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Literature for peptidase M13.001: neprilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Esser,N., Mongovin,S.M., Barrow,B.M. and Zraika,S.
    Gut-specific Neprilysin Deletion Protects Against Fat-induced Insulin Secretory Dysfunction in Male Mice
    Endocrinology165, PubMed  Europe PubMed DOI
  2. Hakata,T., Ueda,Y., Yamashita,T., Yamauchi,I., Kosugi,D., Sugawa,T., Fujita,H., Okamoto,K., Fujii,T., Taura,D., Yasoda,A., Akiyama,H. and Inagaki,N.
    Neprilysin inhibition promotes skeletal growth via the CNP/NPR-B pathway
    Endocrinology165, bqae058-bqae058. PubMed  Europe PubMed DOI
  3. Mizutani,S., Mizutani,H., Mizutani,E., Arita,H. and Kajiyama,H.
    The Fate of Angiotensin II in Placental Tissue and Blood
    Horm Metab Res56, 477-481. PubMed  Europe PubMed DOI
  4. Shigematsu,K., Komori,N., Ideno,M. and Yamagishi,H.
    "Evaluation of neprilysin activity in Adipose-Derived stem cells from Alzheimer's disease patients"
    Neurosci Lett825, 137705-137705. PubMed  Europe PubMed DOI
  5. Thakur,S., Sinhari,A., Gaikwad,A.B. and Jadhav,H.R.
    A structure-based pharmacophore modelling approach to identify and design new neprilysin (NEP) inhibitors: An in silico-based investigation
    Arch Biochem Biophys756, 110019-110019. PubMed  Europe PubMed DOI
  6. Zhang,X., Hu,C., Tian,E., Shen,Y., Liu,W. and Li,J.
    Comprehensive review on neprilysin (NEP) inhibitors: design, structure-activity relationships, and clinical applications
    Front Pharmacol15, 1501407-1501407. PubMed  Europe PubMed DOI  I
  7. Zukowska,J., Moss,S.J., Subramanian,V. and Acharya,K.R.
    Molecular basis of selective amyloid-beta degrading enzymes in Alzheimer's disease
    FEBS J291, 2999-3029. PubMed  Europe PubMed DOI  V
    8. 2023
  8. Ding,J., Li,C., Shu,K., Chen,W., Cai,C., Zhang,X. and Zhang,W.
    Membrane metalloendopeptidase (MME) is positively correlated with systemic lupus erythematosus and may inhibit the occurrence of breast cancer
    PLoS ONE18, e0289960-e0289960. PubMed  Europe PubMed DOI
  9. Esser,N., Mundinger,T.O., Barrow,B.M. and Zraika,S.
    Acute Inhibition of Intestinal Neprilysin Enhances Insulin Secretion via GLP-1 Receptor Signaling in Male Mice
    Endocrinology164, PubMed  Europe PubMed DOI  I
  10. Rowland,H.A., Moxon,S.R., Corbett,N.J., Hanson,K., Fisher,K., Kellett,K.A.B. and Hooper,N.M.
    Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-beta deposition
    Neuronal Signal7, NS20230016-NS20230016. PubMed  Europe PubMed DOI
    11. 2022
  11. Kawabata,H., Suzuki,H., Takei,J., Kaneko,M.K. and Kato,Y.
    Epitope Mapping of an Anti-CD10 Monoclonal Antibody (MME/1870) Using Enzyme-Linked Immunosorbent Assay
    Monoclon Antib Immunodiagn Immunother41, 15-19. PubMed  Europe PubMed DOI
  12. Kawabata,H., Suzuki,H., Ohishi,T., Kawada,M., Kaneko,M.K. and Kato,Y.
    A Defucosylated Mouse Anti-CD10 Monoclonal Antibody (31-mG2a-f) Exerts Antitumor Activity in a Mouse Xenograft Model of CD10-Overexpressed Tumors
    Monoclon Antib Immunodiagn Immunother41, 59-66. PubMed  Europe PubMed DOI
  13. Nakagawa,H. and Saito,Y.
    Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases
    Biology (Basel)11, PubMed  Europe PubMed DOI
  14. Schiemann,R., Buhr,A., Cordes,E., Walter,S., Heinisch,J.J., Ferrero,P., Milting,H., Paululat,A. and Meyer,H.
    Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides
    Nat Commun13, 4420-4420. PubMed  Europe PubMed DOI
    15. 2021
  15. Alves-Lopes,R., Montezano,A.C., Neves,K.B., Harvey,A., Rios,F.J., Skiba,D.S., Arendse,L.B., Guzik,T.J., Graham,D., Poglitsch,M., Sturrock,E. and Touyz,R.M.
    Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension
    Hypertension78, 604-616. PubMed  Europe PubMed DOI
  16. Arfsten,H., Goliasch,G., Bartko,P.E., Prausmuller,S., Spinka,G., Cho,A., Novak,J., Haslacher,H., Strunk,G., Struck,J., Hulsmann,M. and Pavo,N.
    Increased concentrations of bioactive adrenomedullin subsequently to angiotensin-receptor/neprilysin-inhibitor treatment in chronic systolic heart failure
    Br J Clin Pharmacol87, 916-924. PubMed  Europe PubMed DOI  I
  17. Gjorgova-Gjeorgjievski,S., Fritchie,K. and Folpe,A.L.
    CD10 (Neprilysin) Expression: A Potential Adjunct in the Distinction of Hibernoma from Morphologic Mimics
    Hum Pathol PubMed  Europe PubMed DOI
  18. Nemcekova,V., Malikova,E., Goncalvesova,E., Krenek,P. and Klimas,J.
    Altered serum levels of neprilysin in heart failure patients with reduced ejection fraction
    Bratisl Lek Listy122, 28-33. PubMed  Europe PubMed DOI
  19. Polina,I., Spicer,M.J., Domondon,M., Schibalski,R.S., Sarsenova,E., Sultanova,R.F. and Ilatovskaya,D.V.
    Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats
    Ren Fail43, 315-324. PubMed  Europe PubMed DOI  I
  20. Poorgolizadeh,E., Homayouni Moghadam,F., Dormiani,K., Rezaei,N. and Nasr-Esfahani,M.H.
    Do neprilysin inhibitors walk the line? Heart ameliorative but brain threatening!
    Eur J Pharmacol894, 173851-173851. PubMed  Europe PubMed DOI  I
  21. Rofo,F., Ugur Yilmaz,C., Metzendorf,N., Gustavsson,T., Beretta,C., Erlandsson,A., Sehlin,D., Syvanen,S., Nilsson,P. and Hultqvist,G.
    Enhanced neprilysin-mediated degradation of hippocampal Abeta42 with a somatostatin peptide that enters the brain
    Theranostics11, 789-804. PubMed  Europe PubMed DOI
  22. Sankhe,R., Rathi,E., Manandhar,S., Kumar,A., Pai,S.R.K., Kini,S.G. and Kishore,A.
    Repurposing of existing FDA approved drugs for Neprilysin inhibition: An in-silico study
    J Mol Struct1224, 129073-129073. PubMed  Europe PubMed DOI
    23. 2020
  23. Abdulsalam,T.M., Hasanin,A.H., Mohamed,R.H. and El Sayed Badawy,A.
    Angiotensin receptor-neprilysin inhibitior (thiorphan/irbesartan) decreased ischemia-reperfusion induced ventricular arrhythmias in rat; in vivo study
    Eur J Pharmacol882, 173295-173295. PubMed  Europe PubMed DOI  I
  24. Balazki,P., Schaller,S., Eissing,T. and Lehr,T.
    A Physiologically-Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP-1 and GIP and the DPP4 Inhibitor Sitagliptin
    CPT Pharmacometrics Syst Pharmacol9, 353-362. PubMed  Europe PubMed DOI  I
  25. Bellis,A., Mauro,C., Barbato,E., Trimarco,B. and Morisco,C.
    The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V  I
  26. Bendre,S., Zhang,Z., Kuo,H.T., Rousseau,J., Zhang,C., Merkens,H., Roxin,A., Benard,F. and Lin,K.S.
    Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of (68)Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics
    Molecules25, PubMed  Europe PubMed DOI
  27. Bernardi,M.H., Wagner,L., Ryz,S., Puchinger,J., Nixdorf,L., Edlinger-Stanger,M., Geilen,J., Kainz,M., Hiesmayr,M.J. and Lassnigg,A.
