009) 10, 94-100. PubMed Europe PubMed DOI PMC EPMC
Davidson,E., Coppey,L., Lu,B., Arballo,V., Calcutt,N.A., Gerard,C. and Yorek,M. The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy Exp Diabetes Res (2009) 2009, 431980-431980. PubMed Europe PubMed DOI PMC EPMC K
Dempsey,E.C., Wick,M.J., Karoor,V., Barr,E.J., Tallman,D.W., Wehling,C.A., Walchak,S.J., Laudi,S., Le,M., Oka,M., Majka,S., Cool,C.D., Fagan,K.A., Klemm,D.J., Hersh,L.B., Gerard,N.P., Gerard,C. and Miller,Y.E. Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia Am J Pathol (2009) 174, 782-796. PubMed Europe PubMed DOI PMC EPMC K
Dive,V., Chang,C.F., Yiotakis,A. and Sturrock,E.D. Inhibition of zinc metallopeptidases in cardiovascular disease - from unity to trinity, or duality? Curr Pharm Des (2009) 15, 3606-3621. PubMed Europe PubMed DOI V I
Guan,H., Liu,Y., Daily,A., Police,S., Kim,M.H., Oddo,S., LaFerla,F.M., Pauly,J.R., Murphy,M.P. and Hersh,L.B. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease J Neurosci Res (2009) 87, 1462-1473. PubMed Europe PubMed DOI U
Johnson,V.E., Stewart,W., Graham,D.I., Stewart,J.E., Praestgaard,A.H. and Smith,D.H. A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury J Neurotrauma (2009) 26, 1197-1202. PubMed Europe PubMed DOI M
Liu,Y., Studzinski,C., Beckett,T., Guan,H., Hersh,M.A., Murphy,M.P., Klein,R. and Hersh,L.B. Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease Mol Ther (2009) 17, 1381-1386. PubMed Europe PubMed DOI U
Meilandt,W.J., Cisse,M., Ho,K., Wu,T., Esposito,L.A., Scearce-Levie,K., Cheng,I.H., Yu,G.Q. and Mucke,L. Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice J Neurosci (2009) 29, 1977-1986. PubMed Europe PubMed DOI PMC EPMC U
Miners,J.S., Baig,S., Tayler,H., Kehoe,P.G. and Love,S. Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity J Neuropathol Exp Neurol (2009) 68, 902-914. PubMed Europe PubMed DOI
Mohajeri,M.H. and Wolfer,D.P. Neprilysin deficiency-dependent impairment of cognitive functions in a mouse model of amyloidosis Neurochem Res (2009) 34, 717-726. PubMed Europe PubMed DOI
Niv,M.Y., Iida,K., Zheng,R., Horiguchi,A., Shen,R. and Nanus,D.M. Rational redesign of neutral endopeptidase binding to merlin and moesin proteins Protein Sci (2009) 18, 1042-1050. PubMed Europe PubMed DOI PMC EPMC
Pankow,K., Schwiebs,A., Becker,M., Siems,W.E., Krause,G. and Walther,T. Structural substrate conditions required for neutral endopeptidase-mediated natriuretic peptide degradation J Mol Biol (2009) 393, 496-503. PubMed Europe PubMed DOI P
Rose,J.B., Crews,L., Rockenstein,E., Adame,A., Mante,M., Hersh,L.B., Gage,F.H., Spencer,B., Potkar,R., Marr,R.A. and Masliah,E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease J Neurosci (2009) 29, 1115-1125. PubMed Europe PubMed DOI PMC EPMC U
Vepsalainen,S., Helisalmi,S., Mannermaa,A., Pirttila,T., Soininen,H. and Hiltunen,M. Combined risk effects of IDE and NEP gene variants on Alzheimer disease J Neurol Neurosurg Psychiatry (2009) 80, 1268-1270. PubMed Europe PubMed DOI M
Walther,T., Albrecht,D., Becker,M., Schubert,M., Kouznetsova,E., Wiesner,B., Maul,B., Schliebs,R., Grecksch,G., Furkert,J., Sterner-Kock,A., Schultheiss,H.P., Becker,A. and Siems,W.E. Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase PLoS ONE (2009) 4, e4590-e4590. PubMed Europe PubMed DOI PMC EPMC K
Wang,R., Wang,S., Malter,J.S. and Wang,D.S. Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells J Neurochem (2009) 108, 1072-1082. PubMed Europe PubMed DOI PMC EPMC I
Xiao,Z.M., Sun,L., Liu,Y.M., Zhang,J.J. and Huang,J. Estrogen regulation of the neprilysin gene through a hormone-responsive element J Mol Neurosci (2009) 39, 22-26. PubMed Europe PubMed DOI
Yang,L., Hao,J., Zhang,J., Xia,W., Dong,X., Hu,X., Kong,F. and Cui,X. Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin J Pharm Pharmacol (2009) 61, 375-380. PubMed Europe PubMed DOI

2008

Broccolini,A., Gidaro,T., De Cristofaro,R., Morosetti,R., Gliubizzi,C., Ricci,E., Tonali,P.A. and Mirabella,M. Hyposialylation of neprilysin possibly affects its expression and enzymatic activity in hereditary inclusion-body myopathy muscle J Neurochem (2008) 105, 971-981. PubMed Europe PubMed DOI
El-Amouri,S.S., Zhu,H., Yu,J., Marr,R., Verma,I.M. and Kindy,M.S. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease Am J Pathol (2008) 172, 1342-1354. PubMed Europe PubMed DOI PMC EPMC
Hellstrom-Lindahl,E., Ravid,R. and Nordberg,A. Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels Neurobiol Aging (2008) 29, 210-221. PubMed Europe PubMed DOI
Hersh,L.B. and Rodgers,D.W. Neprilysin and amyloid beta peptide degradation Curr Alzheimer Res (2008) 5, 225-231. PubMed Europe PubMed DOI
Horiguchi,A., Chen,D.Y., Goodman,O.B., Jr., Zheng,R., Shen,R., Guan,H., Hersh,L.B. and Nanus,D.M. Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis Prostate Cancer Prostatic Dis (2008) 11, 79-87. PubMed Europe PubMed DOI
Iijima-Ando,K., Hearn,S.A., Granger,L., Shenton,C., Gatt,A., Chiang,H.C., Hakker,I., Zhong,Y. and Iijima,K. Overexpression of neprilysin reduces Alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila J Biol Chem (2008) 283, 19066-19076. PubMed Europe PubMed DOI PMC EPMC
Imokawa,G. Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase Arch Dermatol Res (2008) 300 Suppl 1, S7-S20. PubMed Europe PubMed DOI
Malito,E., Hulse,R.E. and Tang,W.J. Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin Cell Mol Life Sci (2008) 65, 2574-2585. PubMed Europe PubMed DOI PMC EPMC
Miners,J.S., Verbeek,M.M., Rikkert,M.O., Kehoe,P.G. and Love,S. Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid J Neurosci Methods (2008) 167, 229-236. PubMed Europe PubMed DOI A
Morgenthaler,M., Aebi,J.D., Gruninger,F., Mona,D., Wagner,B., Kansy,M. and Diederich,F. A fluorine scan of non-peptidic inhibitors of neprilysin: fluorophobic and fluorophilic regions in an enzyme active site J Fluor Chem (2008) 129, 852-865. DOI I
Spencer,B., Marr,R.A., Rockenstein,E., Crews,L., Adame,A., Potkar,R., Patrick,C., Gage,F.H., Verma,I.M. and Masliah,E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice BMC Neurosci (2008) 9, 109-109. PubMed Europe PubMed DOI PMC EPMC U
Yao,M., Nguyen,T.V., Rosario,E.R., Ramsden,M. and Pike,C.J. Androgens regulate neprilysin expression: role in reducing beta-amyloid levels J Neurochem (2008) 105, 2477-2488. PubMed Europe PubMed DOI

