Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P06307

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	unknown peptidase	1-115	P	release of a signal peptide	MS
44	unknown peptidase	1-115	P		NT	<%Agarwal et al., 2012[]%>
81	CYM1 peptidase (Saccharomyces cerevisiae)	21-115	N			Jonson et al., 2004
95	kexin	21-115	N			Rourke et al., 1997
96	aminopeptidase A	96-103	N			Migaud etal, 1996
96	aminopeptidase Ey	96-103	N			Ichishima, 2004
97	aminopeptidase Ey	97-103	N			Ichishima, 2004
98	aminopeptidase Ey	98-103	N			Ichishima, 2004
98	tripeptidyl-peptidase II	96-103	P			Wilson &etal, 1993
99	aminopeptidase Ey	99-103	N			Ichishima, 2004
99	neprilysin-2	96-103	N		NT	Rose et al., 2002
99	beta-lytic metallopeptidase	96-103	N			Ahmed et al., 2003
100	dipeptidyl-peptidase I	99-103	P		MS	Bernardini & Warburton, 2002
100	aminopeptidase Ey	100-103	N			Ichishima, 2004
100	meprin alpha subunit	96-103	P			Bertenshaw et al., 2001
100	meprin beta subunit	96-103	N			Bertenshaw et al., 2001
100	neprilysin	96-103	P			Turner, 2004
100	unknown peptidase	96-103	N			Corvol et al., 2004
100	unknown peptidase	96-103	N			Bertenshaw et al., 2001
101	meprin alpha subunit	21-115	N			Bylander et al., 2007
101	tripeptidyl-peptidase I	99-103	P		MS	Bernardini & Warburton, 2002
102	meprin alpha subunit	96-103	P			Bertenshaw et al., 2001
102	neprilysin	96-103	N			Turner, 2004
102	family S10 unassigned peptidases	100-103	N		NT	Umetsu et al., 1998
102	unknown peptidase	96-103	N			Bertenshaw et al., 2001
103	calpain-1	96-103	N			McDermott et al., 1985
104	angiotensin-converting enzyme peptidase unit 1	21-115	P		MS	Isaac et al., 1997
104	carboxypeptidase E	96-105	P			Beinfeld, 2002
105	carboxypeptidase E	96-105	P			Beinfeld, 2002
106	kexin	21-115	N			Rourke et al., 1997