    Urinary neprilysin for early detection of acute kidney injury after cardiac surgery: A prospective observational study
    Eur J Anaesthesiol PubMed  Europe PubMed DOI
  28. Campos,C.R., Kemble,A.M., Niewoehner,J., Freskgard,P.O. and Urich,E.
    Brain shuttle neprilysin reduces central amyloid-beta levels
    PLoS ONE15, e0229850-e0229850. PubMed  Europe PubMed DOI  U
  29. Chatterjee,P., Gheblawi,M., Wang,K., Vu,J., Kondaiah,P. and Oudit,G.Y.
    Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications
    Clin Sci (Lond)134, 2319-2336. PubMed  Europe PubMed DOI  V
  30. Chen,H.H. and Burnett,J.C., Jr.
    Neprilysin in HFrEF: Differential Regulation of Tissue Versus Circulating Neprilysin
    JACC Basic Transl Sci5, 727-729. PubMed  Europe PubMed DOI
  31. Chen,S., Mima,D., Jin,H., Dan,Q., Wang,F., Cai,J., Shi,L., Wang,H., Du,A., Tang,Y. and Sun,Y.
    The Association between Neprilysin gene polymorphisms and Alzheimer's disease in Tibetan population
    Brain Behave02002-e02002. PubMed  Europe PubMed DOI
  32. Choi,I.J., Lim,S., Hwang,Y., Lee,D., Lee,W.J., Lee,K.Y., Kim,M.J. and Jeon,D.S.
    Soluble neprilysin and long-term clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: a retrospective cohort study
    BMC Cardiovasc Disord20, 360-360. PubMed  Europe PubMed DOI
  33. Cuthbert,J.J., Pellicori,P. and Clark,A.L.
    Cardiovascular Outcomes with Sacubitril-Valsartan in Heart Failure: Emerging Clinical Data
    Ther Clin Risk Manag16, 715-726. PubMed  Europe PubMed DOI  V  I
  34. Dani,S.S., Ganatra,S. and Vaduganathan,M.
    Angioedema with sacubitril/valsartan: Trial-level meta-analysis of over 14,000 patients and real-world evidence to date
    Int J Cardiol PubMed  Europe PubMed DOI  I
  35. Docherty,K.F., Campbell,R.T., Brooksbank,K.J.M., Godeseth,R.L., Forsyth,P., McConnachie,A., Roditi,G., Stanley,B., Welsh,P., Jhund,P.S., Petrie,M.C. and McMurray,J.J.V.
    Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling
    ESC Heart Fail PubMed  Europe PubMed DOI  I
  36. Esch,T., Kream,R.M. and Stefano,G.B.
    Emerging regulatory roles of opioid peptides, endogenous morphine, and opioid receptor subtypes in immunomodulatory processes: Metabolic, behavioral, and evolutionary perspectives
    Immunol Lett227, 28-33. PubMed  Europe PubMed DOI  V
  37. Galo,J., Celli,D. and Colombo,R.
    Effect of Sacubitril/Valsartan on Neurocognitive Function: Current Status and Future Directions
    Am J Cardiovasc Drugs PubMed  Europe PubMed DOI  I
  38. Gommans,D.H.F., Revuelta-Lopez,E., Lupon,J., Cserkoova,A., Domingo,M., Vart,P., van Royen,N., Bayes-Genis,A. and van Kimmenade,R.R.J.
    Soluble Neprilysin and Corin Concentrations in Relation to Clinical Outcome in Chronic Heart Failure
    JACC Heart Fail PubMed  Europe PubMed DOI
  39. Graykowski,D., Kasparian,K., Caniglia,J., Gritsaeva,Y. and Cudaback,E.
    Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin
    J Neuroimmunol346, 577315-577315. PubMed  Europe PubMed DOI
  40. Gregoriou,G.C., Patel,S.D., Winters,B.L. and Bagley,E.E.
    Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala
    Mol Pharmacol PubMed  Europe PubMed DOI  I
  41. Gruson,D., Fillee,C. and Pouleur,A.C.
    Reply to "Effect of Neprilysin Inhibition on Various Natriuretic Peptide Assays"