2007

Barros,N.M., Campos,M., Bersanetti,P.A., Oliveira,V., Juliano,M.A., Boileau,G., Juliano,L. and Carmona,A.K. Neprilysin carboxydipeptidase specificity studies and improvement in its detection with fluorescence energy transfer peptides Biol Chem (2007) 388, 447-455. PubMed Europe PubMed DOI P
Eisele,Y.S., Baumann,M., Klebl,B., Nordhammer,C., Jucker,M. and Kilger,E. Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin Mol Biol Cell (2007) 18, 3591-3600. PubMed Europe PubMed DOI PMC EPMC
El-Amouri,S.S., Zhu,H., Yu,J., Gage,F.H., Verma,I.M. and Kindy,M.S. Neprilysin protects neurons against Abeta peptide toxicity Brain Res (2007) 1152, 191-200. PubMed Europe PubMed DOI PMC EPMC U
Farris,W., Schutz,S.G., Cirrito,J.R., Shankar,G.M., Sun,X., George,A., Leissring,M.A., Walsh,D.M., Qiu,W.Q., Holtzman,D.M. and Selkoe,D.J. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy Am J Pathol (2007) 171, 241-251. PubMed Europe PubMed DOI PMC EPMC K U
Hemming,M.L., Patterson,M., Reske-Nielsen,C., Lin,L., Isacson,O. and Selkoe,D.J. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease PLoS Medicine (2007) 4, e262-e262. PubMed Europe PubMed DOI PMC EPMC
Horiguchi,A., Zheng,R., Goodman,O.B., Jr., Shen,R., Guan,H., Hersh,L.B. and Nanus,D.M. Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth Cancer Gene Ther (2007) 14, 583-589. PubMed Europe PubMed DOI U
Makretsov,N.A., Hayes,M., Carter,B.A., Dabiri,S., Gilks,C.B. and Huntsman,D.G. Stromal CD10 expression in invasive breast carcinoma correlates with poor prognosis, estrogen receptor negativity, and high grade Mod Pathol (2007) 20, 84-89. PubMed Europe PubMed DOI
Oefner,C., Pierau,S., Schulz,H. and Dale,G.E. Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV Acta Crystallogr D Biol Crystallogr (2007) 63, 975-981. PubMed Europe PubMed DOI S I
Pankow,K., Wang,Y., Gembardt,F., Krause,E., Sun,X., Krause,G., Schultheiss,H.P., Siems,W.E. and Walther,T. Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide Circ Res (2007) 101, 875-882. PubMed Europe PubMed DOI
Pryde,D.C., Cook,A.S., Burring,D.J., Jones,L.H., Foll,S., Platts,M.Y., Sanderson,V., Corless,M., Stobie,A., Middleton,D.S., Foster,L., Barker,L., Van Der Graaf,P., Stacey,P., Kohl,C., Coggon,S. and Beaumont,K. Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder Bioorg Med Chem (2007) 15, 142-159. PubMed Europe PubMed DOI I
Wood,L.S., Pickering,E.H., McHale,D. and Dechairo,B.M. Association between neprilysin polymorphisms and sporadic Alzheimer's disease Neurosci Lett (2007) 427, 103-106. PubMed Europe PubMed DOI M

2006

[YEAR:9-1-2006]Broccolini,A., Gidaro,T., Morosetti,R., Gliubizzi,C., Servidei,T., Pescatori,M., Tonali,P.A., Ricci,E. and Mirabella,M. Neprilysin participates in skeletal muscle regeneration and is accumulated in abnormal muscle fibres of inclusion body myositis J Neurochem (9-1-2006) 96, 777-789. PubMed Europe PubMed DOI I
Daily,A., Nath,A. and Hersh,L.B. Tat peptides inhibit neprilysin J Neurovirol (2006) 12, 153-160. PubMed Europe PubMed DOI
[YEAR:14-8-2006]Eckman,E.A., Adams,S.K., Troendle,F.J., Stodola,B.A., Kahn,M.A., Fauq,A.H., Xiao,H.D., Bernstein,K.E. and Eckman,C.B. Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme J Biol Chem (14-8-2006) 281, 30471-30478. PubMed Europe PubMed DOI K
[YEAR:28-8-2006]Goodman,O.B., Jr., Febbraio,M., Simantov,R., Zheng,R., Shen,R., Silverstein,R.L. and Nanus,D.M. Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2 J Biol Chem (28-8-2006) 281, 33597-33605. PubMed Europe PubMed DOI
[YEAR:16-3-2006]Hong,C.S., Goins,W.F., Goss,J.R., Burton,E.A. and Glorioso,J.C. Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo Gene Ther (16-3-2006) 13, 1068-1079. PubMed Europe PubMed DOI
[YEAR:8-8-2006]Kitabgi,P. Inactivation of neurotensin and neuromedin N by Zn metallopeptidases Peptides (8-8-2006) 27, 2515-2522. PubMed Europe PubMed DOI V
[YEAR:22-9-2006]Madani,R., Poirier,R., Wolfer,D.P., Welzl,H., Groscurth,P., Lipp,H.P., Lu,B., El Mouedden,M., Mercken,M., Nitsch,R.M. and Mohajeri,M.H. Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo J Neurosci Res (22-9-2006) 84, 1871-1878. PubMed Europe PubMed DOI K
[YEAR:8-12-2006]Mazur-Kolecka,B. and Frackowiak,J. Neprilysin protects human neuronal progenitor cells against impaired development caused by amyloid-beta peptide Brain Res (8-12-2006) 1124, 10-18. PubMed Europe PubMed DOI
Miners,J.S., Van Helmond,Z., Chalmers,K., Wilcock,G., Love,S. and Kehoe,P.G. Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy J Neuropathol Exp Neurol (2006) 65, 1012-1021. PubMed Europe PubMed DOI U
[YEAR:14-12-2006]Mouri,A., Zou,L.B., Iwata,N., Saido,T.C., Wang,D., Wang,M.W., Noda,Y. and Nabeshima,T. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory Behav Brain Res (14-12-2006) 168, 83-91. PubMed Europe PubMed DOI I
[YEAR:2-11-2006]Osman,I., Dai,J., Mikhail,M., Navarro,D., Taneja,S.S., Lee,P., Christos,P., Shen,R. and Nanus,D.M. Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression Cancer (2-11-2006) 107, 2628-2636. PubMed Europe PubMed DOI
[YEAR:5-4-2006]Pardossi-Piquard,R., Dunys,J., Yu,G., St George-Hyslop,P., Alves da Costa,C. and Checler,F. Neprilysin activity and expression are controlled by nicastrin J Neurochem (5-4-2006) 97, 1052-1056. PubMed Europe PubMed DOI
Pryde,D.C., Maw,G.N., Planken,S., Platts,M.Y., Sanderson,V., Corless,M., Stobie,A., Barber,C.G., Russell,R., Foster,L., Barker,L., Wayman,C., Van Der Graaf,P., Stacey,P., Morren,D., Kohl,C., Beaumont,K., Coggon,S. and Tute,M. Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides J Med Chem (2006) 49, 4409-4424. PubMed Europe PubMed DOI I
[YEAR:25-9-2006]Rice,G.I., Jones,A.L., Grant,P.J., Carter,A.M., Turner,A.J. and Hooper,N.M. Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study Hypertension (25-9-2006) 48, 914-920. PubMed Europe PubMed DOI
Wisner,A., Dufour,E., Messaoudi,M., Nejdi,A., Marcel,A., Ungeheuer,M.N. and Rougeot,C. Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways Proc Natl Acad Sci U S A (2006) 103, 17979-17984. PubMed Europe PubMed DOI PMC EPMC I
Zou,L.B., Mouri,A., Iwata,N., Saido,T.C., Wang,D., Wang,M.W., Mizoguchi,H., Noda,Y. and Nabeshima,T. Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid beta and impairment of learning and memory J Pharmacol Exp Ther (2006) 317, 334-340. PubMed Europe PubMed DOI I

2005

Battistini,B., Daull,P. and Jeng,A.Y. CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzyme Cardiovasc Drug Rev (2005) 23, 317-330. PubMed Europe PubMed I
Glatzel,M., Mohajeri,M.H., Poirier,R., Nitsch,R.M., Schwarz,P., Lu,B. and Aguzzi,A. No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis J Gen Virol (2005) 86, 1861-1867. PubMed Europe PubMed DOI
[YEAR:18-8-2005]Iwata,N., Higuchi,M. and Saido,T.C. Metabolism of amyloid-beta peptide and Alzheimer's disease Pharmacol Ther (18-8-2005) 108, 129-148. PubMed Europe PubMed DOI
Karoor,V., Walchak,S.J., Miller,Y.E. and Dempsey,E.C. Role of rho in the increased migration of pulmonary artery smooth muscle cells observed in the neprilysin knockout mouse Chest (2005) 128, 582S-583S. PubMed Europe PubMed DOI K
Lew,R.A., Tochon-Danguy,N., Hamilton,C.A., Stewart,K.M., Aguilar,M.I. and Smith,A.I. Quenched fluorescent substrate-based peptidase assays Methods Mol Biol (2005) 298, 143-150. PubMed Europe PubMed DOI
Maruyama,M., Higuchi,M., Takaki,Y., Matsuba,Y., Tanji,H., Nemoto,M., Tomita,N., Matsui,T., Iwata,N., Mizukami,H., Muramatsu,S., Ozawa,K., Saido,T.C., Arai,H. and Sasaki,H. Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease Ann Neurol (2005) 57, 832-842. PubMed Europe PubMed DOI
[YEAR:19-5-2005]Pardossi-Piquard,R., Petit,A., Kawarai,T., Sunyach,C., Alves da Costa,C., Vincent,B., Ring,S., D'Adamio,L., Shen,J., Muller,U., St George Hyslop,P. and Checler,F. Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP Neuron (19-5-2005) 46, 541-554. PubMed Europe PubMed DOI
[YEAR:16-7-2005]Plamboeck,A., Holst,J.J., Carr,R.D. and Deacon,C.F. Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig Diabetologia (16-7-2005) 48, 1882-1890. PubMed Europe PubMed DOI
Sahli,S., Stump,B., Welti,T., Schweizer,W.B., Diederich,F., Blum-Kaelin,D., Aebi,J.D. and Bohm,H.J. A new class of inhibitors for the metalloprotease neprilysin based on a central imidazole scaffold Helv Chim Acta (2005) 88, 707-730. I
Sahli,S., Frank,B., Schweizer,W.B., Diederich,F., Blum-Kaelin,D., Aebi,J.D. and Bohm,H.J. Second-generation inhibitors for the metalloprotease neprilysin based on bicyclic heteroaromatic scaffolds: synthesis, biological activity, and X-ray crystal-structure analysis Helv Chim Acta (2005) 88, 731-750. S I
Shi,J., Zhang,S., Tang,M., Ma,C., Zhao,J., Li,T., Liu,X., Sun,Y., Guo,Y., Han,H., Ma,Y. and Zhao,Z. Mutation screening and association study of the neprilysin gene in sporadic Alzheimer's disease in Chinese persons J Gerontol A Biol Sci Med Sci (2005) 60, 301-306. PubMed Europe PubMed
Wang,D.S., Lipton,R.B., Katz,M.J., Davies,P., Buschke,H., Kuslansky,G., Verghese,J., Younkin,S.G., Eckman,C. and Dickson,D.W. Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging J Neuropathol Exp Neurol (2005) 64, 378-385. PubMed Europe PubMed

2004

[YEAR:20-4-2004]Hama,E., Shirotani,K., Iwata,N. and Saido,T.C. Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons J Biol Chem (20-4-2004) 279, 30259-30264. PubMed Europe PubMed DOI
Helisalmi,S., Hiltunen,M., Vepsalainen,S., Iivonen,S., Mannermaa,A., Lehtovirta,M., Koivisto,A.M., Alafuzoff,I. and Soininen,H. Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients J Neurol Neurosurg Psychiatry (2004) 75, 1746-1748. PubMed Europe PubMed DOI PMC EPMC M
[YEAR:26-8-2004]Huang,J., Guan,H., Booze,R.M., Eckman,C.B. and Hersh,L.B. Estrogen regulates neprilysin activity in rat brain Neurosci Lett (26-8-2004) 367, 85-87. PubMed Europe PubMed DOI
Inguimbert,N., Poras,H., Dhotel,H., Beslot,F., Scalbert,E., Bennejean,C., Renard,P., Fournie-Zaluski,M.C. and Roques,B.P. In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position J Pept Res (2004) 63, 99-107. PubMed Europe PubMed DOI I
Iwase,A., Shen,R., Navarro,D. and Nanus,D.M. Direct binding of neutral endopeptidase 24.11 to ezrin/radixin/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins J Biol Chem (2004) 279, 11898-11905. PubMed Europe PubMed DOI
[YEAR:28-1-2004]Iwata,N., Mizukami,H., Shirotani,K., Takaki,Y., Muramatsu,S., Lu,B., Gerard,N.P., Gerard,C., Ozawa,K. and Saido,T.C. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain J Neurosci (28-1-2004) 24, 991-998. PubMed Europe PubMed DOI
Marr,R.A., Guan,H., Rockenstein,E., Kindy,M., Gage,F.H., Verma,I., Masliah,E. and Hersh,L.B. Neprilysin regulates amyloid beta peptide levels J Mol Neurosci (2004) 22, 5-11. PubMed Europe PubMed DOI
[YEAR:26-3-2004]Mohajeri,M.H., Kuehnle,K., Li,H., Poirier,R., Tracy,J. and Nitsch,R.M. Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease FEBS Lett (26-3-2004) 562, 16-21. PubMed Europe PubMed DOI
Oefner,C., Roques,B.P., Fournie-Zaluski,M.C. and Dale,G.E. Structural analysis of neprilysin with various specific and potent inhibitors Acta Crystallogr D Biol Crystallogr (2004) 60, 392-396. PubMed Europe PubMed DOI S I
[YEAR:29-7-2004]Rice,G.I., Thomas,D.A., Grant,P.J., Turner,A.J. and Hooper,N.M. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism Biochem J (29-7-2004) 383, 45-51. PubMed Europe PubMed DOI PMC EPMC
[YEAR:5-7-2004]Sahli,S., Stump,B., Welti,T., Blum-Kaelin,D., Aebi,J.D., Oefner,C., Bohm,H.J. and Diederich,F. Structure-based design, synthesis, and in vitro evaluation of nonpeptidic neprilysin inhibitors Chembiochem (5-7-2004) 5, 996-1000. PubMed Europe PubMed DOI I
Sakai,A., Ujike,H., Nakata,K., Takehisa,Y., Imamura,T., Uchida,N., Kanzaki,A., Yamamoto,M., Fujisawa,Y., Okumura,K. and Kuroda,S. Association of the neprilysin gene with susceptibility to late-onset Alzheimer's disease Dement Geriatr Cogn Disord (2004) 17, 164-169. PubMed Europe PubMed DOI M
Skidgel,R.A. and Erdos,E.G. Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies Peptides (2004) 25, 521-525. PubMed Europe PubMed DOI
[YEAR:1-3-2004]Song,J., Aumuller,G., Xiao,F., Wilhelm,B. and Albrecht,M. Cell specific expression of CD10/neutral endopeptidase 24.11 gene in human prostatic tissue and cells Prostate (1-3-2004) 58, 394-405. PubMed Europe PubMed DOI
Trapani,A.J., Beil,M.E., Bruseo,C.W., Savage,P., Firooznia,F. and Jeng,A.Y. CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme J Cardiovasc Pharmacol (2004) 44 Suppl 1, S211-S215. PubMed Europe PubMed DOI I
Turner,A.J. Neprilysin [ISSN:0-12-079610-4] (2004) 2, 419-426. V