    Clin Lab66, PubMed  Europe PubMed DOI
  42. Izadpanah,M., Dargahi,L., Ai,J., Asgari Taei,A., Ebrahimi Barough,S., Mowla,S.J., TavoosiDana,G. and Farahmandfar,M.
    Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer's Disease
    Iran J Pharm Res19, 45-60. PubMed  Europe PubMed DOI
  43. Kanuka,M., Ouchi,F., Kato,N., Katsuki,R., Ito,S., Miura,K., Hikida,M. and Tamura,T.
    Endoplasmic Reticulum Associated Degradation of Spinocerebellar Ataxia-Related CD10 Cysteine Mutant
    Int J Mol Sci21, PubMed  Europe PubMed DOI
  44. Kato,J.
    Natriuretic peptides and neprilysin inhibition in hypertension and hypertensive organ damage
    Peptides132, 170352-170352. PubMed  Europe PubMed DOI  V
  45. Kawanami,T., Karki,R.G., Cody,E., Liu,Q., Liang,G., Ksander,G.M., Rigel,D.F., Schiering,N., Gong,Y., Coppola,G.M., Iwaki,Y., Sun,R., Neubert,A., Fan,L., Ingles,S., D'arcy,A., Villard,F., Ramage,P., Jeng,A.Y., Leung-Chu,J., Liu,J., Beil,M., Fu,F., Chen,W., Cumin,F., Wiesmann,C. and Mogi,M.
    Structure-guided design of substituted biphenyl butanoic acid derivatives as neprilysin inhibitors
    ACS Med Chem Lett11, 188-194. PubMed  Europe PubMed DOI  S  I
  46. Kim,N. and Lee,H.J.
    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
    Biomed Res Int2020, 2010728-2010728. PubMed  Europe PubMed DOI  V
  47. Kuwajima,Y., Nagai,M.S., Lee,C., Galaburda,A.M., Kobayashi,T., Nakasato,A., Da Silva,J.D., Nagai,S.I. and Nagai,M.
    Trans-trigeminal transport of masseter-derived neprilysin to hippocampus
    Arch Oral Biol118, 104861-104861. PubMed  Europe PubMed DOI
  48. Li,B., Li,N., Guo,S., Zhang,M., Li,J., Zhai,N., Wang,H. and Zhang,Y.
    The changing features of serum adropin, copeptin, neprilysin and chitotriosidase which are associated with vascular endothelial function in type 2 diabetic retinopathy patients
    J Diabetes Complications107686-107686. PubMed  Europe PubMed DOI
  49. Li,Y., Wang,Y., Wang,J., Chong,K.Y., Xu,J., Liu,Z. and Shan,C.
    Expression of neprilysin in skeletal muscle by ultrasound-mediated gene transfer (sonoporation) reduces amyloid burden for AD
    Mol Ther Methods Clin Dev17, 300-308. PubMed  Europe PubMed DOI  U
  50. Lyle,M.A., Iyer,S.R., Redfield,M.M., Reddy,Y.N.V., Felker,G.M., Cappola,T.P., Hernandez,A.F., Scott,C.G., Burnett JC Jr and Pereira,N.L.
    Circulating neprilysin in patients with heart failure and preserved ejection fraction
    JACC Heart Fail8, 70-80. PubMed  Europe PubMed DOI
  51. Manolis,A.S., Manolis,T.A., Manolis,A.A. and Melita,H.
    The Controversy of Renin-Angiotensin-System Blocker Facilitation Versus Countering COVID-19 Infection
    J Cardiovasc Pharmacol PubMed  Europe PubMed DOI
  52. Moss,S., Subramanian,V. and Acharya,K.R.
    Crystal structure of peptide-bound neprilysin reveals key binding interactions
    FEBS Lett594, 327-336. PubMed  Europe PubMed DOI  P  S
  53. Pavo,I.J., Pavo,N., Kastner,N., Traxler,D., Lukovic,D., Zlabinger,K., Spannbauer,A., Riesenhuber,M., Lorant,D., Bartko,P.E., Goliasch,G., Hulsmann,M., Winkler,J. and Gyongyosi,M.
    Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation
    JACC Basic Transl Sci5, 715-726. PubMed  Europe PubMed DOI
  54. Pavo,N., Prausmuller,S., Bartko,P.E., Goliasch,G. and Hulsmann,M.
    Neprilysin as a Biomarker: Challenges and Opportunities
    Card Fail Rev6, e23-e23. PubMed  Europe PubMed DOI
  55. Promyo,K., Iqbal,F., Chaidee,N. and Chetsawang,B.
    Aluminum chloride-induced amyloid beta accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin
    Food Chem Toxicol146, 111829-111829. PubMed  Europe PubMed DOI  I
  56. Salazar,J., Rojas-Quintero,J., Cano,C., Perez,J.L., Ramirez,P., Carrasquero,R., Torres,W., Espinoza,C., Chacin-Gonzalez,M. and Bermudez,V.