2003

Campbell,D.J. Vasopeptidase inhibition: a double-edged sword? Hypertension (2003) 41, 383-389. PubMed Europe PubMed DOI I
Clarimon,J., Munoz,F.J., Boada,M., Tarraga,L., Sunyer,J., Bertranpetit,J. and Comas,D. Possible increased risk for Alzheimer's disease associated with neprilysin gene J Neural Transm (2003) 110, 651-657. PubMed Europe PubMed DOI M
[YEAR:23-10-2003]Kanemitsu,H., Tomiyama,T. and Mori,H. Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form Neurosci Lett (23-10-2003) 350, 113-116. PubMed Europe PubMed DOI
Le Guen,S., Mas Nieto,M., Canestrelli,C., Chen,H., Fournie-Zaluski,M.C., Cupo,A., Maldonado,R., Roques,B.P. and Noble,F. Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone Pain (2003) 104, 139-148. PubMed Europe PubMed DOI I
[YEAR:15-3-2003]Marr,R.A., Rockenstein,E., Mukherjee,A., Kindy,M.S., Hersh,L.B., Gage,F.H., Verma,I.M. and Masliah,E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice J Neurosci (15-3-2003) 23, 1992-1996. PubMed Europe PubMed
[YEAR:30-10-2003]Newell,A.J., Sue,L.I., Scott,S., Rauschkolb,P.K., Walker,D.G., Potter,P.E. and Beach,T.G. Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid Neurosci Lett (30-10-2003) 350, 178-180. PubMed Europe PubMed DOI I
Rougeot,C., Messaoudi,M., Hermitte,V., Rigault,A.G., Blisnick,T., Dugave,C., Desor,D. and Rougeon,F. Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity Proc Natl Acad Sci U S A (2003) 100, 8549-8554. PubMed Europe PubMed DOI PMC EPMC I
Sezaki,N., Ishimaru,F., Tabayashi,T., Kataoka,I., Nakase,K., Fujii,K., Kozuka,T., Nakayama,H., Harada,M. and Tanimoto,M. The type 1 CD10/neutral endopeptidase 24.11 promoter: functional characterization of the 5'-untranslated region Br J Haematol (2003) 123, 177-183. PubMed Europe PubMed DOI
[YEAR:10-10-2003]Wang,D.S., Iwata,N., Hama,E., Saido,T.C. and Dickson,D.W. Oxidized neprilysin in aging and Alzheimer's disease brains Biochem Biophys Res Commun (10-10-2003) 310, 236-241. PubMed Europe PubMed DOI
Yamada,M., Sodeyama,N., Itoh,Y., Takahashi,A., Otomo,E., Matsushita,M. and Mizusawa,H. Association of neprilysin polymorphism with cerebral amyloid angiopathy J Neurol Neurosurg Psychiatry (2003) 74, 749-751. PubMed Europe PubMed DOI PMC EPMC M

2002

Fischer,H.S., Zernig,G., Hauser,K.F., Gerard,C., Hersh,L.B. and Saria,A. Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide J Mol Neurosci (2002) 18, 129-134. PubMed Europe PubMed DOI
Fukami,S., Watanabe,K., Iwata,N., Haraoka,J., Lu,B., Gerard,N.P., Gerard,C., Fraser,P., Westaway,D., St George-Hyslop,P. and Saido,T.C. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology Neurosci Res (2002) 43, 39-56. PubMed Europe PubMed DOI
[YEAR:1-11-2002]Iwata,N., Takaki,Y., Fukami,S., Tsubuki,S. and Saido,T.C. Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging J Neurosci Res (1-11-2002) 70, 493-500. PubMed Europe PubMed DOI
Lightner,A.M., Jordan,T.H., Bunnett,N.W., Grady,E.F. and Kirkwood,K.S. Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury Surgery (2002) 132, 193-199. PubMed Europe PubMed DOI
[YEAR:20-9-2002]Mohajeri,M.H., Wollmer,M.A. and Nitsch,R.M. Abeta42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo J Biol Chem (20-9-2002) 277, 35460-35465. PubMed Europe PubMed DOI
[YEAR:12-7-2002]Navarrete Santos,A., Wulfanger,J., Helbing,G., Blosz,T., Langner,J. and Riemann,D. Two C-terminal cysteines are necessary for proper folding of the peptidase neprilysin/CD10 Biochem Biophys Res Commun (12-7-2002) 295, 423-427. PubMed Europe PubMed DOI
[YEAR:1-3-2002]Oda,M., Morino,H., Maruyama,H., Terasawa,H., Izumi,Y., Torii,T., Sasaki,K., Nakamura,S. and Kawakami,H. Dinucleotide repeat polymorphisms in the neprilysin gene are not associated with sporadic Alzheimer's disease Neurosci Lett (1-3-2002) 320, 105-107. PubMed Europe PubMed M
Suzuki,T., Ino,K., Kikkawa,F., Uehara,C., Kajiyama,H., Shibata,K. and Mizutani,S. Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway Placenta (2002) 23, 475-482. PubMed Europe PubMed DOI

2001

[YEAR:15-12-2001]Chevrier,A., Mort,J.S., Crine,P., Hoemann,C.D. and Buschmann,M.D. Soluble recombinant neprilysin induces aggrecanase-mediated cleavage of aggrecan in cartilage explant cultures Arch Biochem Biophys (15-12-2001) 396, 178-186. PubMed Europe PubMed DOI
Dai,J., Shen,R., Sumitomo,M., Goldberg,J.S., Geng,Y., Navarro,D., Xu,S., Koutcher,J.A., Garzotto,M., Powell,C.T. and Nanus,D.M. Tumor-suppressive effects of neutral endopeptidase in androgen-independent prostate cancer cells Clin Cancer Res (2001) 7, 1370-1377. PubMed Europe PubMed
Hama,E., Shirotani,K., Masumoto,H., Sekine-Aizawa,Y., Aizawa,H. and Saido,T.C. Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons J Biochem (2001) 130, 721-726. PubMed Europe PubMed
Hubner,R.A., Kubota,E., Casley,D.J., Johnston,C.I. and Burrell,L.M. In-vitro and in-vivo inhibition of rat neutral endopeptidase and angiotensin converting enzyme with the vasopeptidase inhibitor gemopatrilat J Hypertens (2001) 19, 941-946. PubMed Europe PubMed DOI I
[YEAR:25-5-2001]Iwata,N., Tsubuki,S., Takaki,Y., Shirotani,K., Lu,B., Gerard,N.P., Gerard,C., Hama,E., Lee,H.J. and Saido,T.C. Metabolic regulation of brain Abeta by neprilysin Science (25-5-2001) 292, 1550-1552. PubMed Europe PubMed DOI K
Kirkwood,K.S., Bunnett,N.W., Maa,J., Castagliolo,I., Liu,B., Gerard,N., Zacks,J., Pothoulakis,C. and Grady,E.F. Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A Am J Physiol Gastrointest Liver Physiol (2001) 281, G544-G551. PubMed Europe PubMed
[YEAR:15-1-2001]Scholzen,T.E., Steinhoff,M., Bonaccorsi,P., Klein,R., Amadesi,S., Geppetti,P., Lu,B., Gerard,N.P., Olerud,J.E., Luger,T.A., Bunnett,N.W., Grady,E.F., Armstrong,C.A. and Ansel,J.C. Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis J Immunol (15-1-2001) 166, 1285-1291. PubMed Europe PubMed K
[YEAR:15-6-2001]Shirotani,K., Tsubuki,S., Iwata,N., Takaki,Y., Harigaya,W., Maruyama,K., Kiryu-Seo,S., Kiyama,H., Iwata,H., Tomita,T., Iwatsubo,T. and Saido,T.C. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases J Biol Chem (15-6-2001) 276, 21895-21901. PubMed Europe PubMed DOI I
Tsuji,N., Moriwaki,S., Suzuki,Y., Takema,Y. and Imokawa,G. The role of elastases secreted by fibroblasts in wrinkle formation: implication through selective inhibition of elastase activity Photochem Photobiol (2001) 74, 283-290. PubMed Europe PubMed DOI I
Tsukahara,K., Takema,Y., Moriwaki,S., Tsuji,N., Suzuki,Y., Fujimura,T. and Imokawa,G. Selective inhibition of skin fibroblast elastase elicits a concentration-dependent prevention of ultraviolet B-induced wrinkle formation J Invest Dermatol (2001) 117, 671-677. PubMed Europe PubMed DOI I
[YEAR:12-1-2001]Yasojima,K., Akiyama,H., McGeer,E.G. and McGeer,P.L. Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide Neurosci Lett (12-1-2001) 297, 97-100. PubMed Europe PubMed DOI

2000

Aberdam,E., Auberger,P., Ortonne,J.P. and Ballotti,R. Neprilysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins J Invest Dermatol (2000) 115, 381-387. PubMed Europe PubMed DOI
[YEAR:6-4-2000]Chen,H., Noble,F., Mothe,A., Meudal,H., Coric,P., Danascimento,S., Roques,B.P., George,P. and Fournie-Zaluski,M.C. Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities J Med Chem (6-4-2000) 43, 1398-1408. PubMed Europe PubMed DOI I
Dale,G.E., D'Arcy,B., Yuvaniyama,C., Wipf,B., Oefner,C. and D'arcy,A. Purification and crystallization of the extracellular domain of human neutral endopeptidase (neprilysin) expressed in Pichia pastoris Acta Crystallogr D Biol Crystallogr (2000) 56, 894-897. PubMed Europe PubMed DOI E
[YEAR:22-12-2000]Fischer,H.S., Zernig,G., Schuligoi,R., Miczek,K.A., Hauser,K.F., Gerard,C. and Saria,A. Alterations within the endogenous opioid system in mice with targeted deletion of the neutral endopeptidase ('enkephalinase') gene Regul Pept (22-12-2000) 96, 53-58. PubMed Europe PubMed DOI K
[YEAR:1-6-2000]Marie-Claire,C., Tiraboschi,G., Ruffet,E., Inguimbert,N., Fournie-Zaluski,M.C. and Roques,B.P. Exploration of the S1' subsite of neprilysin: a joined molecular modeling and site-directed mutagenesis study Proteins (1-6-2000) 39, 365-371. PubMed Europe PubMed DOI
McDowell,G. and Nicholls,D.P. The therapeutic potential of candoxatril, a neutral endopeptidase inhibitor, in humans Cardiovasc Drug Rev (2000) 18, 259-270. I
[YEAR:18-2-2000]Oefner,C., D'arcy,A., Hennig,M., Winkler,F.K. and Dale,G.E. Structure of human neutral endopeptidase (neprilysin) complexed with phosphoramidon J Mol Biol (18-2-2000) 296, 341-349. PubMed Europe PubMed DOI S I
[YEAR:22-12-2000]Shen,R., Sumitomo,M., Dai,J., Hardy,D.O., Navarro,D., Usmani,B., Papandreou,C.N., Hersh,L.B., Shipp,M.A., Freedman,L.P. and Nanus,D.M. Identification and characterization of two androgen response regions in the human neutral endopeptidase gene Mol Cell Endocrinol (22-12-2000) 170, 131-142. PubMed Europe PubMed DOI
Takaki,Y., Iwata,N., Tsubuki,S., Taniguchi,S., Toyoshima,S., Lu,B., Gerard,N.P., Gerard,C., Lee,H.J., Shirotani,K. and Saido,T.C. Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain J Biochem (2000) 128, 897-902. PubMed Europe PubMed

1999

Grasemann,H., Lu,B., Jiao,A., Boudreau,J., Gerard,N.P. and De Sanctis,G.T. Targeted deletion of the neutral endopeptidase gene alters ventilatory responses to acute hypoxia in mice J Appl Physiol (1999) 87, 1266-1271. PubMed Europe PubMed K
Gurbanov,K., Shuranyi,E., Kaballa,A., Fudim,E., Blumberg,S. and Winaver,J. Renal effects of 2-mercaptoacetyl-L-leucyl-L-phenylalanine, a novel selective inhibitor of neutral endopeptidase 24.11 (neprilysin): comparison with SQ 28,603 Gen Pharmacol (1999) 33, 277-281. PubMed Europe PubMed DOI I
[YEAR:12-2-1999]Johnson,G.D., Stevenson,T. and Ahn,K. Hydrolysis of peptide hormones by endothelin-converting enzyme-1. A comparison with neprilysin J Biol Chem (12-2-1999) 274, 4053-4058. PubMed Europe PubMed DOI
Rabinovitch,M. EVE and beyond, retro and prospective insights Am J Physiol Lung Cell Mol Physiol (1999) 277, L5-L12.
[YEAR:28-9-1999]Sturiale,S., Barbara,G., Qiu,B., Figini,M., Geppetti,P., Gerard,N., Gerard,C., Grady,E.F., Bunnett,N.W. and Collins,S.M. Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P Proc Natl Acad Sci U S A (28-9-1999) 96, 11653-11658. PubMed Europe PubMed DOI PMC EPMC K
Tiraboschi,G., Jullian,N., Thery,V., Antonczak,S., Fournie-Zaluski,M.C. and Roques,B.P. A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11) Protein Eng (1999) 12, 141-149. PubMed Europe PubMed S
[YEAR:15-12-1999]Wen,W., Moses,M.A., Wiederschain,D., Arbiser,J.L. and Folkman,J. The generation of endostatin is mediated by elastase Cancer Res (15-12-1999) 59, 6052-6056. PubMed Europe PubMed
[YEAR:1-6-1999]Zappulla,J.P., Wickham,L., Bawab,W., Yang,X.F., Storozhuk,M.V., Castellucci,V.F. and Desgroseillers,L. Cloning and characterization of Aplysia neutral endopeptidase, a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica J Neurosci (1-6-1999) 19, 4280-4292. PubMed Europe PubMed

1998

Belhacene,N., Maulon,L., Guerin,S., Ricci,J.E., Mari,B., Colin,Y., Cartron,J.P. and Auberger,P. Differential expression of the Kell blood group and CD10 antigens: two related membrane metallopeptidases during differentiation of K562 cells by phorbol ester and hemin FASEB J (1998) 12, 531-539. PubMed Europe PubMed
[YEAR:1-10-1998]Li,C. and Hersh,L.B. Characterization of the promoter region of the rat neprilysin gene Arch Biochem Biophys (1-10-1998) 358, 189-195. PubMed Europe PubMed DOI
[YEAR:6-11-1998]Marie-Claire,C., Ruffet,E., Tiraboschi,G. and Fournie-Zaluski,M.C. Differences in transition state stabilization between thermolysin (EC 3.4.24.27) and neprilysin (EC 3.4.24.11) FEBS Lett (6-11-1998) 438, 215-219. PubMed Europe PubMed DOI