    Neprilysin: a potential therapeutic target of arterial hypertension?
    Curr Cardiol Rev16, 25-35. PubMed  Europe PubMed DOI  I
  57. Salman,A.A., Salman,M.A., Shawkat,M., Hassan,S.A., Saad,E.H., Hussein,A.M., Refaie,O.R.M., Tourky,M.S., Shaaban,H.E., Abd Allah,N., El Domiaty,H.F. and Elkassar,H.
    Effect of Laparoscopic Sleeve Gastrectomy on Vasoactive Mediators in Obese Hypertensive Patients: A Prospective Study
    Clin Endocrinol (Oxf) PubMed  Europe PubMed DOI
  58. Sanchez-Aguilar,M., Ibarra-Lara,L., Del Valle-Mondragon,L., Soria-Castro,E., Torres-Narvaez,J.C., Carreon-Torres,E., Sanchez-Mendoza,A. and Rubio-Ruiz,M.E.
    Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model
    PPAR Res2020, 8894525-8894525. PubMed  Europe PubMed DOI
  59. Sankhe,R., Kinra,M., Mudgal,J., Arora,D. and Nampoothiri,M.
    Neprilysin, the kidney brush border neutral proteinase: a possible potential target for ischemic renal injury
    Toxicol Mech Methods30, 88-99. PubMed  Europe PubMed DOI  V
  60. Sbolli,M. and deFilippi,C.
    BNP and NT-proBNP Interpretation in the Neprilysin Inhibitor Era
    Curr Cardiol Rep22, 150-150. PubMed  Europe PubMed DOI  V  I
  61. Sharma,U., Cozier,G.E., Sturrock,E.D. and Acharya,K.R.
    Molecular basis for omapatrilat and sampatrilat binding to neprilysin-implications for dual inhibitor design with angiotensin-converting enzyme
    J Med Chem63, 5488-5500. PubMed  Europe PubMed DOI  S  I
  62. Tamanna,S., Clifton,V.L., Rae,K., van Helden,D.F., Lumbers,E.R. and Pringle,K.G.
    Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age
    Front Physiol11, 590787-590787. PubMed  Europe PubMed DOI
  63. Teyssier,V.R., Simard,J.M., Dornan,M.H., Tournoux,F. and DaSilva,J.N.
    Radiosynthesis of the (11) C-methyl derivative of LBQ657 for PET investigation of the neprilysin inhibitor sacubitril
    J Labelled Comp Radiopharm63, 65-71. PubMed  Europe PubMed DOI  I
  64. Ugan,R.A., Un,H., Gurbuz,M.A., Kaya,G., Kahramanlar,A., Aksakalli-Magden,Z.B., Halici,Z. and Cadirci,E.
    Possible contribution of the neprilysin/ACE pathway to sepsis in mice
    Life Sci258, 118177-118177. PubMed  Europe PubMed DOI  I
  65. Verbrugge,F.H. and Borlaug,B.A.
    Getting the "Right" Perspective on Angiotensin Receptor-Neprilysin Inhibition in Heart Failure
    J Am Heart Assoc9, e017292-e017292. PubMed  Europe PubMed DOI
  66. Wisniowska-Smialek,S., Dziewiecka,E., Holcman,K., Podolec,P., Wypasek,E. and Rubis,P.
    Comparison of 12-month kinetics of serum markers of fibrosis between treatment with angiotensin receptor neprilysin inhibitor (ARNI) and angiotensin converting enzyme inhibitor (ACE-I) in patients with heart failure with reduced ejection fraction
    Pol Arch Intern Med130, 1017-1020. PubMed  Europe PubMed DOI  I
  67. Wu,S., Zhang,J., Jiang,C., Wang,S., Que,R. and An,L.
    Up-regulation of neprilysin mediates the protection of fructo-oligosaccharides against Alzheimer's disease
    Food Funct11, 6565-6572. PubMed  Europe PubMed DOI
    68. 2019
  68. Bossak-Ahmad,K., Mital,M., Plonka,D., Drew,S.C. and Bal,W.
    Oligopeptides generated by neprilysin degradation of beta-amyloid have the highest Cu(II) affinity in the whole Abeta family
    Inorg Chem58, 932-943. PubMed  Europe PubMed DOI
  69. Cervellini,I., Galino,J., Zhu,N., Fricker,F.R., Bao,L. and Bennett,D.L.H.
    Membrane metallo-endopeptidase is dispensable for repair after nerve injury
    Glia67, 1990-2000. PubMed  Europe PubMed DOI  K
  70. Esser,N. and Zraika,S.
    Neprilysin inhibition: a new therapeutic option for type 2 diabetes?