1997

Dion,N., Cohen,P., Crine,P. and Boileau,G. Characterisation of neprilysin (EC 3.4.24.11) S2' subsite FEBS Lett (1997) 411, 140-144. PubMed Europe PubMed DOI
Guerin,S., Mari,B., Belhacene,N., Rossi,B., Peyron,J.F. and Auberger,P. CD10 (endopeptidase 24.11) is a thymic peptide-degrading enzyme possibly involved in the regulation of thymocyte functions Cell Immunol (1997) 175, 85-91. PubMed Europe PubMed DOI I
Guerin,S., Mari,B., Maulon,L., Belhacene,N., Marguet,D. and Auberger,P. CD10 plays a specific role in early thymic development FASEB J (1997) 11, 376-381. PubMed Europe PubMed I
Guerin,S. and Auberger,P. Regulation of thymic development by neprilysin inhibition Adv Exp Med Biol (1997) 421, 93-99. PubMed Europe PubMed I
Guerin,S., Mari,B., Fernandez,E., Belhacene,N., Toribio,M.L. and Auberger,P. CD10 is expressed on human thymic epithelial cell lines and modulates thymopentin-induced cell proliferation FASEB J (1997) 11, 1003-1011. PubMed Europe PubMed
[YEAR:1-11-1997]Hoang,M.V., Sansom,C.E. and Turner,A.J. Mutagenesis of Glu403 to Cys in rabbit neutral endopeptidase-24.11 (neprilysin) creates a disulphide-linked homodimer: analogy with endothelin-converting enzyme Biochem J (1-11-1997) 327, 925-929. PubMed Europe PubMed PMC EPMC
Medeiros,M.A., Franca,M.S., Boileau,G., Juliano,L. and Carvalho,K.M. Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases Braz J Med Biol Res (1997) 30, 1157-1162. PubMed Europe PubMed A
Norcini,G., Morazzoni,G., Pocchiari,F., Santangelo,F. and Semeraro,C. Novel selective thiol inhibitors of neutral endopeptidase containing heterocycles at P-2' position J.Enz.Inhib. (1997) 12, 155-160.
Saria,A., Hauser,K.F., Traurig,H.H., Turbek,C.S., Hersh,L. and Gerard,C. Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice Neurosci Lett (1997) 234, 27-30. PubMed Europe PubMed DOI K
Turner,A.J. and Tanzawa,K. Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX FASEB J (1997) 11, 355-364. PubMed Europe PubMed V

1996

Bohacek,R., DeLombaert,S., Mcmartin,C., Priestle,J. and Grutter,M. Three-dimensional models of ACE and NEP inhibitors and their use in the design of potent dual ACE/NEP inhibitors J Am Chem Soc (1996) 118, 8231-8249. DOI S I
Carvalho,K.M., Boileau,G., Camargo,A.C. and Juliano,L. A highly selective assay for neutral endopeptidase based on the cleavage of a fluorogenic substrate related to Leu-enkephalin Anal Biochem (1996) 237, 167-173. PubMed Europe PubMed DOI A
Danvy,D., Monteil,T., Plaquevent,J.C., Duhamel,L., Duhamel,P., Gros,C., Noel,N., Schwartz,J.C. and Lecomte,J.M. Studies on the structural feature of S'1 subsite of neprilysin (EC.3.4.24.11): stereochemical requirement for the enzyme-inhibitor docking process Bioorg Med Chem Lett (1996) 6, 2437-2440. I
Fink,C.A., Carlson,J.E., McTaggart,P.A., Qiao,Y., Webb,R., Chatelain,R., Jeng,A.Y. and Trapani,A.J. Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase J Med Chem (1996) 39, 3158-3168. PubMed Europe PubMed DOI I
Fournie-Zaluski,M.C., Coric,P., Thery,V., Gonzalez,W., Meudal,H., Turcaud,S., Michel,J.B. and Roques,B.P. Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action J Med Chem (1996) 39, 2594-2608. PubMed Europe PubMed DOI I
McKittrick,B.A., Stamford,A.W., Weng,X., Ma,K., Chackalamannil,S., Czarniecki,M., Cleven,R.M. and Fawzi,A.B. Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11 Bioorg Med Chem Lett (1996) 6, 1629-1634. DOI I
Spungin-Bialik,A., Ben-Meir,D., Fudim,E., Carmeli,S. and Blumberg,S. Sensitive substrates for neprilysin (neutral endopeptidase) and thermolysin that are highly resistant to serine proteases FEBS Lett (1996) 380, 79-82. PubMed Europe PubMed DOI A
Turner,A.J., Murphy,L.J., Medeiros,M.S. and Barnes,K. Endopeptidase-24.11 (neprilysin) and relatives: twenty years on Adv Exp Med Biol (1996) 389, 141-148. PubMed Europe PubMed V

1995

Dion,N., Le Moual,H., Fournie-Zaluski,M.C., Roques,B.P., Crine,P. and Boileau,G. Evidence that Asn542 of neprilysin (EC 3.4.24.11) is involved in binding of the P2' residue of substrates and inhibitors Biochem J (1995) 311, 623-627. PubMed Europe PubMed PMC EPMC
Haouas,H., Morello,D., Lavenu,A., Billard,M., Jasmin,C. and Boucheix,C. Characterization of the 5' region of the CD10/neutral endopeptidase 24.11 gene Biochem Biophys Res Commun (1995) 207, 933-942. PubMed Europe PubMed DOI
Hupe-Sodmann,K., McGregor,G.P., Bridenbaugh,R., Goke,R., Goke,B., Thole,H., Zimmermann,B. and Voigt,K. Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides Regul Pept (1995) 58, 149-156. PubMed Europe PubMed DOI
Kukkola,P.J., Savage,P., Sakane,Y., Berry,J.C., Bilci,N.A., Ghai,R.D. and Jeng,A.Y. Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin- converting enzyme J Cardiovasc Pharmacol (1995) 26 Suppl 3, S65-S68. PubMed Europe PubMed I
Li,C. and Hersh,L.B. Neprilysin: assay methods, purification, and characterization Methods Enzymol (1995) 248, 253-263. PubMed Europe PubMed DOI A V
[YEAR:1-6-1995]Lu,B., Gerard,N.P., Kolakowski,L.F., Jr., Bozza,M., Zurakowski,D., Finco,O., Carroll,M.C. and Gerard,C. Neutral endopeptidase modulation of septic shock J Exp Med (1-6-1995) 181, 2271-2275. PubMed Europe PubMed DOI PMC EPMC K
Roques,B.P., Noble,F., Crine,P. and Fournie-Zaluski,M.C. Inhibitors of neprilysin: design, pharmacological and clinical applications Methods Enzymol (1995) 248, 263-283. PubMed Europe PubMed DOI V I

1994

De Lombaert,S., Ghai,R.D., Jeng,A.Y., Trapani,A.J. and Webb,R.L. Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme Biochem Biophys Res Commun (1994) 204, 407-412. PubMed Europe PubMed DOI I
[YEAR:15-4-1994]Fournie-Zaluski,M.C., Coric,P., Turcaud,S., Rousselet,N., Gonzalez,W., Barbe,B., Pham,I., Jullian,N., Michel,J.B. and Roques,B.P. New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension J Med Chem (15-4-1994) 37, 1070-1083. PubMed Europe PubMed I
[YEAR:26-4-1994]Fournie-Zaluski,M.C., Gonzalez,W., Turcaud,S., Pham,I., Roques,B.P. and Michel,J.B. Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by the orally active inhibitor mixanpril: a potential therapeutic approach in hypertension Proc Natl Acad Sci U S A (26-4-1994) 91, 4072-4076. PubMed Europe PubMed PMC EPMC I
Goudreau,N., Guis,C., Soleilhac,J.M. and Roques,B.P. Dns-Gly-(p-NO2)Phe-beta Ala, a specific fluorogenic substrate for neutral endopeptidase 24.11 Anal Biochem (1994) 219, 87-95. PubMed Europe PubMed DOI A
Holland,D.R., Barclay,P.L., Danilewicz,J.C., Matthews,B.W. and James,K. Inhibition of thermolysin and neutral endopeptidase 24.11 by a novel glutaramide derivative: X-ray structure determination of the thermolysin-inhibitor complex Biochemistry (1994) 33, 51-56. PubMed Europe PubMed DOI S I
Le Moual,H., Dion,N., Roques,B.P., Crine,P. and Boileau,G. Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11 Eur J Biochem (1994) 221, 475-480. PubMed Europe PubMed