    Diabetologia62, 1113-1122. PubMed  Europe PubMed DOI  I
  71. Feygina,E.E., Katrukha,A.G. and Semenov,A.G.
    Neutral endopeptidase (neprilysin) in therapy and diagnostics: yin and yang
    Biochemistry (Mosc)84, 1346-1358. PubMed  Europe PubMed DOI  T
  72. Hornung,K., Zampar,S., Engel,N., Klafki,H., Liepold,T., Bayer,T.A., Wiltfang,J., Jahn,O. and Wirths,O.
    N-Terminal truncated Abeta4-42 is a substrate for neprilysin degradation in vitro and in vivo
    J Alzheimers Dis67, 849-858. PubMed  Europe PubMed DOI
  73. Labiuk,S.L., Sygusch,J. and Grochulski,P.
    Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan
    Acta Crystallogr F Struct Biol Commun75, 405-411. PubMed  Europe PubMed DOI  S  I
  74. Leite,J.P. and Gales,L.
    Alzheimer's Abeta1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Abeta product
    FEBS Lett593, 128-137. PubMed  Europe PubMed DOI
  75. McKinnell,R.M., Fatheree,P., Choi,S.K., Gendron,R., Jendza,K., Olson Blair,B., Budman,J., Hill,C.M., Hegde,L.G., Yu,C., McConn,D., Hegde,S.S., Marquess,D.G. and Klein,U.
    Discovery of TD-0212, an orally active dual pharmacology AT1 antagonist and neprilysin inhibitor (ARNI)
    ACS Med Chem Lett10, 86-91. PubMed  Europe PubMed DOI  I
  76. Mizerska-Kowalska,M., Kreczko-Kurzawa,J., Zdzisinska,B., Czerwonka,A., Slawinska-Brych,A., Mackiewicz,Z., Nidzworski,D. and Kandefer-Szerszen,M.
    Neutral endopeptidase (NEP) inhibitors - thiorphan, sialorphin, and its derivatives exert anti-proliferative activity towards colorectal cancer cells in vitro
    Chem Biol Interact307, 105-115. PubMed  Europe PubMed DOI  U  I
  77. Ramirez,A.K., Dankel,S., Cai,W., Sakaguchi,M., Kasif,S. and Kahn,C.R.
    Membrane metallo-endopeptidase (neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes
    Mol Metab22, 21-36. PubMed  Europe PubMed DOI
  78. Reddy,Y.N.V., Iyer,S.R., Scott,C.G., Rodeheffer,R.J., Bailey,K., Jenkins,G., Batzler,A., Redfield,M.M., Burnett JC Jr and Pereira,N.L.
    Soluble neprilysin in the general population: clinical determinants and its relationship to cardiovascular disease
    J Am Heart Assoc8, e012943-e012943. PubMed  Europe PubMed DOI
  79. Richards,A.M., Pemberton,C. and Yandle,T.
    How does neprilysin inhibition in heart failure work?
    Eur J Heart Fail21, 606-608. PubMed  Europe PubMed DOI
  80. Sobocinska,M., Gieldon,A., Fichna,J. and Kamysz,E.
    1-Substituted sialorphin analogues - synthesis, molecular modelling and in vitro effect on enkephalins degradation by NEP
    Amino Acids51, 1201-1207. PubMed  Europe PubMed DOI  I
  81. Wang,W., Shen,M., Fischer,C., Basu,R., Hazra,S., Couvineau,P., Paul,M., Wang,F., Toth,S., Mix,D.S., Poglitsch,M., Gerard,N.P., Bouvier,M., Vederas,J.C., Penninger,J.M., Kassiri,Z. and Oudit,G.Y.
    Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs
    Proc Natl Acad Sci U S A116, 13006-13015. PubMed  Europe PubMed DOI
    82. 2018
  82. Becker,M., Moore,A., Naughton,M., Boland,B., Siems,W.E. and Walther,T.
    Neprilysin degrades murine amyloid-beta (Abeta) more efficiently than human Abeta: further implication for species-specific amyloid accumulation
    Neurosci Lett686, 74-79. PubMed  Europe PubMed DOI  P
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