1993

Barnes,K., Turner,A.J. and Kenny,A.J. An immunoelectron microscopic study of pig substantia nigra shows co-localization of endopeptidase-24.11 with substance P Neuroscience (1993) 53, 1073-1082. PubMed Europe PubMed DOI
Gomez-Monterrey,I., Turcaud,S., Lucas,E., Bruetschy,L., Roques,B.P. and Fournie-Zaluski,M.C. Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors J Med Chem (1993) 36, 87-94. PubMed Europe PubMed DOI I
Levy,O.E., Taibi,P., Mobashery,S. and Ghosh,S.S. A mechanism-based inactivation study of neutral endopeptidase 24.11 J Med Chem (1993) 36, 2408-2411. PubMed Europe PubMed I
Watkins,R.W., Vemulapalli,S., Chiu,P.J., Foster,C., Smith,E.M., Neustadt,B., Haslanger,M. and Sybertz,E.J. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor Am J Hypertens (1993) 6, 357-368. PubMed Europe PubMed I

1992

Alton,K.B., Hernandez,A., Alvarez,N. and Patrick,J.E. High-performance liquid chromatographic determination of N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]-L-methionine, the active plasma metabolite of a prodrug atriopeptidase inhibitor (SCH 42495), using a thiol selective (Au/Hg) amperometric detector J Chromatogr (1992) 579, 307-317. PubMed Europe PubMed DOI I
Checler,F., Dauch,P., Barelli,H., Nahon,J.L. and Vincent,J.P. Hydrolysis of rat melanin-concentrating hormone by endopeptidase 24.11 (neutral endopeptidase) Biochem J (1992) 286, 217-221. PubMed Europe PubMed PMC EPMC
Chen,C.Y., Salles,G., Seldin,M.F., Kister,A.E., Reinherz,E.L. and Shipp,M.A. Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site J Immunol (1992) 148, 2817-2825. PubMed Europe PubMed
Kanazawa,M., Casley,D.J., Sybertz,E.J., Haslanger,M.F. and Johnston,C.I. Localization and characterization of neutral metalloendopeptidase (EC 3.4.24.11), the degradative enzyme for atrial natriuretic peptide, in rat kidney using a radioiodinated neutral metalloendopeptidase inhibitor J Pharmacol Exp Ther (1992) 261, 1231-1237. PubMed Europe PubMed I
Kim,Y.A., Shriver,B. and Hersh,L.B. Mutational analysis reveals only one catalytic histidine in neutral endopeptidase ("enkephalinase") Biochem Biophys Res Commun (1992) 184, 883-887. PubMed Europe PubMed DOI

1991

Hersh,L.B. Use of site-directed mutagenesis to elucidate the active site of neutral endopeptidase 24.11 (enkephalinase) NIDA Res Monogr (1991) 111, 188-201. PubMed Europe PubMed
Indig,F.E., Pecht,M., Trainin,N., Burstein,Y. and Blumberg,S. Hydrolysis of thymic humoral factor gamma 2 by neutral endopeptidase (EC 3.4.24.11) Biochem J (1991) 278, 891-894. PubMed Europe PubMed PMC EPMC P
Kanazawa,M. and Johnston,C.I. Distribution and inhibition of neutral metalloendopeptidase (NEP) (EC 3.4.24.11), the major degradative enzyme for atrial natriuretic peptide, in the rat kidney Clin Exp Pharmacol Physiol (1991) 18, 449-453. PubMed Europe PubMed I
Kimura,A., Iwamoto,I., Nakagawa,N., Tomioka,H. and Yoshida,S. Neutral endopeptidase (EC 3.4.24.11) does not hydrolyze recombinant human interleukin-1beta Immunol Lett (1991) 28, 109-114. PubMed Europe PubMed DOI
Le Moual,H., Devault,A., Roques,B.P., Crine,P. and Boileau,G. Identification of glutamic acid 646 as a zinc-coordinating residue in endopeptidase-24.11 J Biol Chem (1991) 266, 15670-15674. PubMed Europe PubMed
Lee,S., Zambas,E.D., Marsh,W.L. and Redman,C.M. Molecular cloning and primary structure of Kell blood group protein Proc Natl Acad Sci U S A (1991) 88, 6353-6357. PubMed Europe PubMed PMC EPMC
Seymour,A.A. The pharmacology of SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11 Cardiovasc Drug Rev (1991) 9, 285-298. I

1990

Bateman,R.C., Jr., Kim,Y.A., Slaughter,C. and Hersh,L.B. N-bromoacetyl-D-leucylglycine. An affinity label for neutral endopeptidase 24.11 J Biol Chem (1990) 265, 8365-8368. PubMed Europe PubMed I
Llorens-Cortes,C., Giros,B. and Schwartz,J.C. A novel potential metallopeptidase derived from the enkephalinase gene by alternative splicing J Neurochem (1990) 55, 2146-2148. PubMed Europe PubMed DOI
Roques,B.P. and Beaumont,A. Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives? Trends Pharmacol Sci (1990) 11, 245-249. PubMed Europe PubMed DOI V I
Vijayaraghavan,J., Scicli,A.G., Carretero,O.A., Slaughter,C., Moomaw,C. and Hersh,L.B. The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase) J Biol Chem (1990) 265, 14150-14155. PubMed Europe PubMed

1989

[YEAR:1-1-1989]Barker,P.E., Shipp,M.A., D'Adamio,L., Masteller,E.L. and Reinherz,E.L. The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3 (q21-q27) J Immunol (1-1-1989) 142, 283-287. PubMed Europe PubMed
Bateman,R.C., Jr., Jackson,D., Slaughter,C.A., Unnithan,S., Chai,Y.G., Moomaw,C. and Hersh,L.B. Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant J Biol Chem (1989) 264, 6151-6157. PubMed Europe PubMed
D'Adamio,L., Shipp,M.A., Masteller,E.L. and Reinherz,E.L. Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions Proc Natl Acad Sci U S A (1989) 86, 7103-7107. PubMed Europe PubMed PMC EPMC
Erdos,E.G. and Skidgel,R.A. Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones FASEB J (1989) 3, 145-151. PubMed Europe PubMed
Monod,L., Diserens,A.C., Jongeneel,C.V., Carrel,S., Ronco,P., Verroust,P. and de Tribolet,N. Human glioma cell lines expressing the common acute lymphoblastic leukemia antigen (cALLa) have neutral endopeptidase activity Int J Cancer (1989) 44, 948-951. PubMed Europe PubMed DOI
Pauwels,S., Najdovski,T., Dimaline,R., Lee,C.M. and Deschodt-Lanckman,M. Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides Biochim Biophys Acta (1989) 996, 82-88. PubMed Europe PubMed

1988

Godeau,G. and Hornebeck,W. Morphometric analysis of the degradation of human skin elastic fibres by human leukocyte elastase (EC 3-4-21-37) and human skin fibroblast elastase (EC 3-4-24) Pathol Biol (Paris) (1988) 36, 1133-1138. PubMed Europe PubMed
Homsy,R., Pelletier-Lebon,P., Tixier,J.M., Godeau,G., Robert,L. and Hornebeck,W. Characterization of human skin fibroblasts elastase activity J Invest Dermatol (1988) 91, 472-477. PubMed Europe PubMed
Letarte,M., Vera,S., Tran,R., Addis,J.B., Onizuka,R.J., Quackenbush,E.J., Jongeneel,C.V. and McInnes,R.R. Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase J Exp Med (1988) 168, 1247-1253. PubMed Europe PubMed PMC EPMC
Vanneste,Y., Michel,A., Dimaline,R., Najdovski,T. and Deschodt-Lanckman,M. Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site Biochem J (1988) 254, 531-537. PubMed Europe PubMed PMC EPMC

1987

Devault,A., Lazure,C., Nault,C., Le Moual,H., Seidah,N.G., Chretien,M., Kahn,P., Powell,J., Mallet,J. and Beaumont,A. Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA EMBO J (1987) 6, 1317-1322. PubMed Europe PubMed PMC EPMC
Malfroy,B., Schofield,P.R., Kuang,W.J., Seeburg,P.H., Mason,A.J. and Henzel,W.J. Molecular cloning and amino acid sequence of rat enkephalinase Biochem Biophys Res Commun (1987) 144, 59-66. PubMed Europe PubMed
Ura,N., Carretero,O.A. and Erdos,E.G. Role of renal endopeptidase 24.11 in kinin metabolism in vitro and in vivo Kidney Int (1987) 32, 507-513. PubMed Europe PubMed

1986

Fulcher,I.S., Pappin,D.J. and Kenny,A.J. The N-terminal amino acid sequence of pig kidney endopeptidase- 24.11 shows homology with pro-sucrase-isomaltase Biochem J (1986) 240, 305-308. PubMed Europe PubMed PMC EPMC
Hersh,L.B. and Morihara,K. Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin J Biol Chem (1986) 261, 6433-6437. PubMed Europe PubMed P
Waksman,G., Hamel,E., Fournie-Zaluski,M.C. and Roques,B.P. Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain Proc Natl Acad Sci U S A (1986) 83, 1523-1527. PubMed Europe PubMed PMC EPMC I

1985

Connelly,J.C., Skidgel,R.A., Schulz,W.W., Johnson,A.R. and Erdos,E.G. Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide Proc Natl Acad Sci U S A (1985) 82, 8737-8741. PubMed Europe PubMed PMC EPMC
Waksman,G., Bouboutou,R., Chaillet,P., Devin,J., Coulaud,A., Hamel,E., Besselievre,R., Costentin,J., Fournie-Zaluski,M.C. and Roques,B.P. Kelatorphan: a full inhibitor of enkephalin degrading enzymes. Biochemical and pharmacological properties, regional distribution of enkephalinase in rat brain by use of a tritiated derivative Neuropeptides (1985) 5, 529-532. PubMed Europe PubMed I

1984

Florentin,D., Sassi,A. and Roques,B.P. A highly sensitive fluorometric assay for "enkephalinase," a neutral metalloendopeptidase that releases tyrosine-glycine-glycine from enkephalins Anal Biochem (1984) 141, 62-69. PubMed Europe PubMed A
Fournie-Zaluski,M.C., Chaillet,P., Bouboutou,R., Coulaud,A., Cherot,P., Waksman,G., Costentin,J. and Roques,B.P. Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes Eur J Pharmacol (1984) 102, 525-528. PubMed Europe PubMed I
[YEAR:1-3-1984]Fournie-Zaluski,M.C., Lucas,E., Waksman,G. and Roques,B.P. Differences in the structural requirements for selective interaction with neutral metalloendopeptidase (enkephalinase) or angiotensin-converting enzyme. Molecular investigation by use of new thiol inhibitors Eur J Biochem (1-3-1984) 139, 267-274. PubMed Europe PubMed I
Hersh,L.B. Reaction of opioid peptides with neutral endopeptidase ("enkephalinase") J Neurochem (1984) 43, 487-493. PubMed Europe PubMed
Szendroi,M., Meimon,G., Bakala,H., Frances,C., Robert,L., Godeau,G. and Hornebeck,W. On the presence of a metalloprotease in human skin fibroblasts that degrades the human skin elastic fiber system J Invest Dermatol (1984) 83, 224-229. PubMed Europe PubMed

1983

Almenoff,J. and Orlowski,M. Membrane-bound kidney neutral metalloendopeptidase: interaction with synthetic substrates, natural peptides, and inhibitors Biochemistry (1983) 22, 590-599. PubMed Europe PubMed I
[YEAR:1-6-1983]Fulcher,I.S. and Kenny,A.J. Proteins of the kidney microvillar membrane. The amphipathic forms of endopeptidase purified from pig kidneys Biochem J (1-6-1983) 211, 743-753. PubMed Europe PubMed PMC EPMC
[YEAR:21-6-1983]Gafford,J.T., Skidgel,R.A., Erdos,E.G. and Hersh,L.B. Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides Biochemistry (21-6-1983) 22, 3265-3271. PubMed Europe PubMed
Gordon,E.M., Cushman,D.W., Tung,R., Cheung,H.S., Wang,F.L. and Delaney,N.G. Rat brain enkephalinase: characterization of the active site using mercaptopropanoyl amino acid inhibitors, and comparison with angiotensin-converting enzyme Life Sci (1983) 33 Suppl 1, 113-116. PubMed Europe PubMed DOI
Matsas,R., Fulcher,I.S., Kenny,A.J. and Turner,A.J. Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli Proc Natl Acad Sci U S A (1983) 80, 3111-3115. PubMed Europe PubMed PMC EPMC
[YEAR:1-12-1983]Relton,J.M., Gee,N.S., Matsas,R., Turner,A.J. and Kenny,A.J. Purification of endopeptidase-24.11 ('enkephalinase') from pig brain by immunoadsorbent chromatography Biochem J (1-12-1983) 215, 519-523. PubMed Europe PubMed PMC EPMC

1982

[YEAR:27-12-1982]Fournie-Zaluski,M.C., Soroca-Lucas,E., Waksman,G., Llorens,C., Schwartz,J.C. and Roques,B.P. Differential recognition of "enkephalinase" and angiotensin-converting enzyme by new carboxyalkyl inhibitors Life Sci (27-12-1982) 31, 2947-2954. PubMed Europe PubMed DOI I
Fulcher,I.S., Matsas,R., Turner,A.J. and Kenny,A.J. Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors Biochem J (1982) 203, 519-522. PubMed Europe PubMed PMC EPMC I
Hersh,L.B. Degradation of enkephalins: the search for an enkephalinase Mol Cell Biochem (1982) 47, 35-43. PubMed Europe PubMed

1981

Orlowski,M. and Wilk,S. Purification and specificity of a membrane-bound metalloendopeptidase from bovine pituitaries Biochemistry (1981) 20, 4942-4950. PubMed Europe PubMed

1980

Danielsen,E.M., Vyas,J.P. and Kenny,A.J. A neutral endopeptidase in the microvillar membrane of pig intestine. Partial purification and properties Biochem J (1980) 191, 645-648. PubMed Europe PubMed PMC EPMC
[YEAR:20-11-1980]Roques,B.P., Fournie-Zaluski,M.C., Soroca,E., Lecomte,J.M., Malfroy,B., Llorens,C. and Schwartz,J.C. The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice Nature (20-11-1980) 288, 286-288. PubMed Europe PubMed DOI I

1979

[YEAR:1-8-1979]Swerts,J.P., Perdrisot,R., Patey,G., De la Baume,S. and Schwartz,J.C. 'Enkephalinase' is distinct from brain 'angiotensin-converting enzyme' Eur J Pharmacol (1-8-1979) 57, 279-281. PubMed Europe PubMed

1978

[YEAR:30-11-1978]Malfroy,B., Swerts,J.P., Guyon,A., Roques,B.P. and Schwartz,J.C. High-affinity enkephalin-degrading peptidase in brain is increased after morphine Nature (30-11-1978) 276, 523-526. PubMed Europe PubMed I

1974

Kerr,M.A. and Kenny,A.J. The molecular weight and properties of a neutral metallo-endopeptidase from rabbit kidney brush border Biochem J (1974) 137, 489-495. PubMed Europe PubMed PMC EPMC I
Kerr,M.A. and Kenny,A.J. The purification and specificity of a neutral endopeptidase from rabbit kidney brush border Biochem J (1974) 137, 477-488. PubMed Europe PubMed PMC EPMC

1968

Wong-Leung,Y.L., George,S.G., Aparicio,S.G. and Kenny,A.J. The intracellular localization of some particulate peptidases in the kidney of the rat and the rabbit Biochem J (1968) 110, 5P-6P. PubMed Europe PubMed PMC EPMC